Cololabis saira (Pacific saury): 133452774 Help Entry 133452774         CDS       T09849                                  Symbol obscnb Name (RefSeq) obscurin isoform X1   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism csai  Cololabis saira (Pacific saury) Pathway csai04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:csai00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     133452774 (obscnb)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:csai01001]     133452774 (obscnb)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:csai04131]     133452774 (obscnb) Enzymes [BR:csai01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      133452774 (obscnb) Protein kinases [BR:csai01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    133452774 (obscnb) Membrane trafficking [BR:csai04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     133452774 (obscnb) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Ig_6 Ig_4 Izumo-Ig SOS1_NGEF_PH fn3 V-set_CD47 RhoGEF Ig_DSCAM-DSCAML_C Adeno_E3_CR1 PH Receptor_2B4 IQ RHG20_PH Motif Other DBs NCBI-GeneID:  133452774 NCBI-ProteinID:  XP_061588371 LinkDB All DBs Position 10:complement(29398598..29467027) Genome browser AA seq 5994 aa AA seqDB search MDQNLFGGAPRFLTRPKAFSVCVGKDATLSCTVVGNPTPLITWEKDKLKITSGSRFKTVE DEDVYRLTIYDLTLEDGGHYMCKAKNSVGEAYAAVTLKVALPGEMSQRAPVFMVKPASTR VGLGGDVVFHCRVAAHPEANFDWEKDGRYLGETTRIKIISDNDSSTLKIQGVRNLDSGTF TCRAQNSVGRANAAAVLTVDAQDSHHAAADKGSSLLSHLQKRKEEMNKDISIYRTEESHS SVSSSVKANMKDALGSLNLEHELRARALAKLPKGVFTRTCTVTEGKHAKLSCFVTGHPKP HIIWRKDGANISEGRRQVIYEDQAENFILKILYCKQSDNGLYTCNATNMAGQTYSAVLVT VKEPKVPFRRKLLDVEVQEKTSATLLCEVPLNATQAEWFMEETRLQQNSKFHMEEQGTLR RLTIHNVTTNDDGVYICEMKEGSRTVAELTVLGNITKKLPRRTVVPVSDTVIFCVELEHP CPDVYWTRNGEKLKEDSRISTACVLRQYTLTIRDCQADDSGEVAFVAGDCKTSTRFTVTP ARKHPPDPPVDAVVQNKTDSSITIHWSPPDSDRPVPIKGYIVERRRVGATTWQRCNVDET ILSTEITIRNFSEESSYQFRISAKNDFGQSPYLEVPGSFYLEPSAEIRQGLMNSTAVSGE EFSISLELSAVCSGFWSLNGRLLRSGAEYLITRSKNTHTLLFRDVDMDMNGAEVKFVGGG SQSSCIISVKAPLVRFTSKSDRPEIVTCSVQETAQLTAELSNYKAEVVWMRNGREVKVGK KYEYVKKDRKRILMVHNVTEEDVGIYECVLADDKLPIQLSLKDEPAKFLNKARGTMGLSS TLKGDLELSCEVSPASAAVVWRKDQVEITEDQRTTIISKGTQRKLVMKSAKKSDEGHYSC ETAADKITFHVKIKESQAAAVFSNKESVQREVKATLSQKATLSCNVSDSKQEVKWYKDGK LLTSSKTVYSEVKGSIRQLVIEKVEKSDAGEYACEAGGEKLVFKILVSDVQSAFSNKESV QREVKASLSQKTTLSCEVADAKTEVKWYKDGKLLTSGKTIHTESKGKSRQLVIDSVERKD VGEYFCEAGSEKMAFKIHGAEAQSIFFNKESVQKEVKATVSQKATLSCEVVDSNTEVKWY KDGKLLTSSKTVHTESKGKSRHLVIESLDKKDAGEYFCEVGTEKLNFKLQVADTQVQSAF FKKESVQKEVKASVSQKATLSCEVADVKTEVKWYKDGKQLTASKTVHTESKGKSRQLVID NIERKDTGEYVCEAGAEKLAFKLHVEETKSAFFNKESVQKEVKSTLSQKATLSCEVADAK TEVKWYKDGKLLTSSKTIHSESKGKSRQLVFESVEKKDAGEYMCEVGTEKLTYKIQVAEP PAGFCNKESVQKEVKASLSQKATLSCEVSDSKTEVKWYKDGKLLTSSKTIHSESKGKSRQ LVFESVEKKDAGEYMCEVGTEKLTYKIQVAEPPASFCNKESVQKEVKASLSQKATLSCEV SDSKTEVKWYKDGKLLTSSKTIHSESKGKSRQLVFESVEKKDAGEYFCEVGTEKLTYKIQ VAEPPAGFCNKESVQKDVKASLSQKATLSCEVSDSKTEIKWYKDGKLLTSSKEVHVESKG KSRQLVIEKVEKKDVGEYTCEAGTEKLVFKLKLTDVAVKFQKKPVKDAFTVEAGESIVLA TELTSESGTVKWFRDGVELKESSKYEIKKDGLSRSLKVKSAETKDSGAYSCQTTDDKVEF KVQVKDLALKFVTPLKPATVVIGDKLSLICELNHASGDVVWHHNGREIKPGARHSVTTEG AKRALTVTGMTKEDEGEYSCECRGDKTSAKVTSSAPRSVRLSTKLNNVAAVEGKDAIFKC VVTPVDANVKWFHKNIPVTIGPKYKTEHGNGTHSLTISSVTQQDAGEISVDAEGKTCTAV