Cheilinus undulatus (humphead wrasse): 121511043 Help Entry 121511043         CDS       T07473                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism cud  Cheilinus undulatus (humphead wrasse) Pathway cud04020   Calcium signaling pathway cud04260   Cardiac muscle contraction cud04261   Adrenergic signaling in cardiomyocytes cud04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cud00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121511043 (ryr2b)    04020 Calcium signaling pathway     121511043 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     121511043 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     121511043 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cud04040]     121511043 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:cud04990]     121511043 (ryr2b) Ion channels [BR:cud04040]  Voltage-gated cation channels   Ryanodine receptor    121511043 (ryr2b) Domain-containing proteins not elsewhere classified [BR:cud04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    121511043 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_8 Motif Other DBs NCBI-GeneID:  121511043 NCBI-ProteinID:  XP_041645474 LinkDB All DBs Position 6:30510122..30607708 Genome browser AA seq 4958 aa AA seqDB search MTDTGEGDEEYQFVRTGDDVVLQSTFTSQEEHVKLCLAAEGFGSRLCRLELTSNCKNVPP DLSVCGFILAQCLSVRALQEMLAHSEHLAEEVGAGGSQRTLLYGQAVLFLHSYSGMYLSC LSSSQSSADKLAFDVGLQEDKAGEACWWTVHPASRQRSEGEKVRVGDDLILVNVSSERYL HLSFGTVFDNKNLSDSLIVNAAFRQTLWSVAPICSGGGVAQGFLKGGDTLRLLHSHSDAC LTASSTEQGEELQRIMHYESGSVCSHARSLWRLEILRVVWSGRHTCWGQPFRLCHVTTGR YLGLTEERGLQLVDRDKADVNTTAFCFRSSKEKPESGKKTNMESMGVPEIKYGDSVCYVQ HVKSGLWLTYQATDSKSARMGVSQRKAILHSEGHMDDGLTLSRSQKEESHTARLIWSATL LFSHFIRKLDASSQKENITLISLSIEKVTHSLQDLISYFQPPEEGLDHEARQNKMTTLKN RQNMFQEEGVIDLVLDCIDHLHQYSSASHFAEAVQVDSGEEWETILNSFYELLAALIRGN RVNCAHFSSSLDWLISKLDRLEASSGVLEVLQCVLMESPEALNVIKEEHINSVMAFLDKH GLNHKVLEVLCSLCVCHGVAVRSNQNLICDNLLPNRDLLLQTRLANQVTSMRPNIFLAMG EDSAQPRRWYYEMVVDHVDYFLTPEPTHLRVGWAYTDGYQPRPTGGEGWGGNGVGDDLCS YGFDGLHLWSGCMSRRVSSPFPHLLRDDDVVSCCLDLSAPCISFRINGLPVQGMFENFGA DGLLYPVVSFSAGVTVRFLFGGRHGEFRFLPPPGFAPCSEALLPRVKLKVEPCQTYILDH GDGRQGLIGCSISATPVTFTPTPVDISKMELPPQLEDIRDKLAENIHELWAVDKIDLGWT HGLVRDEVKRHDPCLVEFSKLPEQERNQNLQMAQDTLRTVLAFGFHISLTDVSAEERVKF MRVSTKYEQPSGFKPAPLDLSQVILSPAHEALVNLLAENDHNVWARERIKQGWTYGAQQD VKAKRSPYLVPYSLLDERSRRVGFESVREAVCTLLAYGYSLDTLNPEQTLLSNPYHFSLE KGRVFRPDKSYAVTQGKWYFEYEIMTAGKVRVGWARPSCSPDKELGLDDQAFVFDGFEAQ WYHQGAEPLGRPWLKGDVVGSLVDMAERTMMVTLNGEMLFNDRGSELAAKDFDRKDGLLP VVSVGVNQTGRLNLGRHVDSLKYFTVCGLQEGYEPFAANMSRDPAMWMSWKQPQFTSIMP DDQNLQVTRVSGSTDSLSSLRVSQRLFAHHVGGSEMGFYRLSMSTECAPILKSPANGVLP VASNSLSPGRKEQEEVDSDFEVLMKSAHSYAGSRDELNHKDHSHDKTSRLKQRFMLKKTK