KEGG   Carlito syrichta (Philippine tarsier): 103251030
Entry
103251030         CDS       T07836                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
csyr  Carlito syrichta (Philippine tarsier)
Pathway
csyr01521  EGFR tyrosine kinase inhibitor resistance
csyr01522  Endocrine resistance
csyr01524  Platinum drug resistance
csyr04010  MAPK signaling pathway
csyr04012  ErbB signaling pathway
csyr04020  Calcium signaling pathway
csyr04066  HIF-1 signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04510  Focal adhesion
csyr04520  Adherens junction
csyr04530  Tight junction
csyr05200  Pathways in cancer
csyr05205  Proteoglycans in cancer
csyr05206  MicroRNAs in cancer
csyr05212  Pancreatic cancer
csyr05213  Endometrial cancer
csyr05215  Prostate cancer
csyr05219  Bladder cancer
csyr05223  Non-small cell lung cancer
csyr05224  Breast cancer
csyr05226  Gastric cancer
csyr05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:csyr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103251030 (ERBB2)
   04012 ErbB signaling pathway
    103251030 (ERBB2)
   04066 HIF-1 signaling pathway
    103251030 (ERBB2)
   04020 Calcium signaling pathway
    103251030 (ERBB2)
   04151 PI3K-Akt signaling pathway
    103251030 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103251030 (ERBB2)
   04520 Adherens junction
    103251030 (ERBB2)
   04530 Tight junction
    103251030 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103251030 (ERBB2)
   05206 MicroRNAs in cancer
    103251030 (ERBB2)
   05205 Proteoglycans in cancer
    103251030 (ERBB2)
   05230 Central carbon metabolism in cancer
    103251030 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    103251030 (ERBB2)
   05226 Gastric cancer
    103251030 (ERBB2)
   05219 Bladder cancer
    103251030 (ERBB2)
   05215 Prostate cancer
    103251030 (ERBB2)
   05213 Endometrial cancer
    103251030 (ERBB2)
   05224 Breast cancer
    103251030 (ERBB2)
   05223 Non-small cell lung cancer
    103251030 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103251030 (ERBB2)
   01524 Platinum drug resistance
    103251030 (ERBB2)
   01522 Endocrine resistance
    103251030 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:csyr01001]
    103251030 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:csyr04147]
    103251030 (ERBB2)
   04090 CD molecules [BR:csyr04090]
    103251030 (ERBB2)
Enzymes [BR:csyr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     103251030 (ERBB2)
Protein kinases [BR:csyr01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   103251030 (ERBB2)
Exosome [BR:csyr04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   103251030 (ERBB2)
CD molecules [BR:csyr04090]
 Proteins
  103251030 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Haspin_kinase Protocadherin Kinase-like CRIM1_C Stevor RIFIN
Other DBs
NCBI-GeneID: 103251030
NCBI-ProteinID: XP_021564028
Ensembl: ENSTSYG00000027118
UniProt: A0A3Q0DQC5
LinkDB
Position
Unknown
AA seq 1225 aa
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPASASLSFLQDIQEVQGYVLIAHNQ
VRRVPLQRLRIVRGTQLFKDNYALAVLDNGDLPNNATPATRASPGGLQELQLRSLTEILK
GGVLIQRNPQLCYQDMILWQDIFHKNNQLPLMQIDTNRSRACRPCSPACKASHCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA
LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHDQEVTAEDGTQR
CEKCSKPCARVCYGLGMEQLREARAVTSDNIQEFAGCKKIFGSLAFLPQSFDGNPASNTA
PLRPEQLRVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRVLHDGAYSLTLQGLNI
SWLGLRSLRELGSGLALIHRNARLCFVHTVPWNQLFRTSHQALLHTANRPENECVGQGLA
CYPLCAQGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ
NGSVTCFGSEADQCVACARYKDPPFCVSRCPSGVKPDLSYMPIWKFPDEEGTCQPCPINC
THSCVDLDDKGCPAEPRASSLTSIISAVVGIMLVVVLAIVFVILIKRRQQKIRKYTMRRL
LQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHV
REHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL
DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE
IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVAEFSRMARDPQRFVVIQ
NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGSTAHHRHRSS
STRSGGGDLTLGLETTEEEAPRSPLAPSEGTGSDVFDGDLGIGAAKGLQSLPPHDPSPLQ
RYSEDPTAPLPPETDGYIAPLTCSPQPEYVNQPDVWLQPASPREGTLPPAQPAGATLERP
KTLSPGKNGVVKDVFAFGGAVENPEYLAPQGGTAPQSHPPPAFSPAFDNLYYWDQDPSER
GSPPGTFEGTPTAENPEYLGLDIPV
NT seq 3678 nt   +upstreamnt  +downstreamnt
atgaagctacgcctccccgccagtcccgagacccacctggacatgcttcgccacctctac
cagggctgtcaggtggtgcagggtaacctggaactcacctacctgccggccagtgccagc
ctctccttcctgcaggatatccaggaggtgcagggctatgtgctcatcgcccacaaccaa
gtgaggcgggtcccgctgcagaggctgcggatcgtgcgaggtacccagctcttcaaggac
aactatgccctggccgtgctggacaatggagacctaccgaacaatgccacccctgccaca
agggcctccccaggagggctgcaggagctgcagcttcgaagcctcacagagatcctgaag
ggaggagtcttgatccagcggaacccccagctctgctaccaggacatgattctgtggcag
gacatcttccacaagaacaatcagctgcctctcatgcagatagacaccaaccgctcacgg
gcctgccgcccctgttctccagcttgtaaagcctcccactgctggggagaaagttccgag
gactgtcagagcttgacgcgtaccgtttgtgctggtggctgtgcccgctgcaagggcccg
ctgcccactgactgttgccatgagcagtgtgctgctggctgcacgggccccaagcactct
gactgcctggcctgcctccacttcaaccacagcggcatctgtgagctgcactgcccagcc
ctggtcacctacaacacggacaccttcgagtccatgcccaaccctgagggccggtataca
ttcggtgccagctgtgtgactgcctgtccctacaactacctatctacggacgtggggtcc
tgtaccctggtctgccccctgcacgaccaagaggtaactgctgaggacggtacacagcgg
tgtgagaagtgcagcaagccctgtgcccgagtgtgctatggtctgggcatggagcaattg
cgagaggccagggcggtcaccagcgacaatatccaggagtttgctggctgcaagaagatc
tttggaagcctggcatttctgccacagagctttgatgggaacccagcctccaacactgcc
ccgctacggccagaacagctccgagtatttgagactctggaggagataacagggtacctg
tacatctccgcatggccagacagccttcctgacctcagtgtattccagaaccttcaagtt
atccggggacgagttctgcatgatggtgcctactcgctgaccctgcaaggtctgaacatc
agctggctgggactgcgctcgctgcgggaactgggcagtggactggcccttatccaccgc
aacgcccgtctctgctttgtacacacggtgccctggaaccagctcttccggacctcgcac
caagccctgctccatactgccaatcggccagagaacgagtgtgtgggccagggcctggcc
tgctacccactgtgtgcccaagggcactgctggggtccggggcccacccagtgcgtcaac
tgcagccagttccttcggggccaggagtgcgtggaggaatgtcgagtactgcaggggctc
cccagggagtatgtgaatgccagacactgtctaccatgccaccctgagtgtcaaccccag
aatggctcagtgacctgttttggatcggaggctgaccagtgtgtggcctgtgcccgctac
aaggatcctcccttctgtgtgtctcgctgccccagcggtgtgaaacctgacctttcctac
atgcccatctggaagttccctgatgaggagggcacgtgccaaccatgccccatcaactgc
acccactcctgtgtggacctggacgacaagggctgccctgccgagccgagagccagctct
ctgacatccatcatctctgccgtggtgggcattatgctggttgtggtcctggcgatcgtc
ttcgtgatcctcatcaagcgacggcagcagaagatccggaagtatacgatgcggaggctg
ctgcaggagacggagctggtggagccactgacgcccagtggagcaatgcccaatcaggct
cagatgcggatccttaaagagacggagctgaggaaggtgaaggtgcttggatctggagct
ttcggcacagtctacaagggcatctggatccctgatggggagaatgtgaaaatcccagtg
gccatcaaagtgttgagggaaaacacatccccgaaagccaacaaagaaatcttggacgag
gcatacgtgatggctggtgtgggctccccgtacgtctcccgcctcctgggcatctgcctg
acatccacagtgcagctggtgacgcagctcatgccctatggctgcctcctagaccatgtc
cgggaacaccgcgggcgcctgggctcccaggacctgctgaactggtgtgtgcagattgcc
aaggggatgagctacctggaggacgtgcgacttgtgcacagggacctggctgctcggaat
gtgctggtcaagagtcccaaccacgtcaagattacagacttcgggctggctcggctgctg
gacattgacgagacagagtaccatgcagatgggggcaaggtacccatcaagtggatggcg
ttggagtccattctccgccggcggttcacccaccagagtgacgtgtggagttacggtgtg
actgtgtgggagctgatgacttttggggccaaaccttatgatgggatccctgcccgggaa
atccctgacctgttggagaagggggagcggcttccccagccccccatctgcaccatcgat
gtctacatgattatggtcaaatgttggatgattgactctgaatgtcggccgagattccgg
gagttggtggccgaattctcccgcatggccagggacccccagcgctttgtggtcatccag
aatgaggacttgggcccagccagccccttggacagtaccttctaccgctcactgctggag
gatgacgacatgggggacctggtggatgccgaggagtatctggtaccccagcagggcttc
ttctgcccagaccctgccccgggcgccgggagcacagctcaccacaggcaccgcagctca
tccactaggagtggtggtggtgacctgacgctggggctagagaccactgaagaggaggcc
cccaggtccccactggcaccctccgaagggactggctccgatgtgtttgatggtgacctg
ggaataggcgcagccaaggggctgcaaagcctccccccacatgaccccagccctctacag
cggtacagcgaagaccccacagcacccctgccccctgagactgatggctacattgccccg
ctgacctgcagcccccagcccgaatatgtgaaccaaccagatgtttggctgcagcccgcc
tcgccccgagagggcactctgcctcctgcccaacctgctggtgccactctggaaaggccc
aagactctctccccagggaagaatggggttgtcaaggacgtttttgcctttgggggtgcc
gtggagaaccccgagtacctggcaccccaaggagggactgcccctcagtcccaccctcct
ccagccttcagcccagcctttgacaacctctattactgggaccaggacccatcagagcgg
gggtctccacctggcacctttgaagggacccctacagcagagaaccctgagtatctgggc
ttggacataccagtgtga

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