Cavia porcellus (domestic guinea pig): 100730338
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Entry
100730338 CDS
T07777
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
cpoc
Cavia porcellus (domestic guinea pig)
Pathway
cpoc05012
Parkinson disease
cpoc05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
cpoc00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100730338 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
100730338 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
cpoc01001
]
100730338 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
cpoc04131
]
100730338 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
cpoc04147
]
100730338 (Lrrk2)
Enzymes [BR:
cpoc01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100730338 (Lrrk2)
Protein kinases [BR:
cpoc01001
]
Serine/threonine kinases: TKL group
LRRK family
100730338 (Lrrk2)
Membrane trafficking [BR:
cpoc04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
100730338 (Lrrk2)
Exosome [BR:
cpoc04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
100730338 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR
Ras
LRR_14
Ank_2
WD40_CDC20-Fz
Arf
WDR55
Beta-prop_RSE1_2nd
Beta-prop_EML_2
LRR_6
LRR_13
nSTAND3
GTP_EFTU
T2SSE
AAA_22
MMR_HSR1
Beta-prop_BBS7
Kdo
ARM_CUL7_CUL9
AAA_7
Beta-prop_EML
AAA_16
PduV-EutP
ABC_tran
Arm
TrwB_AAD_bind
Gtr1_RagA
Septin
NACHT
G-alpha
cobW
MobB
Viral_helicase1
Beta-prop_RIG_2nd
AAA_29
FtsK_SpoIIIE
TniB
Pox_A32
AAA_23
WD40_Prp19
TsaE
LRR_NXF1-5
Motif
Other DBs
NCBI-GeneID:
100730338
NCBI-ProteinID:
XP_013004740
Ensembl:
ENSCPOG00000007935
LinkDB
All DBs
Position
Unknown
AA seq
2592 aa
AA seq
DB search
AVQGCEDQDEETLKKLIVRLNNVQEGKQIDTLVQILEDMLVFTYSEHASKLFEGKNFHVP
LLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDIGNDWEVLGVHQLIIKMLA
VHHASVNLSTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMNTFSNNDEVQKLGCKV
LHVLFERVSEEHLTEFVENKDYMVLLSALNSFKGEEEIVLHVLHCLHSLAIPCNNVEVLM
SGDVRCYNIVSCCVCPEPPAGQGSAAAASSMGLRMGEGVPRQPPLSQLGKGGETLLKESP
REVCAGLRSAQSRRKGGEECGWLNHLWILRPMIDGLDFSPFTSESNFFNILVLNEVHAFV
VKAVQQYPENAALQASALSCLALLTETIFLNQDLEEKDENQENEEEKEEEEDKLFWLEAC
YRALTRHRKNKHVQEAACWALNNLLMYQNGLHQRIGDEDGQFPAHREVMLAMLMHTSSRE
VLQASAAALSTLLEQNVNFRKILLSKGIYVNVLELMQRHIHSPEVAESGCKMLNRLFEGS
NTSSDTMAGLVPKIITVMKSHETSLPVQLEALRAILHFLVPDMPEESRDKSQWKLNMVRR
QCLKNDIHKLVLAALNRFIGNPGIQKCGLRVISSIAHFPEALEVLSLEGAIDSVLRTLQK
YPDDPEIQCLGLSLVGCLITKKHLCLGAGHLVAKILVYSLQRFKDDAEVQFKGFQTILAI
LELSVSFSELLVHYSFDSVIFHQLSSGIVEQKDRKFLSLCCKCFAKLAVDDELKSVMLRR
