KEGG   Carlito syrichta (Philippine tarsier): 103266233
Entry
103266233         CDS       T07836                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
csyr  Carlito syrichta (Philippine tarsier)
Pathway
csyr00562  Inositol phosphate metabolism
csyr01100  Metabolic pathways
csyr01521  EGFR tyrosine kinase inhibitor resistance
csyr01522  Endocrine resistance
csyr01524  Platinum drug resistance
csyr04012  ErbB signaling pathway
csyr04014  Ras signaling pathway
csyr04015  Rap1 signaling pathway
csyr04024  cAMP signaling pathway
csyr04062  Chemokine signaling pathway
csyr04066  HIF-1 signaling pathway
csyr04068  FoxO signaling pathway
csyr04070  Phosphatidylinositol signaling system
csyr04071  Sphingolipid signaling pathway
csyr04072  Phospholipase D signaling pathway
csyr04081  Hormone signaling
csyr04140  Autophagy - animal
csyr04150  mTOR signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04152  AMPK signaling pathway
csyr04210  Apoptosis
csyr04211  Longevity regulating pathway
csyr04213  Longevity regulating pathway - multiple species
csyr04218  Cellular senescence
csyr04360  Axon guidance
csyr04370  VEGF signaling pathway
csyr04380  Osteoclast differentiation
csyr04510  Focal adhesion
csyr04550  Signaling pathways regulating pluripotency of stem cells
csyr04611  Platelet activation
csyr04613  Neutrophil extracellular trap formation
csyr04620  Toll-like receptor signaling pathway
csyr04625  C-type lectin receptor signaling pathway
csyr04630  JAK-STAT signaling pathway
csyr04650  Natural killer cell mediated cytotoxicity
csyr04660  T cell receptor signaling pathway
csyr04662  B cell receptor signaling pathway
csyr04664  Fc epsilon RI signaling pathway
csyr04666  Fc gamma R-mediated phagocytosis
csyr04668  TNF signaling pathway
csyr04670  Leukocyte transendothelial migration
csyr04722  Neurotrophin signaling pathway
csyr04725  Cholinergic synapse
csyr04750  Inflammatory mediator regulation of TRP channels
csyr04810  Regulation of actin cytoskeleton
csyr04910  Insulin signaling pathway
csyr04914  Progesterone-mediated oocyte maturation
csyr04915  Estrogen signaling pathway
csyr04917  Prolactin signaling pathway
csyr04919  Thyroid hormone signaling pathway
csyr04923  Regulation of lipolysis in adipocytes
csyr04926  Relaxin signaling pathway
csyr04929  GnRH secretion
csyr04930  Type II diabetes mellitus
csyr04931  Insulin resistance
csyr04932  Non-alcoholic fatty liver disease
csyr04933  AGE-RAGE signaling pathway in diabetic complications
csyr04935  Growth hormone synthesis, secretion and action
csyr04960  Aldosterone-regulated sodium reabsorption
csyr04973  Carbohydrate digestion and absorption
csyr05010  Alzheimer disease
csyr05017  Spinocerebellar ataxia
csyr05020  Prion disease
csyr05100  Bacterial invasion of epithelial cells
csyr05132  Salmonella infection
csyr05135  Yersinia infection
csyr05142  Chagas disease
csyr05146  Amoebiasis
csyr05160  Hepatitis C
csyr05161  Hepatitis B
csyr05162  Measles
csyr05163  Human cytomegalovirus infection
csyr05164  Influenza A
csyr05165  Human papillomavirus infection
csyr05166  Human T-cell leukemia virus 1 infection
csyr05167  Kaposi sarcoma-associated herpesvirus infection
csyr05168  Herpes simplex virus 1 infection
csyr05169  Epstein-Barr virus infection
csyr05170  Human immunodeficiency virus 1 infection
csyr05171  Coronavirus disease - COVID-19
csyr05200  Pathways in cancer
csyr05203  Viral carcinogenesis
csyr05205  Proteoglycans in cancer
csyr05206  MicroRNAs in cancer
csyr05207  Chemical carcinogenesis - receptor activation
csyr05208  Chemical carcinogenesis - reactive oxygen species
csyr05210  Colorectal cancer
csyr05211  Renal cell carcinoma
csyr05212  Pancreatic cancer
csyr05213  Endometrial cancer
csyr05214  Glioma
csyr05215  Prostate cancer
csyr05218  Melanoma
csyr05220  Chronic myeloid leukemia
csyr05221  Acute myeloid leukemia
csyr05222  Small cell lung cancer
csyr05223  Non-small cell lung cancer
csyr05224  Breast cancer
csyr05225  Hepatocellular carcinoma
csyr05226  Gastric cancer
csyr05230  Central carbon metabolism in cancer
csyr05231  Choline metabolism in cancer
csyr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
csyr05415  Diabetic cardiomyopathy
csyr05417  Lipid and atherosclerosis
csyr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:csyr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103266233 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103266233 (PIK3CA)
   04014 Ras signaling pathway
