KEGG   Cavia porcellus (domestic guinea pig): 100735084
Entry
100735084         CDS       T07777                                 
Symbol
Pik3ca
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
cpoc  Cavia porcellus (domestic guinea pig)
Pathway
cpoc00562  Inositol phosphate metabolism
cpoc01100  Metabolic pathways
cpoc01521  EGFR tyrosine kinase inhibitor resistance
cpoc01522  Endocrine resistance
cpoc01524  Platinum drug resistance
cpoc04012  ErbB signaling pathway
cpoc04014  Ras signaling pathway
cpoc04015  Rap1 signaling pathway
cpoc04024  cAMP signaling pathway
cpoc04062  Chemokine signaling pathway
cpoc04066  HIF-1 signaling pathway
cpoc04068  FoxO signaling pathway
cpoc04070  Phosphatidylinositol signaling system
cpoc04071  Sphingolipid signaling pathway
cpoc04072  Phospholipase D signaling pathway
cpoc04081  Hormone signaling
cpoc04140  Autophagy - animal
cpoc04150  mTOR signaling pathway
cpoc04151  PI3K-Akt signaling pathway
cpoc04152  AMPK signaling pathway
cpoc04210  Apoptosis
cpoc04211  Longevity regulating pathway
cpoc04213  Longevity regulating pathway - multiple species
cpoc04218  Cellular senescence
cpoc04360  Axon guidance
cpoc04370  VEGF signaling pathway
cpoc04380  Osteoclast differentiation
cpoc04510  Focal adhesion
cpoc04550  Signaling pathways regulating pluripotency of stem cells
cpoc04611  Platelet activation
cpoc04613  Neutrophil extracellular trap formation
cpoc04620  Toll-like receptor signaling pathway
cpoc04625  C-type lectin receptor signaling pathway
cpoc04630  JAK-STAT signaling pathway
cpoc04650  Natural killer cell mediated cytotoxicity
cpoc04660  T cell receptor signaling pathway
cpoc04662  B cell receptor signaling pathway
cpoc04664  Fc epsilon RI signaling pathway
cpoc04666  Fc gamma R-mediated phagocytosis
cpoc04668  TNF signaling pathway
cpoc04670  Leukocyte transendothelial migration
cpoc04722  Neurotrophin signaling pathway
cpoc04725  Cholinergic synapse
cpoc04750  Inflammatory mediator regulation of TRP channels
cpoc04810  Regulation of actin cytoskeleton
cpoc04910  Insulin signaling pathway
cpoc04914  Progesterone-mediated oocyte maturation
cpoc04915  Estrogen signaling pathway
cpoc04917  Prolactin signaling pathway
cpoc04919  Thyroid hormone signaling pathway
cpoc04923  Regulation of lipolysis in adipocytes
cpoc04926  Relaxin signaling pathway
cpoc04929  GnRH secretion
cpoc04930  Type II diabetes mellitus
cpoc04931  Insulin resistance
cpoc04932  Non-alcoholic fatty liver disease
cpoc04933  AGE-RAGE signaling pathway in diabetic complications
cpoc04935  Growth hormone synthesis, secretion and action
cpoc04960  Aldosterone-regulated sodium reabsorption
cpoc04973  Carbohydrate digestion and absorption
cpoc05010  Alzheimer disease
cpoc05017  Spinocerebellar ataxia
cpoc05020  Prion disease
cpoc05100  Bacterial invasion of epithelial cells
cpoc05132  Salmonella infection
cpoc05135  Yersinia infection
cpoc05142  Chagas disease
cpoc05146  Amoebiasis
cpoc05160  Hepatitis C
cpoc05161  Hepatitis B
cpoc05162  Measles
cpoc05163  Human cytomegalovirus infection
cpoc05164  Influenza A
cpoc05165  Human papillomavirus infection
cpoc05166  Human T-cell leukemia virus 1 infection
cpoc05167  Kaposi sarcoma-associated herpesvirus infection
cpoc05168  Herpes simplex virus 1 infection
cpoc05169  Epstein-Barr virus infection
cpoc05170  Human immunodeficiency virus 1 infection
cpoc05171  Coronavirus disease - COVID-19
cpoc05200  Pathways in cancer
cpoc05203  Viral carcinogenesis
cpoc05205  Proteoglycans in cancer
cpoc05206  MicroRNAs in cancer
cpoc05207  Chemical carcinogenesis - receptor activation
cpoc05208  Chemical carcinogenesis - reactive oxygen species
cpoc05210  Colorectal cancer
cpoc05211  Renal cell carcinoma
cpoc05212  Pancreatic cancer
cpoc05213  Endometrial cancer
cpoc05214  Glioma
cpoc05215  Prostate cancer
cpoc05218  Melanoma
cpoc05220  Chronic myeloid leukemia
cpoc05221  Acute myeloid leukemia
cpoc05222  Small cell lung cancer
cpoc05223  Non-small cell lung cancer
cpoc05224  Breast cancer
cpoc05225  Hepatocellular carcinoma
cpoc05226  Gastric cancer
cpoc05230  Central carbon metabolism in cancer
cpoc05231  Choline metabolism in cancer
cpoc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cpoc05415  Diabetic cardiomyopathy
cpoc05417  Lipid and atherosclerosis
cpoc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cpoc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100735084 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100735084 (Pik3ca)
   04014 Ras signaling pathway
    100735084 (Pik3ca)
   04015 Rap1 signaling pathway
    100735084 (Pik3ca)
   04370 VEGF signaling pathway
    100735084 (Pik3ca)
   04630 JAK-STAT signaling pathway
    100735084 (Pik3ca)
   04668 TNF signaling pathway
    100735084 (Pik3ca)
   04066 HIF-1 signaling pathway
    100735084 (Pik3ca)
   04068 FoxO signaling pathway
    100735084 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    100735084 (Pik3ca)