ACDQNNSTMVECLLLLGADANQAKETTPLICQVCEKESSPKLVELLLSNGAREQDVRKAL
TISIQKGDSQIISLLLKRLALDMANNSICLGGFCIGKIEASWLAPLFPDKTSNLRKQTNI
GSVLARMVLRYQMRSAVEEEAASDSDRNFSEDVLDKFDDWTFIPESSMDCVFGQSDDLDS
EGSEGSFLVKKKSSSVNVGELYRDPVLQRSSPSAQRHSSSLGPIFDHEDFLRRKRKLLTS
DDSLRTSKLQPHTRHLDSASSMACEREYITSLDLSANELRDIHALSQKCCISSHLEHIEK
LELHQNALTSFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCISNLDVSRNDIGPSVF
VDPSVKCPTLRQLNLSYNQLSSFPETLPEVVERLEQLLLEGNKISEIYFPLSLKELKILN
LSKNRISSLPENFFKACPKMENFSARMNSLDTMPFLPSSITSLKLAQNKFTCIPHSILDL
PHLRSLDMSSNDIDCLPGPANWKSLNLRELLFNYNQISILDLSEKAYTWSRVEKLHLSHN
KLKEIPPEIGCLENLTSLDVSYNVELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKA
KDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGVQGATVGIDVKD
WPIQIKGKKKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVFDLSKGQAEVDAMKPWL
FNIKARASSSPVILVGTHLDVSDEKQHKACISKITKELLNKRGFPAIRNYLFVNATEESD
ALAKLRKTIVSESLNFKIRDQPVVGQLIPDCYVELEKIVLTERKNVPIEFPVIDRKRLLQ
LVKENQLQLDENELTHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKV
EGSPKYPKGIISRRDVERFLSKKRRFPKNYMTQYFKLLEKFQIALPTGEEYLLVPSSLSD
HRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWR
QGIYLNWSPEAYCLVGSEVLDNQQESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGL
LEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQI
APDLILADLPRNIILNNDELDFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLR
LLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELAPKGSLDRLLQQDKASLTRTLQHRIA
LHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT
PGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRILEGLKFPNEFDELAIQGKLPDP
VKEYGCAPWPMVEKLIRKCLKENPQERPTSAQVFDFLNSAELICLTRHILIPENIIAECM
VSMNSNSKNANIWLGCGHNDKGQLSCLDLNTEGHTLEEVTDSRILCLALVHLPAEKESWI
VSGTQSGALLVINTDDRTKRHTLQKMTDSITCLYCNSFPKQSKQNNFLLVGTADGNLAIF
EDKTVKCEGATPLKTLNIGDVSTPLMCLSESMNSSERSIMWGGCGTKIFSFSNDLTIQKL
IETRTNQLFSYSAFSDSNIIAVAVDAALYIAKKNSPVVEVWDKKTEKLCELIDCVHLLKE
VMVKMNQESKYKMSYSGRVKTLCLQKNTALWIGTGGGHVLLLDLSTRRIIRIIYNFCDSV
RVMMTAQLGSLKNVMLVLGYNRKNTEDIQHQKEIQSCLSVWDLNFPHEVQNLEKHIEVRQ
ELAEKMRRTSVE
NT seq
7779 nt
NT seq
+upstream
nt +downstream
nt
gctgttcaggggtgcgaggaccaggacgaggaaactctgaagaagttgatagtcagattg
aacaacgtccaggaaggaaagcagatagacacgctggtccaaatcctggaggacatgctg
gtgttcacatactccgaacacgcctccaagttgtttgaaggcaaaaatttccacgtgcct
ctgttgatcgtcttggactcctacatgagagtggcgagtgtacagcaggtgggttggtcg
cttctgtgcaaattaatagaggtctgtccaggtacaatgcaaagcttaatgggtccccag
gatattggaaatgattgggaagtcctcggtgtacaccaactgattattaaaatgctagca
gttcatcatgccagtgtaaacctgtcaacagttggactaaaggccttagatcttctcctg
acttcaggaaaaatcacactgctgatactggatgaagaaagtgatattttcttgttaatt
