Chlorocebus sabaeus (green monkey): 103246111 Help Entry 103246111         CDS       T04361                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism csab  Chlorocebus sabaeus (green monkey) Pathway csab04020   Calcium signaling pathway csab04371   Apelin signaling pathway csab04713   Circadian entrainment csab04921   Oxytocin signaling pathway csab04970   Salivary secretion csab05010   Alzheimer disease csab05012   Parkinson disease csab05020   Prion disease csab05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:csab00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103246111 (RYR3)    04020 Calcium signaling pathway     103246111 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     103246111 (RYR3)   09154 Digestive system    04970 Salivary secretion     103246111 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     103246111 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     103246111 (RYR3)    05012 Parkinson disease     103246111 (RYR3)    05020 Prion disease     103246111 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     103246111 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:csab04040]     103246111 (RYR3) Ion channels [BR:csab04040]  Voltage-gated cation channels   Ryanodine receptor    103246111 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_ITPR RyR RR_TM4-6 MIR Ins145_P3_rec SPRY RYDR_Jsol RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  103246111 NCBI-ProteinID:  XP_008015617 LinkDB All DBs Position 26:complement(49048161..49587009) Genome browser AA seq 4537 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKADTKSTAFSFRASKELKEKLDSSHKREIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHINPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNTNRDVAMWFSKRLPTFVNVPKDHPHIQVMFHN VCGPGRSGGPRPEAPPRSPVNRQLLTYEAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPS CVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQR SNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVRVASGAETGLSQAWCSRPLHPSTH SASVGLGEIAGFWWVLLPLVWLISCPVLRCVDILELCEQEDLMRFHYHTLRLYSAVCALG NSRVAYALCSHVDLSQLFYAIDNKYLPGLLRAGFYDLLISIHLANAKEWKLMMKKCFQQT SNRKPNSGRIAINGFRWLTPLCPRAGSKVVVAVLGLISMHCSVRGKTMTATVLVPSVVLP ATLKELISQTMICWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISHASVSD TINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVM VNVLSTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLRYLLENSSVGLASPSMRG STPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGE RYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISEN PALDLPSQGYKREVSTEADEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEA IRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVY GIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFA GTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDV PQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKK YDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADGNFDPKPINTVNFSLPEK LEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPAR ESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQ GMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQV NGVIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHD QEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRH RISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKL GKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGMDLLLGAVQISCYHILCSL YSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGM PDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENL PPSTGQCCTKVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRS HFIPTLEKLKKKAVKTVQEEEQLRADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYV DNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKS KMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLA KSRYGHRDTDEEVREHLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQR ISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQ RFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLED DPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQM ISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVL DLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNF LRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIF NSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQD MVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDP DGKGIISKREFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFN VAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEE EEEDEDSSYVLEIAGEEEEDGSFEPASAFAMACASVKRNIADFLKRATLKNLRKQYRNVK KMTAKELVKVLCSFFWMLFLGLFQMLFTILGGIFQILWSTVFGGGLVEGAKNIRVTKILG DMPDPTQFGIHDDTMEAERAEVMEPGITTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLK HGPEVGLGDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGEKE DKDKEEEQAEYLWTEVTKKKKRRCGQKVEKPEAFTANFFKGLDIYQTKLLHYLARNFYNL RFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYM APTLRALAVIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKG QWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAE AASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGF KTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMM TCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAF GELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDE TEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 13614 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgaggactgaggatgaa gtggtactccagtgcatcgccaccattcacaaggagcagaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtacattcct ccagatctctgcgtctgcaattttgtgctggaacagtccctatctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaaggaggtggccac aggaccctgttatacggccatgcagttctcctgaggcactctttcagcggaatgtatcta acatgcttgactacatcaagatcccagacagacaaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggactatacatcctgcttccaaacagaggtcc gaaggagagaaagttagaattggcgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatggtaacatacaagtggatgcctcctttatgcagaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcacgtagtgcgtcttttccatggtcatgatgagtgtctgacgataccatctacagat cagaatgattcccagcacaggaggatattctacgaagctgggggagctgggactcgagcc aggtctctgtggagagtggaaccacttcggataagttggagtggcagtaacatcagatgg ggccaggcttttcgactccggcatctcaccacaggccactacctggccttgacagaagac caaggccttatactgcaagaccgggcaaaggcagacaccaagtccacagctttctctttc cgggcatcaaaggaactcaaggagaaactagattccagtcacaagcgagagatagaaggc atgggagttccagaaatcaagtatggagattctgtctgctttgtacagcatatagccagt ggtctgtgggtgacctacaaagcgcaagatgccaaaacttcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgatggattaacactgcagagatgc