Cuculus canorus (common cuckoo): 104062467 Help Entry 104062467         CDS       T08597                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism cuca  Cuculus canorus (common cuckoo) Pathway cuca04020   Calcium signaling pathway cuca04260   Cardiac muscle contraction cuca04261   Adrenergic signaling in cardiomyocytes cuca04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cuca00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     104062467 (RYR2)    04020 Calcium signaling pathway     104062467 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     104062467 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     104062467 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cuca04040]     104062467 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:cuca04990]     104062467 (RYR2) Ion channels [BR:cuca04040]  Voltage-gated cation channels   Ryanodine receptor    104062467 (RYR2) Domain-containing proteins not elsewhere classified [BR:cuca04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    104062467 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  104062467 NCBI-ProteinID:  XP_053918845 LinkDB All DBs Position 3:63556313..63945024 Genome browser AA seq 4967 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVLKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLSLLDDKTLLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSI CFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIR STVFLFNRFIRGLDALSKKVKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGD DLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREY KQDRNYTRDLLGPTISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKTYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAMRLDVCSG IMEKFRIFRTEKTYAVKTGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGF KAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGAG FLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVLFFRLSMPIECAEVFSRTSAG GLPGSSLFGPKNDLDDYDADSDFEVLMKTAHGHLAPDRTEREKDATKPELNNHKDYVQEK PSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNIFQFELGRV KNVMPLSAGLFKSEHKNPISQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQ CLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHV DESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQ EGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFNNGDLKHILQLIEPRVFKEAMSQEDE TDFLEKEMNLDELKSEEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHR IEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD DKNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNNDLTIRGRLLYLMEKVTYLKK KQAEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRA LPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYL LENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLI SKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGN GLLAAMEEAIQISEDPTRDGASPSNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGR CAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFC PDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLC TAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLR PSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLS RKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNF NPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYK LLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGY TPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELEAKGGGNHPLLVPYDTLTAKE KARDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL EFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEK EMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFL DNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDL ILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIY SIYNTKNARERAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPM LCSYMSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAV FSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTT LARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVV QNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNIC APGDHELIALAKNRFSVRDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDS SDPEKTVERVLDIANVLFHLEQRSACVGRGYFFWVEHPQRSKKAVWHKLLSKQRKRAVVA CFRMAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRV DPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEK QKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYL KDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFR FLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQ GQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQD SSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFL KLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYE EFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGS AKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQ LAAQISESDLNERSANKEENEKDKPEEQDPRMGFFSLVTMKSALLALKYNLMTLMKMLSM KSLKKQMKKVKKMTMKDMVMALFSSYWSILMGLLHFACSVVRGFFRIICSLLLGGSLVEG AKKIKVAELLANMPDPTQDEVRGEGEEGERKPTEAALPTEDLTDLRTLSDESDLLSDIFG LDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEVQEKIQEQVKEDEKEEKEETKSEPE KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFY NMRMLALFVAFAINFILLFYKVSTSAVTEEKEVPVVSADESTKLDVLESGDERVIAVHYV LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD MPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14904 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggagaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaactgttcttaaagagcaacagaaactgtgtcttgcggcagaa ggatttggcaacaggctttgctttttggaatccacatcgaactctaagaatgttccgcct gatttgtccatctgcacctttgtgctggagcagtctctatcagtacgagccctccaggaa atgctggctaacacagaagaaaaggcagaagggctagttgatgtggaaaaatggaaattt atgatgaagtctgcacaaggtggtggtcatcgaacactactctacgggcatgcaatccta ctgcgccattcctacagtggcatgtatctgtgctgcctctctacatctcgatcttcaatg gacaagctggcgtttgatgtaggattgcaagaggacacaacaggtgaggcatgctggtgg accatccatcctgcttccaagcaacggtcagaaggagaaaaagtacgtgttggagatgat cttattttagtcagtgtctcttcagaaagatatttgcatctctcttatggaaatggtagc ttgcatgttgatgcagctttccagcagacactttggagtgtagcaccgatcagttcagga agtgaagttgcccaaggatatctgattggaggggatgttctgaggttgttgcatggtcac atggatgaatgtttgacagtcccttcaggtgaacatggagaagaacaaagaagaactgtc cattatgaaggtggtgctgtgtcaattcatgctcgttccctttggcgactagagacgcta agagttgcgtggagtggcagccacattagatggggacagccattcagactaagacatata acaacgggaaaatatttaagtctcctggatgacaagactcttcttcttacagacaaagag aaggcagatgtgaaatctacggcattctgttttcggtcttccaaggaaaagttggacata ggaacaagaaaagaagtggatggaatgggagcacctgaaataaaatacggggattcaata tgcttcatacaacatgtagatacaggcttatggctcacctaccagtctgctgatgcaaag tctgtaagaatgggttctgtgcagcggaaggcaataatgcaccatgagggtcacatggat gatggtttaacattgtccagatctcagaatgaagaatctcgtacagcacgtgtaatccgt agtacagtcttccttttcaacagatttataaggggccttgatgctctcagcaagaaagta aagtcttccactgtcgatttgcctattgagtcagtcagtctgagccttcaggacttgatt ggctactttcacccccctgatgaacatttggagcatgaagacaaacaaaataggctccga gcactgaagaatcgccagaatctcttccaggaagagggtatgatcaaccttgttctcgaa tgtattgatcgcttgaatgtatacagcagtgcagctcattttgcagatgtagctgggaag