KEGG   Chlorocebus sabaeus (green monkey): 103215686
Entry
103215686         CDS       T04361                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa B kinase subunit beta
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
csab  Chlorocebus sabaeus (green monkey)
Pathway
csab01523  Antifolate resistance
csab04010  MAPK signaling pathway
csab04014  Ras signaling pathway
csab04062  Chemokine signaling pathway
csab04064  NF-kappa B signaling pathway
csab04068  FoxO signaling pathway
csab04150  mTOR signaling pathway
csab04151  PI3K-Akt signaling pathway
csab04210  Apoptosis
csab04380  Osteoclast differentiation
csab04620  Toll-like receptor signaling pathway
csab04621  NOD-like receptor signaling pathway
csab04622  RIG-I-like receptor signaling pathway
csab04623  Cytosolic DNA-sensing pathway
csab04625  C-type lectin receptor signaling pathway
csab04657  IL-17 signaling pathway
csab04658  Th1 and Th2 cell differentiation
csab04659  Th17 cell differentiation
csab04660  T cell receptor signaling pathway
csab04662  B cell receptor signaling pathway
csab04668  TNF signaling pathway
csab04722  Neurotrophin signaling pathway
csab04910  Insulin signaling pathway
csab04920  Adipocytokine signaling pathway
csab04930  Type II diabetes mellitus
csab04931  Insulin resistance
csab04932  Non-alcoholic fatty liver disease
csab04936  Alcoholic liver disease
csab05010  Alzheimer disease
csab05132  Salmonella infection
csab05135  Yersinia infection
csab05142  Chagas disease
csab05145  Toxoplasmosis
csab05160  Hepatitis C
csab05161  Hepatitis B
csab05162  Measles
csab05163  Human cytomegalovirus infection
csab05164  Influenza A
csab05165  Human papillomavirus infection
csab05166  Human T-cell leukemia virus 1 infection
csab05167  Kaposi sarcoma-associated herpesvirus infection
csab05168  Herpes simplex virus 1 infection
csab05169  Epstein-Barr virus infection
csab05170  Human immunodeficiency virus 1 infection
csab05171  Coronavirus disease - COVID-19
csab05200  Pathways in cancer
csab05206  MicroRNAs in cancer
csab05208  Chemical carcinogenesis - reactive oxygen species
csab05212  Pancreatic cancer
csab05215  Prostate cancer
csab05220  Chronic myeloid leukemia
csab05221  Acute myeloid leukemia
csab05222  Small cell lung cancer
csab05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
csab05417  Lipid and atherosclerosis
csab05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:csab00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    103215686 (IKBKB)
   04064 NF-kappa B signaling pathway
    103215686 (IKBKB)
   04668 TNF signaling pathway
    103215686 (IKBKB)
   04068 FoxO signaling pathway
    103215686 (IKBKB)
   04151 PI3K-Akt signaling pathway
    103215686 (IKBKB)
   04150 mTOR signaling pathway
    103215686 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    103215686 (IKBKB)
   04660 T cell receptor signaling pathway
    103215686 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    103215686 (IKBKB)
   04659 Th17 cell differentiation
    103215686 (IKBKB)
   04657 IL-17 signaling pathway
    103215686 (IKBKB)
   04662 B cell receptor signaling pathway
    103215686 (IKBKB)
   04062 Chemokine signaling pathway
    103215686 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103215686 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103215686 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103215686 (IKBKB)
   05206 MicroRNAs in cancer
    103215686 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    103215686 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103215686 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    103215686 (IKBKB)
   05221 Acute myeloid leukemia
    103215686 (IKBKB)
   05220 Chronic myeloid leukemia
    103215686 (IKBKB)
   05215 Prostate cancer
    103215686 (IKBKB)
   05222 Small cell lung cancer
    103215686 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103215686 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    103215686 (IKBKB)
   05161 Hepatitis B
    103215686 (IKBKB)
   05160 Hepatitis C
    103215686 (IKBKB)
