Chlorocebus sabaeus (green monkey): 103230821 Help Entry 103230821         CDS       T04361                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism csab  Chlorocebus sabaeus (green monkey) Pathway csab04020   Calcium signaling pathway csab04024   cAMP signaling pathway csab04260   Cardiac muscle contraction csab04261   Adrenergic signaling in cardiomyocytes csab04371   Apelin signaling pathway csab04713   Circadian entrainment csab04911   Insulin secretion csab04921   Oxytocin signaling pathway csab04972   Pancreatic secretion csab05020   Prion disease csab05022   Pathways of neurodegeneration - multiple diseases csab05410   Hypertrophic cardiomyopathy csab05412   Arrhythmogenic right ventricular cardiomyopathy csab05414   Dilated cardiomyopathy csab05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:csab00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103230821 (RYR2)    04020 Calcium signaling pathway     103230821 (RYR2)    04024 cAMP signaling pathway     103230821 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     103230821 (RYR2)    04921 Oxytocin signaling pathway     103230821 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     103230821 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     103230821 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     103230821 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     103230821 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     103230821 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     103230821 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     103230821 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     103230821 (RYR2)    05414 Dilated cardiomyopathy     103230821 (RYR2)    05415 Diabetic cardiomyopathy     103230821 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:csab04040]     103230821 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:csab04990]     103230821 (RYR2) Ion channels [BR:csab04040]  Voltage-gated cation channels   Ryanodine receptor    103230821 (RYR2) Domain-containing proteins not elsewhere classified [BR:csab04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    103230821 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  103230821 NCBI-ProteinID:  XP_007988084 Ensembl:  ENSCSAG00000009677 LinkDB All DBs Position 25:74169024..74951371 Genome browser AA seq 5002 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSHTDIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQSPLKYFRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFP GQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESFAIDSLCGFGIKRSN CYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVF AQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFL KVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAV CALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNE YIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSVSNECYQYSPEFPL DILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQ LIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKL QMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKE FRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLT IRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAM FVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIR GLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFC RISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEK VVRYLAGCGLQSCQLLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLL IRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHM GNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPT IAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDT AALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKA QRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLP GGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESN YVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSVDKLANGWIYG EIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRT RRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKG GGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYS FLQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLS AASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDART VMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPM LSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAG AFPVAFLETHLDKHNIYSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAES GIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKII YNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEA RGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFI YWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTS LIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAI RWQMALYKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKK AVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDL AKPGADPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEED DDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVA ATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEG LGMVTEEGSASHFESHRLRTGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNN TTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQ GPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSM LEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISK RDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNL SEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQV KESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKER PEEQGPRMAFFSILTVKSALFALRYNVLTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFS SYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGD GEEGERKTLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDL MSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQL HTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTS SVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYMEPTLRILAILHTVISFF CIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYW DKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKY QMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGK QLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGG GIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDME TKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQ ERCWEFFPAGDCFRKQYEDQLN NT seq 15009 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaagacgagatccagttcctgcgaactgatgatgaggtg gttctgcagtgcaccgcaaccatccacaaagaacaacagaaactatgcttggcagcagaa ggatttggcaacagactttgtttcttggagtccacttccaattccaagaatgtgccccca gacctctccatctgcacctttgtgctggagcagtccctctctgtccgggccctgcaggag atgctggctaacaccgtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctctatggacatgccatattg ctgcgccattcctacagtggcatgtatctgtgctgcctgtccacctcccggtcttcaact gataagctggcttttgatgttggcttgcaagaggacaccacaggggaggcttgttggtgg accatacaccctgcctctaagcagcgatcagaaggagaaaaagtacgagttggagatgac ctcatcttagttagcgtgtcctctgaaaggtacttgcacttgtcttacggtaacggcagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaggcagcccaagggtatctcattggtggtgatgtcctcaggttgctgcatggacac atggatgagtgtctcactgtcccttcaggagaacatggtgaagagcagcggagaactgtt cattatgaaggtggcgctgtgtctgttcatgcacgttccctttggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagccgttccgattacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaaaccttctactcatggacaaagag aaagctgatgtaaaatcaacagcatttaccttccggtcttccaaggaaaaattggatgta ggggtgagaaaagaagttgacggcatgggaacatctgaaataaaatacggtgactcagta tgctatatacaacatgtggacacgggcctatggcttacttaccagtctgtggacgtgaaa tccgtgagaatgggatctatacaacgtaaggctattatgcaccatgaaggacacatggat gatggcataagtttatcgagatcccagcatgaagaatcacgcacagcacgagttatccgg agcacagtcttccttttcaatagatttataaggggccttgatgcgctcagcaagaaagca aaggcttctaccgtcgatttgcctatagaatccgtaagtctaagtctgcaggatctcatt ggctactttcacccccccgatgagcatttagaacatgaagacaaacagaacagactacga gccctgaagaatcggcaaaatctcttccaggaagagggaatgatcaacctcgtgcttgag tgcatagaccgattgcacgtctacagcagcgcagcacactttgctgatgttgctgggcga gaagcaggggagtcttggaaatccattctgaattctctgtatgagttgctggcggctcta attagaggaaatcgtaaaaactgtgctcagttttccggctcccttgactggttgatcagc agattggaaagactggaagcttcttcgggcattctggaagttttacactgtgttttagta gaaagtccagaagctctaaatattattaaagaaggacatattaaatccattatctcactt ttagacaagcatggaagaaatcacaaggtcctggacgtgttgtgctcactctgtgtttgc catggggttgcagtccgttctaaccagcacctcatctgtgacaacctcttaccaggcaga gatctgttattgcagacacgccttgtgaaccacgtcagcagcatgagacccaatattttt ctgggcgtcagtgaaggttctgctcagtataagaaatggtactatgaattgatggtggac cacacagagccctttgtgacagctgaagcaacgcacctgcgagtgggctgggcttccact gaagggtattctccctaccctggagggggcgaagagtggggtggaaatggtgttggagat gatctcttctcctatggatttgatggccttcatctctggtcaggttgtattgctcgtact gtaagctcaccaaaccaacatctgttaagaactgatgatgtcatcagttgctgtttagat ctaagtgccccaagcatctcgttccgaattaatggacaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagtcgttagtttctctgcgggaataaaagta cgctttctgcttggggggcgacatggagaattcaaatttcttcctccacctgggtacgct ccttgttatgaagctgttctgccaaaagaaaagttgaaagtggaacacagccgagagtac aagcaagaaagaacttacacacgcgacctgctgggccccacggtttccctgacacaagct gccttcacaccgatccctgtggataccagccagattgtgttgcctcctcatctagaaaga ataagagaaaaactggccgagaatatccatgaactctgggttatgaataaaattgagctt ggctggcagtacggaccggttagagatgacaacaagagacagcacccatgcctggtggag ttctccaagctgcctgaacaggagcgcaattacaacttacaaatgtcacttgagaccctg aagactttgttggcattaggatgtcatgtgggtatatccgatgaacatgctgaagacaag gtgaaaaaaatgaagctacctaagaattaccagctgacaagtggatacaagcccgcccct atggacctgagctttatcaaactcaccccatctcaagaagcaatggtggacaagttggca gaaaatgcacacaatgtgtgggcgcgggatcgaatccggcagggctggacttacggcatc cagcaggacgtaaagaacagaagaaatcctcgccttgttccttacactcttctggatgac cgaaccaagaaatccaacaaggacagcctccgcgaggctgtgcgcacactgctggggtac ggttacaacttggaagcaccagatcaagatcatgcagccagagccgaagtgtgcagtggc accggggaaaggttccgaatcttccgtgccgagaagacttatgccgtgaaggcggggcgg tggtattttgaatttgagacggtcaccgctggagacatgagagttggctggagtcggcct ggttgtcaaccggatcaggagcttggctcggatgaacgtgcctttgcctttgatggcttc aaggcccagcgctggcatcagggcaacgaacactatgggcgctcttggcaagcaggtgat gtcgtgggctgcatggttgacatgaacgaacacaccatgatgttcacactgaatggtgaa atccttctcgatgattcaggttcagaactggctttcaaggactttgatgttggcgatgga ttcatacctgtgtgtagccttggagtggctcaagtgggcaggatgaactttggcaaggat gtcagcaccttgaaatacttcaccatctgtggcttacaagagggctatgaaccatttgct gttaatacaaacagggatattactatgtggctgagcaagaggcttcctcagtttctccaa gttccatcaaaccatgaacatatagaggtgaccagaatagacggcaccatagacagttcc ccatgtttaaaggtcactcagaagtcttttggttctcagaacagccacactgatatcatg ttctatcgcctgagcatgccgatcgagtgcgcggaggtcttctccaagactgtggctgga gggctccctggggctggcctttttgggcccaagaatgatttggaagattatgatgctgat tctgactttgaggttctgatgaagacagctcatggccatctagtgcccgatcgtgttgac aaagacaaagaagctaccaaaccagagtttaataaccacaaagattatgcccaggaaaaa ccctctcgtctgaaacaaagtcctctaaaatatttcagatttttgcttagaagaacaaag ccagattacagcacgagccattctgcaagactcaccgaagatgtccttgctgatgatcgg gatgattatgatttcttgatgcaaacgtccacgtactattactcagtgagaatcttccct ggacaagaacctgctaatgtctgggtgggctggattacatcggatttccatcagtatgac acaggctttgacttggatagagttcgcacagtaacagttactctaggagatgaaaaagga aaagtgcacgaaagctttgccattgactcgctgtgtggctttggcatcaaacgcagcaac