tttgatgccatgaatacattttcaaacaatgatgaagtccagaaactgggatgcaaagtt
ttacatgtgctgtttgagagagtttctgaggaacacctaactgaatttgttgagaacaaa
gattatatggtattgctcagtgcactcaacagttttaaaggtgaagaggaaattgtgctt
catgtactacactgtttgcattctctagcaattccttgcaataatgttgaagtccttatg
agtggtgatgtcagatgttacaatattgtctcttgctgtgtttgcccagagccacctgct
ggtcaggggtcggcagctgctgccagtagcatgggactaagaatgggggaaggagtgccg
aggcagcctccccttagccagcttgggaagggtggggagacccttctgaaagaatctccc
cgggaggtgtgcgcaggcctgaggagtgctcagagcaggcgcaaaggaggagaggagtgt
ggctggctaaaccacctttggattttgaggccaatgattgatggtttggacttcagccct
ttcacatcagagagtaattttttcaatatcctggtattaaatgaggtccatgcttttgtg
gtgaaagccgtgcagcagtacccggagaatgccgccctgcaggcctctgctcttagctgt
ttagcactcctcactgagaccattttcttaaatcaagacttagaggagaaggatgagaac
caggagaatgaggaagagaaggaagaggaggaagataaattgttctggctggaagcctgt
tacagggccttaacacggcacaggaagaacaagcatgtgcaggaggccgcatgctgggca
ctcaataacctccttatgtaccagaacggtttacatcagaggattggagatgaagatggc
cagtttccagctcatagggaggtgatgctggccatgctcatgcatacttcatccagagaa
gtcctccaggcatctgcggctgcgctctccacactcttggagcaaaatgttaatttcaga
aaaatcctattgtccaaaggaatatacgtcaatgtattggaattaatgcagaggcatata
cattctcctgaagttgctgaaagtggctgtaaaatgctgaatcgtcttttcgaaggaagc
aacacttcctcagatacaatggcagggttggtccccaaaataataacagttatgaaaagt
catgagacgtccttgccagtgcagctggaggcgcttcgagctattttacattttctagtg
ccagatatgccagaagaatccagagacaaatctcaatggaaactgaatatggtcagaaga
caatgtttaaagaatgatattcacaaactggttctagcggctttgaacaggttcattgga
aatcctgggattcaaaaatgtggcttaagagtcatttcttccatagcacatttccctgaa
gcattagaggtgttatccctggaaggagctattgattcagtgctccgcactctgcagaag
tatccagatgacccagaaattcagtgcctggggttaagtcttgtaggatgcttgattaca
aagaagcatttatgcctaggagctgggcatctggtggcaaaaattctggtttacagttta
cagcgatttaaagatgatgctgaagtacagtttaaaggatttcagacaatcttggcaata
cttgaattgtcagtatctttttccgagttgctggtgcactactcatttgattcagtaata
ttccatcagttgtcttctggcatagtggaacagaaggatcgaaagtttctaagtctctgt
tgcaagtgctttgcaaaattagctgtggatgatgagttaaaaagtgtgatgctgaggaga
gcatgtgatcagaacaatagcactatggttgaatgtttacttctcctgggagcagatgcc
aatcaagcaaaggagacaacacctttaatttgccaggtatgtgagaaggaaagcagtccc
aaattggtggaactattactcagtaatggagcccgtgagcaagatgtaaggaaagcactg
accataagcatccagaaaggtgacagccagatcatcagcttactcttgaagaggcttgcc
ctggatatggccaacaatagcatttgccttggaggattttgcataggaaagattgaagct
tcttggcttgctcctttatttccagataagacatctaatttaaggaaacaaacaaatata
ggatctgtgctagcaagaatggtgctcagatatcagatgagaagtgctgttgaagaagaa
gcagcctcagacagtgacagaaatttttctgaagatgtacttgataaatttgatgactgg
acctttatcccagagtcttcgatggactgtgtgtttggtcagagtgatgacctggatagc
gaaggaagtgaaggttcatttttggtgaaaaagaaatcaagttcagttaatgtaggagaa