LQVQHEPVTFKKKLENLTVEEQSEVKLEVELSKASDDVKWMRNSVVLQPEGNIQVHVDGA KQVLVFKRITYADRGIYSCETLDDKTQAKLTVEKKKIQVVKGLTETKAHETETVTLEVEL SQADAEGSWTRDGAKLKSGGNCQITAKGMKHALTLSNLKREDAGTICFQAEEVRTSCKLT VAEPPAMISKPITSVSVDEKEKATFECEVSRTDADVKWFKGDVELKAGKNISIHSLGRKR TFAINKCIPEDEGTYICRTTDDNTSAKLTVHARDIKIVKKLQDVEVMEKESATFKCEISH DDVECNWYKGSTKLKASDNIKMRQEGRNYVLLFKCVTPDDMGEIKFTAEKASSAAKLKVK ELPVKFVKKLRDKIAMYKHRAHLECQVSRASAKVKWFKNKTEIQPSKKYEVKSEDVYRKL TINDVDSGDEDTYTCDAADDKTSCKLLVEEQSISIVRDLRSVEVTEPFAAVFEVEISMEL VKPPLWTLDGVAVQEGADVEMEKEGTMHRLTFKKTKASMTGPVQFTAGKSKSAAQLTVKE RPLEIAEPMKDLKAKEKSSALFTCKFSAAPKEVNWFKGQVPLTPSDKYNMKLDATRAQLT ILRLAEEDNGEYYCKSGPAETKGTLAVEEREIKLTKHLADVEVVEDSDAVFTCEINYADE EAQWFLNDKVLFTNEVNTITHDGKVHKITLKNLAPQDGGTITFQVRKVKESVTLTVKEKR AVFLKTLDDVTGEEKGMITLACEASKPRVSPIWRKEGKVLKAGPKYELLHTAKSLGLIIK DITKEDAGEYSCDLGTEVCKSKVTVREIGVGITKWLKSAEVNEGDACSFECILSRESTDE CSWTVNGQTVTNGGRFKISSQGRKYMLAIKDVTPADSGEVVFQLKDLSSKTTLTVEGKAS SVSQGLQHISAVQGEDAVFTCEVTQASSTVKWAKDGTVIKTNQKYEISQQVKVMTLTIHS VSAKDSGEYSCEVIGGATTKAKLEIKEAIHKFTKSLEDSQADEKGSVTLKCETAQTPSNV TWLKGHVDLKAGGRYVMSQDEGVLTLTIQNLEEEDSDIYTCDVGTAKSMAKVTVKVGKVS GPPAASKSESKRQETQEKIEVKMGDSLSKAAKDVEKRQEIIETVEAVTLPTTGEAPKQQL LTQDIQKDWRELGLGGEVKMVDSTSKTTKDVDKRQEIIETVEAVTLPTTGEAPKQQLLKQ EIQKDSRELGLGGEVKMVDSTSKTTKDVDKRQEIIETVEAVTLPTTGEAPKQQLLKQEIQ KDSRELGYGGEVKMGESSFKAATEVQKQQEITEPVEAVTLPTTGEAPKQQLLKQEIQKDS RELGLGGEAEKTVTGTAVKEDNQSQGTKEQEQAAPVSFKKELESQEATEGGEVSLSCETS SPECKVTWLKGTKVLTQGQKYSFQQRASTHILVIHKLTMEDGDKYTCDTGDKKSTAVLAV KERVRIVRELYDVTVTTGQDACFEIELSHSGVTNGEWWLADNLLQNNDLNQMSSHGRVHR LVLKMVTTDESGDVAFVVGEEKTVACLLVEEKPKVLILEKPHNTVALEGETVTLACSISD PNGTVTWIRNSEVIQAGLKYDLRKNEATHQLRIHSVVPGDSGTYTCETRDARCDVTLTVE GAPAFFQKELENQDATEGDDITLHCELSKPGVCVEWRKGGVVLQPSNKYDIKREGCVQQL CIRNLDPEDSGYYTCDAGTQLTTASLAVQVKEVYVVSGLKNSDVFVGEWATFSCHLSGRA LGKVQWWLDGNLLESSPFVEIGLGQGYLHTLTLKNLATDDSGTVTFKAGGLSSAAKLLVK DPAVEVVSEMEDLQAVENQPAEFICQYSRPVKAQWRKDGQPLKPDGRRVVVEQDWTVARL YISRVSAEDVGTYSCEAEGTCVVASLHVEAKPIQIVQGLENAETFDGGEVLFECALSRPE NKDFQWLLNGKPLKESPNAEFVSFESGLRHLLLLKELHVKDTCTVTFKAGTASSSAQLTV KAWKLEIVKDLEDRVAAVGEKVEFCVKLTEPVPAAEVAWYANGAELKPGDLWAMKADGSS FSLVLRQAPLLPQQEITFAARDALSLAKLTIITVPDPPEDPEVLSKTPVSVALSWFTPLH DGGSPIMGYRVEMRLVDSALWLPCLSEPVCNTEYVVENLVSGSGYRFRVAAINRAGIGEP VELPLTVQLDAKAAETMGQPSLPPEAAVEGDLHELWEASAKKRRMSREPTLDSICEQPEV DGKKEKKELISSEKVETKSAEKEQVIMLKKEAESSQSIKSEEETVSGGSSLVAFLKKSSN TSVTASSEEETLATDRFFAHFQMTEQTVQKTEVKTTVVQQKEETQVSLSNTSAMDVTKEE ETELTGAVIKIQAAFKGYKARKDMRPVFKDVFKDQTKAPNDTIHLECITEGKPDKVRWLK DGEPVMDGKHHHIDIYNDGTCSLVITGITTKDTGVYTCEVTNKFGVASHSSKVTVGTVRE VRESSGRRPLTVGYSADSEPESSGSEMDDSLRQASRRLRRLLHTRLPPDVQEEPFVSADE GDLRSTDPQSYREDENYIYIRFDSRTQAEVASKRFQEMFTIHGVPVETNIIAAGAHKVEL RIKKLGYIQDGTQTPTQDQQGPAFMAGAAAAPVFLTEIQSQDVPDGYPVSFDCVVIAKPP PTIRWYKDGKLLEENDHYMINEDQEGCHQLIITAVLPTDMGVYRCTAENSSGIAATKAEL RVDMSCSSDYDTAVDATETSSYVSAKGYASSRDTETFESVTEDDQLPQVVDELHDVHVCP GSPIAKMHLRLKGFPTPRVYWFKDGHPLRGSERILLLTERDVHGLEILEVKREDMGEYSA YISNAAGSAYSSARLIVLNPGEIMPQDKKDSKEPLVPPRFLEKFCNRKVKQGTSITLSVK VEGSPTPMVSWLKEKSAEDVLWIKPETKGYKIASSGRQHSLILMDVSSVYSGIYTCIATN KAGQSICTAHLEVDDMPQPKKETKPSEVLGITVSPPEEETSRGKEGKLPYLGEVGTEEFL MKLTSQITEMVSAKITQDSLQNHEVLQWMKSWPKTTTSLRVPGADSDDETKTPSPSPHHG RSRPPSLMADSSSESDEGDARGEMFDIYVATADYNPTIVSKDSIALKEGQYVEVLDSAHP LKWLVRTKPTKTTPSRQGWVSPAYLDKKLKLSADTGDLPETSSEEVSEGEYKRKLFQLVH