gaagctggagaagcatggaaatctatactgaattctttgtatgaattactagcggctctg attcgagggaatcgtaaaaactgtgctcaattttctggatctcttgactggttgatcagt agattagaaagactggaggcctcttctggaattctagaggttttacactgtgtgctggtg gaaagcccagaagctttaaacattattaaggaaggacatattaagtcaatcatttgtctt ttggataaacatggaagaaaccataaggttttggatgttttgtgttctctctgtgtttgt catggagtagctgtgcgatctaatcaacatctaatctgtgataatcttctgccaggaaga gatctgcttttacagacacgccttgtcaaccacgtcagcagcatgcgacccaacatcttc ttggggattagtgaaggctctgcccaatacagaaaatggtattatgaacttatggtggat catctagagccctttgtgactgcagaatcaactcatctgcgcgtgggctgggcttcaacg gagggctactcaccatatccagggggaggagcagaatggggaggaaatggtgttggtgat gacttgtattcctatggcttcgatggtttgcatctgtggtcaggttgtgtagcacgaaca gtaaattctcccaaccaacacctgttaagaactgatgatgttattagttgctgtttggac ctgagtgcccccagcatctctttccggataaatggtcagccagttcaaggaatgtttgag aatttcaacatagatggcctcttcttcccagttgtcagcttctctgcaggaataaaggta cgtttcttacttgggggccgccatggagagttcaagttccttcctccacctggatatgcc ccttgctttgaagctgtcctaccgaaagagaagttgaaagtggaacacagccgagagtac aagcaggatcgtaactatacaagagatctactgggtcccactatctctctctcacaagca gctttcactccagttcctgtagatactagccagattgttttgcctcctcacctggaaagg attagagagaaattagcagagaacatccatgaactttgggttatgaataagattgagctt ggctggcaatatggaccagttagagatgacaacaaaagacaacacccgtgcttagtggag ttctcaaaattgccagagcaggaaagaaattacaacttgcaaatgtcacttgaaacattg aaaactctgctggcattaggctgtcatgttggaattgctgatgaacatgctgaagaaaaa gtgaaaaaaatgaaactcccaaagacctaccagttgttgagtggatataagcctgccccg atggatctgagttttatcaaactgaccccctctcaagaagctatggtggataaactagca gagaacgctcacaacgtgtgggcaagggaccgtataaggcaaggctggacatacggtatc cagcaggatgtgaaaaatcgacgaaatcctcgccttgtaccttatgctcttttggatgat cgaacaaagaagtcaaacaaagacagtcttcgggaagcagtccgcacccttctaggctat ggttacaacctggaagctcccgatcaagatcatgcaatgagattggacgtgtgcagtgga ataatggaaaaattcaggatcttccgcacggaaaagacatatgcagtgaagactgggaaa tggtattttgagtttgaggcagttactgcaggagacatgagagttggctggaccaggcca ggttgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgatggcttt aaggcacaacggtggcatcaaggtaatgagcattttggtcgctcttggttagcaggagat gttgttggatgtatggttgacatgaatgagcacactatgatgttcaccttaaatggtgaa atcctgcttgatgactcaggttcagaacttgccttcaaggactttgaggttggtgctgga tttctacctgtgtgcagcctgggcccatctcaagtgggaagaatgaacttcggaaaagat gtcagcactctcaaatatttcactatctgtggcttacaggaaggatatgaaccctttgct gttaatactaacagagacatcaccatttggctgagtaaaaggctccctcagtttctacca gtgccacaaaatcatgaacatattgaggtgatgagaattgatggcaccatagacagctgc ccctgcctgaaggtcacacagaagtcctttggttcacagaacagtaaaacagacgtcttg ttttttcgattaagcatgcccattgaatgtgctgaggtgttctccagaacttctgcagga ggattaccaggctctagtctttttggcccaaagaatgacttggatgattatgatgccgat tctgattttgaggttctgatgaaaactgcccatggtcatctagctcctgacaggacagaa agagaaaaagatgccacaaaaccagagttaaacaaccataaagattatgttcaagaaaag ccttcacgtcttaaacaaagatttatgctcaggaggacgaagccggattatagcacgagc cactctgcacggcttactgaggatgtactagcagatgatagagatgattatgattattta atgcaaacttccacgtactattattcagtgagaatatttcccggacaagaacctgctaat gtctgggtgggctggattacatctgactttcaccagtatgacacaagctttgacttggat agagtgcgtactgtcacagttacactgggagatgaaaaagggaaggttcatgagagtata aaacgcagcaactgctatatggtgtgcgcaggggagagcatgagtcctggacaaggacgt aataataatggtctggagattggttgcttggttgatgctgccagtggcctgctaaccttc acagctaatggcaaggaactaggcacgtattatcaggttgaacccagtacaaagttattt cctgctgtatttgctcaagctacaagccccaatattttccagtttgaattaggaagagta aagaatgtaatgccattatctgctggcttgttcaaaagcgaacacaaaaatccaatctct caatgtcctccacgtctccatgtccaatttctgactcatgtgctttggagcagagtgcca aatcacttcttgaaggttgatgtctctcggatcagtgaacgtcaaggctggatgatacag tgcctgaatcctttgcagtttatggctcttcatattcctgaagaaaacagaacaattgat