KEGG   Cavia porcellus (domestic guinea pig): 100729394
Entry
100729394         CDS       T07777                                 
Symbol
Plcb4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cpoc  Cavia porcellus (domestic guinea pig)
Pathway
cpoc00562  Inositol phosphate metabolism
cpoc01100  Metabolic pathways
cpoc04015  Rap1 signaling pathway
cpoc04020  Calcium signaling pathway
cpoc04022  cGMP-PKG signaling pathway
cpoc04062  Chemokine signaling pathway
cpoc04070  Phosphatidylinositol signaling system
cpoc04071  Sphingolipid signaling pathway
cpoc04072  Phospholipase D signaling pathway
cpoc04081  Hormone signaling
cpoc04082  Neuroactive ligand signaling
cpoc04261  Adrenergic signaling in cardiomyocytes
cpoc04270  Vascular smooth muscle contraction
cpoc04310  Wnt signaling pathway
cpoc04371  Apelin signaling pathway
cpoc04540  Gap junction
cpoc04611  Platelet activation
cpoc04613  Neutrophil extracellular trap formation
cpoc04621  NOD-like receptor signaling pathway
cpoc04713  Circadian entrainment
cpoc04720  Long-term potentiation
cpoc04723  Retrograde endocannabinoid signaling
cpoc04724  Glutamatergic synapse
cpoc04725  Cholinergic synapse
cpoc04726  Serotonergic synapse
cpoc04728  Dopaminergic synapse
cpoc04730  Long-term depression
cpoc04742  Taste transduction
cpoc04750  Inflammatory mediator regulation of TRP channels
cpoc04911  Insulin secretion
cpoc04912  GnRH signaling pathway
cpoc04915  Estrogen signaling pathway
cpoc04916  Melanogenesis
cpoc04918  Thyroid hormone synthesis
cpoc04919  Thyroid hormone signaling pathway
cpoc04921  Oxytocin signaling pathway
cpoc04922  Glucagon signaling pathway
cpoc04924  Renin secretion
cpoc04925  Aldosterone synthesis and secretion
cpoc04926  Relaxin signaling pathway
cpoc04927  Cortisol synthesis and secretion
cpoc04928  Parathyroid hormone synthesis, secretion and action
cpoc04929  GnRH secretion
cpoc04933  AGE-RAGE signaling pathway in diabetic complications
cpoc04934  Cushing syndrome
cpoc04935  Growth hormone synthesis, secretion and action
cpoc04961  Endocrine and other factor-regulated calcium reabsorption
cpoc04970  Salivary secretion
cpoc04971  Gastric acid secretion
cpoc04972  Pancreatic secretion
cpoc04973  Carbohydrate digestion and absorption
cpoc05010  Alzheimer disease
cpoc05016  Huntington disease
cpoc05017  Spinocerebellar ataxia
cpoc05022  Pathways of neurodegeneration - multiple diseases
cpoc05142  Chagas disease
cpoc05143  African trypanosomiasis
cpoc05146  Amoebiasis
cpoc05163  Human cytomegalovirus infection
cpoc05200  Pathways in cancer
cpoc05415  Diabetic cardiomyopathy
cpoc05417  Lipid and atherosclerosis
Module
cpoc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cpoc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100729394 (Plcb4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100729394 (Plcb4)
   04310 Wnt signaling pathway
    100729394 (Plcb4)
   04371 Apelin signaling pathway
    100729394 (Plcb4)
   04020 Calcium signaling pathway
    100729394 (Plcb4)
   04070 Phosphatidylinositol signaling system
    100729394 (Plcb4)
   04072 Phospholipase D signaling pathway
    100729394 (Plcb4)
   04071 Sphingolipid signaling pathway
    100729394 (Plcb4)
   04022 cGMP-PKG signaling pathway
    100729394 (Plcb4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100729394 (Plcb4)
   04081 Hormone signaling
    100729394 (Plcb4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100729394 (Plcb4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100729394 (Plcb4)
   04613 Neutrophil extracellular trap formation
    100729394 (Plcb4)
   04621 NOD-like receptor signaling pathway
    100729394 (Plcb4)
   04062 Chemokine signaling pathway
    100729394 (Plcb4)
  09152 Endocrine system
