| Entry |
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| Symbol |
Top2a
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| Name |
(RefSeq) DNA topoisomerase 2-alpha isoform X1
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| KO |
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| Organism |
cpoc Cavia porcellus (domestic guinea pig)
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| Pathway |
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| Brite |
KEGG Orthology (KO) [BR:cpoc00001]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
100730168 (Top2a)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:cpoc03032]
100730168 (Top2a)
03036 Chromosome and associated proteins [BR:cpoc03036]
100730168 (Top2a)
Enzymes [BR:cpoc01000]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
100730168 (Top2a)
DNA replication proteins [BR:cpoc03032]
Eukaryotic type
DNA Topoisomerases
100730168 (Top2a)
Chromosome and associated proteins [BR:cpoc03036]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
100730168 (Top2a)
Centrosome formation proteins
Centriole proteins
100730168 (Top2a)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
1541 aa
MEVSPLQPVNEHMQMNKIKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELLTQQ
MWVYDEDIGINYREITFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISVWN
NGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDERKVTGGRNGYGAKLCNIFSTRFTVE
TASKDYKKMFKQTWMDNMGRAGEMELKPFSGEDYTCITFQPDLSKFKMERLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVTGFRSYVDMYLKDKLDETGNPLKVIHEQVNQRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLMDVVKKKNKGGIAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKMLNVREASHKQIMENAEINNIIKIVGLQYKKNYADEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLQHRFLEEFITPIVKVSKNKQELAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKKHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
VNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLNFLYDDNQRVEPEW
YIPIIPMVLVNGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELASNQYVINGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFIVKMTEEKLSEVERAGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPEEEENEESDSEKEAAKGDPAADSGPTFNYLLDMPLWYLTKEK
KDELCRQRDEKEQELDTLKKKSPSDLWREDLAAFIEELEVVEAKEKQDEQVGLVGKGGKG
KGKKAPAAETLPSLQGIRVVPRVTTEMKAEAEKKIRKKLKTENTEGAPAEDSVEMDSLKL
KLEKKQKTEPGTKAKKQTTLPFKPVKKGKKRNPWSDSDSEMSSTSEGHFDLPSREVKQRR
AAANTRFTMDLDSDEDFSDFDKKNDDDFVPSDASPLKAKSLPQLTKKEPKPQKSIASVAG
PEPEDSEDGGLPASGPSDDAPARLPASSVTTKKTATKAGQSSSPTTGAKKRAVPKRAPTA
GDKKRAVPKRAKKDPALDPEAPEKPDPKTKSRCKRRPSSSSDDSDSSLAKMAPKGARNKR
PKAEGDDFQLDLQSAVAPRAKSARARKPIKYLEESDEDELF |
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| NT seq |
4626 nt +upstreamnt +downstreamnt
atggaggtgtcaccactgcagcctgtcaatgaacatatgcaaatgaacaaaattaagaaa
aatgaagatgccaagaaaagactgtctatcgaaagaatctatcaaaagaaaacgcagttg
gaacatatattgctccgcccagacacttacattgggtctgtggaattactgacccagcaa
atgtgggtttatgatgaagatattggcattaactacagagaaatcactttcgttcctggt
ttgtacaaaatctttgatgagattctagttaatgctgcggacaacaaacagagagatcca
aaaatgtcttgtattagagtcacaattgacccagaaaacaacttaattagtgtatggaat
aatggaaaaggaattcctgttgtggagcacaaagtcgagaaggtgtatgtccccgctctc
atatttggtcagctcttaacatctagtaactatgacgatgatgaaaggaaggtaacaggt
ggacgaaatggctatggagccaaactgtgtaacatattcagtaccagattcactgtcgaa
acagccagtaaagattacaagaaaatgttcaaacagacatggatggataacatggggaga
gctggtgagatggagctcaagccctttagtggggaagattatacctgcatcaccttccag
cctgatttgtctaagtttaaaatggaacgcctggacaaagatattgttgccctgatggtg
aggagagcatatgatattgccggctccactaaagatgtcaaagtctttctcaatggaaat
aagttgccggtaacaggattccgtagctacgtggatatgtatttaaaggataagttagat
gaaactggcaacccactgaaagtgatacatgaacaagtaaaccagcgatgggaggtgtgc
ctcaccatgagtgagaagggcttccagcagatcagcttcgtcaatagcattgctacctcc
aagggtggcagacatgttgactacgtagctgatcagattgtgaccaaactcatggatgta