ELINGESEFVKEVDFFTSHHLKHADSPEVLPDVSSQKETIFRNIDDIKSFHTKTFLPKLN DCETDDDVAMCFLKNKEGFEKYLQYFVGQSQAESAVSDKTVHCFFKEYTEKVQANADPSD PPVRSINAHLKQPVERIQKYKAVLKELIRNKARNGQNCCLLEEAYAMVSGLPQRSDNTHH VSMIENYPATLENLGEPIRQGPFQVWEGAPGIRTSSRGHHRHVFLFKNYCIICKPKRDSN TDTQAYVFKNMMKLNNIDVNETVEGDDRAFEIWHEREDSVRKYTLQARTVTIKNSWLRDL RELQQRYSMPAWSPPDFEEILANCTAELGQTVKLACKATGVPKPAITWYKDGRAVEADPH HIIIEDPDGSCTLILDNMTADDSGQYMCFATSPAGNASTLGKISVQVPPRFVNKMRNAVF VVAEDAQFTCVIQSAPSPKIRWFKDGRLLTDQAKYQTYNELRSGVLVLVIKNLTERDLGH YECELSNRLGSAKCAADLVFPSAVSRAGEQAITIEVTEQDTRLPKKTIIIEETITTVVKN PRMRRHKSPGLTVTGAHRSETSTPEPLTARPRRMPTPRKTAIPTLYVTEPEGAEARATDN KPRWVEVEEVIEYKVNKSPRLSRRRGVSPAASDRAATPSRPKRSTLENPNANNSNNKLVE QPQAHLQGDMSPLLSWEEEESHVASDSAPGEPEELSSVFTTAGGDVEDLDDQQTVIFESD DENDGKQEAMMLKEGDRILTLEDLEDYIPEEGETYGSSDSHHVADEKPCEISVLQREIGG SRVGQPVLLNVGRPEVVPRQRSNFFCRFRDHLSGRLFPSAFPQGSDTQPRTERQIPIQVS HAKLEVKPSYCSEVQRVEGGQQSFKTKVSTQTYGYTSVGNPVTLQIRDNPYQNQ NT seq 17985 nt NT seq  +upstreamnt  +downstreamnt atggatcaaaacttatttggaggagcccccaggtttctcacccgcccaaaggcgttctca gtatgtgtgggcaaggatgccacactcagctgcactgtcgtgggcaaccccaccccgctg atcacctgggaaaaagacaagctcaagatcacgtctggcagccgcttcaagactgtggag gatgaagatgtgtaccgtctgaccatctacgatctaaccctggaggacggtgggcattac atgtgcaaagccaaaaacagtgttggcgaagcttatgctgctgtgaccctcaaagtggcc ctgccaggagaaatgtctcagagggctcctgttttcatggtgaaacccgcatccacgcgc gtgggtttgggaggtgatgttgttttccactgccgggtcgcggctcaccctgaggccaac tttgactgggagaaggatggacgctatctaggggagacgacccgcattaaaattatttct gacaacgacagcagcaccttaaaaatccaaggcgtacgcaacctggacagtggcaccttc acctgcagagcccagaactccgtaggccgagccaacgctgcagcggttcttactgtagac gctcaggattctcaccacgccgccgcagacaagggctcttctctactctcccacctgcaa aagcgcaaagaagagatgaataaagacatctctatctatcgcactgaagaaagtcacagc tcagtttcttcctccgtcaaggccaacatgaaagatgccttgggttctctgaatctggag catgagctgagggcgcgtgcgttggcaaagcttcccaaaggtgtattcacccgtacgtgc accgtgacagaaggcaaacatgccaaactcagctgctttgtgaccggccaccccaaacca cacatcatctggaggaaagatggagccaacatcagcgagggccgcaggcaagtgatttat gaggaccaagctgagaacttcatcctcaagatcctgtactgcaagcagagcgataacggt ctctacacctgcaatgcaaccaatatggccgggcaaacctacagtgctgtgttggttaca gtcaaagagcctaaagtgccattcaggaggaaactgctggatgtggaggtacaggagaaa acctcggccactctcttgtgtgaggttcctcttaatgccacacaggccgagtggttcatg gaggaaacgcggctgcagcaaaattccaaatttcacatggaggagcaaggcaccctgcgt cgtctcaccatccataacgtcactaccaacgatgatggagtttatatctgtgagatgaaa gagggcagccgcaccgtggctgagctcactgtcctgggtaacatcaccaaaaagcttcct cgaaggacagtagtccctgtcagtgacaccgtcatcttttgtgtggagctggagcatccc tgtccggatgtctactggactcggaatggagagaagctgaaggaggattcccgtatttcc accgcctgtgtgctcagacagtacacactcacgattagagattgccaggcagatgactca ggagaagtggcctttgtggctggagactgcaagacctccactcgattcaccgtcacccct gcacggaagcatcctcctgaccccccagtggatgctgtggtgcagaataagacagactca tccatcaccattcactggtctcctcctgacagcgaccgtcctgttcccatcaaaggctat attgtggagaggaggagggttggtgctactacatggcagaggtgcaatgttgatgagacc atcctttcaacagagatcaccatccgtaacttctctgaggagtcgagctaccaattccgc atctctgcaaagaatgactttggccagagtccctacttggaggtacctggaagtttctac cttgagccctctgcagaaatcagacaaggcctgatgaacagtaccgcagtctctggcgag gagttttccatctcgctggagctgtccgctgtctgctcgggcttctggtccctgaatggg cgtctgctgcggagcggagctgagtatctcatcaccaggtccaagaacacgcacactctg ctcttccgtgatgtggacatggacatgaatggcgctgaagtcaaatttgtgggcggaggc tcacagagcagctgcatcatatctgtgaaagctcctttagtcagattcaccagcaagtca