cagcgtgaggagtcccaggctgctcggatcatccggaacactacagccttattcagccag tttgtcagtggaaacaatcgcacagctgcccccatcaccctgcctatagaagaagtcctg cagaccctacaggacttgatcgcctacttccagcccccggaggaggagatgcgacatgaa gacaagcagaacaagctccgctcactcaaaaacagacaaaatcttttcaaggaagaggga atgttggctcttgtcttaaattgcattgaccgcttaaatatctacaatagtgtagcacac tttgcagggattgcaagggaagagagtggcatggcctggaaagaaattctgaacctcctc tacaaattgctggctgctctcattcgtggaaacagaaacaattgcgctcaattctccaat aaccttgattggctcatcagtaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttaactgaaagtccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcacgggcggaatcacaaggttctggatatc ctgtgctccctctgtctctgcaatggggttgcagtgagagccaaccagaatctaatctgt gacaacctgctgccccggagaaacctgctcttgcagacacgactgattaacgatgtaacc agtatccggccaaacatcttcctgggagtcgcggagggctcagcccagtacaagaagtgg tacttcgagctgattatcgaccaggtggaccccttcctaacagcagagcccacacatctg cgggtgggctgggcctcctcctcaggctatgccccgtacccaggcggtggagaaggatgg ggaggcaatggtgttggcgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccggatacccagagctgtggcttccatcaaccagcacctcctgagatcagatgat gtggtaagctgctgcctggacctcggggtgcccagcatttcattccgcatcaatggacag cctgtgcaggggatgtttgagaacttcaacacagacgggctcttcttccctgtgatgagc ttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagagtttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagaaaagatgaga ttggaacctgtcaaagaatataaacgtgatgctgatggcgttagagatctcttgggtacc acccagttcctctcccaagcctctttcatcccatgccccatagacaccagtcaggttgtt ttgccacctcacctagaaaagatccgagacagactagctgaaaacatccatgagctttgg ggaatgaataaaatagagcttggctggactttcggcaagatacgagatgacaataaaaga caacacccttgccttgtggagttttcaaagctccccgaaactgagaagaattataacctg caaatgtcgactgaaaccttgaaaaccctcctggccctggggtgccacattgctcatatt aacccagctgctgaggaggatctcaagaaggtcaaactgcccaaaaactatatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcgcacaatgtttgggcaaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccgtctggtg ccgtatgcattactggacgagcgtaccaagaagtcaaacagggacagcctgcgggaagct gtgcgcacttttgttggttacggatataacattgagccatcagaccaagaactagctgac tcggctgtggagaaagtcagcatagacaagatccgatttttccgggtagagcgatcttat gcagtgagatctggaaagtggtattttgagtttgaggtggtgactggaggagacatgcga gttggctgggccaggccaggctgtcggcctgatgtcgagctgggggccgatgaccaagcc tttgtgtttgaaggtagcaggggccagcgttggcatcaaggaagtgggtattttgggcgt acctggcagccaggagatgtggtcggatgtatgattaacctggatgatgcttcaatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgagaatggctttgtgcccatctgctgtctggggctgtctcagattggccgc atgaatctcgggacagatgccagtaccttcaagttttataccatgtgcggtctccaagag ggctttgagccttttgctgtcaacacgaacagagatgttgctatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggaccatccacacatacaggtaatgttccacaac gtgtgtggccctggcaggtcaggtgggccaaggcccgaagccccccccaggtctcctgtc aacaggcagctgcttacctatgaagctttccagaaaaggaaacagatgcaagaaatactc tctcatacaacaacacagtgctactatgccatccgcatctttgctggacaggatccatcc tgcgtctgggtcggatgggtgactccagactatcacttgtacagtgaaaagtttgacctg aataaaaactgcacagtgactgtcaccctaggggatgaaagaggccgggtacacgaaagt gtgaaacgcagcaactgctacatggtctggggcggggacatagtggccagttcccagaga tcaaatcggagcaacgtggacctggagatcggctgtcttgtggatctggcaatgggcatg ttgtccttctcagccaacggaaaagaactgggcacctgctaccaggtaagggtggcttct ggggccgaaacagggctatcccaggcctggtgttcaagacccctccatccttccacccac