Chlorocebus sabaeus (green monkey): 103221339
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Entry
103221339 CDS
T04361
Symbol
GCLC
Name
(RefSeq) glutamate-cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
csab
Chlorocebus sabaeus (green monkey)
Pathway
csab00270
Cysteine and methionine metabolism
csab00480
Glutathione metabolism
csab01100
Metabolic pathways
csab01240
Biosynthesis of cofactors
csab04216
Ferroptosis
Module
csab_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
csab00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
103221339 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
103221339 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
103221339 (GCLC)
Enzymes [BR:
csab01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
103221339 (GCLC)
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
103221339
NCBI-ProteinID:
XP_007970416
Ensembl:
ENSCSAG00000013162
UniProt:
A0A0D9RL47
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Position
17:19012994..19060617
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AA seq
638 aa
AA seq
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MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSVLEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDDEASRASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKAAQKRDAVL
QGMFYFRKDICKAGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILN
SYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNY
SLILKCNQIANELCECPELLGSAFRKVKYGGSKTDSSN
NT seq
1917 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggaaaccaagcgccatgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgttctcaagtggggcgatgaggtggaatacatgttggtatcttttgatcat
gaaaataaaaaagtccgattggtcctgtctggggagaaagttcttgaaactctacaagag
aaaggggaaaggacaaacccaaaccatcctaccctttggagaccagagtatgggagttac
atgattgaagggacaccaggacagccctacggaggaacgatgtccgagttcaacacagtt
gaggccaacatgcgaaaacgccggaaggaggccacttctgtattagaagaaaatcaggct
ctttgcaccataacttcatttcccagattaggctgtcctgggttcacactgcccgaggtc
aaacccaacccagtggaaggaggagcttccaagtccctcttctttccagatgaagcaata
aacaagcaccctcgcttcagtaccttaacaagaaatatccgacataggagaggagaaaag
gttgtcatcaatgtaccaatatttaaggacaagaatacaccatctccatttatagaaaca
tttcctgaggatgatgaagcttcaagggcttctaagccagatcatatttacatggatgcc
atgggatttggaatgggcaattgctgtcttcaggtgacattccaagcctgcagtatatct
gaggccagatacctttatgatcagttggctactatctgtccaattgtcatggctttgagt
gctgcatctcccttttaccgaggctatgtgtcagacatcgattgtcgctggggagtgatt
tctgcatctgtagatgatagaactcgggaggagagaggactggagccattgaagaacaat
aactataggatcagtaaatcccgatatgactcaatagacagctatttatctaagtgtggt
gagaaatataatgacatcgacttgacaatagataaagagatctacgaacagctgttgcag
gaaggcattgatcatctcctggcccagcatgttgctcatctctttattagagacccactg
acactttttgaagagaaaatacacctggatgatgctaatgagtctgaccattttgagaat
attcagtccacaaattggcagacaatgagatttaagccccctcctccaaactcagacatc
ggatggagagtagaatttcgacccatggaggtgcaattaacagactttgagaactctgcc
tatgtggtgttcgtagtactgctcaccagagtgatcctttcgtacaaattggattttctc
attccactgtcaaaggttgatgagaacatgaaggcagcacagaaacgagatgctgtcttg
cagggaatgttttatttcaggaaagatatttgcaaagcaggtggcaacgcagtggtggat
ggttgtggcaaggcccagaacagcacagagcttgctgcagaggagtacaccctcatgagc
atagacaccatcatcaatgggaaggaaggtgtgtttcctggactgatcccaattctgaac
tcttaccttgaaaacatggaagtagatgtggacactagatgtagtattctgaactaccta
aagctaattaagaagagagcatctggagaactaatgacagttgccaggtggatgagggag
tttatcgcaaaccatcctgactacaagcaagacagtgtcataactgatgaaatgaattat
agccttattttgaagtgtaaccaaattgcaaatgaattatgtgaatgcccagagttactt
ggatcagcatttaggaaagtaaaatatggtggaagtaaaactgactcatccaactag
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