    103266233 (PIK3CA)
   04015 Rap1 signaling pathway
    103266233 (PIK3CA)
   04370 VEGF signaling pathway
    103266233 (PIK3CA)
   04630 JAK-STAT signaling pathway
    103266233 (PIK3CA)
   04668 TNF signaling pathway
    103266233 (PIK3CA)
   04066 HIF-1 signaling pathway
    103266233 (PIK3CA)
   04068 FoxO signaling pathway
    103266233 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    103266233 (PIK3CA)
   04072 Phospholipase D signaling pathway
    103266233 (PIK3CA)
   04071 Sphingolipid signaling pathway
    103266233 (PIK3CA)
   04024 cAMP signaling pathway
    103266233 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    103266233 (PIK3CA)
   04152 AMPK signaling pathway
    103266233 (PIK3CA)
   04150 mTOR signaling pathway
    103266233 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103266233 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103266233 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    103266233 (PIK3CA)
   04218 Cellular senescence
    103266233 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103266233 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    103266233 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103266233 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103266233 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    103266233 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    103266233 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    103266233 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    103266233 (PIK3CA)
   04660 T cell receptor signaling pathway
    103266233 (PIK3CA)
   04662 B cell receptor signaling pathway
    103266233 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    103266233 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    103266233 (PIK3CA)
   04670 Leukocyte transendothelial migration
    103266233 (PIK3CA)
   04062 Chemokine signaling pathway
    103266233 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103266233 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    103266233 (PIK3CA)
   04929 GnRH secretion
    103266233 (PIK3CA)
   04915 Estrogen signaling pathway
    103266233 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    103266233 (PIK3CA)
   04917 Prolactin signaling pathway
    103266233 (PIK3CA)
   04926 Relaxin signaling pathway
    103266233 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    103266233 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    103266233 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103266233 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103266233 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    103266233 (PIK3CA)
   04722 Neurotrophin signaling pathway
    103266233 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103266233 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    103266233 (PIK3CA)
   04380 Osteoclast differentiation
    103266233 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    103266233 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    103266233 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103266233 (PIK3CA)
   05206 MicroRNAs in cancer
    103266233 (PIK3CA)
   05205 Proteoglycans in cancer
    103266233 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    103266233 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    103266233 (PIK3CA)
   05203 Viral carcinogenesis
    103266233 (PIK3CA)
   05230 Central carbon metabolism in cancer
    103266233 (PIK3CA)
   05231 Choline metabolism in cancer
    103266233 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103266233 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103266233 (PIK3CA)
   05212 Pancreatic cancer
    103266233 (PIK3CA)
   05225 Hepatocellular carcinoma
    103266233 (PIK3CA)
   05226 Gastric cancer
    103266233 (PIK3CA)
   05214 Glioma
    103266233 (PIK3CA)
   05221 Acute myeloid leukemia
    103266233 (PIK3CA)
   05220 Chronic myeloid leukemia
    103266233 (PIK3CA)
   05218 Melanoma
    103266233 (PIK3CA)
   05211 Renal cell carcinoma
    103266233 (PIK3CA)
   05215 Prostate cancer
    103266233 (PIK3CA)
   05213 Endometrial cancer
    103266233 (PIK3CA)
   05224 Breast cancer
    103266233 (PIK3CA)
   05222 Small cell lung cancer
    103266233 (PIK3CA)
   05223 Non-small cell lung cancer
    103266233 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103266233 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    103266233 (PIK3CA)