PGLVSSNSSARLLEDVVVDKDNHDHLIQSSRYYYSVRVLPGQEPFSVWVGWVTSSFHQHD ISFDADNVQTVTVTLGDDSGKVQESVKQCNCYMVCAGEATGLSQSRRSAGLEIGCLIDTA TGLLTFTSNGVEMATFYQVEASTKLFPAVFVKPTTSNMFQFELGRIKNVMPLSAGLLRSQ RRNTTPQCPPRLHVQKLSPVSWTRIPDSTLKVVVDHPDECHGWRVQCSEPLQVMSLQIPD ENRCVDILELSEHVDLLTFHHHTLLLYCSLCALGNTRVCHALCSHVDQSQLLHAIQDPQL PGQLRSAFYKLLIQVHLSSHSTACLMMNQEYIVPMTDQTREITLCPSSANGVKDINDQPP EGIVSTSISTSLKPRMNFSSPFFVRSYVMEGDYSVEVFCTDSPEIPLDILKDLTVEMLTA GVYSVGQGVRDPVGGSIELLLVPLIRLFYSLLVMGVFGDEDLGKVLRLIEPGVFSIDAES LEEEEEEEEGESDDEKEWKGGKNKDNETLKQGLLHMKLPEAVKLELCRLLSYLCDCQVRH RVESVIAFSDNFVSQLQENQRFRYNQVMQALNMSAALTARKTKEFRSLPQEQINMLLNFK DDEQQENCPCPVEIQQLLHEFHHLLKTHCGIEMDSEAEDEEAAEKSVKERLLSLVGSVIR LKKTPEEVEESRLQSSKSLKKLISEAMVCWAQETEIEDPELVRAVFRLLHHQYQGLWGQM AGPLRRAYTISQTSVEDTMALLSSLSQIRSLLSVRMGKEEEKLMIRKLGEIMNNKVFYQH PNLMRALGMHETVMEVMVNVLGEGESKEITFPKMVANCCRFLCYFCRISRHNQGALFDHL SYLLENSSVGLASPSMRGATPLDVAAASVMDNNELALALKEHDLEKVVQYLADCGLQSCQ MLVAKGYPDIGWNPVEGERYVDFLRSAVFCNGESVEENAYVVLRLLIRRPECFGPALRGD GGNGLLAAMEEAIRISEDPSMDGPCTTYQSNRTIDVVPNNDDDLIHMGHAIMTFYSALID LLGRCAPEMHLIQGGKGEAIRIRAILRSLIPIQDLEGVISISFEIPSVSKDGVVVEPELS TVFCPYHKAAMVLFLDRVYSIENQTFLLHLLQVGFLPDLQAAVCLDAADLGSTDMALALN RYLCTSVLPLLTKHSALFCAVEDHASLVDALIQAIYNLSRALSLTKAQRDTIEDCLLAVC SKLQPSMMQPLLRRLVFDVPQLIDSTKMPLKLLTSHYEQRWKYYLQTGGQGDQSTASEEE LHLSRKLFWGVFKALAKKPYEPQLFRLCVQCLAAVAKALPPDHIDSSCMSHIERKAFTET EGHFEPQPVDTSNVSVPERLELVVNKYAEHTHEKWSLEKFASGWVHGEQLCENTRVHPLL KPYRALAEKEKEAYRWAIKETIKSMLAFGWTIERTKEGDAFGAHACSRRVSQSGQLSFEG ASTFSPKPLDMSSITLSWDHCAMAEQLAENYHNAWAKRKKSELEGKGGGSHSMLVPYDTL SAKEKTKFRERAQDVLRFLQLNGYTVWRDRKTVELDFPAVANCFSCTVLHRLLAHTEEAQ EHILELEVMQARGQMSKGERAPQQQLLQFFPKVVLPLLEQYVKNHRLYFLSTSLCSSSNQ SHALKREKEMVASLFCKLAALVRHRISLFGDETSQVASCLRALAQALDVRSLMKSASEFV QASLHSFFEAAAADLDITVENLSVILVSLPQSWTQQARGVAKVLSYTTSILLPTLTSLFQ HLGTQNYGVDLLVGSIQMSCYRILSSLYSLGTNSSIYMEGQRSAAGACLAALTGTFPVCF LEPSYNQNNPYSIYNTMSATEREDLGLPDQVEDMCPLLPSLDQALEEVEELAGAGAGACQ APYIHVTEVTLPMLCSYMSLWWCWGPEGEPDNPICTSVTPQHASDLLGHILRIIHNHVGA SRGGWMKQLAVFAQPIICRASSELLNSHFLPLMEKLRKRAECVMMEEEQMKTEGRDTSEA ELQIQEKFTLLVRDLYAFYPLLIPFVDSNRASWLKESNPDAEQLFSMVAEVFTFWAKSHN FKWEEQNFVVQNEINNLAFLVNKANKSKFDYEKRRMKRKGDRYSMHTSLIVASVKRLLPV GLRLCFQSKHSLIVLAKKGFFQMKTEDEIRENVFISLMHLQSQRPHCLRQETQISVHPKQ CETIADTQRAVDKVLEIARVLHYLDQVEHHQKSKKPAWHRVLSKQRKRAVVACLRMAPLY NLPRHRAVNLFLQGYNKSWISAEDHSFEEKLVEDLAVSENRGGVMELCGGETEEEKDVED SAKPIDPLLQLITLFSRSALTERSKLGNDGLYTSYATIMAKSCQREAAAAKEQEPESFEE KEMEKQRLLYQQARLHHRGASEMVLQIISASKGAMGCMIAPTLKLGIAILNGGNAAVQQK MLDYLREKRDVCFFQSMAGLMLSCSVLDLNAFERQNKAEGLGMAMDESSGEKVMPDKDIT CDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYFSGKD VIDEHGQQNFSKAIDVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQM KLSQDSRQIELLKELMDLQKDMVVFLLSMLEGNVVNGTIGKQMVDMLVESSGNVEMILKF