Crotalus tigris (Tiger rattlesnake): 120318826 Help Entry 120318826         CDS       T08476                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism ctig  Crotalus tigris (Tiger rattlesnake) Pathway ctig04020   Calcium signaling pathway ctig04260   Cardiac muscle contraction ctig04261   Adrenergic signaling in cardiomyocytes ctig04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ctig00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120318826 (RYR2)    04020 Calcium signaling pathway     120318826 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     120318826 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     120318826 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ctig04040]     120318826 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ctig04990]     120318826 (RYR2) Ion channels [BR:ctig04040]  Voltage-gated cation channels   Ryanodine receptor    120318826 (RYR2) Domain-containing proteins not elsewhere classified [BR:ctig04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    120318826 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  120318826 NCBI-ProteinID:  XP_039222853 LinkDB All DBs Position Unknown AA seq 4982 aa AA seqDB search MAEAGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRTSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNSSLRVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVTWSGSHIRWGQPFRLRHI TTGKYLNLMDDKSLLLTDKEKADVKSTAFCFRSSKEKLDVGIRKEVDGMGTPEIKYGDSV CFIQHVDTGLWLTYQSVDAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKSSIVDLPIESVSLSLQDLIGYFHPPDDHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGETWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDYVEPFTTAEATHLRVGWASTEGYSPYPVGGEEWGGNGVGD DLYSYGFDGLHLWSGCVARSVNSPNHHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNTDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAILPKEKFKVEPSREY KQDCNCSRDLLGPNISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMSKIEL GWQYGPIRDDNKRQHPCLVEFAKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKLKLPKNYLLSSGYKPAPMDLSCIKLTPSQESMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLINYGYNLEAPDQDHAARPDVFDG MIERFRIFRTEKTYAVKTGKWYFEFEAVTAGDMRVGWTRPGCQPEQELGSDDQAFVFDGF KAQRWHQGNEHFGRTWLTADIVGCMVDLNEHTMIFTLNGEILLDDSGSELAFKDFEVGDG FIPSCSLGLSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPGNHEHIEVTRIDGTADSSPCLKVTQRSFGSQNSKTDIMFYRLSMPIECAEVFSKMPGG GMPNSNLFGPKSDLDDYEAESDFEVLMKTAHGHLVPDRAEKEAAKSEFNNHKDYTQEKPS RLKQRFMLKRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANVW VGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVRESIKRSNCYMVCAGESMSPGQGRNN NGLEIGCLVDAATGILSFTTNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKN VMPLSAGLFKSEHKNPLPQCPPRLHVQFLTHVLWSRVPNQFLKIDISRINERQGWSIQCL ESLQFMSLHIPEENRSVDILELSEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDE SQLLYAIENKYMPGLLRAGYYDLLIDIHLNSYATARLMMNNEFIVPMTDETKSITLFPDE HKKHGLPGIGLSTSLRPRIQFSSPSFVRINSECYQYSPEFPLEILKSKTIEMLTEAVQEG SLHVRDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHILQLIEPSVFKEDNGREDETR ILVKELVTESLNLEAGMDEIRREKVPEEGLLQMKLPEPVKLQMCHLLQYLCDFQIRHRIE AIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLNFKDDK NDCPCPEEIRDHLLDFHEDLMAHCGIQLDEDGILDGNNDLTIKGRLLYLVERVTHLKKKQ AEKLVDDNNKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGVGGLVRALP KTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMR ALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLE NSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQNCPLLISK GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGL LAAMEEAINISEDPTRDGPSSTNGSTRTPSEVEEEDDTVHMGNAIMTFYAALIDLLGRCA PEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGNVAEPDMSGGFCPD HKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTA VLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPS MMQHLLRRLVFDIPLLNEHAKMPLKLLTIHYERCWKYYCLPGGWGNFGAASEEELHLSRK LFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVGVMEKQASMDSDGNFNP QPVDTSNITIPEKLDYFINKYAEHSHDKWCMEKFANGWIYGETYSESSKVQPLMKQYKLL SEKEKEIYRWPIKESLKTMLAWGWRVERTREGDTMALYNRSRRISQTSQISVDTVHGYTP RAIDMSNVTLSRELHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEK AKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILE FDGGSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKE MVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRTFLD NAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLI LEDVQISCYRILASLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLNSHNIYS MYNTKTTRTGLPNSVKELCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYM SHWWEHGPENSHNKSEMCCTALTSDDMNTLLGNILKIIHNNLGIDEGAWMKRLAVFSQPI ISKVKPELLKTHFLPLMEKLKKKAAMVIADEEHLRAEGRGDMSEAELLILDEFNTLARDL YAFYPLLIRFVDYNRAKWLKEPNSEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEIN NMSFLITDTKSKMSKTAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNICAPGDQ ELIALAKNRLSMKDTEDEVRDIIRNNLHLQGKLEDPAIRWQVALYKDLPNRTDITSDPEK TVERVLDIANVLFHLEQNFSNRGWKCFRMVEHPQRSKKAVWHKLLSKQRKRAVVACFRMA PLYNLPRHRAVNLFLQGYEKSWVETEDHYFEDTLIEDLAKPGAEPTEEDECIKRVDPLHQ LILLFSRTALTEKCKLDEDYLYMAYADIMAKCFFQSCHDEEDNNDGEEEVKSFEVTGSQR SKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAVLNGGNSTV QQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGE KVMQDDEFTCDLFRFLQLLCEGHNSGFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISD FYWYYSGKEVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGF LHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESF NNVEMILKFFDMFLKLKDLTFSDAFKEYDPDGKGIISKRDFHKAMESHKHYSQSETEFLL SCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELADSVLN YFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKME LFVNFCEDTIFEMQLAAQISESDLNERSMNKEENENEKLEEQDPRIGFFSLVTITSALIA LRHNIMTLMKMLSMKSIKKQMKKMKKMTMKDMVTALFSSYWTILMGFMHFLSSVFRGFFQ IMYSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEVERKPAEAALPAEDLTDLK ALSEDSDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSSPSLLPLPDVQEKIQDQKTS EDGKDEREDTKFEHEKAEGEDGEKEEKIKEEKEKQKPRQHHKHRHGDLEMQESAFWKKII AYQQKVLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVTEEKEVQVVNTVEKMKLN SLESPSHRIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKE VARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGKDR ISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWY MTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVA FNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRII FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQ LN NT seq 14949 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcgggcgaaggagaagacgagatacagttcctgcgaactgatgatgaagtg gttctgcagtgtactgctactgttcacaaggaacaacagaaattgtgtcttgctgcagaa ggatttggcaacaggctctgcttcttggaatcaacttctaattccaagaatgttcctccg gatctctccatctgcacttttgttctagagcaatcattgtcagtcagagctctccaagaa atgctggctaacacagaggagaaagcagaagggctagttgatgtggaaaaatggaaattt atgatgaagactgctcagggtggtggtcatagaactctcctctatggacatgcaatatta ctgcgccattcttacagtggcatgtatctgtgttgtctctccacatcacgaacatcaatg gataaattggcttttgatgtaggcttgcaagaagataccacaggggaagcctgctggtgg actatacatcctgcttccaaacagcgttcagaaggagaaaaagtgcgtgttggggatgat ctcatccttgtcagtgtctcttcagaaagatatttgcatttatcttatggcaacagcagt ttgcgtgtggatgcagctttccagcaaacactttggagtgttgccccaatcagttccgga agtgaagtagctcaaggctatctaataggaggtgacgtactgaggttattacatggtcat atggatgaatgtctgacggttccttcaggagaacatggagaagagcagagaagaactgtc cattatgagggtggtgctgtgtcaattcatgctcgttctctttggagactggagactttg agggttacatggagtggaagtcacattagatgggggcagccattcagattaagacatata acaacagggaaatatttaaatctcatggatgacaagagtcttcttctaacagacaaagaa aaagctgatgtgaaatctacagcattttgttttcgatcttccaaggagaaattagatgta gggataagaaaagaagtggatggcatgggaaccccagaaataaagtatggagattcagtc tgctttatacagcatgtagacacaggtttgtggcttacctaccaatcagtggatgcaaag tctgtaagaatgggatctgtgcagcgcaaggctatcatgcaccatgaaggccatatggat gatggattgacattatccagatctcagcacgaagaatcacgtacagcacgagtaattcgc agtactgtcttccttttcaacaggttcataaggggccttgatgctctcagcaagaaagct aagtcttccatagttgatttacccattgaatcagtcagccttagccttcaggacttgatt ggttacttccacccaccagatgaccacttagagcatgaagacaaacagaaccgcctaaga gctctgaagaatcgacaaaatctcttccaagaagagggtatgatcaatttagtgcttgaa tgtattgatcgcttacatgtatacagcagtgcagctcattttgctgatgtcgctggaaag gaagcaggagaaacttggaaatctattctaaattcattgtatgaattattagcggctttg attagagggaatcgtaaaaattgtgctcagttctccggatctcttgattggctcattagt agattggagagattggaagcatcttctggaattcttgaagtattacactgtgtgttggtg gaaagtccagaagcactgaatattattaaagaaggacatattaaatcaatcatttgtctt ttggacaaacatgggagaaaccataaggtattagatgttctgtgctcattgtgtgtatgt cacggagtagctgtgcgatccaatcaacatttgatctgtgacaatcttctgccagggaga gacctccttcttcaaactcgccttgttaaccatgtgagcagcatgcgaccaaatattttc cttggaatcagcgagggctctgctcagtacaggaaatggtattatgaattaatggttgat tatgtggagccatttacaacagcagaagctactcaccttcgtgtaggttgggcatcaaca gaaggttattcaccatatcctgtgggtggagaagaatggggtggcaatggtgttggtgat gacttatattcctatggttttgatggacttcatctatggtcaggttgtgtagcaagatct gtcaattctcctaatcatcatctactcaggacggatgatgtcatcagctgctgccttgac ctgagtgctccaagcatttcattccgaataaatggacagccagtccagggaatgtttgag aatttcaacacagatggtcttttctttccagttgtcagcttttcagcggggataaaagta cgatttttgctcggaggccgccatggggaatttaaattccttccccctccaggatatgct ccatgttttgaagctattctgcccaaagaaaagtttaaagtagaacccagcagggaatat aaacaagattgcaattgctcaagggatctcttgggaccaaatatctctttgtcacaagca gcattcactcctgtacctgtagataccagtcagattgtattacctccacatctggaaaga attagagaaaaactagctgagaatatccatgaactttgggtgatgtctaaaattgaactt ggatggcagtatggaccaattagagatgacaacaagcgacagcatccctgtttggtagag tttgctaaactgcctgaacaagaacggaattacaatcttcagatgtcactagaaacatta aaaacattgctggcattaggttgtcatgttggaattgctgatgagcatgctgaagaaaag