gatcgtccagagatcgtgacatgcagtgtccaagaaaccgctcagctgactgccgagttg tcaaattacaaagcagaggtggtttggatgaggaacggacgggaggtaaaagtgggcaag aagtacgaatatgtcaaaaaagatcgcaagaggatcctgatggtacacaatgttacagaa gaagatgtgggcatttatgaatgtgttttagctgatgacaagttgcccattcaactctct cttaaagatgaacctgccaaatttctaaacaaagctagaggtaccatgggattgtcatcg acccttaaaggagaccttgagctcagttgtgaagtatctcctgctagtgctgctgttgta tggagaaaagatcaagtagagatcactgaggaccaaagaactaccatcatctccaagggg actcaaaggaagctcgtcatgaagagcgccaagaaaagtgatgaaggacattattcctgt gagacagcagctgacaaaatcacattccacgtcaagataaaagaaagtcaagccgcagct gtcttctccaacaaggagtcagtccagagggaggtcaaagccactctgtcccagaaagcc actcttagttgtaatgtgtctgacagcaagcaggaggtgaaatggtataaagacggcaag ttgctgacatccagtaagacagtatactcagaggtgaaaggctccatccggcagctggtg attgaaaaagtggagaaaagtgatgcaggagagtacgcctgtgaagctggaggggagaag ctagtctttaagatactcgtgtcagatgttcaatcagctttctctaacaaggagtctgtt cagagggaggtgaaagcttctctctcacagaaaaccacactgagctgtgaggtggctgat gccaagactgaggtgaaatggtacaaagatggcaaactgctgacatccggcaagaccatc cacactgaatcaaaaggcaagagtcgccagctggtgatcgacagcgtcgagaggaaagat gttggagagtacttctgtgaggctgggtctgagaagatggcttttaagatccatggagca gaggcccagtcaatctttttcaacaaggagtcggtccagaaggaggtgaaagccaccgtg tcccagaaggcaactcttagctgtgaggttgttgattcgaacacagaggtgaaatggtac aaagatggaaagcttctcacttccagcaagacggtacatacagagtcaaagggcaagagt cgccatctggtgatagagagtctggacaagaaggatgctggagagtacttttgtgaggtt gggacggaaaagctcaacttcaaacttcaggtggcagacacacaagtccagtcagccttc ttcaaaaaggagtctgtccaaaaggaggtgaaagcttctgtctcacagaaagccactcta agctgcgaagttgctgacgtcaagacggaggtgaaatggtacaaagatggcaagcagcta acagccagcaagacagtccacacagaatcgaaaggcaagagtcgccagctggtgattgac aacatagagaggaaagataccggagaatatgtttgtgaggccggcgctgagaaactggcg ttcaaattacatgttgaagaaaccaagtctgcctttttcaacaaagagtccgtccaaaag gaggtgaaatccactctctctcagaaagccaccctaagctgcgaggtcgctgatgccaag actgaggtgaaatggtacaaggacggcaagctgctgacttccagcaagacaatacactca gagtcaaagggcaaaagccggcagctggtgtttgagagcgtggagaagaaagatgctgga gaatacatgtgtgaggttggcactgagaagctgacttataagatacaggtggcagaaccg ccagctggtttctgcaataaggaatcagttcagaaggaggtgaaagcctccctctcccag aaagctactttgagttgtgaggtttcagattccaaaactgaggtgaagtggtacaaggac gggaagctgctgacttccagcaagacaatacactcagagtcaaagggcaaaagcagacag ctggtgtttgagagcgtggagaagaaagatgctggagaatacatgtgtgaggtcggcact gagaagctaacttataagatacaggtggcagaacccccggctagtttctgcaataaggag tcggtccagaaggaggtgaaagcctccctctcccagaaagctactttgagttgtgaggtt tcagattccaagacagaggtaaagtggtacaaggacggcaagctgctgacttccagcaag acaatacactcagagtcaaagggcaaaagcagacagctggtgtttgagagcgtggagaag aaagatgctggagaatacttctgtgaggttggcactgagaagctaacttataagatacag gtggcagaacccccagctggtttctgcaataaggaatcggtccagaaggacgtgaaagcc tccctctctcagaaagctactttgagttgtgaggtttcagattccaagacggagataaag tggtacaaggacggcaagctgctgacttccagcaaggaagtccacgtcgagtcgaaggga aagagccgtcagcttgtgatcgaaaaagtggagaagaaggatgtgggagaatatacttgt gaagctggaacagagaaactggtgtttaagctgaaacttacagatgtagccgtcaagttc cagaagaagcctgtcaaggacgcatttactgttgaagcaggagaaagcattgttttagcg actgagctgacctcggaaagtggtaccgtgaagtggtttagagatggtgtggagctcaag gagagcagcaagtacgaaataaaaaaagatggcctttctcgaagtctgaaagtgaaatct gcagagaccaaagacagtggagcatactcctgtcaaaccactgatgacaaagtggagttc aaagtacaggtcaaagatttagctttgaagtttgttacacctctgaaacctgctacagtg gtgattggagataaacttagcctcatctgtgaactaaatcatgcctctggggatgttgtc tggcaccataatggtcgtgagattaaacctggcgccaggcactctgtcacaacagagggt