Entry |
|
Symbol |
NF1
|
Name |
|
KO |
|
Organism |
csab Chlorocebus sabaeus (green monkey)
|
Pathway |
csab01521 | EGFR tyrosine kinase inhibitor resistance |
|
Brite |
KEGG Orthology (KO) [BR:csab00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
103242679 (NF1)
04014 Ras signaling pathway
103242679 (NF1)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103242679 (NF1)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
16:24550983..24836311
|
AA seq |
2849 aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
STFKHGLGTASALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAQTLTFKE
KVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLV
QLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQM
LSSTEILKWLREILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEEL
LRTPGASLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCF
RHLCEEADIRCGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPT
AGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSD
TDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVNERKGSMISVMSSEGNTDTP
VSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQ
VLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQ
IKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQ
ASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGR
KRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQG
TEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSR
HLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVIT
SSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQ
ATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKK
PPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKTNFDAARRFFLDIASDCPTSD
AVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPE
HKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVA
RRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFA
YDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLVFIDCPGKLAEHIEHEQQKLPAAT
LALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEE
ICLVDENQFTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDV
PGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVS
ISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQR
VTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEV
MADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSF
NNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLR
LSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALL
EIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRI
LSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNL
YSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFAL
VGHLLKGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVR
SRCSLKHRKSLLLTDVSMENVPMDTYPIHHGDPTYRTLKETQPWSSPKGSEGYLAATYPT
VGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMR
RVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYT
TDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVY
HEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEET
SEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNS
GRTRHGSASQVQKQRSAGSFKRNSIKKIV |
NT seq |
8550 nt +upstreamnt +downstreamnt
atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag
cttccaataaaaacaggacagcagaacacacataccaaagtcagtactgagcacaacaag
gaatgtctaatcaatatttccaaatacaagttttctttggttataagcggcctcactact
atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttatat
ctctctcagttgattattttggatacactggaaaaatgtcttgctgggcaaccaaaggac
acaatgagattagatgaaacgatgctggtcaaacagttgctgccagaaatctgccatttt
cttcacacctgtcgtgaaggaaaccagcatgcagctgaacttcggaattctgcctctggg
gttttattttctctcagctgcaacaacttcaatgcagtctttagtcgcatttctaccagg
ttacaggaattaactgtttgttcagaagacaatgttgatgttcatgatatagaattgtta
cagtatatcaatgtggattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa
tttaaagccctaaagaaggttgcgcagttagcagttataaatagcctggaaaaggcattt
tggaactgggtagaaaattatccagatgaatttacaaaactataccagatcccacagact
gatatggctgaatgtgcagaaaagctgtttgacttggtggatggttttgctgaaagcacc
aaacgtaaagcagcagtttggccactacaaatcattctccttatcttgtgtccagaaata
