Cynoglossus semilaevis (tongue sole): 103382205 Help Entry 103382205         CDS       T04866                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism csem  Cynoglossus semilaevis (tongue sole) Pathway csem04020   Calcium signaling pathway csem04260   Cardiac muscle contraction csem04261   Adrenergic signaling in cardiomyocytes csem04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:csem00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103382205 (ryr2)    04020 Calcium signaling pathway     103382205 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     103382205 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     103382205 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:csem04040]     103382205 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:csem04990]     103382205 (ryr2) Ion channels [BR:csem04040]  Voltage-gated cation channels   Ryanodine receptor    103382205 (ryr2) Domain-containing proteins not elsewhere classified [BR:csem04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    103382205 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  103382205 NCBI-ProteinID:  XP_016889806 LinkDB All DBs Position 8:14840331..14894573 Genome browser AA seq 4974 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSTTIQKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEDKADGHVDVEIWTAQGGGHRTLLYGHAVLLRHSY SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS ISSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECL TVPSGEHGDEQRRAVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKY LSLIEDKCLQLMDKEKADIKSTAFCFRSSKEKLDPGVKKEVDGMGFPDIKYGDSVCFIQH VDTYLWLTYQTADAKCVRMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFL FNLFIRGLDTLRKKGAGSTLELPIESVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNR QNLFQEEGMISLVLECIDRLHVYSSAAHFAEAVGREAGESWSSILNSLYQLLAALIRGNR KNCAQFSGSLDWLVSRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHG RNHKVLDVLCSLCVCNGVAVRSNQNLICDNLLPGRDLLLQTRLVSHVSSMRPNIFLGVSD GSAQYRKWYYELIVDQMLPFVTAEATHLRVGWANTSGYAPYPSGGEGWGGNGVGDDLYSY GFDGLHLWSGCIARSVSSPNQHLLRSEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSD GLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCCEAVLPREKLKLEAGQDQTAARD LLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTFGAVRD DNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKRMKLSST YQLSSGYKPAPLDLNHIKLTSTQEAMVDKLAENAHNVWARDRIHQGWTYGIQQDVKNRRN PRLVPYTLLDERTKKSNKDSLREAVRTLLGYGFNLEAPDQDHAAQSDINGVSTERFRIFR AEKTYSVHSGKWYFELEVLTSGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGN EHFGRAWQMGDVAGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEAGEGLVPVCSLGV GQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIE VLRVDGTVELCPCLKVTQRSFGSQNSHNDLTFYRLSMPIECAESYSRTRTNGGLFSPKRE