| Entry |
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| Symbol |
PLCG2
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| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
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| KO |
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| Organism |
csum Capricornis sumatraensis (Sumatran serow)
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| Pathway |
| csum01521 | EGFR tyrosine kinase inhibitor resistance |
| csum04070 | Phosphatidylinositol signaling system |
| csum04613 | Neutrophil extracellular trap formation |
| csum04625 | C-type lectin receptor signaling pathway |
| csum04650 | Natural killer cell mediated cytotoxicity |
| csum04670 | Leukocyte transendothelial migration |
| csum04750 | Inflammatory mediator regulation of TRP channels |
| csum04933 | AGE-RAGE signaling pathway in diabetic complications |
| csum04935 | Growth hormone synthesis, secretion and action |
| csum05167 | Kaposi sarcoma-associated herpesvirus infection |
| csum05170 | Human immunodeficiency virus 1 infection |
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| Module |
| csum_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
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| Brite |
Enzymes [BR:csum01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
138096157 (PLCG2)
Membrane trafficking [BR:csum04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
138096157 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
138096157 (PLCG2)
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| SSDB |
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| Other DBs |
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| LinkDB |
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| Position |
20:14103883..14255437
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| AA seq |
1310 aa
MRGMNSSWEAAAEHGELSSVLCAVLEGLLVHPLPPRLPPHWEQTTVSTMANVDTLPEYEK
SQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRP
GKNSKDFERAKAVRQKEECCLTILYGTQFVLSTLSLAADSKEDAAKWLSGLKILHQEVMS
ASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSAKFLKDKFLEIGAHKD
ELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFLLGNTDRPDASAVHLHDFQRFLLHEQQ
ELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDVVDMQDMN
NPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDGPDGKPIIYHGWT
RTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARVFKEVFGDLLLTKPKE
ASADQLPSPSQLRGKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELHMWDPIDQKWTRHY
CAIADAKLSFSDDIEQTVEEELPLDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCAETG
GKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTDNLMFTSIYALIQ
HYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRVPRDGAFLIRKRE
GTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMKLRYPV
TPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYRAKQSDELSFCRGAL
IHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISPAEGEEADKQIIEDNPLGSLCRGILNL
NIYNVVKAPHGKNQKPFVFVLEPKKQGDPPVEFATDSVEELFEWFQSIREITWKMDTKEN
NMKYWEKNQSIAIELSDLVVYCKPTSKTKDSLENPDFREIRSFVETKADSIVRQKPSDLL
KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTG
YVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKPGRSIACPFVEVEICGAEYD
NNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPSLAFLRFVVYEEDMFSDPNFLAHATYPI
KGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLF
LYDTHQNLRSANRDALVREFNVNENQLQLYQEKCNRRLREKRVSNSKFYS |
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| NT seq |
3933 nt +upstreamnt +downstreamnt
atgcgtggaatgaacagctcgtgggaagctgctgcggagcacggggagctgagctctgtg
ctctgtgctgtcctcgagggcctccttgttcacccccttcctcctcgcctccccccgcac
tgggagcagacgacggtgagcaccatggccaacgtggacaccctcccggagtacgagaag
agtcagatcaagcgggccctggagctgggcaccgtcatgaccgtgttcagcttccgcaag
tccaccccggagcggaggaccgtccaggtgatcatggagacgcggcaggtggcctggagc