tgctatatggtatgtgcgggtgagagcatgagccccgggcaaggacgcaacaataatgga ctggagatcggctgtgtggtggatgctgccagcggcctgctcacgttcattgccaatggc aaggaactgagcacatactatcaggtggagccgagtacaaaattatttcctgcggttttt gcacaagctacaagtcccaatgttttccagtttgagttgggaagaataaagaatgtgatg cctctctcggcgggattattcaagagtgagcacaagaaccccgtgccacagtgtcccccg cgcctccacgtgcagttcctgtcacacgtgctgtggagcagaatgcccaaccagtttttg aaggtagatgtgtctcgaataagtgaacgccaaggctggttggtgcagtgtttggatcct ctgcagttcatgtctcttcatatccctgaggaaaacagatctgttgacatcttagagttg acagagcaggaggagttgctgaaatttcactatcacactctgcggctctactcagccgtc tgtgctcttgggaaccaccgggtggcccacgccctgtgcagccacgtggatgaacctcag ctcctctacgccattgagaacaagtacatgcctggcttgctgcgtgctggctactatgac ctgctgatcgacatccacctgagctcctatgccactgccaggctcatgatgaacaacgag tacattgtccccatgacagaggagacgaagagcatcaccctgttccctgatgagaacaaa aagcatggccttccagggatcggcctcagcacctccctcaggccacggatgcagttttcc tcccctagttttgtaagtgttagtaatgaatgttaccagtacagtccagagttcccactg gatatcctcaaggccaagaccatacagatgctgacggaagctgttaaagagggcagtctt catgcccgggacccagttggagggactactgaattcctctttgtgcctctcatcaagctt ttctataccctgctaatcatgggcatcttccacaatgaggacttgaagcacatcttgcag ctgatcgagcccagtgtgtttaaagaagcggccactccagaggaggagagtgatacactg gagaaagagctcagtgtggatgacgcaaagctgcaaggagctggtgaggaagaagccaag gggggcaagcggcccaaggaaggcctgctccaaatgaaactgccagagccagttaaattg cagatgtgcctactgcttcaatacctctgtgactgccaggtccggcaccggatagaagcc attgtagccttttcagatgattttgtagctaagctccaagacaatcaacgtttccgatac aacgaagttatgcaagccttaaacatgtcagcggcactcacagccaggaaaacaaaggaa tttagatcaccacctcaagaacagatcaatatgcttctcaattttaaggatgacaaaagt gaatgtccgtgtccagaagaaattcgtgaccaactactggatttccatgaagatttgatg acacattgtggaattgagctggatgaagatgggtctctggatggaaacagtgatttaaca attagagggcgtctgctatccctggtagaaaaggtgacatacctgaagaagaagcaagca gaaaaaccagttgagagtgactccaaaaagtcctctactctgcagcagctgatctctgag accatggtccgatgggctcaggagtctgtcattgaagaccccgagctggtgagggccatg tttgtgttgctccatcggcagtatgatggcattgggggtcttgttcgggccctgccaaag acctacacgataaatggtgtgtccgtggaggacaccatcaacctgctggcgtcccttggt cagattcggtccctgctgagtgtgagaatgggcaaagaagaagagaagcttatgattcgc ggattaggggatattatgaataacaaggtgttttaccagcaccctaacctcatgagggca ctggggatgcatgagactgtgatggaggtcatggtgaacgtccttggaggtggagagtcc aaggaaatcacctttcccaagatggtggccaactgttgccgttttctctgttacttctgt cgtataagtaggcagaatcaaaaagctatgtttgatcatctcagttatttactggaaaac agcagtgttggtcttgcctccccagctatgagaggttcaacacccctggatgtggctgca gcttcggtgatggataataatgaactagcattagctctgcgtgagccggatctagaaaag gtagttcgttacttggctggttgtggactgcaaagttgccagttgctggtgtctaagggt tatccagacattgggtggaatccagttgaaggagagagatatcttgactttctcagattt gctgtcttctgtaatggggagagtgtggaggagaatgcaaatgtcgtggtgagattgctc attcggaggcctgagtgttttggtcctgctttgagaggagaaggtgggaatgggcttctt gcagcaatggaagaagccatcaaaatcgccgaggatccttctcgagatggtccctcacca aatagcggatccagtaaaacacttgatacagaggaggaggaagatgacactatccacatg gggaacgcaatcatgaccttctatgcagctttgattgacctcttgggacgctgtgcgcct gagatgcatttgattcatgctggcaagggagaagccatcagaattaggtctattttgaga tccctaattcccttgggagatttggtgggcgttatcagcatcgcttttcagatgccaaca atagccaaagatgggaatgtggtggaacctgacatgtctgcggggttttgcccagatcac aaggcagccatggttttattccttgacagggtctatggaattgaggttcaagacttcctc ctccatcttcttgaggttggctttctgccagatctccgggcggctgcttctttagatacg gcggctttgagtgctacagacatggccttggccctcaatcggtacctttgcacagccgtc ttgccgttgttaacaagatgtgctcctctctttgctggcacagagcaccacgcttctctc attgactcattacttcatactgtgtatagactttctaagggctgttcacttaccaaagct cagcgggattctatagaagtttgtttgctctctatttgtggacaactgagaccttctatg atgcagcacttactcagaagattagtatttgatgttccattattaaatgaacatgcaaag atgcctcttaaactgctgacaaatcattatgaaagatgctggaaatattactgcctgcct ggagggtggggaaactttggtgctgcctcagaagaagaacttcatttatcaagaaagttg ttctggggcatttttgatgccctgtctcaaaagaaatatgaacaagagcttttcaaactg gcactgccttgcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaat tatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaactttaacccacaa cctgttgatacctcaaatattacaattcctgagaagttggaatacttcattaacaaatat gcagaacactcccatgacaaatggtcagtggacaagttggcaaatggatggatttatgga gaaatatattcagactcttctaaggttcaaccattaatgaagccatataagctattgtct gaaaaggaaaaggaaatttatcgctggccaatcaaagaatctttaaaaactatgctggcc tggggctggagaattgaaagaactcgggagggagacagcatggccctttacaaccggact cgtcgtatttctcagacaagccaggtttctgtagatgctgcccatggttacagtccccgg gccattgacatgagcaacgttacgctatctagagacctgcatgctatggcagaaatgatg gctgaaaactaccataatatatgggcaaagaaaaagaaaatggagttggagtccaaagga ggaggtaaccaccctctgctggtgccctatgatacactgacagccaaagagaaagccaaa gatagagaaaaagcacaggacatcctcaagttcttgcagatcaatggatatgctgtatcc agaggatttaaggacctggaactggacacgccttctattgagaaacgatttgcctacagt ttcctccaacaactcattcgctatgtggatgaagcccatcagtatatcctggagtttgat ggtggcagcagaggcaaaggagaacatttcccttatgaacaagaaatcaagttctttgca aaagtcgttcttcctttaattgatcagtatttcaaaaaccatcgtttatacttcttatct gcagcaagcaggcctctctgctctggaggacatgcttccaacaaagagaaagaaatggtg actagcctattctgcaaacttggagttcttgtcaggcataggatttcactatttggcaat gatgcaacatcaattgtcaactgtcttcatattttgggtcagactttggatgcaaggaca gtgatgaagactggcctggagagtgttaaaagtgcactcagagcttttctggacaatgcc gcagaggatctggagaagaccatggaaaacctcaagcagggccagttcactcacacccga aaccagcccaaaggggttactcagattatcaattacaccacagtggccctgcttccaatg ctgtcgtcattatttgaacatattggccagcatcagttcggagaagacctcatattggaa gatgtccaggtgtcttgttatagaattctgactagcttatatgctttgggaaccagcaag agtatttatgtggagaggcaacgttctgcgctaggagagtgtcttgctgcctttgctggt gcctttcctgtagcatttttggaaactcatctggacaaacataatatttactccatctac aataccaagtcttcacgagaaagagcagctctcagtttgccaactaatgtggaagatgtt tgtccaaatataccgtctttggagaaactcatggaagaaatcgtggaattagctgagtcg ggcattcgctacactcaaatgccacatgtgatggaagtcatactgcccatgctttgcagc tacatgtctcgctggtgggagcatgggcctgagaacaatccagaacgggccgagatgtgc tgcacagccctgaactcagagcacatgaacacacttctagggaacatattgaaaatcata tataacaacttggggattgatgagggagcctggatgaagaggctggcagtgttttcccag cctataataaataaagtgaaacctcagctcttgaaaactcatttcttgccgttaatggag aaactcaagaaaaaggcagccatggtggtgtctgaggaagaccacctgaaagccgaggcc aggggggacatgtcagaggctgaactcctcatcctagatgagttcaccacgctggccaga gatctctatgccttctaccctctcttgattagatttgtggactataacagggcaaagtgg ctgaaggagcctaacccggaagcagaggagctcttccgcatggtggcggaagtgtttatc tactggtcgaaatcccataatttcaaaagagaagagcagaatttcgttgtacagaatgaa atcaacaatatgtctttccttattactgatacgaagtccaagatgtccaaggcagctgtt tctgatcaggaaaggaagaaaatgaagcgcaaaggagatcggtactccatgcagacctct ctgattgtagcagctctgaagcgcttactgcccattgggttgaacatctgtgccccaggg gaccaggagctcattgctctagccaaaaatcgatttagcctgaaagatactgaggatgaa gtacgagatataatccgcagcaatattcatttacaaggcaagttggaggatcctgctatt agatggcaaatggctctttacaaagacttgccaaacaggactgatgatacctcagatcca gagaagacggtagaaagagtattggatatagcaaatgtgctttttcatcttgaacagaag tctaaacgtgtgggtcggagacattactgtctggtggaacatcctcagagatctaaaaag gctgtatggcataaactactctctaagcagaggaaaagggctgttgtcgcctgcttccgg atggcccccttatataatctgccaaggcatcgggctgtcaatctctttcttcagggatat gaaaagtcttggattgaaacagaagaacattactttgaagataaactgatagaagattta gcaaaacctggggctgaccctccagaagaagatgaaggcactaagagagttgatcctcta catcagctgatccttctgtttagtcggacagctttaacagagaaatgcaaactggaggaa gattttttatatatggcctatgcagatattatggcaaagagttgtcatgatgaggaagat gatgatggtgaagaggaagtgaagagttttgaagtcacaggatcccaacgcagcaaggaa aaagaaatggaaaagcaaaagcttctataccagcaagcccgactccacgaccgtggtgcg gctgagatggtgctgcagaccatcagtgccagcaaaggtgaaactggaccaatggtagca gctactttgaaacttggaattgctattttaaatggtgggaactccacagtacagcagaaa atgcttgactacctcaaggagaaaaaggatgtgggcttctttcagagcctggccggcctg atgcagtcatgtagtgtccttgacctaaatgcatttgagcgacaaaacaaagctgaaggt