KEGG   Capricornis sumatraensis (Sumatran serow): 138072822
Entry
138072822         CDS       T10522                                 
Symbol
SOS2
Name
(RefSeq) son of sevenless homolog 2 isoform X1
  KO
K03099  son of sevenless
Organism
csum  Capricornis sumatraensis (Sumatran serow)
Pathway
csum01521  EGFR tyrosine kinase inhibitor resistance
csum01522  Endocrine resistance
csum04010  MAPK signaling pathway
csum04012  ErbB signaling pathway
csum04014  Ras signaling pathway
csum04062  Chemokine signaling pathway
csum04068  FoxO signaling pathway
csum04072  Phospholipase D signaling pathway
csum04150  mTOR signaling pathway
csum04151  PI3K-Akt signaling pathway
csum04510  Focal adhesion
csum04540  Gap junction
csum04630  JAK-STAT signaling pathway
csum04650  Natural killer cell mediated cytotoxicity
csum04660  T cell receptor signaling pathway
csum04662  B cell receptor signaling pathway
csum04664  Fc epsilon RI signaling pathway
csum04714  Thermogenesis
csum04722  Neurotrophin signaling pathway
csum04810  Regulation of actin cytoskeleton
csum04910  Insulin signaling pathway
csum04912  GnRH signaling pathway
csum04915  Estrogen signaling pathway
csum04917  Prolactin signaling pathway
csum04926  Relaxin signaling pathway
csum04935  Growth hormone synthesis, secretion and action
csum05034  Alcoholism
csum05160  Hepatitis C
csum05161  Hepatitis B
csum05163  Human cytomegalovirus infection
csum05165  Human papillomavirus infection
csum05200  Pathways in cancer
csum05205  Proteoglycans in cancer
csum05206  MicroRNAs in cancer
csum05207  Chemical carcinogenesis - receptor activation
csum05208  Chemical carcinogenesis - reactive oxygen species
csum05210  Colorectal cancer
csum05211  Renal cell carcinoma
csum05213  Endometrial cancer
csum05214  Glioma
csum05215  Prostate cancer
csum05220  Chronic myeloid leukemia
csum05221  Acute myeloid leukemia
csum05223  Non-small cell lung cancer
csum05224  Breast cancer
csum05225  Hepatocellular carcinoma
csum05226  Gastric cancer
csum05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:csum00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    138072822 (SOS2)
   04012 ErbB signaling pathway
    138072822 (SOS2)
   04014 Ras signaling pathway
    138072822 (SOS2)
   04630 JAK-STAT signaling pathway
    138072822 (SOS2)
   04068 FoxO signaling pathway
    138072822 (SOS2)
   04072 Phospholipase D signaling pathway
    138072822 (SOS2)
   04151 PI3K-Akt signaling pathway
    138072822 (SOS2)
   04150 mTOR signaling pathway
    138072822 (SOS2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    138072822 (SOS2)
   04540 Gap junction
    138072822 (SOS2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    138072822 (SOS2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    138072822 (SOS2)
   04660 T cell receptor signaling pathway
    138072822 (SOS2)
   04662 B cell receptor signaling pathway
    138072822 (SOS2)
   04664 Fc epsilon RI signaling pathway
    138072822 (SOS2)
   04062 Chemokine signaling pathway
    138072822 (SOS2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    138072822 (SOS2)
   04912 GnRH signaling pathway
    138072822 (SOS2)
   04915 Estrogen signaling pathway
    138072822 (SOS2)
   04917 Prolactin signaling pathway
    138072822 (SOS2)
   04926 Relaxin signaling pathway
    138072822 (SOS2)
   04935 Growth hormone synthesis, secretion and action