   05161 Hepatitis B
    103266233 (PIK3CA)
   05160 Hepatitis C
    103266233 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    103266233 (PIK3CA)
   05164 Influenza A
    103266233 (PIK3CA)
   05162 Measles
    103266233 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    103266233 (PIK3CA)
   05163 Human cytomegalovirus infection
    103266233 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103266233 (PIK3CA)
   05169 Epstein-Barr virus infection
    103266233 (PIK3CA)
   05165 Human papillomavirus infection
    103266233 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103266233 (PIK3CA)
   05135 Yersinia infection
    103266233 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    103266233 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103266233 (PIK3CA)
   05142 Chagas disease
    103266233 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103266233 (PIK3CA)
   05017 Spinocerebellar ataxia
    103266233 (PIK3CA)
   05020 Prion disease
    103266233 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103266233 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    103266233 (PIK3CA)
   05415 Diabetic cardiomyopathy
    103266233 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103266233 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    103266233 (PIK3CA)
   04931 Insulin resistance
    103266233 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103266233 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103266233 (PIK3CA)
   01524 Platinum drug resistance
    103266233 (PIK3CA)
   01522 Endocrine resistance
    103266233 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:csyr04131]
    103266233 (PIK3CA)
Enzymes [BR:csyr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     103266233 (PIK3CA)
Membrane trafficking [BR:csyr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103266233 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 103266233
NCBI-ProteinID: XP_008062044
Ensembl: ENSTSYG00000004236
UniProt: A0A1U7TPX5
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccgagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctgcatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggtatgccagtgtgtgagtttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaattaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaacaagaagtatgttgctatcctctgagcaactaaaa
ctctgtgttttagaatatcagggcaaatacattttaaaagtgtgtggatgtgatgaatac
tttctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatctgatgctgatggctaaggaaagcctctactctcagctgccaatggac
tgttttacaatgccgtcttattccagacgcatttccacagctacaccttatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaattaaaattctttgt
gccacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggcatc
tatcatggaggagaacccttgtgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgccgct
cggctttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacactgacactctagtatctgggaaa
atggctttgaatctctggccagtacctcatggattagaagatctgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggttaagtttccagacatgtcagtgattgaagagcatgccaattggtctgta
tcccgtgaagcaggatttagttattcccatgcaggactgagtaacagactagccagagac
aatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacgagaccctcta
tctgaaatcactgagcaagagaaagactttctatggagccatagacactattgtgtgact
atccccgagattctgcctaaattgctactgtccgttaaatggaattctagagatgaagta
gcccagatgtactgcttggttaaagactggcctccaatcaaacctgagcaggccatggag
cttctggactgtaattacccagatcctatggttcgaagttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcttaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaagtctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcctgtgggatgtatttgaag
cacctgaataggcaagttgaggcaatggaaaaactcattaacttaactgacattctgaag
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgagg
cggccagatttcatggatgctctgcaaggctttctgtctcctctcaaccctgctcatcaa
ctgggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggagatgatttacggcaagatatgctaacacttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctatca
atcggtgactgtgtgggactcattgaggtggtgagaaattctcacactattatgcaaatt
cagtgcaaaggcggcctgaaaggtgcactgcagttcaacagccacacactgcatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttcg
tgtgctggatattgtgtagctaccttcattttgggaattggagatcgacacaatagtaac
atcatggtgaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttgggtataaacgagaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcctatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacagtcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

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