aagacggccgacaagatcgagggcttcctggacatcatggagataaaggagatccggcct
gggaagaactccaaggatttcgagcgcgcgaaagcggtccgccagaaggaagagtgctgc
ctcaccatcctgtacggcacccagtttgtcctcagcacgctcagcctggcagccgactcg
aaggaagatgcagctaagtggctgtctggcttgaagatcttacaccaggaagtgatgagc
gcgtccacccccaccatcatcgagagctggctgagaaagcagatttattctgtggatcaa
accaggagaaacagcatcagcctccgggagttgaagaccatcttgcccctggtcaacttc
aaagtgagcagtgccaagttcctgaaagataagttcctggaaataggcgcacacaaagat
gaactcagctttgaacagttccatctcttctataaaaaacttatgtttgaacagcaaaaa
tcgatccttgacgaattcaaaaaggattcttccgtgttcctcttgggcaacaccgaccgg
ccggacgcctctgctgtccacttgcatgacttccagcggtttctcttgcatgaacagcag
gagctttgggcccaggatctgaacaaagtccgtgagcggatgacgaagtttattgacgac
accatgagggaaactgctgaacccttcttgtttgtggatgagttcctcacgtacctgttt
tcccgggagaacagcatctgggacgagaagtatgacgtggtggacatgcaggacatgaac
aaccccttgtctcattactggatctcctcgtctcacaacacgtacctcacgggggaccag
ctgcggagcgagtcgtccacggaggcctacatccgctgcctgcggatgggctgccgctgc
atcgagctggactgctgggatgggcccgacggcaagcccatcatctaccacggctggacg
cggaccaccaagatcaagttcgacgacgttgtgcaggccatcaaagaccacgcctttgtc
acctccagcttccccgtgatcctgtccatcgaggagcactgctgtgtggagcagcagcgc
cacatggccagggtgttcaaggaggtgtttggagacctgctgctgaccaaacccaaggag
gccagtgccgaccagctgccgtcgcccagccagctgcgtgggaagatcatcatcaagcat
aagaagctgggcccccgcggtgacgtggacgtcaacatggaggacaagaaggacgagcac
aagcagcagggcgaactgcacatgtgggaccccatcgaccagaaatggactcggcactac
tgtgccattgctgatgccaagctgtccttcagcgatgacattgaacagactgtggaagag
gagctgcccctggatataccccccacagagctgcattttggggagaaatggttccacaag
aaggtggagaagaggacaagtgctgagaagctgctgcaggaatactgcgctgagacaggg
ggcaaggatgggaccttcttggtgcgggagagtgagaccttccccaacgactacaccctg
tccttctggcggtcgggccgcgtgcagcactgccggatccgctccaccatggagggcggg
accatgaagtactacctgaccgacaacctcatgttcaccagcatctacgccctcattcag
cactaccgcgagacacacctgcgctgcgccgagttcgagctccggctgaccgaccccgtg
cccaaccccaacccgcacgagtccaagccgtggtactacgatgggctgagccgcggagaa
gcggaggacatgctgatgagggtcccccgggacggggccttcctgatccggaagcgggaa
ggtaccgactcctacgcgatcaccttcagggccaggggcaaagtgaagcactgtcgtatc
aaccgagacggccggcacttcgtgctgggcacctccgcctactttgagagcctcgtggag
ctggtcagctactacgagaagcacgcactctaccggaagatgaaactgcgttaccccgtg
acccccgaactcctggagcgctacaacatggaaagagatataaactccctctatgatgtc
agcaggatgtatgtggatcccagtgaaatcaatccttcaatgcctcagagaaccgtgaaa
gctctgtatgactacagagccaagcagagtgatgagctgagcttttgccgcggtgccctc
atccacaacgtctccaaggagcccgggggctggtggaaaggagactatgggaccagaatc
cagcagtacttcccgtccaattacgttgaggacatttcaccagcagaaggggaggaggcg
gataagcagattattgaagacaatcccttagggtccctttgcagaggaatcctgaatctc
aacatctataatgttgttaaagccccacatgggaagaaccagaagcctttcgtctttgtc
ttggagcccaagaagcagggcgaccctccggtagagtttgccacggacagcgtggaggag
ctgttcgagtggttccagagcatccgggagatcacctggaagatggacaccaaggagaac
aacatgaagtactgggagaagaaccagtccatcgccatcgagctctcagacctggtcgtc
tactgcaagccaaccagcaagaccaaggacagcctcgaaaaccctgacttccgagaaatc
cgctcctttgtggagacgaaggctgacagtatcgtcagacagaagcccagcgatctcctg
aaatacaatcaaaagggcctgacccgtgtgtaccccaaaggacagcgggtggactcgtcc
aactacgaccccttccgcctctggctgtgtggctcccagatggtggcactcaatttccag
actccagataagtacatgcagatgaaccacgcgctcttctccctcaacgggcggacaggc
tacgtcctgcagcctgagagcatgagggcagagaagtacgaccccatgccgcccgagtcc
cagaggaagatcctgatgaccctgacggtcaaggtactgggggcccgtcatctccccaaa
cccggacgaagcatcgcgtgtccctttgtggaggtggagatatgcggagcggagtatgac
aacaacaagttcaagacgacagttgtgaatgacaacggcctcagccctgtttgggcccca
acgcaggagaaggtgacttttgagatttatgaccccagccttgcgtttctgcgctttgtg
gtttatgaggaagatatgttcagcgatcccaactttctggcccatgccacgtaccccatt
aaaggcataaagtcaggatttagatctgtgcctctgaagaacggctacagtgaagacatt
gagctggcgtccctcctggttttctgtgagatgcggccagtcctggagagcgaagaggag
ctgtattcctcctgccgccagctgcggaggcggcaagaagaactgaacaaccagctcttt
ctgtacgacacccaccagaacctgcgcagcgccaaccgcgatgccctggtcagagaattc
aatgtcaacgagaaccagctgcagctgtaccaggagaagtgcaaccgcaggttaagagag
aagagagtcagcaacagcaagttttactcatag |
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