FDMFLKLKDLTSSDVFREYDPDCKGCISRKDFQKAMENCKRFSQTEINFLLTCLQTDDSD IVEYEDFVDRFHEPAKDIGFSISVLLTNLSEHMPNDSRLRTFLELAECILTYFQPYLGRI EILGSEKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMEMFVNFCEDT IFEMQLAAQISGSDSVERCAEKEDREEEGHDSKGMFFICHWIILLTSVLSVKTLKSLMKM TLKDILMSAIFFLRVIVMAQARCIHILVRSFLYLLYIAFISGGLIEGAKRMKISDLLGGI PEPTLDEVMEVPSGVDRLRKYSASLSSQRELREIGQETAVTSLRDVDVLSDIFGLRVKKE GGQYRLITQDLTASLTDLFNTSSRTISTPDFSKKHQGTLKAHTTSEEKTEDEEILLTKGK ESENETGVEESEAISRSKKCPNKSEEKESQRSAFWEMISTYNKNLLSYFARNFYNMRLLA LFVAFAINFILLFYKVSVLVESLPASQDEDYREELNSTAKDDNKGRVYFVLEESRGYMEP SLHFLAVAHTIISFCCIIGYYCLKVPLVIFKREKEVARSLEFDGLYVTEQPPEEDIKGQW DRLVINTPSFPSNYWDKFVKRKVMDKYGDFYGCEKISELLGLDQAALDFSSERRERKRLK RDSAWSALFNSTDVKYQVWKLGVVFTDNSFLYLAWYMAMSVLGHYNNFFFAAHLLDIAMG FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYTKSDDDDNWDMKCNDM LTCYMFHMYVGVRAGGGIGDEIEDPAGDEFEVERIVFDITFFFFVIVILLAIIQGLIIDA FGELRDQQEQVKEDMETKCFICGIGSEYFDKVPHGFETHTLQEHNLSNYLFFLMYLINKD ETEHTGQESYVWKMYQERSWEFFPVGDCFRKQYEDQLG NT seq 14877 nt NT seq  +upstreamnt  +downstreamnt atgactgacacaggagagggggacgaagaataccagtttgtaagaacgggagatgacgtg gttttgcagagtacgttcacctcccaggaggaacatgtgaagctctgtcttgctgcagag ggatttggcagcagactctgcagacttgagctcacctctaactgcaagaatgttccacca gacttgtctgtatgtggcttcatcctggcccaatgtctctctgtacgagccctgcaagaa atgctggcccacagtgagcacctagctgaagaggttggtgcaggaggaagccagcgcaca cttctgtacggccaagcagtgttgtttcttcactcttacagtggcatgtatctcagctgc ctgtcttcatctcagtcttcggctgataaactggcttttgatgtaggtctgcaggaggat aaagcaggtgaggcatgttggtggactgtccatccagcatccagacagaggtcagagggt gagaaagtgcgtgttggagatgacctcattttggtcaatgtgtcctctgagagatatctg cacctgtcctttggcactgtttttgacaacaaaaatttgagtgacagcctgattgttaat gcagccttccggcagactctctggagtgttgctcccatctgctctggaggtggagttgct caaggattcctgaagggtggagacacattgcgactactccacagccacagtgatgcatgt ctgactgcttcgtccacagagcagggagaggagctgcaaaggataatgcattatgagagt ggatcagtctgcagtcatgcccgctccctctggaggctggagattctgcgtgttgtctgg agtggcaggcatacgtgctgggggcagcctttccgactgtgccatgtgacgactgggaga tacctgggactaacagaggagagaggcctgcagctggttgatcgggacaaggctgatgtc aacacaacagccttctgctttcgatcatcaaaggagaagcctgaaagtggcaaaaagact aatatggagagcatgggcgtcccagagatcaagtatggggactctgtttgttacgttcag catgttaagtccgggctgtggctcacctatcaggctactgattccaaatctgcacgcatg ggagtgtctcagagaaaggctattttgcacagcgagggtcatatggatgatggactgact ctgtctcgttctcagaaggaagaatctcacactgccagacttatttggagtgctactctc ctcttcagtcactttatcaggaaactggatgcatctagtcaaaaagaaaacatcacattg atcagtctttcgattgagaaggttacccatagtctgcaggatctgatcagctatttccag cctccagaggagggactggaccacgaagctagacaaaacaaaatgacaacgctgaagaat cggcaaaacatgtttcaagaagagggtgtgatagatttggtcctggattgtattgaccat ctgcaccaatatagtagtgcttctcattttgctgaggctgttcaggttgactcaggagaa gagtgggagaccatcctcaacagtttctatgagcttttggctgctctgatccgtggaaat cgtgtaaactgtgcacatttttcaagctctctagactggcttattagcaaactagaccga