cttgggatggtgacagaggaaggatcagcctctcactttgaaagtcacagactgcggact ggagaaaaggttctacaggacgatgagttcacctgtgacctcttccgattcctgcagcta ctctgtgagggacacaactcagattttcagaattatctgagaactcagactggcaataat acaactgtcaacataatcatctccactgtagactacctactgagagttcaggaatcaatt agtgacttttattggtattactctgggaaagatgttattgatgaacaaggacaacggaat ttctccaaagctattcaagtggcaaaacaagtctttaacactcttacagagtatattcag ggtccttgcactgggaatcaacagagtttggcacacagcaggctgtgggatgctgtggtc ggctttcttcatgtatttgcccatatgcagatgaagttgtcacaggattccagtcaaatt gaacttttaaaagaattaatggatctgcagaaggatatggtggtcatgttgctgtccatg ctagaaggtaatgttgttaatggaacgattggcaaacagatggtagatatgcttgtggaa tcttccaacaatgtggagatgattctcaaattttttgacatgttcttaaaactgaaagat ttgacgtcatctgatacttttaaagaatatgaccccgatggcaagggagtcatttccaag agggacttccacaaagcgatggagagtcataagcactacacgcagtcagaaacggaattt cttttgtcttgtgcggagacggatgagaatgaaacccttgactatgaggagttcgtcaaa cgcttccacgaacctgcaaaggacatcggcttcaacgtcgccgtccttctgaccaacctc tctgagcacatgcccaacgatacccgacttcagactttcctagaattagcagagagtgtc ctgaattatttccagccctttctgggccgcatcgaaatcatgggaagcgccaaacgcatc gagagagtctattttgaaatcagtgagtctagccgaacccagtgggagaagccccaggtc aaggagtccaaacgacagttcatatttgatgtggtcaatgaaggaggagaaaaagagaag atggaactctttgtgaacttctgcgaggacaccatcttcgaaatgcagttggcagctcag atctcagagtcggatttgaacgagaggtcagcgaataaggaagaaagtgagaaggagagg ccggaagagcaggggccgagaatggctttcttctccattctgacggtcaagtcggccctg tttgcactcaggtacaatgtcttgacccttatgcgaatgctcagtctgaagagcctgaag aagcagatgaaaaaagtcaaaaagatgaccgtgaaggacatggtcacggccttcttttca tcctactggagtatttttatgaccctcttgcacttcgtggccagcgttttcagaggcttt ttccgcatcatttgcagcctgctgcttggaggaagcctcgtcgaaggtgctaaaaagatc aaagttgcagaactcttagccaacatgccagaccccactcaggatgaggttagaggagat ggggaggagggagagaggaaaaccctggaagccgccctgccctctgaggatctgaccgac ttaaaggagctgacagaagaaagtgaccttctttcggacatctttggcctggatctgaag agagaaggaggacagtacaaactaatccctcataatccaaatgctgggctcagtgacctc atgagcaacccagtccccatgcctgaggtgcaagaaaaatttcaggaacagaaggcaaaa gaagaagaaaaggaagaaaaagaagaaaccaaatctgaacctgaaaaagccgagggagaa gatggagaaaaagaagagaaagccaaggaagacaagggcaaacaaaagttgaggcagctt cacacacacagatacggagaaccggaagtgcctgagtcagcattctggaagaaaatcata gcataccaacagaaacttctaaactattttgctcgcaacttttacaacatgagaatgtta gccttatttgtcgcatttgctatcaatttcatcttgctcttttataaggtctccacttct tctgtggttgaaggaaaggagctccccactagaagttcaagtgaaaatgccaaagtgacc agcctggacagcagctcccatagaatcatcgcagttcactatgtactggaggagagcagc ggctacatggagcccacgttgcgtatcttagctattctccacacggtcatttccttcttc tgcatcattggatactactgcttgaaagtcccattggttatttttaagcgagaaaaggaa gtagcacggaaattggaatttgatgggctttatattacagaacagccttcagaagatgat attaaaggccagtgggatagactcgtaatcaacacacagtcatttcccaacaactactgg gacaaatttgttaaaagaaaggtaatggataagtacggagagttctacggtcgagacaga attagtgaattacttggcatggacaaggcagctctggacttcagtgatgccagagaaaag aagaagccaaagaaagacagctccttatcagctgtactgaactctattgatgtgaagtat cagatgtggaaactaggcgtcgttttcactgacaactccttcctctacctagcctggtat atgactatgtctgttcttggacactataacaactttttttttgctgctcaccttctcgac attgctatgggattcaagacattaagaaccatcttgtcctcagtaactcacaatggcaaa cagctcgtattaaccgttggcttattagctgttgttgtgtacctgtacactgtggtggca ttcaattttttccgaaaattctacaataaaagtgaagacggtgatacaccagatatgaaa tgtgacgatatgctaacatgctatatgttccacatgtatgttggagttcgtgctggagga gggattggggatgaaatcgaagacccagcaggagatgaatatgagatctatcgaatcatc tttgacatcactttcttcttctttgttattgtcattctcttggccataatacaaggtcta attatcgatgcttttggagaactaagagaccaacaggaacaagtcaaagaagacatggag accaaatgcttcatctgtgggataggcaatgattacttcgacacagtgccacatggcttt gaaacccacactttacaggagcacaacttggctaattacttgttttttctgatgtatctt ataaacaaagatgaaacagaacacacaggacaggaatcttatgtctggaagatgtatcaa gaaaggtgttgggaatttttcccagcaggggattgtttccggaaacagtatgaagaccag ctaaattaa

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