gtgaagaagaagaacaagggtggcattgccgtgaaagcacatcaggtgaagaatcacatg
tggatttttgtgaatgccttaattgaaaacccaaccttcgactctcagacaaaagaaaac
atgactttacaagtcaagagctttggatccacatgccaattaagtgaaaaattcatcaaa
gctgcaattggctgtggcattgtggaaagcatactgaattgggtgaagtttaaggcccag
gtccagttaaacaagaagtgttcagcagtcaagcataacaaaatcaagggaatccccaag
ctggacgatgccaatgatgcaggaagccgaaattccacagagtgcacgcttattctgact
gagggggactcagccaaaactttggctgtttcaggccttggcgtggttggacgagacaaa
tacggggttttccctcttagaggaaaaatgctcaatgtccgggaagcgtctcataagcag
atcatggaaaatgctgaaattaataacatcatcaagattgtgggtcttcaatataagaaa
aactatgcagatgaagattcactgaagactcttcgttatggaaaaataatgattatgact
gatcaggatcaagatggttcccatatcaaaggcttgctgattaattttatccatcacaac
tggccctctcttctgcaacatcgttttctggaggaatttatcactcccattgtgaaggtg
tctaaaaataagcaagaactggccttctacagccttcctgaatttgaagaatggaagagt
tctactccaaatcataaaaaatggaaagtcaagtattacaaaggtttgggcaccagcaca
tcaaaagaagccaaggaatactttgcagatatgaaaaaacatcgaatccaattcaaatat
tctgggcccgaagatgatgctgccattagcttggcctttagcaaaaagcagatagatgat
cgaaaggagtggttaactcatttcatggaagacagaagacaacggaagttacttggtctt
cctgaggattatttgtacgggcaaactaccacttacctgacatataatgacttcatcaac
aaggaacttatcctgttctcaaattctgataacgagagatctatcccatctatggtggat
ggtttgaaaccagggcagagaaaggttttgtttacttgtttcaagcggaatgacaagcga
gaggtgaaggttgcccagttagctgggtcagtggcagaaatgtcctcttaccatcatggc
gagatgtcactaatgatgacaatcatcaatttggctcagaattttgtgggcagcaataat
gtgaacctcttgcaacccattggtcagtttggcaccaggctgcatggtggcaaggattct
gctagtcctcgatacatcttcacaatgctcagccctttggctcggttgttgtttccaccg
aaagatgaccacaccctgaacttcttgtacgatgacaaccagcgtgtggagccagagtgg
tacatccccatcattcccatggtgctggtgaacggggccgaggggatcggcaccggctgg
tcctgcaagatccccaacttcgatgtgcgggaaattgtaaataacatcaggcgtttaatg
gatggagaagaacctctgccgatgcttccaagttataagaacttcaagggtactattgaa
gaactggcttcaaatcagtatgtgattaatggtgaagtagccattctgaattctacaacc
attgaaatctcagagcttcccatcagaacatggacccagacatacaaagagcaagtccta
gaacccatgttgaatggcaccgagaagaccccacctctcataacagactacagggagtac
cacacagacactaccgtcaagttcattgtgaagatgactgaagaaaagctgtcagaggtg
gagagagccgggctccataaagtcttcaaactccagaccagcctcacctgcaactccatg
gtgctctttgaccacgtaggctgtttaaagaaatacgacacagtgctggacatactgaga
gacttctttgaactcaggcttaaatactatggattaaggaaagagtggctcctaggaatg
cttggcgctgaatcctctaaattgaacaatcaagctcgctttatactggagaagatagat
ggcaaaataatcattgaaaacaagcccaagaaagagctgattaaggttctgattcagagg
ggctatgactccgaccctgtgaaggcctggaaagaagcccagcagaaggttccagaggaa
gaagaaaatgaagaaagcgacagcgaaaaggaggccgcaaagggtgaccctgcagctgac
agcgggccaaccttcaactacctcctggacatgcccctctggtacctgaccaaggaaaag
aaggacgagctgtgccgacagagggatgaaaaggagcaagagctggacacactaaagaaa
aagagtccatccgacttgtggagggaagacctggctgctttcattgaagagctggaggtt
gttgaagccaaagaaaaacaagatgagcaagtgggacttgtgggaaaaggaggaaaaggg
aaagggaaaaaggcacccgcagctgaaaccctgccttctctgcaaggaatcagagtcgtc
ccccgagtgaccacagagatgaaagcagaggcagaaaagaaaatcaggaaaaaacttaag
actgaaaatactgaaggggcccctgctgaagacagtgtggaaatggatagcctgaaacta
aagttagaaaagaaacagaagacagaaccaggtaccaaggcaaagaaacaaaccacattg
ccatttaagcctgtcaaaaaaggaaagaagagaaacccctggtctgactctgactcagaa
atgagtagcacttctgaaggtcattttgacctcccgtcacgggaggtgaagcagcggcga
gctgcagcaaacaccagattcaccatggatttggactcagatgaagatttctcagatttt
gataaaaaaaatgatgatgactttgttccatcagatgctagtcctctgaaggccaagagc
ctcccacaacttactaaaaaagaaccaaagccacagaaaagcattgcgtcagtcgctggc
cctgagcctgaggactcagaggatggggggctccctgcctctggcccttccgacgatgcc
cctgccaggctgcctgcaagcagcgtgaccaccaagaagacagcaaccaaagcaggtcag
tcttccagccctaccactggggccaagaagagggcggtgcccaagagggcccctaccgct
ggggacaagaagagggcggtgcccaagagggccaaaaaggacccagccttggaccctgaa
gcccctgaaaaacctgatcccaaaaccaagagccgctgcaaaaggaggccctcttcctcc
tcggatgactccgactccagcttagcaaagatggctcccaaaggggccaggaacaagaga
cccaaggcagaaggtgacgacttccagctggacctccagtcggccgtggccccgcgggcg
aagtctgcccgtgccaggaagcccataaagtacctggaggagtccgatgaggacgagctg
ttttaa |
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