ctggaggcctcctctggagtcttggaagttctgcagtgtgtcctaatggaaagtcctgag gctcttaatgtcattaaagaggaacacataaattctgtcatggctttcctggacaaacat ggacttaaccacaaggtgctggaggtgctatgctctctgtgtgtgtgccatggagtagca gtgcggtccaatcaaaacctcatctgtgacaacctgctgccaaaccgagacttgctgctc cagacgcgtctggctaatcaggtcacaagcatgagaccaaacatcttcttggccatggga gaagattcagctcagccccggaggtggtattatgaaatggttgtggatcatgttgactac ttcctcacacctgaacctacacacctgcgtgttggctgggcgtacactgacggctaccag ccgagaccaacaggtggtgaaggctggggaggcaatggggtgggagatgacctctgctcc tatggctttgatgggcttcacctctggtcaggttgcatgagccgcagagtgagctctcca ttccctcacctgctcagagatgatgatgtggtcagctgctgtctcgacctcagcgctccc tgcatctccttccggatcaatggtctacctgtgcagggcatgtttgagaatttcggtgct gacgggcttctctatcctgttgtcagcttctctgctggagtcacggtgcgttttctgttt gggggcaggcatggagagtttcgctttctgcctccaccaggttttgctccatgctctgag gctctgctcccgagggttaagctaaaagtagagccttgtcagacatacattttggatcac ggagatggaagacaagggcttatcggctgctcaatatctgccactccagtgacctttact ccaacaccagtggacatcagcaagatggaattgcctccacaacttgaggatatccgagat aaactggcagagaatatccatgaactttgggcagtggacaagattgatcttggatggaca catggactggtgagagatgaagttaaaagacatgatccctgtcttgtggagttttccaaa ctaccagagcaggagaggaaccagaaccttcagatggctcaggacactctcaggacggtg cttgcctttggcttccacataagtttgactgatgtcagtgctgaagaaagagtcaaattt atgagagtttccaccaagtatgagcagcccagtggctttaaacctgcccctctagacctg agccaggtcattctgagcccagcccatgaggcattggttaacttgctggcagagaacgat cacaatgtgtgggccagagagcgtatcaaacagggatggacctacggagctcaacaggat gttaaagcgaagcggagcccatatcttgtgccatacagccttcttgatgaaaggagtaga agagtgggctttgagagtgtcagagaggctgtctgtaccctgttggcttatggttacagc ctggacaccctcaacccggagcagaccttattatcaaatccatatcatttctctctggag aaaggcagagtgtttcgcccagataaatcatacgctgtaacccaggggaagtggtacttt gaatatgaaataatgacagcggggaaagtgagagtaggctgggctcgaccaagctgttcc cctgataaagagcttggcttggatgaccaggcatttgtcttcgatggatttgaggctcag tggtaccatcagggtgccgagcccctgggacgtccttggctgaaaggcgatgttgtgggc agtctagtggacatggctgagcgcactatgatggtcacgctcaatggagagatgctgttt aatgacagaggatcagaactggctgccaaggactttgatagaaaagacggtttgttgcct gtggtcagtgttggagtaaaccagacagggaggctgaatttgggccgccatgtggactcc ctgaagtacttcacagtatgtggcttgcaggagggatatgaacctttcgctgccaacatg tctagagatccagccatgtggatgagttggaagcagcctcagtttacctcaataatgcct gatgaccaaaacttacaggtcacccgagtgagtggctcaacagattccttatccagccta agggtttctcagcggttgtttgcacaccatgttggaggcagtgagatgggcttttaccgg ctcagcatgtccactgaatgtgcccccatcctcaagagccctgcaaacggcgtgcttcca gtggcctccaactctctttctccaggaagaaaagagcaggaggaggtggactctgacttt gaagttttgatgaagtcagcccacagttatgccggctcaagagatgagctcaaccacaag gatcatagtcacgacaaaacatcaagactgaaacaacggttcatgcttaagaagactaaa ccaggcctggtcagcagcaactcttctgcacggcttttagaagatgtcgtagttgacaag gataatcacgatcatctcatacagagctccagatattattactctgtgagggttctgcct ggccaggagccattcagtgtgtgggttggctgggtgacctcgagctttcatcaacatgac