LEDFETVSDFEVLMKSPHGPNGPGGPERDEFNNHKDYNQEKPSKLKQRFTLKKNKPDNSC ATSARLSEEVMGDDRDDYDFLFQASTYYYSVRIFPGQEPSSVWVGWVTSDFHQYDPGFEL HKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGENSSPGQGRNNNGLEIGCLVDTTNGLLT FTANGKELSTYYQVEPSTKLFPAVFAKATSPNIFQFELGRMKNVMPLSAGLFRSERKNVV PQCPPRLHVQFLTPVLWSRVPNHFLKVAVSRVNDRHGWLIQCNEPLQFMSLHIPEENRSM DVLELSERKDILKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIQNKYMPGLLR AGYYDLLIDIHLSSYATARLMMNNEYIVPMTDETKSITLFPQEEKKHGLPGIGLSTSLRP RMHFSSPSFVSGTGSLYRNNSSSSTAGGGGGSGDCFQYSPEFPLEILKVKTIEMLTEAVR EGSMHVRDPIGGSTEFLFVPLIKLFYTMLIMGVFQNGDLKNILCLIEPSVFSERRDSQDD GRAQKAGKEAQAEGGEDGGRSLLKEGLLQMKLPEPVKLQMCHVLQYLCDCQIRHRIEAVV AFSDDFVACLQENQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQDC PCPEYIREQLLDFHEDLMRHCELDEDRGLDSDSDFTIRGRLLSLVEKVSYLKKKMVNLPN EKKDRKPSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTI NSVSIEDTINLLAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMH ETVMEVMVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVG LASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCAMLLRKGYPDI GWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAVE EAIRISEDPSRDGPSPTTESSKSLSDILEDEEDDTIHMGNAIMTFYAALIDLLGRCAPEM HLIHAGKGEAIRIRAILRSLIPIQDLVGVISIPFSMPSLGKDGMVVEPDMSAGFCPDHKA AMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLP LLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQ HLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLVGGWGNFGAASDEELHLSRKLFW GIFDALSHKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPA DTTNVTVPEKLDYIISRYSEHNHEKWCIEKFSSGWTFADQQCDVNRTHPLLKPYKGLSEK DKESYCGSVRESLKTMLSWGWSIDRIREGDPASLHNKSRRISQASQLSFEGTSAFSPRPI DMSNVTLSRDMQSMAELLAENYHNIWARKKKTELEAKGGGNHPLLVPYDTLTAKEKSRDR ERAQDIFKFLQINGYTVSRGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMEFDAG VRLKGETIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTS LFCKLGVLVRHRISLFGNNATSIVNCLQILGQSLDARTVMKTGLESVKVALRSFFDSAAE DLEKTQENLKLGQFTHSRDQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDV QVSCYRILNSLYLLGTNKSIYVERQRPALGQCLAAFSAAFPVAFLEPHINKFNSFSIYNS RGTKDRGALGLPGHVDDVCAVIPNLDKSLEEIMDLAESGMRYNQMPHVMEVVLPMLCSYM SHWWEHGPENHMDQADSCCTAVTSEYMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPI ISKAKPELLKTHFLPLMEKLKKKAAIVLMDEEHSKAEGRGEMSETELLIMDQFTILVRDL YAFYPLLIRFVDYNRARWLKESNPGAEALFRMVAEVFIFWAKSHNFKREEQNFVVQNEIN NMSFLITDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNMCAPGEQ ELITLAKNRFTQKDTEDEVRDIVKNNLHLQGKLEDPAIRWQMALYRDLPNHCENNPDPEK TVERVLDIAHVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVN LFLQGYDKSWIEAEEHYFEDKLIEDLAKPGEEEQCEEEEALKHMDPLHQLIQLLSRTALT EKCKLDEDNLYMAYADIMAKSCHDEEDEDGEVKSFEEKEMEKQKLLYQQARLHDRGAAEM VLQTISASKGEMGLMVASTLKLGIAILNGGNSTVQQKMLDYLKNKKDVGFFQSLAGLMQS CSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLR TQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNT LTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMV VMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDTDG KGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENEQLDYEEFVERFHEPAKDIGFNVA VLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQ WEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKEEN EKEKPDEENPDIGFFSVTTVCMALVALRYNVMLLIKVLSMKSLKKQMKKIKNMTVKDLVT TLVSLYWSILLGLLHVAFSVARGFCRIFYNTFMGGNLVEGAKTIKVSELLANMPDPTQDE VRGEGEDRERRPSDRSSTKEDLADLVVNPSETELLSDIFGLDLRREGGQYKISPHNPNAS LTELLNSPVPAQTSATTAPPTELRRRHQSKGSEEKEVALESEGEPEKPSGEGVVEEPGKL QKNDKMKPKVRRHRKSRSDEPDLQESAFIKKIIAYQRKLLNYFARNFYNMRMLALFVAFA INFILLFYKVSTSSSVVEDKGPVYANTPSDGGVRWNSLGGGGEVVETKEEVLEETGEPQK PVTVRFVLEESSGYMEPTLRILAVLHTVIAFFCIIGYYCLKVPLVIFKREKEVARKLEFD GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMD KAALDFSDAHKKRKPRRDGSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH NLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14925 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagaaggagaagatgagatccagttcctgcggactgatgatgaggtg gttcttcagtgctcaactaccatccagaaggaacaacagaaactgtgtttggctgctgaa ggatttggaaacagactctgtttccttgagtccatctctaactctaagaatgttcctcca gatctttccatctgtaccttcgtcctggagcagtctctgtcagtacgggctctgcaggag atgctggccaacactgaggacaaggctgatgggcatgtagatgtggagatctggacggcc cagggtggaggtcatagaaccttactgtatggacatgctgtcctcctgagacactcctac agtggaatgtacctctgctgtctgtccacctcacggtcctccactgacaaactagccttt gacgttggactgcaggaagacaccacaggcgaggcgtgctggtggaccatccacccagca tcaaagcagcgttcagagggagagaaggtcagggtcggagatgatctcatcctggtcagc atctcatcagagagatatctgcatctgtcctatggtaacggcagcctacatgtggacgcg gccttccagcagactctgtggagcgtcgcccccatctgttctgggagtgaagttgcacaa ggtttcctgatagggggcgacgtcctacgtctacttcacggtcacatggacgagtgtctg accgttccgtctggggaacacggagacgagcagaggagggcagttcactatgagggagga gctgtgtccagtcacgcccggtccctgtggagactggagactctgagggtggtctggagc gggagccacatccgctggggtcaacctttccgactgagacatgtgaccaccgggaaatat ctgagtctgattgaagacaagtgtctgcagctaatggacaaggagaaggcagacatcaag tccacagccttctgcttcaggtcctccaaggagaagttggaccctggtgtgaagaaggaa gtcgatgggatgggcttccctgacatcaagtacggagactccgtgtgtttcatccaacat gtggacacctacctgtggctgacctatcagacggccgacgccaagtgtgtccgcatgggc ggagttcaaagaaaggccatcatgcaccacgaaggtcacatggacgacgggctgactctg tcacggtcgcagcacgaggagagtcgaacggccagggtgatccgcagcaccgtctttctc ttcaacctcttcatcaggggtctggacacgctgaggaaaaagggagcgggttccacgtta gagctgcccatagagtcagtcagcctgagtctgcaggacctgattggctacttccaacca ccaggggaccacctagaacacgaggacaagcagaaccgcctgagagcactgaagaaccga cagaacctctttcaggaggagggcatgatcagcctggtgctggagtgcatcgaccgtctc cacgtctacagcagcgccgctcactttgcagaggccgttggtcgggaggcaggagagtcc tggagctccatcctcaactccctctaccaactgctggcggctctgatcagagggaacagg