Cheilinus undulatus (humphead wrasse): 121528293 Help Entry 121528293         CDS       T07473                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism cud  Cheilinus undulatus (humphead wrasse) Pathway cud04020   Calcium signaling pathway cud04260   Cardiac muscle contraction cud04261   Adrenergic signaling in cardiomyocytes cud04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cud00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121528293 (ryr2a)    04020 Calcium signaling pathway     121528293 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     121528293 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     121528293 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cud04040]     121528293 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:cud04990]     121528293 (ryr2a) Ion channels [BR:cud04040]  Voltage-gated cation channels   Ryanodine receptor    121528293 (ryr2a) Domain-containing proteins not elsewhere classified [BR:cud04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    121528293 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  121528293 NCBI-ProteinID:  XP_041671593 LinkDB All DBs Position 20:2956189..3119670 Genome browser AA seq 4971 aa AA seqDB search MSDGGEGEDEIQFLRTDDEVVLQCSATLHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEDRNEGTAQGGSHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQDDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNSSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSLLEDK SLQLLDKEQADVKSTAFCFRSSKEKCDPGVKKEVDGMGVPDIKYGDSVCYIQHVNTCLWL TYQTVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNLFIRG LDSLRKKGRGSTPDLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNRQNLFQEE GMISLVLECIDRLHVYSSAAHFTEAAGREAGDTWSSILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLSNHVSSMRPNIFLGVSDGSAQYRK WYYELIVDQAQPFVTAEATHLRVGWANTSGYAPFPSGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVSSPNQHLLKAEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVA SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEPCQDQTGARDLLGPTIT LSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRDDNKRQHP CLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLSDEHAVEKVKSLKLSHTYELSSGY KPAPLDLSHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYT LLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAQCDPSNMSAERFRIFRAEKTYSVN TGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAWQ TGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFDAGEGFIPVCSLGVCQVGRMNF GKDVSSLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPLHQHIDVTRIDGTV ESCPCLRVTQRSFGSQNSHNEITFYRLSMPIECAESFNRSPHDGVFSPKRELEDFETVSD FEVLMKTPHGPNGPDKDEFNNHKDYNQEKPSKLKHRFLLKKNKPDNSCPTSTRLSEEVMA EDREEYEFLMNASTHYYSVRIFPGQEPSSVWVGWVTSDFHQYDPGFELHKVRTVTVTLGD EKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTHGLLTFTANGKELSTYY QVEPSTKLFPAVFAKATSPNVFQFELGRVKNVMPLSAGLFKSEKKNPVPQCPPRLHVQFL