atctcttttgatgctgacaatgtccaaactgtgactgtcactctgggagatgacagtggt aaagtccaggaaagtgtgaagcaatgtaactgttacatggtttgtgctggagaggctaca ggcctttctcagagtcgcagaagtgcagggctggaaatcggctgtttaatcgacactgcc actgggctgctcacctttacttccaatggagtggagatggccaccttttaccaagtagag gccagtacaaagctgtttcctgctgtttttgtgaagcccaccaccagcaacatgtttcag tttgagcttggacgaattaagaatgtgatgcctctgtcggcaggtttgcttcgcagtcaa agaaggaataccacacctcagtgtcctccaaggcttcatgtgcagaaacttagtccagta tcatggaccaggataccagacagcactctaaaggtggtggtggatcacccagatgagtgc cacggatggagagttcaatgctctgagcccctgcaagtcatgtcactccagatccctgat gaaaacaggtgtgttgacattttagagctgtcagaacatgtagacctcttgacatttcac caccacactctcctactctactgctccttatgcgcccttggaaacacccgagtgtgccat gccttgtgcagtcatgtggaccaatcccagctccttcatgccattcaagatccccaactc cctgggcaactccgctctgcattttacaagctgctcattcaggttcacctcagcagccac tcaacagcatgcctcatgatgaaccaggagtacattgtacctatgactgaccagaccaga gaaataaccctttgtcccagctctgcaaacggagtgaaagacattaatgatcaacctcca gaaggcattgtcagcactagtattagtacatccctaaaacctcggatgaatttctcatct cctttttttgtaagaagctatgttatggaaggagattattcagttgaagtattctgcaca gacagcccagaaatccccctggacatactgaaggatctgacagttgagatgctgactgct ggggtgtactcagtgggtcagggtgtgagggatcctgtaggaggcagcattgagctgctg ctggtccctctaattagacttttctactccctgctggttatgggggtatttggggatgag gaccttgggaaagttctgagactgattgagccaggagtcttttccatagatgctgaatct cttgaggaggaagaagaagaagaagaaggagaaagtgatgatgaaaaagaatggaaaggg ggcaagaataaagacaatgaaaccttgaaacagggacttcttcatatgaagcttccagag gctgtcaaacttgagctctgccgtcttctgtcttacctgtgcgactgccaggtgcgtcac agggtagagtctgtgatcgccttctctgacaactttgtgagtcaactgcaggagaaccaa cgatttcgctacaaccaggtcatgcaagcacttaatatgtcagccgctctgactgcacgc aagacaaaggagttccgctctcttccacaggagcagatcaacatgctgctaaacttcaaa gatgatgagcagcaggagaactgcccctgcccagtagaaatccaacaacttctgcatgaa tttcatcacctgctcaaaacacactgtggaattgaaatggacagtgaagcagaggatgaa gaggctgctgagaaatctgtgaaagagcgactcctcagtctagtgggaagtgtcatcagg ttgaagaagacacctgaagaggtggaggagagtaggctgcagagttccaaatccctgaaa aagctcatctcagaggcgatggtatgttgggctcaagagactgagatagaggaccctgaa ctggtaagggctgtcttcagactgctgcaccatcagtatcagggcctatggggccaaatg gcaggacccctccgcagagcctatacaattagccagacttcagtggaggataccatggcc cttttgtcctccctgagccaaatccgctctctcctcagtgtccgcatgggaaaagaagag gagaagctgatgatcagaaaactaggggaaatcatgaataataaagttttctatcagcac cctaatctgatgagagcattggggatgcatgagactgtgatggaggtgatggtcaatgtc ctgggagaaggagagtcaaaggagatcacctttcccaagatggtagccaactgctgtcga ttcctgtgttatttttgccgcataagccgtcacaatcagggagccctgtttgatcatctc agctacctgctggaaaacagcagtgttggtctcgcttcaccatcaatgcgtggagccact cctttggatgtggctgcagcctctgtaatggataataatgaacttgcattagcactgaag gaacatgacttagagaaggtggtgcagtaccttgctgactgtggtctgcagagctgtcaa atgcttgtggctaaaggctaccctgatattggatggaatcctgtggagggcgagcgttat gttgattttctacgttctgcagtcttctgcaatggtgagagtgtcgaagagaatgcttat