| Entry |
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| Symbol |
SOS1
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| Name |
(RefSeq) SOS Ras/Rac guanine nucleotide exchange factor 1
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| KO |
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| Organism |
csab Chlorocebus sabaeus (green monkey)
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| Pathway |
| csab01521 | EGFR tyrosine kinase inhibitor resistance |
| csab04650 | Natural killer cell mediated cytotoxicity |
| csab04935 | Growth hormone synthesis, secretion and action |
| csab05207 | Chemical carcinogenesis - receptor activation |
| csab05208 | Chemical carcinogenesis - reactive oxygen species |
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| Brite |
KEGG Orthology (KO) [BR:csab00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
103220440 (SOS1)
04012 ErbB signaling pathway
103220440 (SOS1)
04014 Ras signaling pathway
103220440 (SOS1)
04630 JAK-STAT signaling pathway
103220440 (SOS1)
04068 FoxO signaling pathway
103220440 (SOS1)
04072 Phospholipase D signaling pathway
103220440 (SOS1)
04151 PI3K-Akt signaling pathway
103220440 (SOS1)
04150 mTOR signaling pathway
103220440 (SOS1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
103220440 (SOS1)
04540 Gap junction
103220440 (SOS1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
103220440 (SOS1)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
103220440 (SOS1)
04660 T cell receptor signaling pathway
103220440 (SOS1)
04662 B cell receptor signaling pathway
103220440 (SOS1)
04664 Fc epsilon RI signaling pathway
103220440 (SOS1)
04062 Chemokine signaling pathway
103220440 (SOS1)
09152 Endocrine system
04910 Insulin signaling pathway
103220440 (SOS1)
04912 GnRH signaling pathway
103220440 (SOS1)
04915 Estrogen signaling pathway
103220440 (SOS1)
04917 Prolactin signaling pathway
103220440 (SOS1)
04926 Relaxin signaling pathway
103220440 (SOS1)
04935 Growth hormone synthesis, secretion and action
103220440 (SOS1)
09156 Nervous system
04722 Neurotrophin signaling pathway
103220440 (SOS1)
09159 Environmental adaptation
04714 Thermogenesis
103220440 (SOS1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103220440 (SOS1)
05206 MicroRNAs in cancer
103220440 (SOS1)
05205 Proteoglycans in cancer
103220440 (SOS1)
05207 Chemical carcinogenesis - receptor activation
103220440 (SOS1)
05208 Chemical carcinogenesis - reactive oxygen species
103220440 (SOS1)
05231 Choline metabolism in cancer
103220440 (SOS1)
09162 Cancer: specific types
05210 Colorectal cancer
103220440 (SOS1)
05225 Hepatocellular carcinoma
103220440 (SOS1)
05226 Gastric cancer
103220440 (SOS1)
05214 Glioma
103220440 (SOS1)
05221 Acute myeloid leukemia
103220440 (SOS1)
05220 Chronic myeloid leukemia
103220440 (SOS1)
05211 Renal cell carcinoma
103220440 (SOS1)
05215 Prostate cancer
103220440 (SOS1)
05213 Endometrial cancer
103220440 (SOS1)
05224 Breast cancer
103220440 (SOS1)
05223 Non-small cell lung cancer
103220440 (SOS1)
09172 Infectious disease: viral
05161 Hepatitis B
103220440 (SOS1)
05160 Hepatitis C
103220440 (SOS1)
05163 Human cytomegalovirus infection
103220440 (SOS1)
05165 Human papillomavirus infection
103220440 (SOS1)
09165 Substance dependence
05034 Alcoholism
103220440 (SOS1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103220440 (SOS1)
01522 Endocrine resistance
103220440 (SOS1)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
14:68259509..68404167
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| AA seq |
1333 aa
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS |
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| NT seq |
4002 nt +upstreamnt +downstreamnt
atgcaggcgcagcagctgccctacgagtttttcagcgaagagaacgcgcccaagtggcgg
ggactgctggtgcctgcgctgaaaaaggtccaggggcaagttcatcctactctcgagtct
aatgatgatgctcttcagtatgttgaagaattaattttgcaattattaaatatgctatgc