ttgtaccgagatcctgtgttgcagcgttcctctccaagtgcgcagagacattccagttca
ttggggcctatttttgatcatgaagactttctgaggaggaaaagaaaactattgacttca
gatgattccctcaggacatcaaaacttcagccacatacaaggcatttggacagtgcttct
tcaatggcttgtgagagagaatatattacatctctagacctttctgccaatgaactcaga
gatatccatgccctgagccagaaatgctgcatcagtagccatctggagcacatcgagaag
ctggagctccaccagaatgcgctcacaagctttccacagcagctctgcgagactctgaag
tgtttgacacatttggatttacacagtaataaatttacatcatttccctcttacttgctg
aaaatgaattgtatctccaaccttgacgtctctcgaaatgacattggaccctctgtcttt
gtggatccctcagtgaagtgtcccaccctgagacagctgaatctatcatacaatcagctg
tcttcttttcctgagacccttcctgaggtggtggaaaggttggagcaactccttttagaa
ggaaataaaatatcagagatatatttccccttgagtctgaaggaactgaagattttaaat
cttagtaaaaatcgtatttcatctctaccagagaacttttttaaagcttgtccaaaaatg
gagaatttcagtgccagaatgaattctcttgatactatgcctttcttgccttcttctata
acaagcctaaaattggctcaaaacaagtttacatgtattccacattcaattttagatcta
ccacacttgcggtccttagatatgagtagcaatgatattgactgtctgccaggtcctgca
aactggaaatctctgaatttaagagagctcttatttaactataatcagatcagcatcttg
gacttgagtgaaaaagcatatacatggtccagagtagagaaactccatctttctcataat
aaactgaaagagattcctcctgagattggctgccttgaaaatttgacctctctcgatgtt
agttacaacgtggaactgagatcctttcccaatgaaatggggaaattaagcaaaatatgg
gatcttcctttggatgagttgcatcttaactttgattttaaacatataggatgtaaagcc
aaagatatcataaggtttcttcaacagcgattgaaaaaagctgtgccctataatagaatg
aaacttatgattgtgggaaatactggaagtggtaaaaccactttattacagcaattaatg
aaaaccaagaaatccgatcttggagtgcagggtgccacagtgggcatagatgtgaaagac
tggcctatccagataaaaggcaaaaagaagaaagaccttgttctcaatgtgtgggatttt
gcaggtcgtgaggaattctacagtactcatccccacttcatgacccagagagcactgtac
cttgccgtcttcgacctcagcaaagggcaggcagaagtggatgccatgaagccctggctc
ttcaacataaaggcacgggcttcgtcctcccccgtgattcttgttggtacgcatttggat
gtttctgatgagaagcagcacaaagcctgcataagtaaaatcaccaaagaactcctgaac
aagcgagggtttcctgcaattcgaaattacctctttgtgaatgctactgaggagtccgac
gctttggcaaagcttcggaaaaccatcgtaagcgagagtcttaatttcaagatcagggat
cagcctgttgtggggcagctaattccagattgctacgtagaactcgagaaaatcgtttta
acagagcgcaaaaatgtgccaattgaatttcctgtaattgaccggaaaagattgttacaa
ctggtaaaggaaaatcagctgcaattagatgaaaatgagcttactcatgctgttcacttc
ctaaacgaatcaggagttcttcttcattttcaagaccctgcattgcagttaagtgactta
tattttgtggaacccaagtggctttgtaaagtcatggcacagattctgacagtaaaagtg
gaaggctctccaaaatatcctaagggaatcatttcacgtagagatgtggaaagatttctt
tcaaagaagaggagatttccaaagaactacatgacacaatattttaaactcctagaaaaa
tttcagattgccttgccaacaggagaagaatacttactggttccaagcagtttgtctgac
cacagacctgtgatagagcttccccactgtgagaactctgaaattatcattcgactatat
gagatgccatattttcccatgggattttggtcaagattaatcaatcggttacttgaaatt
