Entry |
|
Symbol |
RYR2
|
Name |
(RefSeq) ryanodine receptor 2
|
KO |
|
Organism |
csum Capricornis sumatraensis (Sumatran serow)
|
Pathway |
csum04261 | Adrenergic signaling in cardiomyocytes |
csum05022 | Pathways of neurodegeneration - multiple diseases |
csum05412 | Arrhythmogenic right ventricular cardiomyopathy |
|
Brite |
KEGG Orthology (KO) [BR:csum00001]
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
138087739 (RYR2)
04020 Calcium signaling pathway
138087739 (RYR2)
04024 cAMP signaling pathway
138087739 (RYR2)
09150 Organismal Systems
09152 Endocrine system
04911 Insulin secretion
138087739 (RYR2)
04921 Oxytocin signaling pathway
138087739 (RYR2)
09153 Circulatory system
04260 Cardiac muscle contraction
138087739 (RYR2)
04261 Adrenergic signaling in cardiomyocytes
138087739 (RYR2)
09154 Digestive system
04972 Pancreatic secretion
138087739 (RYR2)
09159 Environmental adaptation
04713 Circadian entrainment
138087739 (RYR2)
09160 Human Diseases
09164 Neurodegenerative disease
05020 Prion disease
138087739 (RYR2)
05022 Pathways of neurodegeneration - multiple diseases
138087739 (RYR2)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
138087739 (RYR2)
05412 Arrhythmogenic right ventricular cardiomyopathy
138087739 (RYR2)
05414 Dilated cardiomyopathy
138087739 (RYR2)
05415 Diabetic cardiomyopathy
138087739 (RYR2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:csum04040]
138087739 (RYR2)
04990 Domain-containing proteins not elsewhere classified [BR:csum04990]
138087739 (RYR2)
Ion channels [BR:csum04040]
Voltage-gated cation channels
Ryanodine receptor
138087739 (RYR2)
Domain-containing proteins not elsewhere classified [BR:csum04990]
EF-hand domain-containing proteins
Other EF-hand domain-containing proteins
138087739 (RYR2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
10:complement(34477072..35055271)
|
AA seq |
4971 aa
MSGLLYVSHCDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICT
FVLEQSLSVRALQEMLANTVEKSEGKVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYS
GMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV
SSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHLDECLT
VPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYL
SLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHI
NTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLF
NRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQ
NLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRK
NCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGR
NHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEG
SAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYG
FDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDG
LFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTY
TRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGP
VRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEKVKKMKL
PKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKN
RRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFR
IFRAEKTYAVKAGRWYFEFEAITSGDMRVGWSRPGCQPDQELGSDECAFAFDGFKAQRWH
QGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCS
LGVAQVGRLNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHE
HIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAAGGIPGTG
LFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDKDKEATKPEFNNHKDYAQEKPSRLKQ
RFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWI
TSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGLE
IGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPL
SAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCVEPLQ
FMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLL
YAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDEKKKH
GLPGIGLSTSLRPRMQFSSPSFVSINSEGYQYSPEFPLDILKAKTIQMLTEAVKEGSLHA
RDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHVLQLIEPSVFKEAASPEEESEVAEK
EPFVEDSKLEGAAEEENKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIV
AFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSEC
PCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNNDLTIRGRLLSLVEKVTYLKKKQAEK
PVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTY
TINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALG
MHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSS
VGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYP
DIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAA
MEEAIKIAEDPSRDGPSPTTGSSRTPDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEM
HLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKA
AMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLP
LLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQ
HLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFW
GIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPV
DTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEK
EKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAI
DMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAKEKAKDR
EKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGG
SRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTS
LFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAE
DLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDV
QVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNT
KSSRERAALNLPANVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVMEVILPMLCSYM
SRWWEHGPENNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPI
INKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEARGDMSEAELLILDEFTTLARDL
YAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEIN
NMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQ
ELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPALRWQMALYKDLPNRTEDTSDPEK
TVERVLDIANVLFHLEQKSTSMRRRYYNLGSTVEHPQRSKKAVWHKLLSKQRKRAVVACF
RMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDP
LHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSK
EKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQ
KMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEF
TCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGK
DVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQ
MKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILK
FFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDEN
ETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGR
IEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCED
TIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIMTVKSALFALRYNILTL
MRMLSLKSLKKQVKKVKKMTVKDMITAFFTSYWSILMSLLHFVASVFRGFSRIIGSLLLG
GSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKTLEGALPSEDLTDLKELTEESDL
LSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKANEEKEEKEESK
SEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFA
RNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENARVSSLDRSSPRIIA
VHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLY
ITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAA
LDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNN
FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS
EDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIV
ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA
NYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN |
NT seq |
14916 nt +upstreamnt +downstreamnt
atgtcgggccttttgtatgtcagtcactgtgatgatgaagtggtcctacagtgtaccgca
accatccacaaagaacaacagaaactctgtttggcggcagaaggatttggcaacagactt
tgcttcttggagtccacttcgaattccaagaatgtccctccagacctctccatctgcacc
ttcgtgctggagcaatccctgtctgtccgggccctgcaggagatgctggctaacactgtg
gaaaagtctgaagggaaggttgatgtggaaaaatggaaattcatgatgaagactgctcaa
ggtggtggccaccgaacgctcctctacggtcatgcaatactgctgcggcattcctacagc
ggcatgtatctgtgctgcctgtccacctctcggtcttcaactgataagctggcttttgat
gttggcttgcaagaggatacaacaggtgaagcttgttggtggaccatccatcctgcctct
aagcagcgctcagaaggagaaaaagtgcgggttggagatgacctcatcttagtgagcgtg
tcctctgaaaggtacctgcacttgtcttacggtaacggcagcttgcacgtggatgctgct
ttccagcagaccctctggagtgtggcgcccatcagctcaggaagtgaagcagcccaaggg
tatctgattggtggtgacgtcctcaggttgcttcatggacacttggatgaatgcctcact
gtcccttcaggagaacacggtgaagagcagcggagaactgttcattacgaaggtggtgct
gtatcggttcacgcacgttccctgtggcgactagagacactaagagttgcgtggagtgga
agccacataaggtggggacaaccttttcgactacgccatgtcacaacgggaaaatacttg
agtctcatggaagacaaaagccttctactcatggacaaagaaaaagctgatgtcaaatca
actgcatttacgttccgatcttccaaggaaaaattggatgtaggagtgagaaaagaagtt
gatggcatgggaacctctgaaataaaatatggagactcggtatgttatatacagcatatc
aatacaggcttgtggctcacttaccagtctgtggatgtgaaatcggtgagaatgggatcc
atacaacgtaaggctattatgcatcatgaaggacacatggatgatggcctaaatttatcc
agatctcagcatgaagaatcacggacagcacgtgtcatccggagcacagtcttccttttt
aatagatttattaggggccttgatgctctcagcaaaaaggtgaaggcttccacagtagac
ttacctatagagtctgtaagtctgagtctgcaggaccttattggctacttccacccacca
gatgagcatttagagcatgaagataagcagaacaggttacgagctctgaagaataggcag
aatctcttccaggaagagggaatgatcaaccttgtgctcgagtgtatagacaggctgcat
gtgtatagcagtgctgcacacttcgctgatgttgctgggagagaagcaggggaatcttgg
aaatcgattctgaattctctgtatgagttgctggcggcattaattagaggaaatcgtaaa
aactgtgctcaattctctggctcgcttgactggttaatcagccgactggaaagactggaa
gcttcttctggtattcttgaagttttacactgtgtgttagtagaaagtccagaagctcta
aatattattaaagaaggccatataaaatccattatctcacttttagacaagcatggaaga
aatcacaaggttctggatgtcctatgctctctctgtgtttgccatggagtagcagtccgt
tctaaccagcatctcatctgtgacaatcttctgccaggaagagacctgttattgcagaca
cgccttgtgaaccatgtgagcagcatgagacccaatatttttctgggtgtcagtgaagga
tctgcacagtataagaagtggtattatgagttgatggtggaccacactgagccattcgtg
actgctgaagccactcacctgcgagtgggctgggcttccacagaggggtactcaccctac
cccggagggggtgaagagtggggtggaaatggtgtcggagatgacctcttctcctacgga
tttgatggccttcacctctggtcaggttgtattgcccggactgtcagctcaccaaaccag
catctcttgagaactgatgatgtcatcagttgctgtttagatctaagtgccccaagcatc
tccttccgaattaatggacaacctgttcaaggcatgtttgagaatttcaacattgatggc
ctgttctttccagttgtcagtttctctgcaggaatcaaagtacgctttctgcttgggggg