caagctcagccccgaagtgcttcagatgtagaggaacgtgttcaaaaaagtttccctcat
ccaattgataagtgggcaatagctgatgcccaatcagctattgaaaagaggaagcgaaga
aaccctttatctctcccagtagaaaaaatccatcctttattaaaggaggtcctaggttat
aaaattgaccatcaggtttctgtttacatagtagcagtcttagaatacatttctgcagac
attttaaagctggttgggaattatgtaagaaatatacggcattatgaaattacaaaacaa
gatattaaagtggcaatgtgtgccgacaaggtattgatggatatgtttcatcaagatgta
gaagatattaatatattatctttaactgatgaagagccttccacctcaggagaacaaact
tactatgatttggtaaaagcatttatggcagaaattcgacaatatataagggaactaaat
ctaattataaaagtttttagagagccctttgtctccaattcaaaattgttttcagctaat
gatgtagaaaatatatttagtcgtatagtagatatacatgagcttagtgtaaagttactg
ggccatatagaagatacagtagaaatgacagatgaaggcagtccccatccactagtagga
agctgctttgaagacttagcagaggaactggcatttgatccatatgaatcgtatgctcga
gatattttgcgacctggttttcatgatcgtttccttagtcagttatcaaagcctggggca
gcactttatttgcagtcaataggcgaaggtttcaaagaagctgttcaatatgttttaccc
aggctgcttctggcccctgtttaccactgtctccattactttgaacttttgaagcagtta
gaagaaaaaagtgaagatcaagaagacaaggaatgtttaaaacaagcaataacagctttg
cttaatgttcagagtggtatggaaaaaatatgttctaaaagtcttgcaaaacgaagattg
agtgaatctgcatgtcggttttatagtcaacaaatgaaggggaaacaactagcaatcaag
aaaatgaatgagattcagaagaatattgatggttgggagggaaaagacattggacagtgt
tgcaatgaatttataatggaaggaactcttacacgtgtaggagccaaacatgagagacac
atatttctctttgatggcttaatgatttgctgtaaatcaaatcatgggcagccaagactt
cctggtgctagcaatgcagaatatcgtcttaaagaaaagttttttatgcgaaaggtacaa
attaatgataaagatgacaccaatgaatacaagcatgcttttgaaataattttaaaagat
gaaaatagtgttatattttctgccaagtcagctgaagagaaaaacaattggatggcagca
ttgatatctttacagtaccggagtacactggaaaggatgcttgatgtaacaatgctacag
gaagagaaagaggagcagatgaggctgcctagtgctgatgtttatagatttgccgagcct
gactctgaagagaatattatatttgaagagaacatgcagcccaaggctggaattccaatt
atcaaagcaggaactgttattaaacttatagagaggcttacgtaccatatgtacgcagat
cccaattttgttcggacatttcttacaacatacagatccttttgcaaacctcaagaacta
ctgagtcttataatagaaaggtttgaaattccagagcctgagccaacagaagctgatcgc
atagctatagagaatggagatcaacccttgagtgcagaactgaaaagatttagaaaagaa
tatatacagcctgtgcaactgcgagtattaaatgtatgtcggcactgggtagagcaccac
ttctatgattttgaaagagatgcatatcttttgcaacgaatggaagaatttattggaaca
gtaagaggtaaagcaatgaaaaaatgggttgaatccatcactaaaataatccaaaggaaa
aaaattgcaagagacaatggaccaggtcataatattacatttcagagttcacctcccaca
gttgagtggcatataagcagacctgggcacatagagactttcgacctgctcaccttacac
ccaatagaaattgctcgacaactcactttacttgaatcagatctataccgagctgtacag
ccatcagaattagttggaagtgtgtggacaaaagaagacaaagaaattaactctcctaat
cttctgaaaatgattcgacataccaccaacctcactctgtggtttgagaaatgtattgta
gaaactgaaaatttagaagaaagagtagctgtggtgagtcgaataattgagattctacaa
gtctttcaagagttgaacaactttaatggtgtccttgaggttgtcagtgctatgaattcc
tcacctgtttacagactagaccacacatttgagcaaataccaagtcgccagaagaaaatt
ttagaagaagctcatgaattgagtgaagatcactataagaaatatttggcaaaactcagg
tctattaatccaccatgtgtgcctttctttggaatttatctcactaatatcttgaaaaca
gaagaaggcaaccctgaggtcctaaaaagacatggaaaagagcttataaactttagcaaa
aggaggaaagtagcagaaataacaggagagatccagcagtaccaaaatcagccttactgt
ttacgagtagaatcagatatcaaaagattctttgaaaacttgaatccgatgggaaacagc
atggaaaaagaatttacggattatcttttcaataaatccctagaaatagaaccacgaaac
cctaagcctctcccaagatttccaaaaaaatatagctatcccctaaagtctcctggtgtt
cgtccatcaaacccaagaccaggtaccatgaggcatcccacacctctgcagcaggagcca
aggaaaatcagttacagtaggatccctgaaagtgaaacagaaagtacagcatctgcaccc
aattctccaagaacaccgttaacacctccgcctgcttctggtgcttccagtaccacagat
gtttgcagtgtatttgattccgatcattcgagcccttttcactcaagcaatgataccgtc
tttatccaagttacactgccccatggcccaagatctgcttctgtatcatctataagttta
accaaaggcactgatgaagtgcctgtccctcctcctgttcctccacgaagacgaccagaa
tctgccccagcagaatcttcaccatctaagattatgtctaagcatttggacagcccccca
gccattcctcctaggcaacccacatcaaaagcctattcaccacgatattcaatatcagac
cggacctctatctcagaccctcctgaaagccctcccttattaccaccacgagaacctgtg
aggacacctgatgttttctcaagctcaccactacatctccaacctccccctttgggcaaa
aaaagtgaccatggcaatgccttcttcccaaacagcccatccccctttacaccacctcct
cctcaaacaccttctcctcacggcacaagaaggcatctgccatcaccaccattgacacaa
gaagtggaccttcattccattgctgggccgcctgttcctccacgacaaagcacttctcaa
catatccctaaactccctccaaaaacttacaaaagggagcacacacacccatccatgcac
agagatggaccaccactgttggagaatgcccattcttcttga |
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