aagaactgtgctcagttttctggttctctggactggctggtcagcaggctggagcgcctg gaggcgtcctctggaatcctagaggttcttcactgtgttctggtggaaagtcctgaagct ctgaacatcatcaaggaaggacacatcaagtccatcatatctctgctggacaaacacgga cggaaccacaaggttctggatgttctgtgttctctgtgtgtgtgtaacggcgtggctgtt cgctccaaccagaacctgatctgtgacaacctgctgccgggacgagacctgctgctgcag acaagactggtcagccatgttagcagcatgcgtccaaacatcttcctgggcgtcagtgat ggctccgcccagtacaggaagtggtactacgagctgatcgtggaccagatgctgccgttt gtcacagcggaggccactcacctcagagtgggctgggccaacaccagtgggtacgccccc tacccaagcgggggggaaggatggggtggcaacggggtgggtgatgacctttactcctac ggctttgatggactccacctgtggtcaggctgcatcgcccgtagcgtcagctccccgaat cagcacctgctgcgttcagaggacgtggtgagctgctgcctggacctcagcgtgcccagc atctccttcagaatcaatggtcagccggtccaggggatgtttgagaacttcaactcggac ggcctcttcttccctgtggtcagcttctctgctggagtcaaggttcgtttcctcctgggg ggtcgacacggagagttcaagttccttcctcctccgggttacgccccctgctgtgaggct gttctgcccagagagaagctgaaactggaggctggtcaggaccagaccgctgccagagac ctgctgggaccaacagtgaccctgagccaggctgcgttcaccccaacaccagtggacacc agccagattgtgttgcctcctcacctggagaggatcagggagaaactggcagaaaacatc catgaactgtgggtgatgaacaagatcgaactgggctggaccttcggtgctgtgcgggac gataacaagcgacagcacccctgtctggtggagttctctaaacttcctgaacaggagcgc agctacaacctgcagatgtcgctggagacgctcaagaccctcctggccttgggctgccac gttggtcttgcagacgaacacgcagtggagaaagtgaagagaatgaaactttcatcgacc taccagttgtccagtggttataaacctgctcctctggacctgaaccacatcaaactgacc tccacccaggaggccatggttgacaaactggctgagaacgcacacaacgtgtgggccagg gaccgcatccaccagggctggacctacggcatccagcaggacgttaagaaccgtaggaac cctcgtctggtgccgtacactctgctggacgagaggacaaagaagtccaacaaggacagt ctgcgagaggccgtcaggactctgctgggatatggctttaacctggaggctccagaccag gaccacgctgctcagtccgacatcaacggcgtgtccactgagaggttccgcatcttcagg gcagagaagacctacagcgtccactctgggaagtggtactttgagctggaggtgctgacg tcaggagagatgagagtgggctgggccagaccaggatgtctcccagaccaggagctgggc tctgatgatcaggccttcgtctttgatgggttcaaggtccagcgctggcaccagggtaat gagcactttgggcgggcgtggcagatgggtgacgtcgcgggctgcatggtggatctgaat gaacacacaatgatgttcacgctgaacggagaagtcctgctggatgattcaggctccgag ctggccttcaaggactttgaagcaggagaaggtttggtcccagtctgcagtctgggtgtg ggtcaggtgggcaggatgaactttggcaaagacgtcagcaccttgaagtacttcaccatc tgtgggctgcaggagggctacgagccctttgctgtcaacatgaacagggacgtgaccatg tggctcagcaagaggctgccacagtttgtaccagttcctccaaaccaccagcacatagag gtgctgagggttgacgggacggtggagctgtgtccatgcctgaaggtcacccagaggtca tttggttcacagaacagtcacaacgacttgaccttctacagactcagcatgcctatagag tgtgccgagtcctactccaggaccaggacgaatggaggactcttctcacccaagagggaa ctggaggactttgaaacagtctcagactttgaggttctgatgaagtcccctcatggacca aacggacccgggggcccagagagggacgagttcaacaaccacaaggactataaccaggag aaaccgtccaagctcaaacagaggttcaccctgaagaagaacaaacctgacaacagctgc gcaacatctgcccgactgtcagaggaagtgatgggggacgacagagacgactatgacttc ctgtttcaggcctccacctactactactctgtgaggatcttcccgggccaggagcccagc agcgtgtgggtcggctgggtcacctcagacttccaccagtacgaccctggatttgaactg