gcgaagcgggctctcactgtgaccggtatgacgaaggaagatgaaggagaatacagctgt gaatgcaggggtgacaagacctctgctaaagtaacctcctcagcaccaagatcggtgagg ctgagtaccaaactgaacaatgtagctgcggtggagggaaaagatgccattttcaagtgt gtcgtcacaccagtggatgccaacgtcaaatggttccacaaaaatatccccgtcaccatt ggaccgaagtacaagaccgagcatggcaacgggactcactcacttacgatcagctctgtt acccagcaagatgctggggagatcagtgttgatgcagaagggaaaacctgcacagctgtc ctgcaagtgcaacatgaacctgtgacctttaagaaaaagctggaaaacctgacagtggag gagcaaagtgaagtaaaactggaagtcgagctcagtaaagcttcagatgatgtcaagtgg atgaggaacagtgttgtgttgcagcctgaaggaaacattcaggttcacgttgatggagcc aagcaggttctggtcttcaaaagaataacttacgctgatcgtgggatctactcttgtgaa actctggatgacaagacccaggccaaacttactgtggagaagaagaagattcaggtggta aaaggtctgacagaaactaaagcacatgaaacagagacagtgacactggaggtggaactc agccaggctgatgctgaaggctcgtggaccagagatggggccaaattaaaatcggggggg aactgccagataacagccaagggaatgaagcacgccctgacgctgtcgaaccttaagagg gaagatgctggaactatttgcttccaagcagaggaagttcgtacatcatgcaaactgact gttgcagaaccccctgctatgatctccaaacccattacaagcgtcagtgttgatgagaag gagaaggctacgtttgaatgtgaagtctccagaaccgatgcagacgttaaatggttcaag ggtgatgttgaactgaaagcagggaagaacataagcattcactccttgggtcgaaaacgc acgttcgccatcaacaaatgcatccctgaagatgagggcacttacatttgtcgtactact gatgacaacacctctgccaagctcactgttcatgccagagatatcaagattgttaagaag ctacaggatgtggaggtgatggagaaggagagcgctacatttaagtgcgaaatctcgcac gatgatgtggagtgcaactggtacaaaggaagcaccaaacttaaagccagtgacaacatc aagatgagacaagaaggcagaaactacgtactgcttttcaagtgtgttacacctgacgat atgggtgagattaaattcacagccgagaaagcatcatcagctgccaaacttaaagtaaaa gaactgcctgtcaagtttgtgaagaaactcagagataagatagcgatgtataagcatcgc gctcatcttgaatgccaagtgtcgcgcgccagtgcaaaggtgaagtggttcaaaaacaag acggagatccaaccaagcaaaaagtatgaggttaaaagcgaagatgtgtatagaaagctc accatcaacgacgtggactccggtgacgaggatacatacacctgtgatgccgctgatgac aagacgtcctgtaaactacttgtggaagagcagtccattagcatagtgcgggatctaaga tcagtagaggttacagagccctttgcagctgttttcgaagtggaaatcagtatggagctg gtgaaaccccctctgtggactttggacggagttgctgtgcaggagggtgctgatgttgag atggagaaagaaggcacgatgcaccgcctcactttcaaaaagaccaaagcatcgatgaca ggacctgtgcagtttacggctgggaagagcaaatctgcagctcagctcacagttaaagag cgccctcttgagattgcagagcctatgaaagacttgaaagctaaggaaaaaagctccgct cttttcacctgcaaattctcagctgcccccaaagaggttaactggttcaaaggtcaggta cctctgaccccgtcagacaagtacaatatgaagctagatgctacaagggcccaacttacc attctacggttggccgaggaagacaacggagaatattactgcaagtcaggacctgctgag accaaaggcacacttgctgttgaagagcgtgagattaagctcaccaagcacctggctgac gtggaggttgttgaagacagcgatgcagtgttcacgtgtgagataaactacgcagatgaa gaggcgcagtggtttttgaatgacaaggttctttttactaatgaagtgaacaccatcaca catgatggaaaggtccacaagatcacgctgaagaacttggcccctcaggatggggggacc atcacctttcaagtgcgaaaggtgaaagagtctgtcacactcacggttaaagagaagcgt gccgtgttcctaaagacattagatgatgtcactggagaagagaagggtatgataactctg gcatgtgaggcatccaagccacgggtttccccaatatggaggaaggaaggtaaagttttg aaagccggaccaaaatatgagctccttcacacagccaagtctttgggactgatcatcaag gatatcactaaagaggatgctggagagtacagctgtgatcttgggacagaagtctgtaaa tcaaaggtcactgtaagagaaatcggtgtcggaatcactaaatggctgaaatcggctgag gtgaatgagggagacgcatgcagtttcgagtgcattctttctcgagaaagcacagatgag tgctcgtggactgttaacgggcaaactgttacaaacggtgggcgctttaaaatctccagt caaggacgcaagtacatgctcgcgattaaggacgtcactcctgctgattctggggaggtg gtcttccaacttaaggacctgagctccaaaacaacattaacagttgagggaaaagcttca tcggtatcacaaggacttcagcacatctctgctgttcaaggcgaagatgcagtttttacc tgtgaggtgacacaggctagttctacggtcaagtgggctaaggatgggacagtgatcaaa