TPVLWSRVPNHFLKVSSSRVSDRLGWLVQCNEPLQFMSLHIPEENRCVDILELSEQSDLL KFHYHTLRLYSAICALGNNRVAHALCSHVDESQLLQAIQNKYMPGLLRAGYYDLLIDIHL SSYATARLMMNSEYIVPMTEETKSITLFPDQDKKHGLPGIGLSTSLRPRMHFTSPSFVSG VAPSHRNHSNNGSFSTDCFQYSPEFPLDVLKVKTIEMLTEAVREGSMHVRDPVGGSTEFL FVPLIKLFYTMLIMGVFQNGDLKNILRLIEPSVFSEKGKEKDNGHGQQEALKEHNGGGRG EDGGRSMPKEGLLEMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSEDFVACLQDNQR FRYNEVMLALNMSAALTARKTKEFRSPPQEQINMLLNFKDNKQDCPCPEYIREQLLDFHE DLMRHCGIELDEERAMGGDNDFTIRGRLMSLVEKVSYLKSKMADLPAEKKHRKPSTLQQL ISDTMVRWAQESVIEDPDLVRAMFVLLHRQYDGIGGQVQALPKTYTINSVSIEDTITLLA ALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSG GDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLD VAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVHKGYPDIGWNPVEGERYLDF LRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEDAIKISQDSSRDG PSPSSESSKTLSDITEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRI RAILRSLIPIEDLVGVISIPFSMPSLGTDGHVVEPDMSAGFCPDHKAAMVLFLDRVYGIE DQNFLLHLLEVGFLPDLRAAASLDTVSLSATDMALALNRYLCTAVLPLLTKCAPLFAGTE PFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPLL NEHTKMPLKLLTNHYERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGIFDALSHKKYDQ ELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTANVCVPEKLDY FITRYAEHIHEKWSIEKFSSGWSFGETLCEISKSHPLLKPYKGLYEKDKESYCVPVREAL KTMLSWGWSIERIREGDPANLHNKSRRISQASQQLSFDGGPAFSPRPIDMSNVTLSRDMQ SMAELLAENYHNIWARKKKSELEAKGGGNHPLLVPYDTLTAKEKSKDRERAQDILKFLQI NGYTVSRGVKCHELDTPAIEKRFAYTFLQQLITYVDQARQHMMEFDLGTRQKGEKIPHEQ QIKFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRIF LALFHGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSFFVSAAEDLEQTQENLKQ GQFTHSRDQPRGVTQIINYTTFALLPVLSSLFEHIGLHGFGEDLILDDVQVSCYRILNSL YLLGTNKSIYVERQRPALGKCLAAFSAAFPVAFLEPHMNKFNSFSIYNNRTHNDLKALGL PEQVEDVCPHIPNLEKSLEEIMELAESGMRYNQMPHIMEVVLPMLCSYMSHWWEHGAESY LDRCDTCCTSVTSDHMNSLLGNILKIIYNNLGVDEGTWMKRLAVFSQPIISKAKPELLQT HFLPLMDKLKKKAAVVLLDEEQSRAEGRGEMSETELLIMDQFTVLVRDLYAFYPLLIRFV DYNRARWLKESSPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKC KMSKGMVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEHELIGLAKNRFN QKDTEEEVREIIRNNLHLQGKLEDPAIRWQMALYRDLPNHQEDSTDPQRTIDRVLDIAHV LFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKLWI EAEEHYFEDKLIEDLAKPGDEEACEEEEGTKHIDPLHQLIQLFSRTALTEKCKLDEDNLY MAYADIMGKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKG EMGLMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFE RQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTG NNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEY IQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLL SMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVI SKRDFHKAMESHKHYTQSETDFLLSCAETDENELLDYEEFVKRFHEPAKDIGFNVAVLLT NLSEHMPHDTRLQTFLELADSVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKP QVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERLANKEESEREK PDEESPDMGFFSITTVRMALLALRYNVMMLIKVLSMKSVKKQMKKMKNMTLKDLLTTLMA