agacatggagaatttaaattccttcctccgcctgggtatgctccttgttatgaagctgtt
ctgccaaaagagaagttgaaagtggagcacagccgagagtacaagcaagaaaggacttac
acgcgggacctcctgggccccacggtttccctgacacaagctgccttcacaccaatccca
gtggacaccagccagattgtgttgcctccccacctggagaggatacgagaaaaactggca
gagaatatccatgagctctgggtgatgaataaaattgaacttggctggcagtatggtccg
gttagagacgacaataagagacagcacccgtgtctggtggagttctccaagctgcctgaa
caggaacgcaattacaatttacagatgtcactcgagaccctgaagacgttgttggcttta
ggatgtcatgtgggtatatcagatgaacacgctgaagaaaaggtgaagaaaatgaagctg
ccaaagaattaccaactgacaagtggatataagcctgccccgatggacctgagctttatc
aaactcaccccgtctcaggaggctatggtggacaagttggcagaaaacgctcataatgtg
tgggctcgggatcgaattcgacagggctggacctacggcatccaacaggatgtaaagaac
agaagaaaccctcggcttgttccctatgcccttctagatgaccgaactaagaaatccaat
aaggatagcctccgtgaggctgtacgcacactgctgggatatggctacaacctggaggca
cctgatcaagatcatgctgccagagctgaagtgtgcagcggcacgggagagaggttccgc
atcttccgtgctgagaaaacgtatgctgtgaaagctggaaggtggtattttgaattcgag
gcgatcacttctggagacatgcgagttggctggagcaggccagggtgtcaacctgatcag
gagcttggctcagatgaatgtgcctttgcttttgatggcttcaaggcccagcggtggcac
cagggcaatgagcactatgggcgctcctggcaagctggcgatgttgtggggtgtatggtt
gacatgacagaacacaccatgatgttcacactgaatggcgaaatccttcttgatgattca
ggttcagaactggctttcaaggactttgatgttggtgacggattcatacctgtgtgtagc
ctgggagtggctcaagtgggcaggctgaactttggaaaggatgtcagcaccttgaaatat
ttcaccatctgtggcttacaagagggctatgagccatttgccgttaacacaaatagggat
attaccatgtggctgagcaagaggcttcctcaatttcttcaagttccatcaaaccatgaa
catattgaggtgaccagaatagatggcaccatagacagttccccatgtttaaaagtcact
cagaagtcctttggctctcagaacagcagcacggatatcatgttttatcgtctgagcatg
cccatcgagtgtgcagaggtcttctccaagactgcagctggagggatccctggcaccggc
ctctttgggcccaagaatgatctggaggattatgatgtggattcagactttgaggttctc
atgaagacagctcacggccatctggtgccagatcgaggagacaaagacaaagaagctaca
aaaccagagtttaataaccacaaagattatgctcaggaaaaaccctctcgtctgaaacag
aggtttttgcttcgaagaacaaagccagattatagcaccagccattctgcaagactcact
gaagatgtccttgcagatgagagggatgactatgattacttgatgcaaacgtccacgtac
tattactcagtgagaatctttcctggacaagaacctgccaatgtctgggtgggctggatc
acatccgatttccatcagtatgatacaggctttgacttggacagagttcgtacagtgacc
gtgactctgggagatgaaaaaggaaaggtgcacgaaagcatcaaacgcagcaattgctac
atggtgtgtgcgggtgagagcctgagcccggggcaaggacgcaacaacaatggcctggag
attggctgcgtggtggatgctgccagtgggctgctcaccttcacggccaacggcaaggaa
ctgagcacctattatcaggtggaaccaagcacaaaattatttcctgcagtttttgcacaa
gctacaagtcccaatgtttttcagtttgagttgggaagaataaagaatgtgatgcctctc
tcagcgggattattcaagagtgagcacaaaaatcctgtaccacagtgtcccccacgtctc
catgtgcagtttctctcacatgtcctgtggagcagaatgcccaaccagttcttgaaggta
gatgtctctcgaataagtgaacgccagggctggctggtgcagtgcgtggagcctctgcag
ttcatgtcacttcatatcccagaggagaacagatccgtggacatactggaactgacagag
caggaggaactgctgaaattccactaccacactctccggctctactcggctgtctgcgcg
ctcgggaaccaccgggtggcccacgccttgtgcagccacgtggacgagccgcagctgctc
tacgccatcgagaacaagtacatgcccggcttgctgcgcgccggctactacgacctgctg
attgacatccacctcagctcctacgccaccgccaggctcatgatgaacaacgagttcatc
gtccccatgaccgaggagacgaagagcatcaccctcttcccagatgagaagaaaaagcac
gggctcccgggcatcggcctcagcacctccctcaggccgcggatgcagttttcctccccg
agttttgtcagcattaacagcgagggttaccagtatagcccggagttcccactggacatc
ctgaaggccaagaccatacagatgctgacagaagccgtgaaagagggcagccttcacgcc
cgagaccccgttgggggcaccactgagttcctcttcgtgcctctcatcaagctgttctat
accctgctcatcatgggtgtcttccacaacgaggacttgaaacacgtcttgcagttgatt
gagcctagtgtgttcaaggaagccgccagccccgaggaggagagcgaggtggcggagaag