acaaaccagaagtatgagatcagccaacaggtgaaggtcatgacgctcactatccacagt gtctctgctaaagactctggagagtacagttgtgaagttattggaggtgcaacgactaaa gctaaattggaaataaaagaagcaatccataaattcactaaatccctggaggacagccaa gcggacgagaagggctccgtgaccttgaagtgtgagacggcacaaaccccatccaacgtg acgtggctcaaaggccacgtggacctcaaagctggaggtcgatatgtcatgtcccaggac gagggggttttaactctcaccatccaaaatctggaggaagaagacagcgatatctacacg tgtgacgttggaacagccaagagcatggcgaaggtcactgttaaagttgggaaggtatcg ggtcctcctgcagcatcaaaatcagaatccaagaggcaggagacccaagaaaaaatagaa gtcaagatgggtgattctctttccaaagctgctaaagatgtggagaagaggcaggagata attgaaactgtggaagctgtgacgctgccaactactggagaagcaccgaaacagcagctt ctcacacaagatattcagaaagattggagagagcttggattgggaggtgaagtcaagatg gtggattctacttccaaaactactaaagatgttgataagaggcaggagataattgaaact gtcgaagctgtgacgctgccaactactggagaagcaccgaaacagcagcttctcaaacaa gagatacagaaagattcgagagagcttggattgggaggtgaagtcaagatggtggattct acttccaaaactactaaagatgttgataagaggcaggagataattgaaactgtcgaagct gtgacgctgccaactactggagaagcaccgaaacagcagcttctcaaacaagagatacag aaagattcgagagagcttggatatggaggtgaagtcaagatgggtgagtcttctttcaaa gcagctacagaagttcagaagcagcaagagataactgaacctgtggaagctgtgacgctg ccaactactggagaagcaccgaaacagcagcttctcaaacaagagatacagaaagattcg agagagcttggattgggaggtgaagctgaaaagacagtcactggaacagctgtcaaggaa gataaccagagccaagggactaaagagcaagagcaagcggcaccagtatcattcaagaag gaactggagagtcaagaggccacagagggaggtgaagtctcgctgtcctgcgagacctcc agccctgaatgtaaggtgacctggctgaagggcacaaaagtactcacgcaagggcagaaa tactctttccagcagagagcttccactcacatccttgttatacacaagctgacaatggag gatggcgataaatatacctgcgacacaggagacaagaaaagcaccgctgtcctggctgta aaagagcgcgtgcgcattgttcgagagctctatgatgtaactgtgaccactggccaggac gcttgttttgagattgagctgtcgcactctggcgttaccaatggggagtggtggctcgca gacaacctccttcaaaataatgatctgaatcaaatgagcagtcacggcagagtgcaccgc ttggttctgaagatggtgaccacagatgaatccggggatgttgcctttgtagtgggagag gagaagactgtggcctgtcttctggtggaagagaaacccaaagtgctaatattagagaaa cctcacaacactgtggctttagagggtgaaacggtcactcttgcctgctccatctctgac cccaatggcacagtcacctggatcaggaacagtgaggtgatccaagcaggtctcaagtat gacctgaggaagaatgaagcaacccatcaacttcggatccacagtgtggtgcccggggac tcaggaacgtacacctgtgaaactcgagatgcccggtgtgatgtcacgttgactgtggaa ggtgcacctgcatttttccagaaagagcttgaaaaccaggatgccacagaaggtgatgat atcaccttgcactgtgagctgtctaaaccaggtgtttgtgttgagtggaggaaaggaggc gttgtcctccaacccagtaacaagtatgacataaagcgggaagggtgcgttcaacagctt tgcattcgaaacctcgatcctgaggacagtggctactacacctgtgatgcaggaacccag ctcactacagcttctttagcagtgcaagtgaaagaagtctacgttgtttcgggtcttaag aacagtgacgtctttgttggggaatgggcaactttctcctgccacctctctggcagggct cttggtaaggtgcagtggtggctggatggcaacttgttggagagcagcccctttgtcgag ataggactggggcagggctacctccacacactcaccttaaagaacctggccacagacgac tctggcactgtcaccttcaaagcaggcggtttatcctcagcagccaagctcttagtcaaa gatccagcagtggaagtggtgagcgagatggaggaccttcaggcggttgaaaaccaaccg gctgagttcatctgtcagtattcaaggccagtcaaagctcagtggcggaaagatgggcag cctttaaagcctgatggtcgaagggtggtagtggagcaggactggactgtggcgcggttg tacattagccgtgtgtccgctgaggacgtgggcacatactcctgtgaggcagaggggacc tgtgtggttgcttcacttcatgtggaagccaaacccattcagattgttcaaggcctggag aatgcagaaacctttgatggaggtgaagtgctttttgagtgtgccctttctcgtcctgag aacaaagatttccagtggcttcttaatgggaaaccattgaaagaatcccctaatgctgag ttcgtgtcgtttgagagtggtctccgccatctgctcctcctgaaagagttacacgttaaa gatacttgtacagtgacctttaaggctggtacagcctccagctctgcccagctgacggtc