attttagagctgacagaacaagaagaattgctgaaatttcactaccataccctccgatta tattcagctgtttgtgctttaggcaacaaccgagtggctcatgctatgtgtagccatgtg gatgaatctcagctcctatatgctattgagaataaatatatgccaggattattacgtgca ggatattatgacttactcattgatatccatctcaatacctatgcaactgccaggttaatg atgaataatgaatttatagttccaatgacagatgagacaaagagtattactttgtttcct gatgaaaacaaaaagcatggcctcccaggtataggacttagcacatcattaaggccaaga atgcagttctcctctccgagttttgtaagcattagcagtgaatgctttcagttcagccct gaattccctctggaaatcttgaaggccaaaaccatagagatgctgactgaagctgttcag gaaggcagcctccatgtcagagatccagttggaggttccacagaatttctatttgtccct ctcatcaaactcttttatactctcctaattatggggattttcaacaatggggatctgaaa cacatcttgcagttgattgagccccgggttttcaaagaagcaatgagtcaagaggatgaa accgatttcttggagaaggagatgaatttagatgagctcaagtctgaagaaggagaggaa gaaaccagaggggagcaagtgccaaaggaaggactccttcagatgaaacttccagaacct gttaagttacagatgtgtcatctactccagtacctgtgtgattgccaagtacgacaccga atagaagccattgtagcattttcagatgattttgtggccaagcttcaagaaaatcagcgc ttccgatacaatgaagtgatgcaggccttgaacatgtctgctgccttgacagctagaaaa acaaaagaatttcgatccccacctcaggaacagattaacatgctgctgaactttaaagat gataaaaatgattgtccttgccctgaagaaattcgggatcaactcttggatttccatgaa gacctaatgacacactgcggaatagaactagatgaagatggaaccttggatggaaacaat gatttaaccattaggggacgccttctataccttatggaaaaagttacgtatctgaagaag aagcaagcagagaagccagttgatgatgatgctaagacatcctctactcttcagcagttg atttcagacacaatggtacgctgggcccaggaatcagtgatagaagatccggagttagtg agggccatgtttgtattactgcatcgccagtatgatggtattggtggcctggttcgagcc ctaccaaagacctacaccataaatagcgtgtcagtggaagacacaatcaatcttctggca tccctcggccaaatccgttccttgcttagtgtcagaatggggaaggaggaagagaaactt atgattcgtggattaggagacatcatgaataataaagtattttaccaacatccaaatctc atgagagctttaggcatgcatgaaactgtcatggaagtgatggtaaatgtccttggtgga ggagaatccaaggaaatcactttcccaaagatggtggcaaactgctgtcgttttctatgc tatttttgccgcatcagcagacagaatcaaaaagctatgtttgatcatcttagctactta ctggaaaacagcagtgttggccttgcctctccttctatgcgaggatcaactcctttagat gttgcagcagcctctgtgatggataacaatgaacttgcgctagctttaagggagcctgat ctggagaaggtggttcgctacttggctggatgtggattgcagagttgtcctttgttgatt tctaaaggctacccagacataggatggaatccagttgaaggagaacgatatttggatttt cttcgttttgctgttttttgcaatggagagagtgtggaggagaatgctaatgttgtagtc agactgcttattcgtcgacctgagtgctttggtccagctttaagaggagaaggaggcaat gggttacttgctgccatggaagaagcgatacaaatatcagaagatccgacaagagatgga gcttccccaagtaatggatctagtaaaaccctagaaatagaagaacaagaagatgacact attcacatgggaaatgcaatcatgaccttttatgctgctttgattgatctcttaggacgt tgtgcccctgaaatgcatctaatccatgctggtaaaggggaagccattagaatcagatca attctacggtctttgattccactggaagatttggtgggagtaattagtattcctttccac atgccaaccatagctaaagatggtactgtggtggaacctgacatgtctgcggggttttgc ccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggaccag gattttcttctacaccttcttgaagttggctttctgccagatcttcgtgctgctgcttct ttagatacagctgctttaagtgctacagatatggctttggctctgaatcgatacctctgc acagcagtcttgccactattgactagatgtgctcctcttttcgctggcacagagcaccac gcttcacttatcgattccttgttacatactgtgtacagactctcaaagggatgctctctt accaaagctcagcgagattctattgaagagtgtttgctgtctatctgtgggcaattgcgg ccttccatgatgcagcatttgctaaggagattagtatttgatgttcctctattaaatgaa catgcaaagatgcctctcaagttgctgacaaatcattatgaaagatgctggaagtattat tgtttgccaggtggatggggtaactttggcgctgcctcggaagaagaactccatttatcc agaaagttgttctggggtatttttgatgctctgtctcaaaagaagtatgaacaagaactg ttcaaattggctttgccttgtttgagcgcagttgcaggagccttacctccagactatatg gaatcaaattatgtcaatatgatggaaaaacagtcttcaatggattcagatgggaacttt aatcctcagcctgttgatacgtcaaacattacaatccctgaaaagctagaatatttcatt aacaaatatgcagaacactctcatgacaaatggtcgatggaaaagtttgccaatggatgg acatatggtgaaacgtattctgaatctgcaaaagtgcagccattgatgaaacaatataag ttactatctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcattaaaaact atgctggcatggggatggcgaattgaaagaacaagggagggagattccatggcactgtat aatcggacacgtcgcatatctcaaaccagtcaaatctctgtagatacagcccatggttac actcctcgagcaattgacatgagcaatgtcaccctttccagagacttacatgctatggct gagatgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggagcttgaa gcaaaaggaggaggcaaccatcctcttcttgttccttacgatacactcacagccaaagaa aaagccagggacagagaaaaagcgcaagatattctgaaatttctacagattaatggatat gttgtctccagaggacttaaggacctggaattagacacaccttccattgagaagcgcttt gcgtacagcttccttcagcaacttataagatacgtggatgaagcccatcagtacattctg gaatttgatggtggcagcagaggcaaaggagaacacttcccatatgaacaagaaatcaag ttttttgccaaagttgtgctacctctgattgatcagtattttaaaaatcatcgcctgtat ttcttatctgcagcaagtaggcctctcagcagtggaggtcatgcctctaataaggagaaa gaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaatgatgcaacatcaatagtcaactgtcttcacatactgggccagaccttggat gcgaggactgtgatgaaaactggcctggaatccgttaagatggcattgagagcatttttg gacaatgctgctgaggatctggagaagacaatggaaaatcttaaacaaggccagtttaca cacagcagaaaccagccaaagggagttacacaaatcattaattataccacagttgctctc ctgccagtactatcttcattatttgagcatattggacagcaccagtttggggaagatttg atattggaagatgttcaggtctcctgttacagaatattggccagtttatatgctctggga accagcaagagtatctatgtagagcggcaacgatcagcactaggagaatgcttggctgct ttctcaggtgccttcccagtggcttttttggaaactcatttgaacaaacataatatctac tcaatttacaataccaagaatgcaagagagagagcagttctcaatttgcctactagtgta gaagaggtttgcccaaatattccttccttggtgaagctaatggaagaaattgtggaactg gctgagtctggtattcgttacacacaaatgccacatatcatggaagtaatactgcctatg ctatgtagttatatgtcacactggtgggagcatgggccagaaaacaaccctgacaaggct gaaatgtgttgcacagccttgacatcagagcacatgaatactctgttgggcaacatattg aaaatcatatataacaaccttggtattgatgaaggagcctggatgaagagattagcagtg ttttcccagcccatcataagcaaagcgaagccgcagctcttaaagacacacttcctgcca ctgatggataagctaaagaaaaaagcagcagtggttgtttcggatgaagaacatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgcttatcctagatgagttcactact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagg gcaaaatggctgaaagaacccaaccctgaagcagaagaattgttccgcatggtggctgag gtcttcatttactggtcaaagtctcacaatttcaaaagggaagagcagaactttgtggta caaaatgaaatcaacaacatgtctttcctcatcagtgacaccaaatctaagatgtccaag gcagcagtttctgaccaggagaggaagaagatgaagcgaaaaggtgaccggtactctatg caaacatctctcattgtggcagcactgaagagattacttcccattggcctaaacatttgt gcacctggagaccacgaactaattgcactggccaaaaatcgattcagtgtgagagatact gaagatgaagtacgagatgtcatccgcagtaatcttcatctccagggcaagcttgaggat cctgccattagatggcagatggcactttacaaagatttaccaaacagaactgaagattcc tcagatccagagaagactgtggaaagggtccttgatatagctaatgtactgtttcacctg gaacagagatctgcttgcgtaggccgaggctatttcttttgggttgagcatcctcagcgg tcaaaaaaagcagtgtggcataaacttttgtctaaacagaggaaaagagctgtagttgcc tgctttagaatggcaccattgtataatcttccaaggcaccgagctgtcaatctctttctt caaggctatgataaatcttggattgaaacagaagaacactattttgaagacaaactgata gaagacttagcaaaacccggggaggaaccaccagaggaagatgaaagccttaaaagagtt gatcctttacatcaacttattctgctattcagtcgaacagccttaactgaaaaatgcaaa ctggaagaagatttcctgtatatggcttatgctgacattatggcaaagagctgccatgat gaggaagatgatgatggtgaggaagaagtgaagagttttgaagaaaaagaaatggaaaag caaaaacttctgtatcaacaagccagactgcatgatcgaggtgctgctgagatggttctg cagacaatcagtgctagtaaaggtgagatggggccaatggttgcagctaccctaaagcta gggattgccatcttaaatggaggaaattccaccgttcaacagaaaatgcttgactacctc aaggacaaaaaggatgtgggattctttcagagccttgctgggcttatgcagtcctgtagt gttcttgacctaaatgcatttgagcgtcagaacaaagcagaaggccttggcatggtgact gaagagggatcaggagaaaaggtgatgcaggatgatgagttcacctgtgacctcttccgc ttccttcaattgctttgtgaaggacataattcagattttcagaattacctaagaactcag