tctgcctccgttgggctgggtgaaattgctggattctggtgggttcttctccccttggtg tggctgatttcttgtcctgtcctcaggtgtgtggatatcctggagctctgtgagcaggag gacctgatgcggttccattaccacacactgaggctctacagcgcggtgtgcgccctggga aacagccgcgtggcctacgccctgtgcagccacgtggacctctcccagctcttctatgcc attgacaacaagtacctccccggcctccttcgagctggcttctatgacctactcatcagc atccacctggccaatgccaaggagtggaagctgatgatgaagaaatgctttcagcaaaca agcaacaggaagcccaactcaggtagaatagccattaatggatttcgctggctgacacct ctttgccctcgagctggcagtaaggtcgtggttgccgttctgggcctcatatccatgcac tgcagtgtccgagggaaaaccatgacagccacagtcctggtcccttctgttgtccttcca gcaacattgaaggagctcatctcacagacgatgatctgctgggcccaggaggaccagatc caggatgcagagctggtccgaatgatgttcaacctcctccggaggcagtatgacagcatc ggggagctgctgcaggcgctgcggaagacgtacaccatcagccatgcctctgtaagcgac accatcaacctgctggctgccctgggccagatccgctccctcctcagtgtcaggatgggc aaggaagaggagttgctcatgatcaacgggctgggagacataatgaacaacaaggtgttt taccagcatcccaacctcatgagagtcctgggcatgcacgagacggtgatggaggtgatg gtgaacgtgttgagtacagagaaatctcagattgcatttccaaagatggttgctagctgc tgccgtttcctttgctatttctgtcgaattagccggcaaaatcagaaggccatgtttgag catctgaggtatcttctggagaatagcagcgttggcctagcctccccgtcgatgagggga tccaccccgctggatgtggcagcgtcctctgtgatggacaacaacgagttagcgctgggc ttggaggaaccagacctggagaaggtggtgacctacttggcaggctgtggcctacagagc tgccccatgcttctggccaaaggataccctgatgtgggctggaaccccattgaaggggaa cgctacctgtccttcctgaggtttgccgtcttcgtgaacagtgagagtgtggaagaaaac gccagcgttgtggtcaagctgctcatcagacgcccagagtgcttcggcccggccctgcgg ggcgagggaggaaacggactgttggcggccatgcagggtgccattaagatctctgagaac cccgcacttgacctcccctctcaaggatacaaaagagaagtcagcacggaggccgatgaa gaggaagaagaaatcgtgcatatgggcaatgcaattatgtcattttattcggcccttata gatctactgggccgctgtgctcctgaaatgcacctcatccagacaggaaagggggaggcc atccgcatcaggtccatactgcgctccctggtccccacagaagacctggttgggatcatc agcatccccttgaaactgccctcccttaacaaagatgggtcggtcagtgagccggatatg gcggccaacttctgccctgaccacaaggcacccatggtgctgttcttggaccgcgtctat ggcatcaaggatcaaacttttctgctccacttgctggaggttggatttttacctgacctg agagcttctgcctctctagatacagtttccctgagcaccacagaggctgcgcttgcacta aataggtatatatgttctgctgtgctcccgctcctcacaagatgtgcccctctctttgcc ggaacagaacactgcacctctctgattgattccacactgcagacgatatacaggctttcc aagggacgttccctcaccaaagcacaaagggacactatagaagaatgtctgcttgccatt tgcaatcacttgaggccttccatgttacagcagctcctgcgacgcctcgtttttgatgtg ccccaactcaatgaatactgcaaaatgcctctcaagcttctgacgaatcactatgaacag tgctggaagtattactgcctgccctcaggatgggggagctacgggctagctgtggaagaa gagctgcacctaacggagaagcttttctgggggatttttgactctctctcccataagaaa tatgacccagatcttttccgaatggccctgccttgtctcagtgctatagctggggccttg ccaccggattatttagataccagaatcacagccactttggagaaacagatctcagtggat gcagatggcaactttgatcccaaacctatcaacactgtgaatttttccttgcctgaaaaa ttggaatacatcgtcaccaagtatgctgagcattcacatgataaatgggcctgtgacaag agtcagagtggatggaaatatgggatttccctggatgaaaatgtgaagacccacccactg ataaggcctttcaagacattaacggagaaggagaaggaaatttatcgctggcctgcccgg gagtccctgaaaaccatgctagctgtgggctggactgtggagaggaccaaagagggagaa gccttggttcaacagcgggaaaatgagaagcttcgaagcgtgtcccaggccaaccagggc aacagctacagccctgctcccctcgacctctcaaacgtcgtgctctccagagagctccag ggaatggtggaggttgtggctgagaactatcacaatatctgggccaagaagaagaagctg gaactggagagcaaaggtggtggcagtcaccctcttctggtaccatatgacactctgact gccaaggaaaagttcaaggaccgggagaaggcacaggacctgttcaagttcctccaagtc aatggcgtcatagtttccaggggtatgaaggatatggagctggatgcctcctccatggaa