aaagcctggaaactggaaatcgtgaaagatttggaggacagggtggctgcagtgggagag aaggtggagttttgcgtgaagctgactgagccggtccctgcggcagaagtggcctggtac gccaacggagctgaactcaagcccggtgacctctgggctatgaaggctgatggcagttct ttcagcctcgtcctgaggcaggcccctctcttgccccagcaggaaattacttttgctgca agagatgctctctctttggccaagcttacaatcatcactgtacctgatcccccagaagac ccggaggtcctcagtaagactccagtatctgtcgccctgtcttggtttactcctctccat gatggagggagtcctattatgggctacagggtggaaatgcggctggtggacagtgcactc tggctcccgtgtctttctgagcctgtgtgcaacacagagtatgtggttgaaaatctggtc tcagggagcggctacagatttagagtggcagccataaacagagcagggattggagagcct gttgaactgcctctaactgtgcagcttgatgcaaaagcagcagaaacaatgggacaaccg agtctacctcccgaagctgccgtagaaggtgatctccatgagctgtgggaagcatcggcc aagaaacggcgcatgagtagagaacccaccctggactccatttgtgaacaacctgaggtt gatggtaagaaagagaagaaagagctcatatcatctgagaaagtggaaacaaaatcagct gagaaggaacaggtcattatgttgaaaaaggaggcagaatccagccagtccatcaagtcg gaggaagagactgtttctgggggctcatcgcttgtggctttcctcaaaaagagtagtaac acctccgtcacagcatcctctgaggaagagactctagctactgacaggttctttgcacat ttccagatgacagagcagacagtgcagaaaactgaagtaaaaacaactgtagttcagcaa aaagaagaaacacaggtgtctttgtcgaacaccagcgctatggatgtcaccaaagaagaa gagacagagcttacaggtgccgtcattaagattcaagccgccttcaagggttacaaagct cgcaaggatatgcgccctgtcttcaaagatgttttcaaagaccaaaccaaagcacctaat gacaccatacaccttgaatgtataacagaaggtaaacctgacaaagtgcgctggttgaaa gatggggaaccggtgatggatggcaagcaccatcatatcgatatctacaatgatggcacc tgctctctggtcattactgggatcaccacaaaggacactggggtttacacatgtgaggtc accaacaagtttggagtagcttcccacagttctaaggtgacagtgggaacagtgagagaa gtgagagaatcgtcaggccggcggccgctcacagtgggctacagtgcagacagtgaaccg gagagctctggcagtgagatggacgactctctgagacaggcgagcagacgcctcaggcgg ctgctgcacacacgcctgccgccagatgtccaggaagaaccgtttgttagcgcagatgaa ggagaccttcgttctacagatcctcagtcttaccgcgaggatgaaaactacatctacatt cgctttgattcacgaacccaggctgaagtggcctctaagagattccaggagatgtttaca atccacggggtccccgtggagaccaacatcatcgcagcaggggctcacaaagtggagctt cgtattaaaaagttgggatacatccaagatggtacacaaacccccacacaagatcaacag ggtcctgctttcatggctggagctgcagctgccccagttttcctgacagagatacaaagt caggacgttccagacgggtatcccgtcagcttcgactgcgttgtgatcgccaagccaccg cccaccattcgctggtacaaggatggcaaactgctggaggagaatgaccactacatgatc aatgaggaccaggagggctgccaccagctcatcatcaccgctgtgttacccactgacatg ggcgtctatcgctgcacagctgaaaacagcagcgggattgctgccactaaagctgaactc agggttgacatgtcttgcagctcagattatgacactgctgttgacgccactgagacatcc tcctatgtcagtgccaaaggctacgcttccagcagggataccgagacctttgagtcggta actgaagatgatcaactccctcaagttgtggacgagcttcatgatgttcacgtatgtcca ggttcaccgattgcaaagatgcacctcagattaaagggttttcccacacccagagtatac tggttcaaagatggtcacccactgcgaggatcagaaaggattctgttattgacagaacga gatgttcatgggttggagatcctggaggtgaagagagaggatatgggggaatactctgct tacatcagcaatgcagccgggtctgcttactcctctgctcgactaatagttttaaatcca ggagagattatgccacaagacaaaaaagactccaaggaacccctggtcccaccgcgcttc cttgagaagttctgcaacagaaaagtaaaacagggaacaagcatcaccctgtctgtcaaa gttgaaggctctcctactcccatggtctcctggctgaaggagaaatcagcagaggatgtc ttgtggatcaagcctgaaactaagggctacaaaatagcgagctctgggcgccagcacagc ctcatcttgatggacgttagctcagtgtattctggcatctacacttgtatcgccacaaat aaagcagggcagtccatctgcaccgctcacctcgaagtggacgacatgccacaaccgaag aaagagaccaaaccttcagaggtacttggcattacagttagtcctccagaagaggagact agcagagggaaagagggcaaactaccctacctaggtgaagtgggcacagaagaattcctc atgaaactcacttctcagatcactgaaatggtctcagcaaagatcacgcaagacagttta cagaatcatgaagtgctccagtggatgaaatcttggcccaaaactaccacttcgttacga