gtgaagaaactaaaacttcccaaaaattatctattatcaagtggatataaacctgctcct atggacctaagttgcatcaagttgactccatcccaggaatccatggttgataaacttgca gagaatgctcacaatgtatgggcaagagatcgaataaggcagggatggacatatggaatt caacaggatgtgaagaaccgtcgaaatccccgccttgtcccttatacacttctagatgat cgcactaagaaatcaaacaaagatagcctccgggaagcagttcgtactctcatcaactat ggctataaccttgaagctccagatcaagaccatgctgcaagacctgatgtgtttgatggc atgattgaaaggttcaggatattccgaacagaaaaaacatatgctgtaaaaaccgggaag tggtactttgaatttgaggcagtaactgctggagatatgagagttggctggaccagacca ggttgtcagccagagcaagagcttggctcagatgatcaagcatttgtatttgatggtttc aaggcccagcgatggcaccagggaaatgagcattttgggcgtacttggctaacagcagat attgtgggatgcatggtggatctgaatgagcataccatgatatttacgctaaatggtgaa atccttcttgatgactcaggttctgaacttgcatttaaagattttgaggttggtgatggc tttataccttcctgtagcctgggattgtcacaggtgggcagaatgaactttggcaaagat gttagcactttgaaatatttcactatttgtggcttacaagaaggctatgaaccttttgct gtgaatacaaatcgtgacattactatatggctgagcaagagattacctcagtttcttcca gtaccaggaaatcatgaacatatagaggttaccaggattgatggaacggcagatagttct ccatgcttgaaagtcacacagaggtcctttggatctcaaaacagcaaaacagatatcatg ttttatcgtctaagcatgcccattgaatgtgcagaagtcttttctaaaatgcctggagga ggaatgccaaattctaatctttttggcccaaagagtgatttggatgattatgaagcagaa tctgattttgaagttctcatgaagactgctcatggtcatcttgtacctgaccgtgcagaa aaagaagctgcaaaatcagagttcaataaccataaagactatacacaagagaaaccttca cgcctcaagcaaagatttatgctgaaaaggacaaagccagactacagcacaagtcattct gcaagactaactgaagatgtcctagcagatgaaagagatgattatgattatctaatgcaa acttctacatattattactctgtacgtatatttcctggacaagaacctgctaatgtttgg gtaggctggattacatctgatttccatcaatatgacacaagctttgatttggacagagtc cgtactgttacagtaaccttaggagatgaaaaagggaaagttcgtgagagtatcaaacga agcaattgctatatggtgtgtgccggagaaagcatgagtccagggcaaggacgcaataat aatggattagagattggttgcttggttgatgctgcaactggtatcctatccttcactacc aatggcaaagagttaagcacttattatcaggtagagccaagtactaaattatttcctgca gtatttgcacaggccacaagccctaacgttttccaatttgagttgggacgaataaagaat gtaatgccattgtcagctggattgttcaaaagtgagcacaaaaatccacttcctcaatgc ccaccccgtctccatgttcagtttctgacacatgttctttggagcagagtgccaaatcag tttctgaagattgatatatcacggatcaatgaacgtcagggctggtcaatacagtgcctg gagtctttgcagttcatgtcccttcacattccagaggaaaacaggtctgtagatatttta gaactgtcagaacaagaagaactgctaaagtttcattatcatactctcagactatactca gcagtgtgtgctcttgggaataaccgagttgcacatgctatgtgcagccatgttgatgaa tctcagcttctctatgcaattgagaacaaatacatgccaggcttgttacgtgcgggctat tatgatcttctcattgatattcatcttaatagctatgccactgcaaggttgatgatgaac aatgaattcattgtcccaatgacagatgagactaaaagtattactttgtttcctgatgaa cacaaaaagcatggcctaccaggtatcgggcttagtacatctttacgacccagaatacag ttttcttctcccagttttgtaagaattaacagtgagtgctaccaatatagtcctgaattt cctctagaaattttaaagtctaaaaccatagagatgttgacagaagcagttcaggagggt agccttcatgtcagagatccagtaggtggtactacagaatttctgtttgttcctttgatc aagcttttttatacccttcttataatgggtgtcttccacaatgaagatctgaagcatatc ttgcagctcattgagcccagtgtgtttaaagaagataacggccgtgaagatgaaacccga atattagtgaaggaactggttacagaaagtctaaatttagaggcaggtatggatgaaatc agaagagagaaggttccagaagaaggacttcttcaaatgaaacttcctgagcccgtaaaa ttacagatgtgccatttactccaatatctgtgtgacttccagatacgccatagaatagaa gccattgtagcattttcagatgattttgtagcaaaacttcaagaaaatcagcgtttccga tataatgaagttatgcaggctttaaatatgtctgcagctctgacagccaagaaaacaaaa