gtggtgttgagactgttgattcgacgccctgagtgttttggccctgccctgagaggtgat ggtgggaacggtcttcttgctgccatggaggaagcaataaggatctcagaggacccctct atggatggaccctgcaccacataccagtccaacagaacgatagatgtggtcccgaacaat gatgatgacctcatccacatggggcacgccatcatgaccttctactcggcacttatcgac ttgctgggccgctgcgctcctgaaatgcatctgattcaaggagggaaaggtgaagccata cgcatcagggccattctgaggtcgctcatcccaatccaagatctggaaggagttatcagc atctcctttgaaattccttcagtgtctaaagatggtgtggtggttgagccagagctctct acagtcttctgtccataccacaaggcagccatggttctgtttctggaccgggtttacagc attgagaaccaaacttttcttctccacctccttcaagttggctttctgcccgaccttcag gctgctgtgtgtcttgatgctgctgacttaggatccactgatatggccctggccctcaac agatacttgtgcacgtctgttcttcccttgctcaccaaacattcagctctcttctgtgct gtggaggatcacgcctcactggtggatgctcttatccaggcaatctacaacctctcccgg gctctgagcctgaccaaggctcagagagacactatagaagattgtttgttggctgtgtgc agtaaactccaaccatctatgatgcagcctcttcttagacgcttggtcttcgatgttccc cagctcatagactccaccaagatgccactaaagctcctgacaagtcactatgagcagagg tggaagtactacttgcaaacaggagggcagggtgatcagagcactgcctctgaggaggag cttcacctgtccaggaagttattctggggtgtctttaaggccttggcgaagaagccttat gagcctcagttattcaggctttgtgttcagtgcctggctgccgtggcaaaggctctgcct ccagaccacatcgactcaagctgcatgtctcatattgagagaaaagccttcacagaaaca gaaggacactttgaaccccagcctgtagacacatcaaacgtgtcagtgccagagagactg gagcttgtggttaacaagtatgcagagcacactcatgagaagtggtcactggaaaagttt gccagtggctgggttcatggggagcagctctgtgagaacacgagggttcatcctctcctc aagccatacagggctttggctgagaaggagaaggaggcttatcgttgggccattaaggag acaataaagagtatgctggcctttggatggacaatagagaggactaaagaaggagatgca tttggtgcacatgcctgttcacgcagagtctctcagtctggacagctctcttttgaagga gcatcaactttcagccccaaacctttggacatgagcagcatcaccttatcatgggaccac tgtgctatggctgagcagttagctgagaactaccataatgcttgggctaagaggaagaaa tcagagctggagggaaaaggagggggtagccattcaatgcttgtaccttatgatacgctg tctgccaaagagaaaactaagtttagagaaagagcccaggatgtcctcaggtttctccag cttaatggatacactgtgtggagggaccggaagactgtggagttggattttccagctgtt gcaaactgcttcagctgcactgttctccacagactcctggctcataccgaggaggcccaa gagcacatcctggagctagaggtgatgcaagccagaggacagatgtcaaaaggcgagaga gctccacagcagcaactcttacagttttttcctaaggttgttcttcctcttttggagcaa tatgtgaagaaccatcgactatatttcctgtctacttctctctgctcaagcagcaatcaa agccatgccttgaaaagagaaaaggagatggttgccagcctcttttgtaagcttgcagcc ttagtgagacacaggatatctctctttggtgacgaaacctctcaagttgccagctgcctc cgtgctttggctcaggctctggatgtgaggtcattgatgaagtcagcctcagagttcgtc caagcatctctgcattcattctttgaggcagctgcagctgatctggatattacagttgaa aatctgtctgtgatcctggtctctttgcctcagagttggactcagcaggccagaggagtg gccaaggttctcagctacaccacttccattcttttgcctactctcacatctctttttcag catcttggcacccaaaattatggtgtggacctcttggtggggagcatccagatgtcctgt taccggatactcagcagcctgtactcactcggcaccaatagcagcatctacatggagggg cagaggtcggcagcaggagcttgtctggcagccctgacagggactttccctgtatgcttc ctggagccttcctataatcaaaacaacccttactccatttacaacaccatgagtgctact