   05171 Coronavirus disease - COVID-19
    103215686 (IKBKB)
   05164 Influenza A
    103215686 (IKBKB)
   05162 Measles
    103215686 (IKBKB)
   05163 Human cytomegalovirus infection
    103215686 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103215686 (IKBKB)
   05169 Epstein-Barr virus infection
    103215686 (IKBKB)
   05165 Human papillomavirus infection
    103215686 (IKBKB)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103215686 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    103215686 (IKBKB)
   05142 Chagas disease
    103215686 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103215686 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103215686 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    103215686 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103215686 (IKBKB)
   04936 Alcoholic liver disease
    103215686 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    103215686 (IKBKB)
   04931 Insulin resistance
    103215686 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    103215686 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:csab01001]
    103215686 (IKBKB)
Enzymes [BR:csab01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     103215686 (IKBKB)
Protein kinases [BR:csab01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   103215686 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH Glyco_hydro_65m
Other DBs
NCBI-GeneID: 103215686
NCBI-ProteinID: XP_007960514
Ensembl: ENSCSAG00000015039
UniProt: A0A0D9RRA6
LinkDB
Position
8:40267532..40325282
AA seq 756 aa
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGRTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQMEEEEHSCLEQAS
NT seq 2271 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttccctgacaactcagacatgtggggcctgggaaatgaaagagcgc
cttgggacagggggatttggaaatgtcatccgatggcacaatcaggaaacaggtgagcag
attgccatcaagcagtgccggcaggagctcagccccaggaatcgagagcggtggtgcctg
gagatccagatcatgagaaggctgacgcaccccaatgtggtggctgcccgagatgtccct
gaggggatgcagaacttggcgcccaatgacttgcccctgctggccatggagtattgccaa
ggaggagatctccggaagtacctgaaccagtttgagaattgctgtggtctgcgggaaggt
gccatcctcaccttgctgagtgacattgcctctgcacttagataccttcatgaaaacaga
atcatccatcgggatctaaagccagaaaacattgtcctgcagcaaggagaacagaggtta
atacacaaaattattgacctaggatatgccaaggagctggatcagggcagtctttgcacg
tcattcgtggggaccctgcagtacctggccccagagctgctggagcagcagaagtacaca
gtgaccgtcgactactggagctttggcacgctggccttcgagtgcatcacgggcttccgg
cccttcctccccaactggcagcccgtgcagtggcattcgaaagtccggcagaagagtgag
gtggatattgttgtcagcgaagacttgaatggaactgtgaagttttcaagctctttaccc
taccccaataatcttaacagcgtcctggctgagcgactggagaagtggctgcaactgatg
ctgatgtggcatccccgacagaggggcacagatcccacgtatgggcccaatggctgcttc
aaggccctggatgacatcttaaacttaaagctggttcatatcttgaacatggtcacaggc
accatccacacctaccctgtgacagaggacgagagtctgcagagcttgaaggccagaatc
cagcaggacacgggcatcccagaggaggaccaggagctgctgcaggaagcgggcctggcg
ttgattcccgataaacctgccactcagtgtatttcagatggcaagttaaatgagggccgc
acattggacatggatcttgtttttctctttgacaacagtaaaatcacctatgagactcag
atctccccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaac
ctcgccttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagacccta
aaggaggattgcaaccggctgcagcagggacagcgagccgccatgatgaatctcctccgg
aacaacagctgcctctccaagatgaagaattccatggcttccatgtctcagcagctcaaa
gccaagttggatttcttcaaaaccagcatccagattgacctggagaagtacagcgagcaa
actgagtttgggatcacatcagataaactgctgctggcctggagggaaatggagcaggcc
gtggagctctgtgggcgggagaacgaagtgaaactcctggtagaacggatgatggctctg
cagacggacatcgtggacttacagaggagccccatgggccggaagcaggggggaacgttg
gacgacctagaggagcaagcaagggagctgtacaggagactaagggaaaagcctcgagac
cagcgaactgagggtgacagtcaggaaatggtacggctgctgcttcaggcaattcagagc
ttcgagaagaaagtgcgagtgatctatacacagctcagtaaaactgtggtttgcaagcag
aaggcgctggaactgttgcccaaggtggaagaggtggtgagcttaatgaatgaggatgag
aagactgttgtccggctgcaggagaagcggcagaaggagctctggaatctcctgaagatt
gcttgtagcaaggtccgtggtcctgtcagtggaagcccggatagcatgaatgcctctcga
cttagccagcctgggcagctgatgtctcagccctccacggcctccaacagcttacccgaa
ccagccaagaagagtgaagaactggtggccgaagcacataacctgtgcaccctgctagaa
aatgccatacaggacaccgtgagggagcaagaccagagtttcacggccctagactggagc
tggttacagatggaagaagaagagcacagctgcctggagcaggcctcctga

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