    138072822 (SOS2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    138072822 (SOS2)
  09159 Environmental adaptation
   04714 Thermogenesis
    138072822 (SOS2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138072822 (SOS2)
   05206 MicroRNAs in cancer
    138072822 (SOS2)
   05205 Proteoglycans in cancer
    138072822 (SOS2)
   05207 Chemical carcinogenesis - receptor activation
    138072822 (SOS2)
   05208 Chemical carcinogenesis - reactive oxygen species
    138072822 (SOS2)
   05231 Choline metabolism in cancer
    138072822 (SOS2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    138072822 (SOS2)
   05225 Hepatocellular carcinoma
    138072822 (SOS2)
   05226 Gastric cancer
    138072822 (SOS2)
   05214 Glioma
    138072822 (SOS2)
   05221 Acute myeloid leukemia
    138072822 (SOS2)
   05220 Chronic myeloid leukemia
    138072822 (SOS2)
   05211 Renal cell carcinoma
    138072822 (SOS2)
   05215 Prostate cancer
    138072822 (SOS2)
   05213 Endometrial cancer
    138072822 (SOS2)
   05224 Breast cancer
    138072822 (SOS2)
   05223 Non-small cell lung cancer
    138072822 (SOS2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    138072822 (SOS2)
   05160 Hepatitis C
    138072822 (SOS2)
   05163 Human cytomegalovirus infection
    138072822 (SOS2)
   05165 Human papillomavirus infection
    138072822 (SOS2)
  09165 Substance dependence
   05034 Alcoholism
    138072822 (SOS2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138072822 (SOS2)
   01522 Endocrine resistance
    138072822 (SOS2)
SSDB
Motif
Pfam: RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH RHG20_PH PH_19
Other DBs
NCBI-GeneID: 138072822
NCBI-ProteinID: XP_068820147
LinkDB
Position
2:59476415..59577202
AA seq 1332 aa
MQQAPQPYEFYSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
EKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKI
CSEEHEDRECLNQAITALMNLQGSMDRIYKQFSPRRRPGDPVCPFYNRQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG
CSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALI
SLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLTERFEIPEPEPTEADKLA
LEKGEQPISTDLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLEFFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAILSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
DAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSAFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS
EEPLIPPPLPPRKKFDQDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPTGPFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVNTCPNSPN
TPPSTPSPRVPRRCYVLSSSQNNLAHLQAPPVPPRQNSSPLLPKLPPKTYKRELSHPPMY
RLPLLENAETPQ
NT seq 3999 nt   +upstreamnt  +downstreamnt
atgcagcaggcgccgcagccttacgagttctacagcgaagagaacagtccgaaatggcgg
ggactgttggtctcggccctgcggaaggttcaggagcaagtacatcccaatctctcagct
aatgaagagtctctctattatattgaagagctgatttttcagctgcttaataaattatgc
atggcccaaccaaggactgttcaagatgtggaggaacgagttcaaaagacctttcctcat
ccaattgataaatgggctattgctgatgcacagtctgccatagagaaacgaaaaagaaga
aatcctctcttactgcctgtggacaaaatccatccttcattgaaggaagttttagggtac
aaagtggactaccatgtatccctgtatattgtggctgtgctagagtatatctcagctgat
attttgaaattggctggtaattatgtttttaatatccgacattatgaaatatctcaacaa
gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac
ataggcttggtttctctttgtgaagatgaacctagttcttcaggcgaattaaactactat
gaccttgttagaactgaaattgcagaagaaagacagtatctacgggaactaaatatgatc