gaaccctttgtagaagactccaagctggaaggagccgctgaagaagaaaacaaagggggt
aagaggcccaaggagggcctgctccaaatgaaactgccagagccagtaaaattgcagatg
tgcctgctacttcaatacctctgtgactgccaggtccggcaccggatagaagccattgtg
gccttttcagatgactttgtagccaagctccaggacaatcaacgattccgatataatgaa
gttatgcaagccttaaacatgtcagctgcactcacagccaggaaaacaaaggaattcaga
tccccgcctcaagagcagatcaatatgcttctcaattttaaggatgacaaaagtgaatgt
ccatgtcctgaagaaatccgagaccaactcttggattttcacgaagatttgatgacacat
tgtggaattgagctggatgaagataggtctctggacggaaacaacgatttaactattaga
ggacgcctgctgtccttggtagaaaaggtgacatacctgaagaagaagcaagctgaaaag
ccagttgagagtgactccaagaagtcatccactcttcagcagttgatttctgagaccatg
gtccgatgggctcaagagtctgtaattgaagaccctgagttggtgagggccatgtttgta
ttgctccatcgacagtatgatggcattgggggtctggtacgggctctcccaaagacctac
actataaatggtgtttctgtggaggataccatcaatctgctggcatctcttggtcagatt
cgttctctgctaagtgtgagaatgggcaaagaggaagagaaactaatgattcgtggatta
ggggatatcatgaacaataaagtgttttaccagcatcctaatctcatgagggcgcttggg
atgcacgagacagtgatggaggtcatggtgaatgtccttggaggcggagagtccaaggaa
atcacttttccgaagatggtggccaactgttgccgttttctctgttacttctgtcgtata
agtaggcagaatcagaaagctatgtttgatcatctcagttatttactggaaaacagcagt
gttggtcttgcctcaccagctatgagaggttcaacaccactggatgtggcagcagcctcg
gtgatggataataatgaactagctttagctttgcgggagccagatctggaaaaggtggtt
cgatatttggctggttgtggactgcagagttgccagatgctagtgtcaaagggttatcca
gacattgggtggaatccagttgaaggagagagatatcttgactttctcagatttgctgtc
ttctgtaatggggaaagcgtggaggagaacgcaaatgtcgtggtgagattgctcatccgg
aggcctgagtgttttggtcctgccctgaggggggaaggtgggaatggcctgctcgcagcc
atggaagaagccataaaaatagctgaggatccctctagagatggtccctcaccaactact
ggatccagcaggacccctgatacagaagaggaagaggatgataccatccacatgggaaat
gccatcatgaccttttatgcagctttgattgacctgttaggacgctgtgctcctgaaatg
catttgattcatgctgccaaaggagaagccatcagaatcaggtctattttgagatctctg
attccactgggagatttggtgggagtaatcagcattgcttttcagatgcccacaatagcc
aaagacgggaatgtggtggagcctgacatgtctgcggggttttgtccagatcacaaggca
gccatggttttgttccttgacagggtctatggaattgaggttcaagatttcctcctccat
cttctcgaggttggctttctgccagatctccgggctgctgcttctttagacacggctgct
ttgagtgctacagacatggccctggccctcaatcgctacctgtgcacagccgtgttaccc
ttgttaacaaggtgtgctcctctttttgctggcaccgagcaccatgcttctctcattgac
tcattacttcacactgtgtacaggctttctaagggctgctcacttaccaaagctcaacgg
gattccatagaagtgtgtttactctctatttgtggccaattgagaccttctatgatgcaa
cacttactcagaagattagtatttgatgtcccattattaaatgaacatgcaaagatgcct
cttaagctgctgacaaatcattatgaaagatgctggaaatattactgcctgcctggaggg
tggggcaactttggagctgcctcagaagaagaacttcatttatcaagaaagctgttctgg
ggcatctttgatgccctgtctcaaaagaaatatgaacaagaacttttcaaactggcactg
ccttgcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtc
agtatgatggaaaaacagtcatcaatggattctgaagggaactttaatccacaacctgtt
gatacctcaaatattacaattcctgagaagttggaatacttcattaacaaatatgcagaa
catgcacatgacaagtggtcaatggataagttggcaaatggatggatttatggagaaata
tattcagactcatctaaagttcaaccattaatgaagccatataaactattatctgaaaag
gaaaaagaaatttatcgctggccaatcaaagaatctttaaaaactatgctggcttgggga
tggagaattgaaaggacccgagagggagacagcatggccctttataaccgtactcgtcgt
atttctcagacaagtcaggtttctgtagatgctgcccatgggtacagcccacgagccatt
gacatgagcaatgtcacactatccagagatctgcacgctatggcagaaatgatggctgaa
aactaccataatatatgggcaaagaaaaagaaactggaactagaggccaaaggaggtgga
aaccatcccctgctggtaccttatgatacactgacggccaaagagaaagccaaggatagg
gaaaaagcacaggacatcctcaagttcctgcagatcaatggctatgctgtgtccagaggg