gaatttcgatccccaccacaggagcagatcaacatgctgctgaattttaaggacgataaa aatgattgtccttgtcctgaagaaataagagatcatctcctggattttcatgaagatctg atggcacattgcggaattcagctagatgaagatggaattctagatggaaacaatgattta actattaaaggtcggctgctatatcttgtagaaagagtcacacacttgaaaaagaaacaa gcagagaagctagttgatgataataacaagaaaccatcaactctccaacagctgatatca gaaactatggtacgttgggcacaagaatctgtaatagaagacccagagttggtgagggcc atgtttgttttgctacaccgccaatatgatggggttggtggcctggttcgagccttgccc aagacatacactataaatggtgtatcagttgaagataccatcaacttgcttgcatctctt ggccagatccgttctctcctcagtgttaggatgggcaaggaagaagagaagcttatgatt cgtggattaggggacattatgaacaataaagttttttatcagcatcctaatcttatgagg gcactagggatgcatgagactgtaatggaagtaatggtgaatgtacttggaggaggagaa tcaaaggaaatcacctttcctaagatggtggcaaattgctgtcgttttctatgttatttt tgccgcatcagcagacagaatcagaaagccatgtttgatcatcttagctatcttttggaa aacagcagtgttggacttgcttctccttctatgcgtggatcaacacctttagatgttgca gcagcttcagtaatggataataatgaacttgcattggctttacgagaacctgacttagag aaggtagtccgctacttggctggctgtggtttgcagaactgtcctttactaatttctaaa ggctatccagatattggatggaacccagttgaaggagaacgatacctggatttccttcgt tttgctgttttttgcaatggagagagtgttgaagaaaatgctaatgtggtggttagactg ctcattcgacgtcctgaatgttttggaccagcactgagaggtgaaggtggaaatggtttg cttgctgccatggaagaagccataaatatatcagaagatcccacaagagatggtccttca tcaactaatggatccactagaacaccaagtgaagtagaagaagaggacgatactgttcac atgggaaatgccatcatgactttttatgctgccctgattgatctcttgggacgctgtgct ccagaaatgcatctcatccatgctggcaaaggggaagccattagaatcagatctattcta aggtctttgattcctttggaggacttagtgggtgtaattagcattccttttcatatgcca acaatagcaaaagatggcaatgttgcggaacctgatatgtcaggggggttttgccctgat cacaaggcagcgatggtattgtttctcgatagggtctacggaattgaagaccaagatttt cttcttcaccttctagaagttggctttctgccagatcttcgtgcagctgcttcattagat acggttgccctgagtgccacagatatggccctggctcttaatcgatacctctgcactgct gttttgcctttattaacaagatgtgctcctctttttgctggaacagaacatcatgcttcc cttatagattccttgctacatactgtatatcggctttccaaaggctgttctcttaccaaa gctcagcgggattctattgaagagtgcctactctccatttgtggtcagctaagaccttca atgatgcaacatttgttgagaagattagtatttgatatccctcttctaaatgaacatgcc aaaatgcctcttaagttgctgacaattcattatgaaagatgctggaaatattactgttta ccaggagggtggggcaactttggtgctgcatcagaagaggaacttcatttgtccagaaag ttattctggggtatttttgatgctttatctcaaaagaaatatgaacaagaactattcaaa ttagcactgccatgcctgagtgctgtagctggggctttacctcctgattacatggaatca aattatgttggtgttatggaaaaacaggcttccatggattcagatgggaacttcaatcca cagcctgttgatacttcgaacattacaattcctgaaaaactagactactttataaacaaa tatgctgaacattctcacgataaatggtgcatggaaaagtttgcaaatgggtggatatat ggtgaaacatattcagaatcttccaaagtgcagccattaatgaaacaatataaactatta tcagaaaaggaaaaagaaatttatagatggccaattaaagagtctctgaaaaccatgctt gcttggggatggcgggttgaaagaacgagggaaggagatactatggctctttataatcgt tcacgtcggatatcacagacaagtcagatttctgtagatactgtccatggctataccccc cgtgcaattgacatgagtaatgttacactgtccagagagttacatgcaatggctgagatg atggctgaaaattatcataacatatgggcgaaaaaaaagaaaatggagcttgaagccaaa gtgggaggaggaaatcacccactacttgtaccctatgatacactgacagccaaagaaaaa gctaaggatagagagaaagcccaagatattctgaagttcctccagatcaatggctatgtt gtgtccagaggcttaaaggatttagaattagacacaccatccattgaaaaaagatttgct tacagttttctccagcaattgatacgctacgtagatgaagcccatcagtatattctggaa ttcgatggtggcagcagagggaaaggagaacagtttccttatgaacaagaaatcaaattc tttgctaaagttgtacttcctttaattgatcagtatttcaaaaatcaccgcctgtatttc