ataaaagtgtttcgagaagcttttctttctgacagaaagctgtttaaaccttctgatatt
gaaaagattttcagtaacattttagatatacatgagttgactgtgaaacttttaggttta
attgaagacacagttgaaatgactgatgaaagtagccctcatcccttagctggcagctgt
tttgaagatctggcagaggagcaagcatttgatccttatgaaacattatcccaggatatt
ctttcaccaaagtttaatgaacattttagtaagttgatggccagacctgcagtggctctg
cactttcagtccattgctgatggttttaaagaggcagttcgttacgtccttccacgcctt
atgctggtgccagtatatcattgttggcactattttgaattattaaagcaattgaaaata
tgtagtgaagagcatgaagacagagaatgtttgaaccaagctattactgctctcatgaat
ctccaaggtagtatggaccgaatttacaagcagttttcacctagacgccgacctggggat
cctgtttgccctttttataatcgtcaattaagaagcaagcacctggctattaaaaaaatg
aatgaaattcagaaaaacatagatggatgggaaggcaaagacattggacagtgttgtaat
gaatttattatggaaggcccattgacaagaattggtgctaaacatgaacggcatattttt
ctctttgacggcttaatgatcagctgcaaacccaaccacagccagtcacgcctcccagga
tgcagcagtgcagagtacagactaaaagagaaatttgtcatgaggaagatacagatatgc
gataaagaagatacttgtgagtgcaagcacgcttttgagttagtatccaaagatgaaaac
agcataatatatgctgctaagtctgctgaagagaaaaataactggatggcagcacttatt
tcccttcagtatcgtagtactctggatcgaatgctggattcggtattattgaaggaagaa
aatgaacaaccattgagattaccaagtcctgaagtgtatcgttttgtggtaaaagactct
gaggaaaacattgtttttgaagacaacttgcagagtagaagtggaatccccattattaaa
ggaggaactgtggtgaaattaattgaaaggctaacatatcatatgtacgcagatcccaat
tttgttcgtacctttcttactacgtatcgttcattttgtaaaccacaggaattactaagc
ttactgactgaacgatttgaaattccagagccagaacctactgaagcagataaattggca
ttagaaaaaggcgagcagcccatcagtacagaccttaaaaggtttcgcaaggaatacgtc
caaccagtacaacttagggtcttaaatgtgtttcggcactgggttgaacaccatttttat
gactttgaaagagacttggagctgcttgaaagactagaattcttcatttcaagtgtaaga
gggaaagctatgaagaaatgggtagagtcaattgctaagatcatcaagaggaaaaaacaa
gctcaggcaaatggtataagccataatattacctttgaaagtccacctccaccaattgaa
tggcatatcagcagaccaggacagtttgaaacatttgatctcatgacacttcatccaata
gaaattgcacgtcagctgacgcttttggaatctgatctctacaggaaagttcaaccttct
gaactcgtagggagtgtatggaccaaagaagataaagaaataaactctccaaatttatta
aaaatgattcgccacaccacaaatcttaccctctggtttgaaaaatgcattgtggaggca
gaaaattttgaggaacgggtggcaatactgagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattggagatcgtcagtgcagtaaattcagtatca
gtctatagactagatcatacatttgaggcgttgcaggaaagaaaaaggaaaattttggat
gatgctgtggaattaagtcaagatcattttaaaaaatatctagtgaaacttaagtcaatc
aatccaccctgtgtgcctttttttggaatatatttaacaaatatactgaagactgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcaaaatcaaccttactgtttacgg
atagaaccagaaatgaggagattctttgaaaaccttaaccccatgggatgtgcttctgaa
aaagagtttacagattatttgttcaacaagtcactagaaattgaaccccgaaactgcaaa
cagccaccgcgatttcctaggaaatcagctttctccttaaaatctcctggaataaggcct
aatacaggccgacatggctctacctcaggtactttgcgaggtcacccaacaccattagaa
agagaaccgtgtaaaataagctttagtcggattgctgaaacggagcttgaatcaacagtg
tcagcaccaacctctccaaatacaccatctaccccaccagtatctgcttcttcagacctt
agtgtgtttttagatgtggatctcaacagttcctgtggaagcaatagcatctttgctcca
gtcctcttgcctcattcaaagtctttcttcagttcgtgtggtagtttacataagctaagt
gaagagccactgattcctcctccacttccacctcgaaaaaaatttgatcaggatgcttca
aattccaagggaactatgaaatctgatgatgacccccctgctattccaccaagacaacct
cctcctccaaaggtaaaacccagagttcctgctcctactggtccatttgatgggcctctg
catagtccacctccaccaccgccgagagatcctcttcctgatacccctccaccggttcca
cttcggcctccagaacactttataaactgtccgtttactcttcagccacctccactggga
catcttcacagagatccagactggttcagagacgttaatacgtgtccaaattctccaaac
actcctcctagcacaccctctccaagggtacctcgtcgatgctatgtgctcagttctagt
caaaataatcttgctcatcttcaagctccccctgttccaccaaggcagaattcaagccct
cttctaccaaaactgccaccaaagacttacaaacgggagctttcacaccccccaatgtat
agactgccattgttagaaaatgcagaaactcctcaatga

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