ttcaaagacctggaactggatacaccttctattgagaaacgatttgcctatagtttcctt
cagcaactcattcgctatgtagacgaggcccatcagtatatcctggagtttgatggtggc
agcagaagcaaaggagaacatttcccttatgaacaagaaatcaagttctttgctaaagtt
gttcttcctttaattgatcagtatttcaaaaaccaccgtttatacttcttatctgcagca
agcagacctctctgttctggaggacatgcatcaaacaaagagaaagaaatggtgactagc
ctattctgcaaacttggagttcttgtcaggcataggatttcactatttgggaatgatgca
acatcaattgtcaactgtcttcatattttgggtcagactttggatgcaaggactgtgatg
aagactggcctggagagtgttaaaagtgcgctcagagccttcctggacaatgccgcagag
gatctggagaagacgatggagaatctcaagcagggccagttcacccacacccgaaaccaa
cccaaaggtgttactcagattatcaattataccacggtggcactgttgccaatgctgtca
tcattatttgagcatattggccagcatcaattcggagaagatctaatattggaagatgta
caggtgtcatgttatagaattctgactagcttgtatgctttgggaaccagcaagagtatt
tatgtggaaaggcaacgttctgcattgggagaatgtctggctgcttttgctggtgccttt
cctgtagcatttttggaaactcacctggacaagcacaatatttactccatctacaataca
aagtcttcgagagagagagcagctcttaatttgcctgctaacgtggaagatgtttgtcca
aatataccgtctttggagaagctcatggaagaaattgtggacttggctgagtccggtatt
cgctacacacagatgccacacgtgatggaagttatcctgcccatgctttgtagctacatg
tctcgttggtgggagcatggacctgagaataatccgggaagggctgagatgtgctgtact
gctctgaactcagagcacatgaacacactgctgggcaatatcctgaaaatcatatataat
aacttgggtattgatgagggagcctggatgaagaggttagcagtgttttcccagcctatt
ataaataaagtgaaacctcagcttttgaaaactcatttcttgccattaatggagaagctc
aagaaaaaggcagcgatggtggtatcagaagaggaccatctgaaatctgaggccagggga
gatatgtctgaagccgaacttctcatcctagatgagttcaccaccctggccagagatctc
tatgccttctatccactcctgattagatttgtggactataacagggcaaagtggctgaaa
gagcctaaccaagaagcagaagatcttttccgcatggttgctgaggtgtttatctactgg
tcaaaatcccataatttcaaaagggaggaacagaacttcgtggtgcagaatgaaatcaac
aatatgtctttccttattatggacaccaaatcaaagatgtcaaaggcagctgtttctgat
caggaaaggaagaaaatgaagcgcaaaggggaccgatattccatgcagacatctcttatt
gtggctgctctgaagcggttactgcccattgggttgaacatctgtgcccctggggaccag
gagctcattgctctggccaaaaatcgctttagtctgaaagacactgaggatgaagttcga
gatataatccgcagtaatattcacttacaaggcaagttggaagatcctgctcttagatgg
caaatggctctttacaaagacttacccaataggacagaagacacttcagatcctgagaag
acagtggaaagggtcttggatatagcaaatgtactttttcatcttgaacagaaatctaca
agtatgcgccggagatattacaatctgggaagtacagttgagcatcctcagagatcgaaa
aaggccgtgtggcacaaactgctctctaagcagaggaaacgtgccgtggttgcctgcttc
cggatggctcctttatataatctgccgaggcatcgggctgtcaatctctttcttcaggga
tatgaaaagtcttggattgaaaccgaagaacattactttgaagataaattgatagaagac
ttagcgaaacctggagcagaacctccagaagaagatgaaggaactaagagggttgatcct
cttcatcagctgatccttctgtttagtcgaacagctttaacggagaaatgcaaactggag
gaagattttttatatatggcttatgcagatattatggcaaagagttgtcatgatgaggaa
gatgatgatggggaagaggaagtgaagagttttgaagtcacaggatcccaacgcagcaag
gaaaaagaaatggaaaagcaaaagcttctataccaacaagccaggctgcacgaccgcggt
gctgctgagatggtgctgcagaccatcagtgccagcaaaggtgaaactggacccatggtg
gctgctactttgaaacttggaattgctatcttaaatggaggaaactctacagtacagcag
aaaatgcttgactacctcaaggagaaaaaggacgtgggcttctttcagagcctggctggc
ctgatgcagtcctgcagcgtcctcgacctaaatgcatttgagcggcaaaacaaagctgaa
ggacttgggatggtgactgaggaaggatcaggagaaaaggttctgcaggatgacgaattc
acctgtgacctcttccgcttcttgcaactgctttgtgagggacacaactcagattttcaa
aattatctgagaactcagactggcaataatacaactgtcaacataatcatctctactgta
gactaccttctgagagttcaggaatcaattagtgatttctattggtattactctgggaaa
gatgtcattgatgaacaaggacaaaggaatttctccaaagctattcaagtggcaaaacaa
gtctttaacactcttacagagtacattcagggtccttgcactggcaaccagcagagtttg