ctatctgcagcaagcaggcctctgagcagtgggggtcatgcttctaacaaggaaaaagaa atggtaaccagccttttctgcaaacttggagttcttgtcaggcataggatttcactgttt ggaaatgatgcaacttccattgtcaattgtcttcatatcttgggtcagaccttggatgca cggacagtgatgaaaacaggtttggaatctgttaagatggctttgaggacatttttggat aatgctgcagaggacctggaaaaaacaatggaaaatcttaagcaggggcaattcacacat accaggagtcagccaaaaggagtaacacaaattattaattacacaacagtggctctcttg ccagtattgtcttcactatttgagcacattggacagcatcagtttggtgaagatttgata ttggaagatgttcaaatctcttgttatagaatactagccagcttatatgctttgggaacc agcaagagcatctatgtggaacgtcaacgatcagctttaggtgaatgtttagctgctttt gctggtgcttttcctgtggcatttttagaaactcatttgaatagtcacaatatttattct atgtacaataccaagacaacaagaacaggtttgccaaacagcgtaaaggaactttgtcca aatattccatctctggaaaaattaatggaagaaattgtggaattagctgaatcaggcatt cgctatacacaaatgcctcatgtaatggaagttatattgcccatgctttgtagttatatg tcacattggtgggaacatggaccagaaaacagtcataacaagagtgaaatgtgctgcaca gcattgacttcagatgatatgaatactcttctgggaaacattctaaaaatcatacataac aatttgggcatagatgaaggagcctggatgaagagattggcagtgttttcgcagcctatc ataagtaaagtgaagccggagcttctgaaaacacattttcttccattgatggagaaactg aagaaaaaagcagctatggtgatcgctgatgaagaacacttacgagcagaaggcaggggt gatatgtctgaggcagaactgctcatcctagatgaattcaatacacttgcccgggacctt tatgccttctatccattgttaatcagatttgtggactacaacagagcaaagtggctcaaa gagcccaactctgaagctgaagatttgtttcgcatggttgcagaagttttcatttactgg tcgaaatcccataattttaaaagggaagaacagaactttgtggtgcaaaatgaaatcaac aatatgtcttttcttattaccgacactaaatcgaagatgtccaagacagctgtttctgat caagaaagaaaaaaaatgaaacggaagggggatcgttactcaactcagacttctctgatt gtggctgcattaaaaagattgcttcctattgggctaaatatttgtgcacctggtgaccaa gaattaattgctctggcaaaaaatcgattgagcatgaaggacaccgaggatgaagttcga gatattattcgcaacaaccttcatttacagggcaagcttgaagatcctgcaattagatgg caggtggccctttacaaagatctaccgaacagaactgatatcacttcagatccagaaaag actgtagagcgggttctggatatagctaatgtacttttccatctggaacagaacttctct aatcgtggatggaaatgtttcagaatggttgagcatcctcaaaggtcaaaaaaggcagta tggcataaactcttgtccaaacagagaaaaagagctgtggtggcttgcttcagaatggcg ccactatataatcttccacggcaccgagctgtcaatctttttcttcagggatatgaaaag tcctgggtggaaacagaagaccattattttgaagatacgttgatagaagacttagcaaaa cctggagcagaaccaacagaagaagatgaatgtattaagcgagttgatcctttgcatcaa cttattttactattcagtcgaacagctttaactgaaaaatgtaaattggacgaagattac ttgtatatggcatatgctgatattatggcaaagtgtttttttcagagttgccatgatgaa gaagataacaatgatggtgaagaggaagtgaagagctttgaagtcacaggatcccaacgc agcaaggaaaaagaaatggaaaagcaaaagctcctgtaccagcaagcaagactccatgat cggggggctgcagaaatggtcctgcagacaattagtgccagcaaaggtgaaatgggacca atggttgcagccaccctcaaacttggaattgctgtcttgaatggaggaaattcaactgtt cagcagaaaatgcttgactatctcaaggacaaaaaagacgtaggcttctttcagagtctt gctggtcttatgcaatcttgcagtgttcttgacctaaatgcttttgaacgtcagaataaa gcagaaggccttggaatggtaacagaagaaggatcagtcatcactcatgagcgtggagaa aaggtgatgcaggatgacgaatttacctgtgacctcttccggttccttcagttgctttgt gaaggtcataattcaggttttcaaaattacttgagaactcagactggtaataatacaact gtcaacattatcatatccactgtggattatttattgagagttcaggaatcaattagtgat ttttattggtattattctggaaaggaagttattgatgaacaaggacaacgtaatttctct aaagctattcaagttgcaaaacaggtcttcaatactctgacagaatatattcagggccca tgtacaggtaatcaacagagtctagcacacagcaggctttgggatgctgtggttggtttt cttcatgtctttgcccacatgcagatgaagctctctcaggattctagtcaaattgaatta