FYWSVLLALLHMAFSVARGFCRIFYNTFMGGNLVEGAKTIKVSELLANMPDPTQDEVRGE GEEREKRPSPQEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNASLTELLNSP VPSPTPPAPPTAASSTAPPPELRRRHQSKSSSSEEKEVTADTQTEPEKTEVVEKEEKQQK KEKLKPKVRRHHMSKSDEPDLQESAVLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAIN FILLFYKVSTSSSSLVEEKQVVLSNSQSESSVQWEALGGEGAELKEEVQEEAGEVLKPVT VRFVLEESSGYMEPMLRILAILHTVIAFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLY ITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGLDKAA LDFSDSHKKRKPRRDSSLTAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNN FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKG EDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA NYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14916 nt NT seq  +upstreamnt  +downstreamnt atgtctgacggaggagaaggagaggacgagatccagttcctgcggactgatgatgaggtg gtcctgcagtgttcggccactctccataaagaacaacagaaactctgtttggctgctgaa ggcttcgggaacagactctgcttcctcgagtccatctccaactccaagaatgttcctcct gatctgtccatctgcaccttcgtgttggagcagagtctgtctgtacgagcgctgcaggag atgttggccaacacggaggacaggaatgaggggacggcgcagggtggcagccatcgaacg ttactgtacggacacgccgtgctgctcagacactcctacagcgggatgtacctgtgctgt ctctccacgtctcgctcgtccacagacaaactggcctttgatgtcggactgcaggacgac accacaggcgaggcgtgctggtggaccatccatccggcatccaagcagcgatcagaagga gagaaggtcagagtgggagacgacctcatcctggtcagcgtctcctcggagagatacctg cacctgtcgtatggaaacagctctctccatgtggatgcagccttccagcagactctgtgg agcgtcgctcccatctgttcaggaagtgaggtggctcaagggttcctaattggaggagac gtcctgcgcctcctccacggtcacatggatgagtgtctgactgttccttcaggagaacac ggggatgagcagaggaggacagttcactatgagggcggagctgtgtcgagtcacgccaga tccctgtggaggctggagactctgagggtggtgtggagtgggagtcacatccgctggggt cagcccttcagactgcgtcatgtgaccacgggaaaatacctgagtctgttagaggacaaa tctctgcagctactggacaaagagcaagctgacgtcaaatctacagcgttctgcttcagg tcttctaaggaaaagtgtgaccccggtgtaaagaaggaagtggacgggatgggtgttcct gacattaaatatggagattctgtgtgttacatacaacacgtcaacacctgtctgtggctc acctatcagaccgtagatgccaaatgtgctcgcatgggcggagtccagaggaaggccatc atgcaccacgagggtcacatggatgacgggctgactctgtctcgatctcaacacgaggag agtcggaccgcccgagtcatcaggagtactgtgttcctgtttaacctgttcatcaggggg ctggactctctgaggaaaaaggggcggggctccactcctgatttaccaatagattcagtc agcctgagcctgcaggatctgattggatacttccagccacctggagatcacctggagcat gaagacaagcagaaccgcctgagagcgctgaagaaccggcagaaccttttccaagaggag ggaatgatcagcctggtgctggagtgtattgatcgtctgcacgtttacagcagcgctgct cattttactgaagctgcaggacgagaagcaggagacacctggagctccatcctcaactct ctgtaccagctgctggcggctctgatcagaggaaacaggaagaactgcgctcagttctca ggatcgttggattggttgatcagccgactggagagactggaggcttcctcaggtatcctg gaggttcttcactgtgtcctggtggagagtcctgaagctctgaacatcatcaaagaggga cacatcaagtccatcatctcactgctggacaaacatggacgcaaccacaaggtcttagac gtgctgtgctctctgtgtgtctgtcatggcgttgctgttcgctcaaaccaacacctgatc tgtgataacctgctgccaggacgagacctgctgctccagaccaggctgagcaaccacgta agcagcatgcgccccaacatctttctgggggtcagcgatggttccgcccagtacaggaag tggtactacgagctgattgtagatcaggcccagccgttcgtcactgcagaggcgacacac ctcagagtgggctgggccaacaccagcggctacgccccctttcccagtggaggggagggg