tcaccttacatgctttcaggaagagaacgagcacttcgcccaaacagaatgtactggcga
cagggcatctacttgaattggtctcctgaagcttattgtctggtaggatctgaggtctta
gacaatcagcaagagagtttcttaaaaattacagttccttcttgtagaaaaggctgtatt
cttttgggacaagttgtggaccacattgattctctcatggaagaatggtttcctgggcta
ctggagattgatatttgtggtgaaggagaaactctgttgaagaaatgggcattatatagt
tttaacgatggtgaagagcatcaaaagatcttacttgatgatctgatgaagaaagctgaa
gaaggagacctcctagtaaatccagatcagccaagactcacaattcctatatctcagatt
gctcctgacttgatcttggctgacctgcctagaaatattattttgaataatgatgaattg
gactttgagcaagctccagaattccttttaggtgatggaagttttggatccgtttatcga
gcagcctatgaaggagaggaagtggctgtgaagatttttaataaacatacatcacttagg
ctgttgagacaagagctggtggtgctttgccaccttcaccatcccagcttaatatctctg
ctggcagctgggattcgtccccggatgctggtgatggagctggcccctaagggttccctg
gatcgtttgctgcagcaggacaaagccagcctcacccggaccctccagcacaggatcgcg
ctccacgtggctgatggtttgagatacctccattcggccatgattatctaccgagacctg
aagccccacaatgtgctgcttttcaccctgtatcccaacgctgccatcattgccaagatt
gccgactacgggattgctcagtactgctgcaggatgggcataaagacgtcagagggcacc
ccagggttccgtgctcctgaagttgccagaggaaatgtcatttataaccaacaagctgac
gtttattcatttggtttactactctatgacattttgacaaccggaggtagaatactagag
ggtttgaagtttccaaatgagtttgatgaattagcaatacaaggaaaattgcctgatcca
gtgaaagaatatggttgtgccccatggcctatggttgagaagttaattagaaagtgtttg
aaagaaaatcctcaggaaaggcctacttctgcccaggtctttgacttcttgaactcagct
gagttaatttgtcttacgagacatattttgatacctgaaaacattattgctgaatgcatg
gtttctatgaattctaatagcaagaatgcaaatatttggcttggctgtgggcacaatgac
aaagggcagctctcctgccttgacctaaacaccgaaggacacactttggaggaggtgact
gacagtagaatactgtgcttagccttggtgcaccttcctgccgagaaggagagctggatt
gtgtctgggacacagtctggtgctctcctggttatcaacactgatgacaggacaaagaga
cacactctgcagaagatgacagattctattacttgcttgtattgcaattctttccccaag
caaagcaagcaaaataattttcttttggtcggaactgctgatggcaacttagcgattttt
gaagataaaactgttaagtgtgaaggagccacacctttgaagacgctgaacatcggggat
gtcagcacaccactgatgtgtctgagtgaatccatgaattcaagtgaaaggagcattatg
tggggcggatgcggcacaaagattttctcattttctaatgacctcacgattcagaaactc
attgagacaaggacaaatcaactgttttcttactcagctttcagcgattccaacatcata
gcagtggcagtcgatgcagctctctatattgctaagaaaaacagtcctgttgtggaagtg
tgggacaagaagactgaaaaactctgtgaactaatagactgtgtgcatttattaaaggaa
gtaatggtgaagatgaaccaggaatcaaaatacaaaatgtcctattctgggagagtgaaa
actctgtgccttcagaagaatactgccctctggatagggactggaggcggccatgtttta
ctccttgatctttccactcgtaggatcatacgcataatttacaacttttgtgattctgtt
agagtcatgatgacggcacaattaggaagccttaaaaatgtcatgctggttttggggtat
aaccggaaaaatactgaagatatacagcaccagaaagagatacaatcttgtttgtcagtt
tgggacctcaattttccacatgaagtgcaaaatttagaaaaacacattgaagtgcgacaa
gaattagctgaaaaaatgagaagaacatctgttgaataa
DBGET
integrated database retrieval system