gagagagaagacctggggctgcctgatcaggtggaggacatgtgtccccttctgccctct ctggatcaggccctggaggaggtcgaggagttggcaggtgctggtgctggagcttgccag gccccttacatccatgtcacagaggtcaccttgcccatgctgtgcagctacatgtccctc tggtggtgctggggccctgagggagaaccagacaacccaatctgcacctctgtcactcct cagcatgctagtgacctacttggccacatccttcgtattatccacaaccatgtgggtgct agcaggggtggctggatgaaacagctggcagtttttgctcagccaatcatatgcagagcc agctctgagctgttaaacagccacttcctgccgctgatggaaaagctaaggaagagggcc gaatgtgtgatgatggaggaagagcagatgaaaacagaagggcgtgatacttctgaagca gagctgcagatacaggagaagttcaccctactagtgcgagacctctatgccttctaccct cttcttatcccatttgtggactctaatcgagccagctggctcaaagagtcaaatcctgat gcagagcagctgttcagcatggtggcagaggtctttacattctgggccaaatctcacaat tttaaatgggaggagcagaacttcgtggtccaaaatgaaatcaacaacttagctttcttg gtcaataaagccaacaaatccaagtttgactatgaaaaaaggaggatgaagaggaagggg gatcgttattccatgcatacctctctcatagtagcttctgtgaagagactgctccctgtg ggactgaggctttgttttcagagcaagcacagcttaattgttttggcaaagaagggtttc tttcagatgaagactgaagatgagattcgggagaatgttttcattagcttgatgcatctc cagagccagaggcctcactgcttgaggcaggagacccaaatctctgtacacccaaagcag tgtgagaccattgctgacacccaaagggctgttgacaaggttttggaaatagctcgagtc ttgcattacctggaccaggtggaacaccatcagaaaagtaaaaaacctgcatggcacagg gttttatccaaacagaggaagcgagcggtggtggcctgcctgaggatggctcctctctac aacttgcccaggcacagagctgtcaacctgtttctccaaggctacaataaatcctggata tctgctgaggaccacagctttgaggagaagcttgttgaggatttagctgtgagtgaaaat aggggaggagtgatggagctgtgtggaggcgagacagaggaagaaaaggatgtggaggac agtgccaaaccaatcgatcccctcctacaactcattacactcttcagtcgaagcgccctg acagaaaggagtaagcttgggaatgacggtctttatacatcctatgctactatcatggca aagagctgccagagagaagctgctgccgctaaagaacaggagcctgaaagctttgaagag aaggagatggagaaacagaggctgctctaccagcaggccaggctgcatcatcgaggagct tctgagatggtcctgcaaatcatcagtgcaagcaaaggagccatggggtgcatgattgcc cccacattgaagcttggcattgctattctgaatggtgggaatgctgctgtccaacagaaa atgctggattacctgagagagaagcgagatgtttgcttctttcagagcatggctggactc atgctgtcatgcagtgttctggatctcaatgcatttgagaggcagaacaaagctgaagga ttaggcatggccatggatgagagctcaggagagaaggtgatgcctgacaaagacataact tgtgacctgtttcgttttttacaactgctctgcgaaggacacaactcagatttccagaat tatttaagaacacagacaggcaacaacaccactgtcaacatcatcatatccactgtggat tatttactgagagtgcaggaatcaatcagcgacttttactggtacttttcagggaaagat gtgattgatgaacacggccaacagaacttttccaaggccattgatgtggctaaacaagtc ttcaacacactcacagagtacatacagggtccatgcactgggaaccaacaaagccttgct cacagtcgactgtgggacgcagttgtgggcttcctccatgtatttgcccatatgcagatg aagctctctcaggattcaagacaaattgagctcctgaaagagctcatggatctacagaag gacatggttgtgttcctgctttccatgttagaaggtaatgtggtaaatggaacgattgga aagcaaatggtggacatgttggtggaatcatctggaaatgtggagatgatcctgaagttt ttcgacatgttccttaaactcaaagacctcacctcctctgatgtcttcagagagtatgac cccgattgtaagggctgcatctctagaaaagacttccagaaagccatggagaattgcaag cgcttctcccaaactgagattaatttcctcctcacttgcttacagactgatgacagtgac attgtggagtatgaggactttgtggatcgcttccatgagccagccaaagacatcggcttc