tgggggggtaacggtgtgggggatgacctatactcgtatggcttcgatggactccacctg tggtcaggctgcatcgcccgcaccgtcagctctcctaaccagcacctcctgaaggcggag gatgtggtcagctgctgtctggatctgagcgtgcccagtatctccttcaggatcaacgga cagccggtacagggcatgtttgagaacttcaactctgacggactcttcttccctgtggcc agcttctctgcaggagtcaaggttcgtttcctcctggggggtcgtcatggagagtttaag ttcctcccccctccaggttacgctccgtgttatgaggccgtgttacccagagagaagctg aagctggagccgtgtcaggaccagacgggagccagagacctgctggggcccaccatcact ctgagccaggccgcattcaccccgacaccagtggacaccagccagatcgttcttcctcct cacctggagagaatcagggagaaactagctgaaaacatccatgaactctgggtgatgaac aagattgagctgggctggacctacggagctgtgagggatgataacaagaggcagcacccg tgccttgtggagttctccaaacttcctgagcaggagcggagctacaacctgcagatgtcc ttggagacgttaaagacgctgctggctctgggttgccatgttggcctttctgatgagcac gctgtggagaaggtcaagagtctgaaactgtcccatacctatgaattatccagtggttat aaacctgctcctctggacctgagtcacatcaaactgacctccacccaggaagccatggtg gacaaactggctgagaacgctcacaacgtgtgggcgagagaccgcatccgccagggctgg acttacggcatccagcaggatgtaaagaaccgtaggaaccctcgcctggtcccctacact ctgctggatgagaggaccaaaaagtccaacaaggacagtctgagagaggctgtcaggact ctgctgggctatgggtacaacctagaggctccagaccaggaccacgctcagtgcgacccc agtaacatgtccgccgaacggttcaggatcttcagagcagagaagacatacagcgtgaac acagggaagtggtactttgagctggaggtgttaacagctggagaaatgagggtgggctgg gcaagaccggggtgtctcccagaccaggagctgggctctgatgatcaggctttcgttttt gatgggttcaaggtccagcgctggcaccagggtaatgaacactttggtcgggcgtggcaa acgggggacgtggtgggctgcatggtagacctgaacgaacacaccatgatgttcacgctg aacggggaggtgctgctggatgactctgggtctgagctggcattcaaagactttgatgct ggtgaaggtttcatcccggtctgcagtctgggggtctgtcaggtggggaggatgaacttc ggtaaagacgtcagctctctgaagtatttcaccatctgtggccttcaggagggatacgaa ccgttcgccgtcaacatgaaccgagacgtcaccatgtggctcagcaagaggctgccccag tttgtccctgtgccccccctccaccagcacatcgatgtcaccaggatcgacgggacggtg gagtcgtgtccgtgtctaagggtcacccagaggtcattcggctctcagaacagtcacaat gaaatcaccttctaccgactgagcatgcctatagagtgcgcagaatcctttaacagatcg ccacacgatggcgtcttctctccaaagagggagctggaggactttgagacagtgtcagac tttgaggttttgatgaagactccccacggtcccaatggtcctgacaaagacgagttcaac aaccacaaagattacaaccaggagaaaccgtccaagctgaaacaccggttcttgctgaag aaaaacaaaccagacaacagctgtcccacatcgactcgtctgtctgaggaggtgatggct gaagacagagaggagtatgagtttctcatgaacgcctcaacgcattactactcggtgagg atcttccccggtcaggagcccagcagtgtgtgggtgggttgggtcacctcagactttcat cagtacgaccccggctttgagcttcacaaggtccgaacggtgaccgtaaccctgggagac gagaagggcaaagttcacgagagtattaaacgcagtaattgctacatggtgtgggctgga gagagcagcagtccgggtcagggcaggaacaacaacggtctggagattggctgtttggtt gataccacacacggtctgctgaccttcaccgccaacgggaaagagcttagcacgtactac caggtggagcccagcaccaaactgttccctgcagtgttcgccaaagccaccagtccaaac gtcttccagtttgaactgggaagagtgaagaatgtgatgccgctctcagccggtctcttt aagagtgagaagaagaacccggttcctcagtgtcctccgcgtcttcacgtccagttcctc accccggtcttatggagtcgagtaccaaatcacttcctgaaggtttcttcatccagagtg agtgatagactgggctggttggttcagtgtaacgaacctctgcagttcatgtctctgcac atcccagaggagaacaggtgtgtagacatcctggagctgtcggagcagagtgacctgttg aagtttcactaccacacgctcagactctactcagccatctgtgctctgggaaataaccga