   04072 Phospholipase D signaling pathway
    100735084 (Pik3ca)
   04071 Sphingolipid signaling pathway
    100735084 (Pik3ca)
   04024 cAMP signaling pathway
    100735084 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    100735084 (Pik3ca)
   04152 AMPK signaling pathway
    100735084 (Pik3ca)
   04150 mTOR signaling pathway
    100735084 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100735084 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100735084 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    100735084 (Pik3ca)
   04218 Cellular senescence
    100735084 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100735084 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    100735084 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100735084 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100735084 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    100735084 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    100735084 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    100735084 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    100735084 (Pik3ca)
   04660 T cell receptor signaling pathway
    100735084 (Pik3ca)
   04662 B cell receptor signaling pathway
    100735084 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    100735084 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    100735084 (Pik3ca)
   04670 Leukocyte transendothelial migration
    100735084 (Pik3ca)
   04062 Chemokine signaling pathway
    100735084 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100735084 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    100735084 (Pik3ca)
   04929 GnRH secretion
    100735084 (Pik3ca)
   04915 Estrogen signaling pathway
    100735084 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    100735084 (Pik3ca)
   04917 Prolactin signaling pathway
    100735084 (Pik3ca)
   04926 Relaxin signaling pathway
    100735084 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    100735084 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    100735084 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100735084 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100735084 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    100735084 (Pik3ca)
   04722 Neurotrophin signaling pathway
    100735084 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100735084 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    100735084 (Pik3ca)
   04380 Osteoclast differentiation
    100735084 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    100735084 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    100735084 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100735084 (Pik3ca)
   05206 MicroRNAs in cancer
    100735084 (Pik3ca)
   05205 Proteoglycans in cancer
    100735084 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    100735084 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    100735084 (Pik3ca)
   05203 Viral carcinogenesis
    100735084 (Pik3ca)
   05230 Central carbon metabolism in cancer
    100735084 (Pik3ca)
   05231 Choline metabolism in cancer
    100735084 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100735084 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100735084 (Pik3ca)
   05212 Pancreatic cancer
    100735084 (Pik3ca)
   05225 Hepatocellular carcinoma
    100735084 (Pik3ca)
   05226 Gastric cancer
    100735084 (Pik3ca)
   05214 Glioma
    100735084 (Pik3ca)
   05221 Acute myeloid leukemia
    100735084 (Pik3ca)
   05220 Chronic myeloid leukemia
    100735084 (Pik3ca)
   05218 Melanoma
    100735084 (Pik3ca)
   05211 Renal cell carcinoma
    100735084 (Pik3ca)
   05215 Prostate cancer
    100735084 (Pik3ca)
   05213 Endometrial cancer
    100735084 (Pik3ca)
   05224 Breast cancer
    100735084 (Pik3ca)
   05222 Small cell lung cancer
    100735084 (Pik3ca)
   05223 Non-small cell lung cancer
    100735084 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100735084 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    100735084 (Pik3ca)
   05161 Hepatitis B
    100735084 (Pik3ca)
   05160 Hepatitis C
    100735084 (Pik3ca)
   05171 Coronavirus disease - COVID-19
    100735084 (Pik3ca)
   05164 Influenza A
    100735084 (Pik3ca)
   05162 Measles
    100735084 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    100735084 (Pik3ca)
   05163 Human cytomegalovirus infection
    100735084 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100735084 (Pik3ca)
   05169 Epstein-Barr virus infection
    100735084 (Pik3ca)
   05165 Human papillomavirus infection
    100735084 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100735084 (Pik3ca)
   05135 Yersinia infection
    100735084 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    100735084 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100735084 (Pik3ca)
   05142 Chagas disease
    100735084 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100735084 (Pik3ca)