aagaggtttgcctataagttcttgaagaagatcctgaaatacgttgattcggcacaagaa tttattgcccatttagaagccattgtcagcagtgggaaaaccgaaaagtctcctcatgac caggagatcaaattctttgccaaagttctcctcccactggttgaccagtacttcaccaat catcgcctctacttcttgtcatcccctctgaagccccttagcagcagtggatacgcctct cataaggagaaagaaatggtggccagcctgttctgcaaacttgctgctcttgttagacac agaatttctctctttggtagtgattctactacaatggtgagctgtcttcacatcttagct cagacacttgacacaaggactgtcatgaagtcaggctcagagctggtgaaggctgggtta cgagcattctttgaaaatgctgcagaagacttggagaagacttcagaaaacctgaaactt gggaagttcacccattcccgaacgcagattaaaggcgtttctcagaatattaactatact acagtggctctgctccccatcctgacgtccatctttgagcacgtcgctcagcatcagttt ggaatggatctactcttgggtgctgtgcagatttcctgctaccacatactgtgcagcctc tactcccttgggacaggaaagaacatttatgttgaaaggcaacgccctgcccttggagaa tgtctggcctcgctggcagctgccataccagtggcattcctggagcccaccctcaatcgc tacaatcctctctcggtcttcaacaccaaaacccccagggagaggtctattctggggatg ccagacacggtagaagacatgtgtcctgacatcccccagctggaaggcctgatgaaggaa atcaacgacctggccgagtcaggggcgcggtacacagagatgccgcatgtcatcgaggtg atcttacccatgctctgcaactacctgtcctactggtgggagcgggggcctgagaacctg ccccccagcacggggcagtgctgcaccaaggtcacctctgaacacctcagtctcatcctg ggcaacattctgaaaatcatcaacaacaacctgggcatcgatgaagcctcctggatgaag cgcattgcagtgtatgcacagcccatcatcagcaaagccaggcccgacctgctgagaagc cacttcatcccaactctggagaagctgaagaaaaaggctgtcaagaccgtgcaggaggag gagcagttgagagccgatggcaaaggggacacccaggaggcggagctcctcatcctggac gaattcgcggtcctctgccgagatctctatgccttctaccccatgctgatccgctacgtg gacaacaacagatctaactggctgaaaagccctgatgctgattctgaccagctcttccgc atggtggcagaagtcttcatcctgtggtgtaaatctcacaacttcaagagggaagagcaa aattttgtgattcagaatgaaattaataatttggcatttttaactggagacagcaaaagc aagatgtcaaaagccatgcaagtaaagtctggaggacaagaccaggagcggaagaagaca aagcggcggggagacttgtattccatccagacctccctcatcgtggctgccctcaagaaa atgctgcccattggtttgaatatgtgtactccaggcgaccaggagctgatctccctcgca aaatcacgatacggccatagggacacagatgaagaggtcagagaacatctgcggaacaac ttgcacttgcaggaaaagtctgatgacccagctgtaaaatggcaactgaacctctacaag gatgttctgaagagtgaagaacctttcaatccagaaaagacagtagagcgtgtgcagaga atttcagcagctgtcttccacctggaacaggtggaacagcctttgaggtccaagaaggcc gtctggcacaaactgctatcaaagcaacggaaacgggcagtggtggcctgcttcaggatg gcccctctctacaacctgcccaggcaccgctctattaacctcttcctccatggctatcag agattttggatagaaacagaggagtattcctttgaagagaaactagtacaggatttggct aaatctccaaaggtggaagaggaggaggaggaagagaccgaaaaacaacctgacccactg catcagatcattctctattttagccgcaacgctctcacggagaggagcaaattggaagac gaccctttgtacacctcctattccagcatgatggctaagagttgtcaaagtggtgaggat gaagaagaagatgaagacaaggagaaaacattcgaagagaaggagatggagaagcagaaa accctgtatcagcaagctcggctgcatgagcgtggtgccgcggagatggtccttcagatg ataagcgctagcaaaggtgagatgagccccatggtggttgagactctgaagctggggatc gccattctgaacggaggcaatgctggtgtgcaacagaaaatgctagattacctaaaggag aaaaaggatgctggattctttcaaagcctttctggtcttatgcagtcttgcagtgtcctt gatttgaatgcatttgagaggcagaataaagctgaaggcctggggatggtgactgaagaa ggaacactcattgttcgtgaacgtggtgaaaaagtactccagaatgacgagttcacgcgt gatctctttagattcctacagttactttgtgagggacataacagtgactttcagaacttc ctgcggactcagatgggtaacaccaccaccgtgaatgtcatcatcagcactgtggactac cttctgcgtctgcaggaatcaatcagtgatttctactggtattattcagggaaggacatc attgatgaatccggacagcacaatttctccaaagctctggcagtcaccaagcagattttc aattctcttacagaatacatccagggcccttgcattggtaatcagcagagcctggctcac agcaggctgtgggacgccgtggtcggcttcctccatgtctttgctaatatgcagatgaaa