gtggctcacgctctctgctctcacgtggacgaatcgcaactgctgcaggccatccagaac aaatacatgccaggccttctacgggcgggttactacgacctcctgatcgacatccacctg agcagctacgccacggcgcgcctcatgatgaatagcgagtacatcgtccccatgacggag gagaccaagagcatcacactgttcccagaccaggacaagaagcacggcctgccaggcatt ggcctcagcacctcgctccgacccagaatgcatttcacctcacccagcttcgtctccggg gttgccccatctcaccgtaaccatagcaacaatggctctttttccactgactgtttccag tacagccctgagttcccgctagacgtgctcaaggtgaagaccatcgagatgctgacggag gcggtgagggagggcagtatgcacgtcagagatcctgtagggggcagcactgagttcctg ttcgtacctctcattaaactcttctacaccatgctgatcatgggcgtgttccagaacggg gacctgaagaacatcctgaggctgatcgagccctccgtcttctctgagaaagggaaggag aaggacaatggacacggccagcaggaggcgctaaaggagcacaacgggggagggaggggg gaggacggggggaggagcatgcccaaagaaggactactggagatgaaactgcctgagcct gtcaaactgcagatgtgccatgtgctccagtacctgtgcgactgtcaggtccgtcaccgg atcgaggctgtggtcgcgttctccgaagactttgtagcctgtctccaagacaaccagcgt ttccgctacaacgaggtgatgctcgctctcaacatgtctgcagcgctgaccgccaggaag actaaagagttcagatcacctccacaagaacagatcaacatgctgctgaactttaaagac aacaaacaggactgtccttgcccagaatacatccgagaacagctgctggacttccacgag gacctcatgagacactgtggaatagagctggacgaggagcgagcgatgggtggagacaat gattttaccatcagagggcggctcatgtcattggtggagaaagtgtcctacctgaagagc aagatggccgaccttcctgcagagaagaagcacaggaagcccagtacactgcagcagctg atctcagacaccatggtccgctgggctcaggagtcagtcatcgaggatccagatctggtc agagccatgtttgttctgctgcaccgacagtatgacggtatcggagggcaggtccaggct ctcccaaagacttacaccataaactcagtctccatcgaggacaccatcaccctgctggct gctctgggtcagatcaggtctctgctcagcgtcagaatgggccgagaggaggagaagctg atgatcagagggctgggtgacatcatgaacaataaggtgttctaccagcatcctaacctg atgagagctctggggatgcacgagacggtgatggaggtgatggtgaacgtgctgagtgga ggagactcaaaggagatcacgtttcctaagatggtggctaactgctgtcgcttcctgtgt tacttctgtcggatcagccgtcagaaccagaaggccatgtttgatcacctgagctacctg ctggagaacagcagtgtgggactagcctccccctccatgagaggttccacccccctggat gtggctgcagcctcagtcatggataataatgaactggctctggctctaagggagcctgac ctggagaaggtggtccagtacctggcgggctgcggtctgcagagctgtgtgatgcttgtc cataaaggttaccctgacatcggctggaacccggtggagggagagcgctacctggacttc ctgagattcgccgtcttctgtaacggtgagagtgtagaggagaacgctaatgtggtggta aggctcctgattcggcgccctgagtgcttcggccccgccctcagaggtgaaggcggagac gggctgttagcggcgatggaggacgccatcaaaatctcccaggattcttccagagatgga ccatcaccgtcatcagagagcagcaagacactcagtgacatcacagaggaggaggaggac gacaccatccacatggggaacgccatcatgaccttctacgccgctctgattgacctgctt ggacgctgcgctccagagatgcacctgatccatgcaggtaaaggtgaggccatcaggatc cgagccatcctcaggtccctgatccccatcgaggatctggttggagtcatcagtatcccg ttctccatgcccagtctgggcacagacggtcacgtggtagagcccgacatgtcagctggt ttctgtccagatcataaagccgccatggttctgttcctggaccgggtctatggcatcgag gatcagaacttcctgctgcacctgctagaagttggcttcttaccagacctgagagctgcc gcctcattggacacggtgtctctaagtgccaccgacatggccctggccctgaacaggtat ctttgtacggctgtcctccctctcctcactaaatgtgcccctctgttcgctgggaccgag ccgttcgcctccttgatcgactccctgctccacaccgtgtaccgcctgtcgaaaggatgc tgcctcaccaaggcccagagggacgccatcgaggagtgtctgctcgctgtctgtgggaag ctgcgtccgtccatgatgcagcatctcctgcggaggttggtgtttgacgtccctctgctc