gctcacagcaggctctgggatgctgtggtgggttttcttcatgtatttgcccacatgcag
atgaagctgtctcaggactccagtcaaattgagctactaaaagaattgatggatcttcag
aaggacatggtggtcatgttgctgtccatgttggaaggcaatgttgttaatggcaccatt
ggcaaacagatggttgatatgctcgtggaatcttccaacaacgtggagatgattctcaag
ttttttgacatgttcttaaagctcaaggacttgacgtcttctgatactttcaaagagtat
gaccccgatggtaagggagttatttccaagagggactttcacaaagccatggagagccat
aaacactacacccagtccgagactgagttcctcctgtcctgtgcagagacagatgaaaat
gaaaccctggactatgaagaatttgtcaaacggttccatgagcctgccaaggacattggc
ttcaatgtggcagtgcttctgacaaacctctccgaacacatgcccaatgacacccggctg
cagacttttctggaattggccgagagcgtgctcaattacttccagcccttcctgggccgc
atcgagatcatgggcagtgcaaagcgcatcgagagggtgtattttgaaatcagtgagtcc
agccgaacccagtgggagaagccccaggtcaaggaatccaaaaggcaatttatatttgat
gtggtcaatgaagggggagaaaaagagaagatggagctcttcgtgaacttctgcgaggat
accatctttgagatgcagctggcggctcagatatcagagtcagatctgaatgagaggtca
gcgaataaagaggagagtgagaaggagaagccggaggagcagggtccgaggatgggtttc
ttttccatcatgacggtcaagtccgccctgtttgccctcaggtacaatatcttgaccctt
atgcggatgctcagcctgaaaagcttgaagaagcaggtgaagaaggtgaagaagatgaca
gtgaaggacatgatcacagccttctttacatcctactggagtattttgatgagcctcctg
cactttgtagccagcgttttcagaggcttctctcgcatcatcggcagcctcctgctggga
ggaagcctggtcgaaggtgcaaagaagatcaaagtggcggagctcttggccaacatgcca
gaccccacgcaagatgaggttcgaggagacggggaggagggagagaggaaaaccctggaa
ggggccctgccctctgaagatctgacggacttgaaggaactgacagaggagagtgacctg
ctttccgatatctttggcttggacctgaagcgagaaggggggcagtacaaactgattcct
cacaatcccaatgctggcctgagtgacctcatgagcaaccccgtccctatcccagaggtg
caagaaaagttccaggaacagaaggcaaacgaagaaaaggaagaaaaagaagaaagcaaa
tccgaacccgagaaagctgaaggagaagacggagaaaaagaagaaaaagccaaagaagac
aagggtaaacaaaaactgaggcagctccacacacacagatacggagagccagaagttcct
gagtcagcattctggaagaaaatcatagcctatcaacagaaacttctaaactattttgct
cgcaacttctacaatatgagaatgttagccttatttgtcgcatttgcgatcaatttcatc
ttgctcttttataaggtctccacttcttctgtggttgaaggaaaggaactacccactcgc
agttcaagtgaaaatgccagagttagcagcttggaccgcagctcgcctagaatcatcgca
gtgcactatgtgctggaggagagcagtggctacatggagcccacactgcggatattagcc
attctgcacacggtcatctctttcttctgcatcattggatactactgcttgaaagtccca
ctggttatttttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctttat
attacagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaac
acacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaa
tatggagagttctatggccgagacagaatcagcgagttacttggcatggacaaagctgcc
ttggacttcagtgatgcccgggaaaagaagaagccaaagaaagacagctccctgtcagct
gtactgaactctattgatgtgaagtatcagatgtggaaactaggagtcgttttcactgac
aactccttcctctaccttgcctggtatatgaccatgtccattcttggacactacaacaac
tttttttttgctgctcatcttctggacattgctatgggattcaagacgttaagaaccatc
ttgtcatcagtaactcacaatggcaaacagcttgtattaactgttggcttattggctgtc
gttgtatacctatatactgtcgtggcattcaattttttccgaaaattctacaataaaagt
gaagatggcgatacaccagacatgaagtgtgatgacatgctaacatgctatatgttccac
atgtatgttggagtacgtgccggagggggtatcggtgatgaaattgaagatccagcaggt
gatgagtatgagatatatcgaatcatctttgacatcaccttcttcttttttgtaattgtc
attctcttggccataatacaaggtttaatcatcgatgcttttggggaactaagagaccaa
caggaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaatgat
tactttgacaccgtgcctcatggcttcgaaacccacactttacaggaacacaacttggcc
aattatctgttttttctgatgtatctcataaacaaagatgaaacagagcacacaggacag
gaatcttatgtttggaagatgtatcaagaaaggtgctgggaatttttcccagctggagac
tgtttccggaaacagtatgaagaccagctaaattaa |