cacaaagtcagaactgtcactgtgaccctgggagacgagaagggcaaagttcatgagagt ataaagcgcagtaactgctacatggtgtgggctggagagaacagcagccccggacaggga cggaacaacaacggtctggagatcgggtgtttggtggacaccacaaacggactcctgacc ttcactgctaacggcaaagagctcagcacctactaccaggttgagcccagcaccaaactg tttcctgccgtctttgccaaagccaccagtccaaacatcttccagtttgaactgggacga atgaagaatgtgatgcctctgtcagctggtctgttcaggagtgagaggaagaacgtcgtt cctcagtgtcctcctcgtcttcacgtccagttcttaactccggttttatggagtcgtgtt ccaaaccacttcctgaaggtggcagtatccagagtgaatgacagacatggctggttgatc cagtgtaatgaacctctgcagttcatgtctctgcacatcccagaggagaacaggtccatg gacgtcctggagttgtctgagcgtaaagacatcctgaagttccactaccacaccctcaga ctgtactccgccatctgtgctctgggcaacaaccgcgtggcccacgctctgtgctcgcac gtggacgaagctcagctgctgcaggccatacagaacaagtacatgccaggtttgctgcgt gctggctactacgacctcctgatcgacatccacctgagcagctacgccactgctcgcctc atgatgaacaacgagtacattgttcccatgacggatgaaaccaagagcatcacactgttt ccccaggaggagaagaaacatggcctcccaggcatcggcctcagcacatccctaagaccc agaatgcacttctcctctccgagttttgtctctggcactgggtcgttgtatcgtaacaac agtagcagcagtacggcaggtggaggaggaggatctggggactgtttccagtacagccca gagtttcctctggagatcctgaaagtcaaaaccatagagatgctaacagaggcagtgcgg gagggaagcatgcatgtgagagacccaatagggggcagcacagagttcctctttgtccca ctcattaaacttttttacaccatgctaattatgggagtgttccaaaacggagacctgaag aacatcctgtgtctcatcgagccgtctgtgttctctgaaagacgagactcacaggacgac ggccgggcacagaaggcagggaaggaggcgcaggctgaaggaggtgaggacggtgggagg agtttgctcaaagaaggactactgcagatgaagctgcctgagccggtgaagctgcagatg tgtcacgtgctgcagtatttgtgcgactgtcagatccgtcaccgtattgaggcggtcgtt gccttctccgacgactttgtagcgtgtctccaggaaaaccagcgtttccgctacaacgag gtgatgctagcgctcaacatgtccgcggctctcactgctaagaaaaccaaagagttcagg tcacccccacaggagcagatcaacatgctgctgaacttcaaggacgagaagcaggactgt ccatgtcctgagtacatcagggaacagctgctggacttccacgaagacctgatgagacac tgtgagttggacgaggaccgaggtctggacagtgacagtgatttcaccatcagagggcgc cttctgtccttggtggagaaagtgtcctacctgaagaagaagatggtcaacctgcccaac gagaagaaagacaggaagcccagtacactgcagcagctgatctcagacaccatggtccgg tgggctcaggagtcggtcatagaagacccagaactggtcagagccatgtttgtcctgctg caccgtcagtacgacggcatcgggggtctggtccgggctcttcctaagacctacaccata aattcagtgtccattgaggacacaatcaacctgctggcagctctgggtcagataaggtct ctgctgagtgttcgcatggggagagaggaggagaaactcatgatccgaggcctgggggac atcatgaacaacaaggtcttctaccagcacccaaacctgatgagggctctggggatgcat gagaccgtcatggaggtcatggtcaatgttctgagtggaggagactctaaggaaatcacc tttccaaagatggtggctaactgctgcaggttcctctgttacttctgtaggatcagccgg cagaaccagaaggccatgttcgatcatctcagttatctgctggagaacagcagcgtcggc ctcgcctctccctccatgcgaggctccacccctctggacgtggctgcagcctcagtgatg gataataatgagttggctctggctctgagggaaccagacctggagaaggtggtccagtac ctggccggctgtggtctacagagctgcgccatgttgctgcggaaaggttaccctgacatc ggctggaaccctgtggagggagaacgatacctggacttcctacgcttcgccgttttctgc aatggtgaaagcgtagaagagaacgctaacgttgtggtgcggctgctgatccgtcgccct