ctgaaagaattaatggatcttcagaaagatatggtggtcatgctgctatctatgttggaa ggtaatgttgtaaatggaacaatcggcaagcaaatggttgacatgctggtggaatcgttc aacaatgtagaaatgattctaaagttttttgatatgtttctaaaactgaaggatttaact ttctctgatgcattcaaagaatatgatccagatggaaagggcattatttccaaaagagat ttccataaagcgatggagagccacaaacattatagtcaatcggaaactgagtttctgctc tcctgtgctgaaacagatgagaatgaaactttggactacgaggaatttgtgaaacggttt catgagccagctaaagacattggcttcaacgttgctgttttgctgacaaacttgtcagag cacatgccccatgatacaagactgcaaactttccttgaattggcagacagtgttttaaac tacttccagccctttctaggtcgcatagaaataatgggcagtgcaaagcgcattgaacga gtttactttgaaatcagtgaatcaagtcggacgcaatgggagaaacctcaggttaaagag tcaaagaggcagtttatttttgatgttgtaaacgagggaggggaaaaggaaaaaatggaa ctttttgttaacttttgtgaagacaccatctttgaaatgcaattggctgctcagatctca gaatcagatctgaacgagcggtctatgaataaagaagaaaatgaaaacgagaagctggaa gagcaagaccctcgaataggattcttctctctagtgaccatcacgtcagcattaatagcc ctcaggcataacataatgactctcatgaaaatgttaagcatgaaaagtataaagaagcaa atgaagaagatgaaaaaaatgaccatgaaggacatggtcacggctttgttttcttcctac tggaccattttaatgggtttcatgcattttttatccagtgtcttcagaggcttctttcaa atcatgtacagcttgctgcttggagggagcctggttgaaggagccaagaaaattaaagta gctgaacttctagctaatatgccagaccccactcaggatgaagtccgtggtgatggagaa gaagtagaaaggaagccagccgaagctgctttgcctgcagaagacctgactgatctcaaa gctctgtcagaagatagtgacctcctctcagatatttttggcttagatttaaaacgggag ggaggacaatataaactaattccacataatccaaatgcaggcttgagcgatttgttaagc agtccttctttgctccctttacctgatgtgcaagaaaaaatacaggaccagaagacaagt gaagatggaaaagatgaaagagaagatactaaatttgaacatgaaaaagcagagggtgaa gatggagaaaaagaagaaaaaataaaagaagagaaggaaaagcagaaaccaaggcagcat cacaaacataggcatggtgatctagaaatgcaagaatccgccttctggaaaaaaattatt gcatatcaacagaaagttcttaattattttgctcggaatttttacaatatgaggatgctg gctttatttgttgcatttgccattaatttcattcttttgttctacaaggtgtctacatct tcagtgacagaagaaaaggaagtacaagtagttaatactgttgagaaaatgaagctaaac agcctagaaagcccttctcatagaatcatcacagtacactatgtccttgaagaaagcagt ggctacatggaacctacacttcgcattttagcgattttacacactgtcatttcctttttt tgcatcattgggtattactgtctgaaagttccattggtaatatttaagcgagaaaaagaa gttgcgagaaaattggaatttgacgggctatatattacagaacaaccttcagaagatgat attaagggacagtgggacagacttgtcatcaatacacagtcttttcctaataactattgg gacaagtttgtgaaaagaaaggttatggataaatatggagagttctatggcaaagacagg atcagtgaattgctgggaatggacaaggctgctctagatttcagtgatgctcgagaaaaa aagaaacccaaaaaggatagttctttatcagctgtgctgaattctattgatgtaaagtat caaatgtggaaactaggtgttgttttcactgataattcttttctgtacctggcctggtat atgaccatgtcaatccttggtcattacaacaactttttctttgctgcacacctccttgac atagcaatgggatttaaaacattacgaacgattctatcgtcagtgacccacaatggaaaa cagcttgtactaactgtgggattactagcagtggtagtttacctatacacagtagttgct ttcaatttcttccgaaaattctacaataagagtgaagatggagatatgccagatatgaaa tgtgatgacatgctaacgtgctatatgtttcacatgtatgtgggagtacgtgctggtggt ggaattggtgatgaaattgaagatcctgcaggcgatgaatatgaaatatatcgaatcatc tttgatattacatttttcttttttgtaattgttattctactagctatcatacaaggcttg attattgatgcatttggagaattaagagatcagcaagaacaagttaaagaagacatggag actaaatgttttatctgtggaataggtaatgattattttgatacagtgccacatggcttt gaaacacacactctacaggagcacaacttggctaattatttattttttctgatgtatctc attaataaagatgaaactgaacacactggtcaagagtcctatgtgtggaaaatgtatcaa gaacgatgctgggaattttttcctgccggtgactgttttcgaaagcagtatgaagatcag cttaattaa

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