ctgtctcaggattccagtcagatcgagctgctgaaggaactcttggatctccttcaggac atggtggtgatgcttctgtccctcctggaagggaatgtggtaaatggcaccattggcaag cagatggttgacacactggtagaatcatctaccaatgtagaaatgatcttgaaattcttt gacatgttcttgaaacttaaagacttaaccagctcagacaccttcaaagaatacgaccca gatggtaaaggaattatctccaaaagagaattccagaaggccatggaagggcaaaaacag tacacgcagtcagagattgactttctcctttcgtgtgcagaagctgatgagaatgacatg tttaattacattgattttgtagaccggtttcatgagccggccaaggacatagggtttaat gtggctgtgttattgacaaatctttctgaacacatgccaaacgattcccgcctgaagtgt ctgttggacccagcagagagtgtgctaaattacttcgaaccctacctaggacgcatcgag atcatgggtggcgccaagaaaattgagcgtgtctattttgaaatcagtgagtccagtcgc actcagtgggagaagccccaggtgaaggaatctaagcgacagttcatttttgatgttgtc aacgaaggtggggagcaggaaaagatggagctgtttgtgaacttctgtgaggacaccatc tttgaaatgcagttagcatctcagatctctgaatccgattcagcggacaggccagaagag gaggaagaagatgaagattcttcttacgtgttagaaattgcgggtgaagaggaggaagac gggtctttcgagccggcctctgcatttgcaatggcctgtgcctctgtgaagaggaatatc gccgactttctgaagagagcaaccctgaagaacctcaggaagcagtacaggaacgtgaaa aagatgactgcgaaggagctggtgaaggtgctctgctcctttttctggatgctgttcctg gggctgttccagatgctcttcaccatcctgggaggaatctttcagatcctctggagcaca gtgttcggagggggcctggtagaaggggcaaagaacatcagagtgaccaagatcctgggt gacatgcctgacccaacccaatttggtatccatgatgacactatggaggctgagagggca gaggtgatggagccaggtatcaccactgaactagtacacttcataaagggggagaaggga gatacagatatcatgtcagacctctttggactccacccaaagaaagagggcagcttaaag catgggcctgaagtgggtttgggtgacctctcagaaattattggcaaggatgaaccccct acgttagagagtactgtacagaagaagaggaaagctcaggcagcagagatgaaagcagca aatgaagcagaaggaaaagtagaatccgagaaggcagacatggaagatggagagaaggaa gacaaagacaaagaagaggagcaagccgagtacctgtggacagaggtgacaaaaaagaag aagcgacggtgtggtcagaaggttgagaagccggaagctttcacagccaatttctttaaa gggctggacatctatcagaccaagttactgcattacctggccaggaatttctacaacctg aggttccttgctctgtttgtagccttcgctatcaacttcatcctgcttttttataaggtc actgaagaacctttagaagaagagacagaggatgttgcaaacctatggaattcatttaat gacgaggaagaggaagaagcgatggtgttctttgttcttcaggagagcactgggtatatg gcaccaacgctgcgggccctggccgtcatccacaccatcatctctctagtctgtgtggtg ggctactactgcctgaaggtgcctttggtggtattcaaaagggaaaaagaaatcgccagg aagctggagtttgatggcctatatatcaccgaacagccatctgaagatgacatcaagggg cagtgggaccgcttggtgatcaacacaccatcttttcctaataactactgggacaagttt gtaaagaggaaggtgatcaacaagtatggcgatctctacggagcagagcgcattgccgaa cttctgggtttggacaaaaatgctcttgacttcagcccagtagaagagaccaaagcagag gcggcttctctggtgtcatggctaagttccatagacatgaagtaccatatctggaagctt ggagttgtgtttactgacaactcctttctctaccttgcctggtatacaaccatgtcagtc ctgggccactacaataacttcttcttcgctgctcacctgctggatatcgcaatgggcttc aagacactgaggaccattctatcatctgtaactcacaatggcaaacagttggttctgacg gtcggtctcctggccgtggtggtgtatctgtataccgtggtggctttcaacttcttccgc aagttctacaacaaaagcgaagacgatgacgagcctgatatgaagtgtgacgacatgatg acgtgttaccttttccacatgtacgtgggagtgagagcaggaggtggcattggtgacgag attgaagaccctgctggtgatccttatgaaatgtatcgcattgtctttgacattaccttt ttcttctttgtcattgtcatcttgctggccatcattcaaggtcttattattgatgctttc ggagagctaagagaccagcaggaacaagtgcgagaagatatggagaccaaatgtttcatc tgtgggattggcaatgactactttgacacgacccctcatggttttgaaacacatacatta caagagcacaacttagccaactacttgttctttctgatgtatttgattaataaagatgaa acagagcacacgggtcaggaatcttatgtctggaagatgtaccaagaaaggtgctgggat ttcttcccagccggtgactgctttcgtaaacagtatgaagatcagcttggataa

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