   05017 Spinocerebellar ataxia
    100735084 (Pik3ca)
   05020 Prion disease
    100735084 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100735084 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    100735084 (Pik3ca)
   05415 Diabetic cardiomyopathy
    100735084 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100735084 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    100735084 (Pik3ca)
   04931 Insulin resistance
    100735084 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100735084 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100735084 (Pik3ca)
   01524 Platinum drug resistance
    100735084 (Pik3ca)
   01522 Endocrine resistance
    100735084 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cpoc04131]
    100735084 (Pik3ca)
Enzymes [BR:cpoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100735084 (Pik3ca)
Membrane trafficking [BR:cpoc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100735084 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_p85B PI3K_C2 DUF2321 ABC1
Other DBs
NCBI-GeneID: 100735084
NCBI-ProteinID: XP_003467591
Ensembl: ENSCPOG00000006574
LinkDB
Position
Unknown
AA seq 1052 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLXYDIYIPDLSLFRYEHCPLAWGNINLFDYTDTL
VSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHA
NWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPLSEITEQEKDFLWSHRH
YCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAV
RCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMH
NKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLV
EQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQN
NEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHT
IMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDR
HNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTRE
FERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEAL
EYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3159 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctcgtagaatgtttactaccaaatggaatgatcgtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactgtttaaggaagcaagaaaataccctctccatcaa
cttcttcaagacgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactatgtgaccttcggcttttccaaccctttttaaaa
gtaattgaaccagttggcaaccgtgaggaaaagatcctcaatcgagaaatcggttttgtt
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttcaga
agaaatattttgaatgtttgtaaagaagctgtggaccttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcatcaccagagctgccaaagcac
atatacaataaattagacaaaggacaaataattgtggtgatttgggtaatagtttctcca
aacaatgacaagcagaagtatactttgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcagctgccaatggac
tgttttacaatgccatcctattccagacgcatctctacagctacaccgtatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgataagatctatgttcgaacgggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcagagagtaccttgttccaat
cctaggtggaatgaatggctgnnatacgatatatacattcccgatctctcactttttaga
tatgagcattgtccattggcctggggaaatataaacttgtttgattacacagacacacta
gtatctggaaaaatggccttgaatctttggccagtacctcatggattagaagacttgctg
aatcctattggtgttactgggtcaaatccaaataaagaaactccatgcttagaattagag
tttgattggttcagcagtgtggtaaagtttccagatatgtcagtgattgaggagcatgca
aattggtctgtatcccgagaagcaggatttagttattcacatgcaggactgagtaacaga
ctagctcgagacaatgaattaagagaaaatgacaaagaacagctccgagcaatttgtaca
cgagaccctctgtctgaaatcactgagcaagagaaagattttctgtggagtcacagacac
tattgtgtaactatccctgaaattctacccaaattgcttctgtccgttaaatggaactct
agagatgaagtagctcagatgtactgcttagtgaaagactggcccccaattaaacctgag
caggcaatggaacttctggactgcaactacccagaccctatggttcgaggttttgctgtt
cgatgcttggaaaaatacttgacagatgacaaactttctcagtaccttatccagctagta
caggtcctaaaatatgaacaatatttggataatcttcttgtgagatttttactcaagaaa
gcattaacaaatcaaaggattggacactttttcttttggcatttaaaatctgagatgcac
aataaaacagtgagtcaaagatttggtctgcttttggagtcctattgccgcgcctgtggg
atgtacctaaagcacctgaacaggcaagttgaggccatggaaaagctcatcaacttaact
gacatcctcaaacaggagaagaaggatgaaacacagaaggtacagatgaaattcttagtt
gagcaaatgaggcaaccagatttcatggatgcactacaaggctttttgtctcctctaaac
cctgctcatcaactgggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaa
aggccactgtggttgaattgggagaacccagacatcatgtcagagttactgtttcagaac
aatgagatcatctttaaaaatggggatgatttacggcaagatatgctaacgcttcagatt
attcgcataatggaaaatatctggcaaaatcaaggccttgatcttcgaatgctgccgtat
ggttgtctctccattggggactgtgtaggactgatcgaggtggtgagaaattctcacacg
atcatgcagattcagtgcaaaggtggcctgaaaggtgcactgcagttcaatagccacacg
ctgcatcagtggctcaaagacaagaacaaaggagaaatatacgatgcagccattgaccta
tttacacggtcgtgtgccggatactgcgtagctaccttcattttgggaattggtgaccgt
cacaacagtaacatcatggtgaaagatgatggacagctgtttcatatagactttggacac
tttttggatcacaagaagaaaaaatttggttataaacgagaacgtgtaccatttgttttg
acacaagatttcttaatagtgataagcaaaggggcccaagaatgtacaaagaccagagaa
tttgaaaggtttcaggagatgtgttacaaggcgtatctagctattcggcagcatgctaat
ctcttcataaatcttttctcaatgatgcttggctctggaatgccagaactacagtctttt
gatgacattgcatatattcgaaagaccctagccttagataaaactgagcaagaggctttg
gaatatttcatgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggat
tggatcttccacacaattaagcagcatgcattgaactga

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