gaatgtttcgggcctgccctccgaggtgaaggtggtgacggtctgctggcagccgtggag gaggccatcaggatctcagaagatccgagcagagatggtccttctccaacaacagagagc agcaaatccctcagtgacatactggaggatgaggaggacgacaccatccacatgggaaac gccatcatgactttctatgctgctctgattgacctgttggggcgctgtgctccagagatg cacctcatccatgcaggtaaaggagaagcgatccggatcagagccatcctcaggtccctc atccccatccaggacctggtgggagtcatcagtattccgttctccatgcccagtctgggt aaagatgggatggtggtggagcctgacatgtctgctggcttctgtccggaccacaaagca gccatggttctgttcctggaccgggtctacggcatcgaggaccagaacttcctgctgcat ctgctggaagtgggattcctgccagacctgagagcagcggcctcgctggacactgttgcc ctcagtgccacagacatggctctggctctgaacagatacctgtgcacggccgtcctcccc ctcctcaccaagtgcgctcccctctttgctggcaccgagccgttcgcctccctcatcgac tccctgctccacaccgtctaccgtctgtccaaaggctgctgtctgaccaaagctcagaga gatgccatcgaggagtgtctgctggccgtctgcgggaagctgaggccgtccatgatgcag catctcctcaggaggttggtgtttgatgttcctctgctcaacgagcacaccaagatgcct ctgaagctgctgaccaatcactacgagcgttgctggaagtactactgtctggttggaggc tggggaaactttggagcagcttcagatgaagagcttcatctctccaggaaactcttctgg ggaatatttgatgccctgtcgcacaagcgttacgaccaggagctgttcaagttggcgttg ccctgtctgagcgccgtggctggagctctgcccccagactacatggagtccaactacatg gccatgatggagaaacagtcgtccatggactcagagggaaacttcacaccgcagcctgca gacaccaccaatgtgactgttccagagaagctggactacatcatcagcagatactcagaa cacaaccatgagaagtggtgcatagaaaagttttccagcggctggacattcgctgatcaa cagtgtgacgtcaacaggacacaccctctgctgaaaccatacaaaggcctgagtgagaag gataaggagtcgtactgtgggtcggtcagagagtccctgaagaccatgctgtcctggggc tggagcattgaccggatcagggagggagatccagccagtctccacaacaagtccaggagg atctcacaggctagtcagctgtcctttgaaggaacttcagcctttagtcctagacccatc gacatgagcaacgtgactctgtccagagacatgcagtccatggcagaactgttggcagag aattatcacaacatctgggccaggaagaagaagacagagctggaggctaaaggtggagga aaccatcctctcctggttccctacgacacactgacggccaaagagaaatccagagacaga gaaagagctcaagacattttcaagttcctgcagatcaacggttacaccgtgtccagaggt gtgaagtcccaggagctggacactccagccatagagaagagattcgcctacaccttcctc cagcagctcatcacatacgtggaccaggctcatcagcacatgatggagtttgatgcagga gtgagactgaagggggagacaattcctcacgagcagcagatcaagttctttggaaaggtg gttttacctctagtggaccagtactttaaaaaccaccggctctacttcctgtccacggcc attcacccaatcagcagcggtggccacgcctccaataaagagaaagagatggtgaccagt cttttctgcaaactgggagttctggtcagacacaggatttccttgtttggtaacaacgcc acgtccatcgtcaactgtcttcagatcctgggacagagtctagacgccaggacagtgatg aaaactggtcttgagtcagtgaaggtggcgctgcggtccttctttgacagtgcagcagaa gatctagagaagacgcaggagaacctgaagctgggtcagttcacccacagcagagatcag cccaggggggtcactcagatcatcaactacaccaccttcgccctgctgccggttctgtcc tcgctctttgaacacatcggacagaacatgtttggagaagacctgatactggacgacgtc caggtctcctgttacagaatcctcaacagtctgtacctgctgggaaccaacaagagcatc tacgtggagagacagcggccggcattgggacagtgtctcgctgccttctcagcagcgttc cctgtggccttcctagaacctcacatcaacaagttcaacagcttctccatctacaacagc agaggaaccaaagacagaggagctctcggtctgccgggacacgttgacgatgtctgcgcc gtgatcccaaacctggacaagtctttggaggagatcatggacttggcagagtccggcatg