agcatatccgttctccttactaatttgtccgaacacatgccaaatgattcaagactaagg acattcctggaactggcagagtgtatcctgacttactttcagccctatcttggccgtata gagatccttggcagtgagaagcgcattgaacgtgtctactttgaaatcagcgaatccagc cgcacacaatgggagaaacctcaggtgaaagagtccaagagacagttcatttttgatgtg gtcaatgagggcggagagaaggagaaaatggagatgtttgtcaatttctgtgaggatacc atctttgagatgcagcttgccgctcagatatctggctctgattctgtagagaggtgtgct gaaaaagaagatagggaagaagaaggtcatgacagcaaagggatgtttttcatttgtcat tggataatattgctgacatctgttctttcagtcaaaactctgaaatcactgatgaagatg accctgaaggatatcctaatgtcagccattttcttcctcagagtcattgttatggctcag gcccggtgtattcatatcctggttcgcagcttcttatatttgctatatatagctttcatc agtggtgggctcatagagggagccaaaaggatgaaaatatctgacttgctgggtgggatc ccagaaccgactcttgatgaggtcatggaagtgccaagcggtgtggatcggctgaggaag tactctgccagtttgtcttcccagagagaattgagggagattgggcaggagacagctgtg acctccctgagggatgtggatgtactgtcagacatatttggtctcagagtgaagaaagag gggggtcaatacaggcttataacacaagacctcactgccagtctgactgacctgttcaac acttcctccagaacaatttccacccctgatttctccaagaagcaccaggggacgcttaag gctcacaccacctcagaggaaaaaacagaagatgaggaaatactcctcacaaaaggaaaa gaatctgaaaatgaaacaggagttgaggaatcagaggcaatatcaagatccaagaaatgc cccaacaagtcagaggaaaaagagagccaacgttctgcattctgggagatgataagcact tacaacaagaatctgctgagttactttgcaaggaatttttataacatgcgtttgctggct ctgtttgttgcctttgcaatcaatttcatcctcctcttctacaaggtgagtgttcttgtc gagtctttgcctgcatcacaagatgaggattacagagaggaactgaactctactgcaaaa gacgataacaagggcagagtctattttgtactggaggagagcagaggatacatggagcca tcactccatttcctggctgtagcacatacaatcatctccttctgttgtattattggttac tactgcctcaaggtaccactggtaatcttcaaacgtgagaaggaagtggcacgaagtctg gagtttgacgggctgtatgtgacagagcaaccgcctgaggaggacatcaaagggcaatgg gaccgactggtcattaacacaccatcatttccaagtaattactgggataaatttgtgaag aggaaggtgatggataagtacggtgacttctatggctgtgagaagatcagtgagctcctg ggtctggaccaagccgctttagacttcagctctgagagaagagaaagaaagaggctcaag agagactctgcctggagtgctctatttaactccactgacgtgaagtatcaggtctggaaa ctgggagttgtgttcactgataattccttcttatatttggcctggtacatggccatgtca gtcttgggtcattataacaacttcttctttgcggcccaccttttggacattgcaatgggc tttaagacgcttcgcaccatcctttcttctgtcacacacaatgggaaacagctggtcctg actgtcggcctgttggcggttgtcgtgtatctatatactgttgtggccttcaacttcttc aggaagttctacaccaagagtgatgatgatgacaactgggacatgaagtgcaatgacatg cttacttgctacatgttccacatgtatgtgggagtgcgtgccggcgggggcattggagac gagattgaggaccctgctggagatgagtttgaagtggaacgcatcgtcttcgacatcaca tttttcttctttgtcatcgtcatcctcctagccatcatccagggtctgataattgatgcc tttggtgagctgcgtgatcagcaggagcaggtgaaagaggatatggagactaaatgtttt atatgtggaataggaagtgaatactttgataaagtcccacatggctttgagactcacact ctccaggaacacaacctttccaactatctattttttctgatgtaccttattaataaggat gaaactgaacatacggggcaggaatcctatgtgtggaaaatgtaccaggagcgttcctgg gaattctttcctgtgggagactgtttccgtaagcaatacgaggatcaactgggatga

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