atccaggatatatccaaggatgtggttgatgaaaacaacatgaataagaagttatttctg
gacagtctacgaaaagctcttgctggccatggaggaagtaggcagctgacagaaagtgct
gcaattgcctgtgtcaaactgtgtaaagcaagtacttacatcaattgggaagataactct
gtcattttcctacttgttcagtccatggtggttgatcttaagaacctgctttttaatcca
agtaagccattctcaagaggcagtcagcctgcagatgtggatctaatgattgactgcctt
gtttcttgctttcgtataagtcctcacaacaaccaacactttaagatctgcctggctcag
aattcaccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat
agcactttcaagcatggacttggcactgcttcggcattggattggtggcctaagattgat
gctgtgtattgtcactcggttgaacttcgaaatatgtttggtgaaacacttcataaagca
gtgcaaggttgtggagcacacccagcaatacgaatggcacagactcttacatttaaagaa
aaagtaacaagccttaaatttaaagaaaaacctacagacctggagacaagaagctataag
tatcttcttttgtccatggtgaaactaattcatgcagatccaaagctcttgctttgtaat
ccaagaaaacaggggcccgaaacccaaggcagtacagcagagttaattacagggctcgtc
caactggtccctcagtcacacatgccagagattgcgcaggaagcaatggaggctctgctg
gttcttcatcagttagatagcattgatttgtggaatcctgatgctcctgtagaaacattt
tgggagattagctcacaaatgcttttttacatctgcaagaaattaactagtcatcaaatg
cttagtagcacagaaattctcaagtggttgcgggaaattttgatctgcaggaataaattc
cttcttaaaaataagcaggcagatagaagttcctgtcactttctccttttttatggggta
ggatgtgatattccttctagtggaaataccagtcaaatgtccatggatcatgaagaatta
ctacgtactcctggagcctctctccggaagggaaaagggaactcctctatggatagtgca
gcaggatgcagcggaacccccccgatttgccgacaagcccagaccaaactagaagtggcc
ctgtacatgtttctctggaaccctgacactgaagctgttctggttgccatgtcctgtttc
cgccacctctgtgaggaagcagatatccggtgtggggtggatgaagtgtcagtgcataac
ctcttgcccaactataacacattcatggagtttgcctctgtcagcaatatgatgtcaaca
ggaagagcagcacttcagaaaagagtgatggcactgctgaggcgcattgagcatcccact
gcaggaaacactgaggcttgggaagatacacatgcaaaatgggaacaagcaacaaaacta
atccttaactatccaaaagccaaaatggaagatggccaggctgctgaaagccttcacaag
accattgttaagaggcgaatgtcccatgtgagtggaggaggatccatagatttgtctgac
acagactccctacaggaatggatcaacatgactggcttcctttgtgcccttgggggagtg
tgcctccagcagagaagcaattctggcctggcaacctatagcccacccatgggtccagtc
aatgaacgtaagggttccatgatttcagtgatgtcctcagagggaaacacagatacacct
gtcagcaaatttatggatcggctcttgtccttaatggtgtgtaaccatgagaaagtggga
cttcaaatacggaccaatgttaaggatctggtgggtctagaattgagtcctgctctgtat
ccaatgctatttaacaaattgaagaataccatcagcaagttttttgactcccaaggacag
gttttattgaccgataccaatactcagtttgtagaacaaaccatagctataatgaagaac
ttgctagataatcataccgaaggcagctctgaacatctggggcaagctagcattgaaaca
atgatgttaaatctggtcaggtatgttcgtgtgcttgggaatatggtccatgcaattcaa
ataaaaacaaaactgtgtcagttagttgaagtaatgatggcaaggagagatgacctctca
ttttgccaagagatgaaatttaggaataagatggtagaatacctgacagactgggttatg
ggaacatcaaaccaagcagcggatgatgatgtaaaatgtcttacaagagatttggaccag
gcaagcatggaagcagtagtttcacttctagctggtctccctctgcagcctgaagaagga
gatggtgtggaattgatggaagccaaatcacagttatttcttaaatacttcacattattt
atgaaccttttgaatgactgcagtgaagttgaagatgaaaatgcacaaacaggtggcagg
aaacgtggcatgtctcggaggctggcatcactgaggcactgtacagtccttgcaatgtca
aacttactcaatgccaacgtagacagtggtctcatgcactccataggcttaggttaccac
aaagatctccagacaagagctacatttatggaagttctgacaaaaatccttcaacaaggc
acagaatttgacacacttgcagaaacggtattggctgatcggtttgagagattggtggaa
ctggtcacaatgatgggtgatcaaggagaactccctatagcgatggctctggccaatgtg
gttccttgttctcagtgggatgaactagctcgagttctggttactctgtttgattctcgg
catttactctaccaactgctctggaacatgttttctaaagaagtagaattggcagactcc
atgcagactctcttccgaggcaacagcttggccagtaaaataatgacgttctgtttcaag
gtatatggtgctacctatctacagaaactcctggatcctttattacgaattgtgatcaca
tcctctgattggcaacatgttagctttgaagtggatcctaccaggttagaaccatcagag
agccttgaggaaaaccagcggaacctccttcagatgactgaaaagttcttccatgccatc
atcagttcctcctcagaattcccccctcaacttcgaagtgtgtgccactgtttataccag
gcaacttgccactccctactgaataaagctacagtaaaagaaaaaaaggaaaacaaaaaa
tcagtggttagccagcgtttccctcagaacagcatcggtgcagtaggaagtgccatgttc
ctcagatttatcaatcctgccattgtctcaccgtatgaagcagggattttagataaaaag
ccaccacctagaatcgaaaggggcttgaagttaatgtcaaagatacttcagagtatcgcc
aatcatgttctcttcacaaaagaagaacatatgcggcctttcaacgattttgtgaaaacc
aactttgatgcagcacgaaggtttttccttgatatagcatctgattgtcctacaagtgat
gcagtaaatcatagtctttccttcatcagtgacggcaatgtgcttgctttacatcgtcta
ctctggaacaatcaggagaaaatcggccagtatctttccagcaacagggatcataaagct
gttggaagacgaccttttgataagatggcaacacttcttgcgtacctgggtcctccagag