agatacaaccagatgcctcacgtcatggaggtggtgctgcccatgttgtgcagctacatg tcccactggtgggaacatggaccagagaaccacatggaccaggctgacagctgctgcact gctgtcacctcagagtacatgaacactctgctgggaaacatcctgaagatcatctacaac aacctgggcatcgacgagggagcctggatgaagagactggctgtcttctctcagccaatc atcagcaaggctaagcctgagctactgaagactcatttcctgcctctgatggagaaactg aaaaaaaaagcagccattgttctgatggatgaagagcacagtaaagctgaggggcggggt gagatgtcagagacagagcttctcatcatggaccagttcaccatcctggtcagagacctg tacgccttctatccgctcctcatacgcttcgtggactacaacagggcccgctggctgaag gagtccaaccctggggctgaggcactgttccgaatggtggctgaggttttcatcttctgg gccaagtctcataacttcaagagggaggagcagaactttgtggttcagaatgaaatcaac aacatgtccttcctcatcactgacaccaagtgtaagatgtccaagggaatcgtttcagat caggagaggaagaagatgaagaggaagggagatcgctactccatgcagaccagtctgatc gtagccactctgaagcgcctcctgcctgtcggactgaacatgtgcgctcctggagagcag gaactgatcacactggccaagaaccgatttacacagaaagacacagaggacgaagtcaga gacatcgtcaagaacaacctgcacctgcaggggaagttggaggatcccgccattcgctgg cagatggcgctgtacagagacctgcccaaccactgtgaaaacaaccccgacccagagaag acggtggagagagttctggacatcgctcatgtcctcttccacctggagcaggtagaacat cctcagcgaagtaaaaaagctgtgtggcacaaacttctgtccaaacaaaggaagagagca gtggtggcctgcttcaggatggcaccgctctataatctgcccaggcaccgggctgtgaac ctgttcctgcagggctacgacaaatcctggatcgaggctgaggagcactactttgaagac aaactgatcgaggacctggccaaacccggagaagaggagcagtgtgaggaggaggaggcg ctgaagcacatggaccctctgcaccagctgatccagctgctcagcaggacggccctgact gagaagtgtaaactggatgaggataatctgtacatggcctatgctgacatcatggctaag agctgccacgacgaagaagatgaagatggagaagttaagagttttgaggagaaggagatg gagaagcagaagctgttgtaccagcaggctcgacttcatgatcgtggagctgctgagatg gttctccagaccatcagtgccagcaaaggtgaaatgggtctgatggtggcctccaccctg aagctgggcatcgccatcctgaacggaggaaactccaccgtacagcagaaaatgttggat tatctgaagaacaagaaggacgtgggcttcttccagagtctggccggtctcatgcagtcc tgcagtgtcctggatctaaatgcctttgagagacagaacaaagctgaaggactggggatg gtgacggaggagggatcaggtgagaaggtcatgcaggacgacgagttcacctgtgacctt ttccgcttcctgcagctgctgtgtgaaggacacaactcagacttccagaactacctacgg acccagacaggaaacaacaccactgtgaacatcatcatctccactgttgactacctgctg agagtccaggagtccatcagtgacttctactggtactactctggtaaagatgtcatcgac gaacagggacagaggaacttctccaaggccatcaatgtggccaagcaggtgttcaacacc ctgacggagtacatccagggcccctgcactgggaaccagcagagtctggctcacagtcgt ctgtgggacgctgtggtggggtttctccacgtcttcgctcacatgcagatgaagctgtcc caggactccagtcagatcgagttgttgaaggaactgatggacctgcagaaggacatggtg gtcatgctgctgtccatgctggagggtaacgtggtgaacggaaccattggaaagcagatg gttgacatgttggtggagtcgtccaacaacgtggagatgatcctcaagttctttgacatg ttccttaaactgaaggacctgacatcgtctgatgccttcaaggagtacgacactgatggg aaaggcgtcatctccaagagggacttccacaaagccatggagagccacaaacactacacc cagtcagagacggagttcctgctgtcctgcgctgagacggacgagaacgaacagttggac tatgaagagtttgtggaacgttttcatgaaccagccaaggacatcggcttcaacgtggcc gttctcctcaccaacctgtcggagcacatgccccacgacactcgtctgcagaccttcttg