actggtaacaacacaactgttaacattatcatttccactgtggattacttattaagagtt caggaatccattagtgatttttattggtattattctgggaaggatgttattgatgagcaa ggacaacgcaacttttccaaagccatccaagttgcaaaacaagtttttaatactctcaca gagtacatccagggtccgtgtactgggaatcagcaaagtctggctcacagcaggctatgg gatgctgtggttggttttcttcacgtgtttgcccacatgcagatgaagctgtctcaggat tccagtcaaattgaattactgaaggaattaatggatcttcagaaagatatggttgtcatg ttgctgtctatgctggaaggtaatgttgtgaatggaactattggcaagcagatggtcgat atgcttgttgaatcgtccaacaatgtagagatgatactgaagttttttgatatgttctta aaattgaaggatttgacttcctctgatgcattcaaagaatacgaccctgatggtaaaggg ataatttcaaagagggattttcacaaggcaatggaaagccataagcattacacccagtct gaaactgagtttctgctatcatgtgctgagacagatgagaatgagactctagactatgag gagtttgtgaagcgattccatgaacctgccaaagacattggtttcaatgttgctgttctc ctgaccaatctgtcagaacacatgccccatgacacccgcttgcaaacttttcttgaactg tcagaaagtgtgctgaattactttcaacctttccttggacgcattgaaatcatgggcagt gcgaagcgcattgaacgagtttattttgaaataagtgagtcaagtcggactcagtgggag aaacctcaggtaaaagagtcaaagagacagtttatatttgatgttgtaaatgaaggtggg gagaaagaaaagatggagctttttgttaatttctgtgaggacaccatctttgaaatgcaa ctggctgcccagatctccgagtcagatctgaatgaaaggtcagcaaataaagaggagaat gagaaggataagcctgaggaacaggatcctagaatgggtttcttttctctcgtaaccatg aagtcggcattgttagctcttaagtataatttaatgactctcatgaaaatgcttagcatg aagagcctaaagaaacagatgaaaaaagtgaagaaaatgaccatgaaggacatggtcatg gctttgttttcttcctattggagcattttgatgggcttactacattttgcttgtagtgtt gtccgaggcttctttcgcatcatatgcagtttgctgcttggaggaagcctggtagaagga gcaaagaaaatcaaagtggctgaattattagctaatatgccagatcccactcaggatgaa gtgcgtggggaaggagaagaaggggaaaggaagccaacagaagctgcattgcctacagaa gacttaacagatctgagaactttatcagatgagagtgatctactctcagatatatttggg ttggatttgaaacgagaaggtggacagtataaattgatccctcacaatccaaatgctggt ttgagtgatttactgagcactccctccttagctccaatgcctgaggtgcaggagaaaatc caggagcaggtgaaggaagatgagaaggaagagaaggaagaaacaaaatctgaacctgaa aaagcagaaggagaagatggagaaaaagaagagaaagccaaggaagacaaagggaaacag aaattaagacaacttcatactcacagatatggggaaccagaagttcaggaatcagctttc tggaagaaaatcattgcataccaacagaagcttcttaactattttgcacgaaacttttac aacatgaggatgttggcattgtttgttgcttttgccatcaacttcatcctgcttttctat aaggtctcaacctctgctgtgacagaagaaaaggaagttcctgtggtgtctgctgatgaa agtaccaagttggacgtcctggaaagtggtgatgaaagggtcattgcagtgcattatgtc ctggaagaaagcagtggctatatggagcccacactgcggattttggccatcctacacaca gtcatctcattcttctgcatcataggatattactgtttgaaagttcctctggttattttt aagagagaaaaggaagtggcaaggaaattggaatttgatgggctgtatataactgaacag ccttcagaagatgatattaaagggcagtgggatagacttgtaatcaacacacaatctttt ccaaacaactattgggacaaatttgtgaaaagaaaggtcatggataaatatggtgagttc tatggccgtgacaggatcagtgagttattaggaatggacaaagctgctctcgatttcagt gatgctcgagaaaagaagaaaccaaagaaggatagctccttatctgctgtgctaaattcc attgatgttaagtatcagatgtggaaattaggagttgttttcactgataattctttcctt tacctagcgtggtacatgaccatgtctgtccttggccattacaacaattttttctttgct gctcatctccttgacattgcaatgggattcaagacattacgaactatcctgtcatcagtg acccacaatggcaaacagcttgtcctaacagtgggattactggcagtagtagtatatttg tatacagtagtggcattcaattttttccgcaaattctacaacaagagcgaagatggtgat atgccagacatgaaatgtgatgatatgctaacatgctacatgtttcacatgtatgttgga gtacgtgcaggtggaggcattggtgatgaaatagaggatccagcaggagatgaatatgaa atatatcgtattatctttgacatcactttcttcttctttgtgattgtcatcctgcttgca attattcaaggtttaattattgatgcttttggtgagttaagagaccagcaggagcaagtt aaggaagacatggagacaaagtgctttatctgtggaataggaaatgactacttcgataca gtgccccatggctttgaaacacatacactacaggaacacaacttggccaattatttgttt tttctgatgtatcttattaacaaagatgaaacagagcatacaggacaggagtcctatgta tggaaaatgtatcaagaacggtgctgggagtttttccctgccggtgattgcttccgaaaa caatatgaagaccagctcaactaa

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