cacaagcccgtggcagatacacactggtccagccttaaccttaccagttcaaagtttgag
gaatttatgactaggcatcaggtacatgaaaaagaagaattcaaggctttgaaaacgtta
agtattttctaccaagctgggacttccaaagctgggaatcctattttttattatgttgca
cggaggttcaaaactggtcaaatcaatggtgatttgctgatataccatgtcttactgact
ttaaagccatattatgcaaagccatatgaaattgtagtggaccttacccataccgggcct
agcaatcgctttaaaacagactttctctctaagtggtttgttgtttttcctggctttgct
tacgacaacgtctccgcagtctatatctataactgtaactcctgggtcagggagtacacc
aagtatcatgagcggctgctgactggcctcaaaggtagcaaaaggcttgttttcatagac
tgtcctgggaaactggctgagcacatagagcacgaacaacagaaactacctgctgccacc
ttggctttagaagaggacctgaaggtattccacaatgctctcaagctagctcacaaagat
accaaagtttctattaaagttggttctactgctgtccaagtaacctcagcagagcgaaca
aaagtcctaggacaatcagtctttttaaatgacatctattatgcttcggaaattgaagaa
atctgcctagtagatgagaaccagttcaccttaaccattgcaaaccagggcacgccgctc
accttcatgcaccaggagtgtgaagccattgtccagtctatcattcatatccggacccgc
tgggagctgtcacagcccgactctatcccccaacacaccaagattcggccaaaagatgtc
cctggtacactgctcaatatcgcattacttaatttaggcagttctgacccgagtttacgg
tcagctgcctataatcttctgtgtgccttaacttgtacctttaatttaaaaatcgagggc
cagttactagagacatcaggtttatgtatccctgccaacaacaccctctttattgtctct
attagtaagacactggcagccaatgagccacacctcacgttagaatttttggaagagtgt
atttctggatttagcaaatctagtattgaattgaaacacctttgtttggaatacatgact
ccatggctgtcaaatctagttcgtttttgcaagcataatgatgatgccaaacgacaaaga
gttactgctattcttgataagctgataacaatgaccatcaatgaaaaacagatgtaccca
tctattcaagcaaaaatatggggaagccttgggcagattacagatctgcttgatgttgta
ctagacagtttcatcaaaaccagtgcaacaggtggcttgggatcaataaaagctgaggtg
atggcagatactgctgtagctttggcttctggaaatgtgaaattggtttcaagcaaggtt
attggaaggatgtgcaaaataattgacaagacatgcttatctccaactcctactttagaa
caacatcttatgtgggatgatattgctattttagcacgctacatgctgatgctgtccttc
aacaattcccttgatgtggcagctcatcttccctacctcttccacgttgttactttctta
gtagccacaggtccgctctcccttagagcttccacacatggactggtcattaatatcatt
cactctctgtgtacttgttcacagcttcattttagtgaagagaccaagcaagttttgaga
ctcagtctgacagaattctcattacccaaattttacttgctgtttggcattagcaaagtc
aagtcagcagctgtcattgccttccgttccagttaccgggacaggtcattctctcctggc
tcctatgagagagagacttttgctttgacatccttggaaacagtcacagaagctttattg
gagatcatggaggcatgcatgagagatattccaacgtgcaagtggctggaccagtggaca
gaactagctcaaagatttgcattccagtataatccatccctgcaaccaagagctcttgtt
gtctttgggtgtattagcaaacgagtgtctcatgggcagataaagcagattatccgtatt
cttagcaaggcacttgagagttgcttaaaaggacctgatacttacaacagtcaagttctg
atagaagctacagtaatagcactaaccaaattacagccacttcttaataaggactcacct
ctgcacaaagccctcttttgggtagctgtggctgtgctgcagcttgatgaagtcaacttg
tattcagcaggcacagcacttcttgaacaaaacctgcatactttagatagtctccgtata
ttcaatgacaagagtccagaggaagtatttatggcaatccggaatcctctggagtggcac
tgcaagcaaatggatcattttgttggactcaatttcaactctaactttaactttgcattg
gttggacaccttttaaaagggtacaggcatccttcacctgccattgttgcaagaacagtc
agaattttacatacactactaactctggttaacaaacacaggaattgtgacaaatttgaa
gtgaatacacagagcgtggcctacttagcagctttacttacagtgtctgaagaagttcga
agtcgctgcagcctaaaacatagaaagtcacttcttcttactgatgtttcaatggaaaat
gttcctatggatacatatcccattcatcatggtgatcctacctataggacactaaaggag
actcagccatggtcctctcccaaaggttctgaaggataccttgcagccacctatccaact
gtcggccagaccagtccccgagccaggaaatccatgagcttggacatggggcagccttct
caggccaacactaagaagttgctgggaacaaggaaaagttttgatcacttgatatcagac
acaaaggctcctaaaaggcaagaaatggaatcagggatcacaacaccccccaaaatgagg
agagtagcagaaactgattatgaaatggaaactcagaggatttcctcatcacaacagcat
ccacatttacgtaaggtttcggtgtctgaatcaaatgttctcttggatgaagaagtactt
actgatccaaaaatccaggcgctgcttcttactgttctagctacactggtaaaatatacc
acagatgagtttgatcaacgaattctttatgaatacttagcagaggccagtgttgtgttt
cccaaagtatttcctgttgtgcataatttgttggactctaagatcaacaccctgttatca
ctgtgccaagatccaaatctgttaaatccaatccatggaattgtgcagagtgtggtgtac
catgaagaatccccaccacaataccaaacatcttacctgcaaagttttggttttaatggc
ttgtggcggtttgcaggacccttttcaaagcaaacacaaattccagactatgctgagctt
attgttaagtttcttgatgccttgattgacacgtacctgcctggaattgatgaagaaacc
agtgaggaatccctcctgacacccacatctccttaccctcctgcactgcagagccagctt
agtatcactgccaaccttaacctctctaattccatgacctcacttgcaacttcccagcat
tccccaggaatcgacaaggagaacgttgaactctcccctaccactggccactgtaacagt
ggacgaactcgccacggatccgcaagccaagtgcagaagcaaagaagcgctggcagtttc
aaacgtaatagcattaagaagatcgtgtga |