gagttggctgagagcgtcctgaactacttccagccgtacctgggccgcatcgagattatg ggcagcgccaagcgcatcgagagggtctactttgagatcagtgagtccagccggactcag tgggagaaaccgcaggtgaaggagtccaagcgacagttcatctttgatgtggtgaacgaa ggcggtgagaaggagaagatggagctgttcgtcaacttctgtgaggacaccatctttgaa atgcagctggccgctcagatgtccgatgctggagaacgatcggctgtgaaggaggagaat gagaaggagaagccggatgaggagaacccagacatcggcttcttctccgtcaccacggtc tgcatggcgctggtggctctgcgctacaacgtcatgctgttgataaaagttctgtccatg aagagcctgaagaagcagatgaagaagataaagaacatgacagtgaaggacctggtcacc accctggtctccttgtactggtccatcctactgggtctcctccatgtcgccttcagtgtg gccagagggttctgtcgaatcttctacaacaccttcatgggtggtaacctggtggaagga gccaagaccataaaggtgtcagagctcctggccaacatgcccgaccccacccaggacgag gttcgaggagaaggtgaggacagagagaggagaccctcagaccgcagctccaccaaggag gacctggccgacctggtcgtgaaccccagtgagacggagctgctgtccgacatatttggt ctggacctgaggagggaggggggccagtacaagatcagccctcacaaccccaacgcaagt ctgacggagctgctcaactcacctgttcctgctcagacctcagcaacaacagcgcccccc actgagctcagacggaggcatcagtccaaaggttcagaggagaaggaagtagcgctggaa tctgaaggagaaccagagaaaccatcaggggagggggtcgtggaggagccagggaaacta cagaagaacgacaagatgaagcccaaagtgagaagacatcgaaagtccaggtctgatgaa ccagatcttcaggagtcggcctttatcaagaagatcatagcctatcagaggaaactgctg aactattttgccaggaacttctacaacatgaggatgttggctctgttcgtggccttcgcc atcaacttcatcctcttattctacaaggtctctacgtcctcctctgtggtcgaggacaag ggtcctgtgtacgccaacaccccttctgacggtggtgttcggtggaactcactgggcgga ggaggtgaagtggtggagacgaaggaggaggttctggaggagacaggagaaccacagaaa cctgttacggtgcgttttgtcctggaggagagcagtggatacatggagcccacgctccgc atcctggccgtccttcacaccgtcatcgccttcttctgcatcatcggctactactgtctg aaggttcctctggtgatctttaagagggagaaggaagtggccaggaagctggagtttgat ggactgtacatcacagagcagccctcagaagatgacatcaaaggacagtgggacagactg gtcatcaacacacagtcgtttccaaacaactactgggacaagtttgtgaagaggaaggtg atggacaaatacggagaattttatggacacgaccgaatcagcgagctcctggggatggac aaggccgctctggacttcagtgacgctcacaagaagaggaagcccaggagagacggctcc ctggctgctgttttaaactccatcgacgttaaataccagatctggaagctgggggtggtc ttcacagacaactccttcctgtatctggcctggtacatgaccatgtccatcctgggtcac tacaacaacttcttcttcgctgctcacctgctggacatcgccatgggcttcaagacgctg cggaccatcctgtcgtcggtcacacacaacggcaaacagctggtgttgaccgtgggcctg ctggccgtggtggtttacctctacacggtggtggcctttaacttcttcaggaagttctac aacaagagtgaagatggagagctgccggacatgaagtgtgacgacatgctgacgtgctac atgttccacatgtacgttggcgtcagagcgggtgggggcattggggaccagattgaggac ccggcgggggacgagtacgagatctaccgcatcatctttgacatcaccttcttctttttc gtcattgtaatcctgctggccatcatccaaggtttgattattgatgcctttggagaactg agggaccagcaggaacaagtcaaagaagacatggagaccaaatgtttcatctgtggaatc ggtaacgactactttgacacggtgcctcacggctttgaaacgcacacgttacaggagcac aacttagctaactacctattctttgtgatgtatctgatcaacaaagatgaaaccgagcac acaggacaggagtcctatgtttggaagatgtaccaggaacgttgttgggaattcttccct gctggagactgtttccggaaacagtatgaggatcagctgaactga

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