gtaccgggcgccgacagtgatgatgagaccaaaactccttctccatcacctcatcacggc cgctctcgtcccccttctctcatggctgactcctcctcagagtctgatgagggggatgcc aggggagagatgttcgacatctatgtggcaacggctgattacaacccaaccatcgttagc aaagactccatcgctctaaaggagggacagtatgttgaagtgttggactcagctcatcca ctcaagtggttagtccgtaccaaaccaaccaaaacaacaccgtcccgccaaggctgggtc tcacctgcctacttggacaaaaaactcaaactctctgctgatacgggcgaccttccagaa acaagttcagaggaggtgtctgagggcgaatacaagagaaagttattccaactggttcat gaactgataaatggagaatcagagtttgtcaaagaggtggatttctttacctcccaccac ctgaagcacgccgacagccccgaggtgctgcctgacgtctccagccagaaggaaaccatt ttcaggaacatcgatgacatcaaatccttccataccaagacattcctccccaagttaaat gactgtgagacggatgatgatgtagccatgtgcttcctgaagaacaaggagggctttgag aaatatctccagtattttgtgggtcaaagtcaggctgaatctgcagtcagtgacaaaact gtccactgcttctttaaggagtacactgagaaagtgcaggccaatgcagacccctcagat ccccctgtacgaagcatcaatgcccatctcaaacaaccagtggaaaggattcagaagtac aaggccgtcctcaaggagctcattcgtaacaaggcaagaaatggccagaactgctgccta ctggaagaagcatacgcgatggtgtcgggactccctcaacgatctgataatacccaccac gtctcaatgattgagaactatccggctacgctggaaaatctgggagaaccaattagacag ggacctttccaagtatgggaaggagctccaggaattagaacgtcctctaggggtcaccac cgtcatgtcttcctctttaaaaactactgtataatctgcaaacccaagcgagacagcaac actgatacacaggcttatgttttcaagaacatgatgaagttgaataacattgacgtgaat gaaacagtggagggcgatgaccgtgccttcgagatctggcatgaacgagaggactctgtg agaaaatatactttacaggctcgaactgttaccatcaaaaactcttggttgagagacctc cgtgaactgcagcagcgctacagcatgcctgcatggagccctcctgactttgaagaaatc ttggcaaactgtacagcagagttgggccagactgtgaaactggcctgcaaagccaccgga gtgccgaaacctgcgatcacctggtacaaggatggacgtgcagtagaggccgaccctcat cacatcattattgaggaccctgatggttcctgcacactcatcctggataatatgactgca gatgattctggccagtatatgtgcttcgccacaagtccagctggcaacgccagtactctt ggaaaaatcagtgttcaagtacctcctcgttttgtaaataaaatgaggaatgccgtcttt gttgttgctgaagatgctcagttcacctgcgtaatacaaagtgcacccagccccaagata aggtggttcaaggatggccggctgctgactgaccaagccaagtatcagacctacaatgag cttcgtagtggggtgcttgttctggttattaaaaacttgacggagagagaccttggacac tatgagtgtgagttgtctaaccgcctgggcagtgccaagtgtgctgctgatttagtcttc ccctctgctgtgtctcgcgctggcgagcaggccatcaccattgaagtcaccgagcaagat actagattaccaaagaaaaccatcattattgaggagactattaccactgtggtgaagaac ccgcgtatgaggagacacaaatctcctggtctgactgtcaccggtgcccaccgctctgag acgtctacgcctgagcccctcacagccaggcccaggaggatgcccaccccgaggaagacg gccattccaaccctgtatgttactgagcccgagggggctgaagcccgggccacggacaac aagcccaggtgggttgaagtagaagaggtcatcgagtacaaggtcaataagtctcccagg ctgtcgaggaggagaggcgtctcacctgcagcgtctgatcgcgcagccactccctcaaga ccaaagagatctaccttggaaaacccaaatgcgaacaactctaacaacaagctggtggag cagccacaagcacaccttcagggagacatgagccccctgctgtcctgggaggaagaggaa tctcatgttgcttcggactctgctcccggtgaaccagaagagctgtcatctgtctttaca actgctggaggagacgttgaggacttggatgatcaacaaacggtcatctttgaatctgat gatgaaaatgatggaaagcaggaggccatgatgctgaaagaaggagatcgtattttgact ctggaggacttagaggattacatcccggaggagggagagacctatggctcttccgacagc caccatgttgctgacgaaaagccttgcgagatctcggtgctccagagggagattggcggg tccagagtgggacagccggtgcttctcaatgtggggcggcctgaagtagtgccaaggcag aggagcaacttcttctgtcgcttcagggatcatctctccggcaggctcttcccatcagcc ttcccacaaggcagtgacactcaacctaggacagagaggcaaatcccaatccaagtgagc catgcaaagctggaggtgaagccttcatactgctcagaggtgcagagggttgagggaggt cagcaaagctttaaaaccaaagtgtccactcagacctacggctacacatcagtcggcaac cctgtaactcttcaaatcagagataacccttaccagaaccagtag

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