   04911 Insulin secretion
    100729394 (Plcb4)
   04922 Glucagon signaling pathway
    100729394 (Plcb4)
   04929 GnRH secretion
    100729394 (Plcb4)
   04912 GnRH signaling pathway
    100729394 (Plcb4)
   04915 Estrogen signaling pathway
    100729394 (Plcb4)
   04921 Oxytocin signaling pathway
    100729394 (Plcb4)
   04926 Relaxin signaling pathway
    100729394 (Plcb4)
   04935 Growth hormone synthesis, secretion and action
    100729394 (Plcb4)
   04918 Thyroid hormone synthesis
    100729394 (Plcb4)
   04919 Thyroid hormone signaling pathway
    100729394 (Plcb4)
   04928 Parathyroid hormone synthesis, secretion and action
    100729394 (Plcb4)
   04916 Melanogenesis
    100729394 (Plcb4)
   04924 Renin secretion
    100729394 (Plcb4)
   04925 Aldosterone synthesis and secretion
    100729394 (Plcb4)
   04927 Cortisol synthesis and secretion
    100729394 (Plcb4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100729394 (Plcb4)
   04270 Vascular smooth muscle contraction
    100729394 (Plcb4)
  09154 Digestive system
   04970 Salivary secretion
    100729394 (Plcb4)
   04971 Gastric acid secretion
    100729394 (Plcb4)
   04972 Pancreatic secretion
    100729394 (Plcb4)
   04973 Carbohydrate digestion and absorption
    100729394 (Plcb4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100729394 (Plcb4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100729394 (Plcb4)
   04725 Cholinergic synapse
    100729394 (Plcb4)
   04728 Dopaminergic synapse
    100729394 (Plcb4)
   04726 Serotonergic synapse
    100729394 (Plcb4)
   04720 Long-term potentiation
    100729394 (Plcb4)
   04730 Long-term depression
    100729394 (Plcb4)
   04723 Retrograde endocannabinoid signaling
    100729394 (Plcb4)
  09157 Sensory system
   04742 Taste transduction
    100729394 (Plcb4)
   04750 Inflammatory mediator regulation of TRP channels
    100729394 (Plcb4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100729394 (Plcb4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100729394 (Plcb4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100729394 (Plcb4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100729394 (Plcb4)
   05142 Chagas disease
    100729394 (Plcb4)
   05143 African trypanosomiasis
    100729394 (Plcb4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100729394 (Plcb4)
   05016 Huntington disease
    100729394 (Plcb4)
   05017 Spinocerebellar ataxia
    100729394 (Plcb4)
   05022 Pathways of neurodegeneration - multiple diseases
    100729394 (Plcb4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100729394 (Plcb4)
   05415 Diabetic cardiomyopathy
    100729394 (Plcb4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100729394 (Plcb4)
   04934 Cushing syndrome
    100729394 (Plcb4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cpoc04131]
    100729394 (Plcb4)
Enzymes [BR:cpoc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100729394 (Plcb4)
Membrane trafficking [BR:cpoc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100729394 (Plcb4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100729394 (Plcb4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 100729394
NCBI-ProteinID: XP_013015251
Ensembl: ENSCPOG00000000458
UniProt: A0A286XU25
LinkDB
Position
Unknown
AA seq 1194 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESYVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLGAIPKDPKILAALEALGKSENDLEGRIVCVCSGTDLVNISFTYMVAENAE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNPSGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDVKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEQGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKKM
MEAGESATPASILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVVNSVKKGLV
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA
LGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
TKEWSEMINTHSAEEQEIRDLHLNQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSVTLQSAD
NT seq 3585 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagtgccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctatgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacttggaaaagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtattcggctgggagccatcccaaaggatcccaaaatccta
gctgctcttgaagctcttggaaaatctgaaaatgatctggaagggcggatagtctgtgtc
tgcagtggtacagatctggtgaacatcagcttcacgtacatggtggcagaaaatgcagaa
gtcactaagcaatgggtggaaggcctgagatcgatcatacacaacttcagggccaacaac
gtcagtccaatgacctgcctcaagaaacactggatgaaattggcgtttatgaccaacccc
agtggcaaaattccagtgaggagtattactagaacctttgcatcggggaaaacagaaaaa
gtgatctttcaagcactcaaggagttaggtcttccaagtggaaagaacgatgaaattgag
cctgctgcatttacttatgaaaagttctatgaacttacacaaaagatttgtcctcggaca
gatatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattt
ccattttacgatgttaaaagggcaatgcagatcattgagatgtacgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagtgatgggttttgcagatatctgatgtcagacgaa
aatgccccagtctttttagatcgcttagaactttaccaggaaatggatcatcctctggct
cactatttcatcagttcttcccataacacctatctcactggccgacagtttggcgggaaa
tcctcggtggagatgtacagacaagttctcctggctggctgcaggtgtgttgaacttgac
tgttgggatggaaaaggtgaagatcaagagccaataataactcatgggaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccactcgaacaaggcaggcctttgccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaagttgaaaaaaaacagcttgaagctttgaaaaaaatg
atggaagccggagagtctgcaactccagctagcatcttagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgagctt
tctgcagatgacttgggtcataaagaagctgtggtcaatagtgtcaagaagggtctggtt
actgtggaagacgagcaggcttggatggcatcttataaatacgtaggtgctaccactaat
atccacccgtatttgtccacaatgatcaactacgcacaacctgtaaagtttcaaggtttc
catgtggcagaagaacgcaatattcattataacatgtcatcttttaatgaatcagttggt
cttggctacttgaagacgcatgcgattgaatttgtaaattataacaaacggcaaatgagt
cgcatttaccccaagggaggccgagttgattccagtaattacatgcctcagattttctgg
aacgctggctgccagatggtttcactgaactatcaaaccccagatttagcaatgcaattg
aatcagggaaaatttgagtataatggatcgtgcgggtacctcctcaaaccagacttcatg
aggcggccagatagaacattcgaccccttctcggagaccccagtcgacggggtcattgcg
gccacgtgttcagtgcaggtcatatcagggcagttcttgtcagataagaaaatcggcaca
tatgtagaagtagatatgtatggattgccaaccgacaccatacgcaaggaattccgaact
cgcatggtcatgaacaatggactgaatccagtatataatgaagaatcatttgtgtttcgg
aaggtgatcctgcccgacctggctgtcttaagaatagcagtgtatgatgataacaacaag
ctgattggccagaggatccttcccctggatggcctccaagcagggtaccgacacatttcc
cttcgaaatgaaggaaataaacctttgtcactgccaacaattttctgcaatattgttctt
aaaacatacgtgcctgatggatttggagatattgtggatgctttatcagatccaaagaaa
tttctttcaattactgaaaagagagcagaccaaatgagagctatgggcattgaaacgagt
gacatagctgatgtccccagcgacacttccaagaatgacaagaaaggaaaggccaataca
gccaaagcaaacgtgactcctcagagcagctctgagctcagaccaacaaccacagctgcc
ctaggctctggcgtggaagccaagaaaggtattgaacttatccctcaagtgaggatagaa
gatttaaagcaaatgaaggcctacttaaagcatttaaagaagcaacagaaagagctcaat
tctttaaagaagaaacatgcaaaggagcacagtaccatgcagaagttacattgcacacaa
gttgacaaaatcgtggcacagtacgacaaagagaagtcgactcatgagaagatcctagag
aaggctatgaagaaaaaggggggaagcaattgtcttgaaatgaaaaaagaaacagaaatt
aaaattcagacattgacatcagatcacaaatctaaggtcaaagagattgtggcacagcac
acaaaggaatggtcagaaatgatcaacactcatagtgctgaggagcaagaaatccgggac
ctgcaccttaaccagcagtgtgagttgctgaagaagctactgataaatgctcacgagcag
caaacccagcagctgaaattgtctcatgacagggaaagcaaggaaatgcgagcccaccag
gctaagatttctatggaaaatagcaaagccatcagccaagataaatctatcaagaataaa
gcagagcgagaaaggcgagtcagggagttaaacagcagtaacaccaagaaatttctagaa
gaaagaaagagacttgcaatgaagcaatccaaagaaatggatcaattaaaaaaagtacaa
ctcgaacaccttgaattcctagagaaacaaaacgagcagcttttgaaatcctgtcatgca
gtgtcccaaacgcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagtagtgtgacactccaaagcgcagactga

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