aacgaacacaccaagatgcctttaaagctgctgaccaatcactatgagcgttgttggaag tattactgtctggctggaggctgggggaatttcggagcagcgtctgatgaggagcttcac ctgtccaggaaactcttctgggggatctttgatgctctgtcacacaagaagtacgatcag gagctgtttaaactggctctgccgtgtctgagcgccgtggccggagctcttcctccagac tacatggagtcaaactacatggccatgatggagaaacagtcgtctatggactcagagggg aacttcacaccgcagccagctgacactgcaaatgtttgtgtcccagagaaactggattat tttattacccgatacgctgaacacatccacgagaagtggagcatcgagaagttttccagc ggctggtcgtttggagagacgctctgtgagatatcgaagagtcaccctctactaaagcct tacaaaggactgtatgaaaaggataaggagtcgtactgcgttcctgtaagagaggcgtta aagaccatgctgtcatggggatggagcatcgagaggatcagagaaggagaccctgctaac ctgcacaataaatccaggaggatctcacaggccagccagcagctgtcgtttgacggaggc ccggcgtttagccccagacccatcgacatgagcaacgtgacgctctccagagacatgcag tccatggctgagctgctggctgagaactaccacaacatctgggccaggaagaagaagagt gagctggaggctaaaggaggaggaaaccatcctctgctggttccttacgacactctaaca gccaaagagaaatctaaagacagagagagagctcaggacatcctcaagtttctgcagatc aatggatacaccgtttccagaggtgttaaatgtcatgagttggacaccccggccatagag aagcgttttgcctacaccttcctgcagcagctcatcacctacgtggaccaggctcgccaa cacatgatggagtttgatctgggaacacggcagaagggagagaagattcctcatgaacag cagattaaattcttcggaaaggtggttctcccactggtggatcagtactttaaaaaccac cggctctacttcctgtctacagccatccatccaatcagcagtggaggccacgcctccaac aaggagaaggagatggtgaccagtctgttctgtaaactgggagttctggtcaggatcttt ttggctttgtttcatggtaacaatgccacctccattgtgaactgtctacagatcctggga cagagtctggatgccaggacagtaatgaagaccggtctggagtcggtgaaggcagctctc cgctcgttttttgtcagtgcggcggaggacttggagcagactcaggagaacctgaagcag ggtcagttcactcacagtcgagatcagcctcgaggagtcactcagatcatcaactacacc accttcgccctactgcctgtcctctcctcactatttgaacatatcggtctgcacggcttt ggagaggatctcatacttgatgacgtccaggtctcctgctacaggatcctcaatagtctc tacctgctgggaacaaacaagagcatctatgtggagagacagcgtccagcgttagggaaa tgcctggcggcattctctgcagcgtttcctgtagctttcctggagccgcacatgaacaag ttcaacagtttctcaatttacaacaacagaacacacaacgacctgaaagctctgggtcta cctgagcaggtagaagacgtctgtcctcacatcccaaacctggagaaatctctggaggag atcatggagctggcagagtctggcatgagatacaaccagatgcctcacatcatggaggtg gtgctgcccatgctctgcagctacatgtctcactggtgggaacacggagcagagagttac ctggacaggtgtgatacctgctgtacgtcggtcacctctgatcacatgaactctctgctg gggaacatcctgaagattatctacaataacctgggagtcgatgagggcacctggatgaag agactggctgtgttctctcagccaatcatcagtaaagccaaacctgagctgttacagact catttcctgcctctaatggacaaactgaagaagaaagcagcagtggtcttattggatgag gagcagagtcgggccgaggggcgtggagagatgtcagagacggagctcctcatcatggat cagttcactgtcctggtcagagatctctacgccttctaccctctgctcatacgattcgtc gactacaacagagctcgctggctgaaggagtccagtcctgaggccgaggaactgttcagg atggtggctgaggtcttcatcttctgggcaaagtctcacaacttcaagcgtgaggagcag aactttgtggtccagaatgagatcaacaacatgtcgttcctcatcacagacaccaagtgt aaaatgtccaagggcatggtttcagaccaggagaggaagaagatgaagaggaagggagat cggtactccatgcagaccagtctgattgtggccactctgaagcgtctgctacctgtgggt ctgaacatctgcgcacctggagaacacgagctgatcggcctcgccaaaaaccgatttaac cagaaagacacagaggaagaagtccgagagatcatcaggaacaacctccatctccagggg aagctggaggacccggcgatccgttggcagatggcactgtacagagatctaccaaaccac caggaggactcgactgatcctcagaggaccatagaccgagtgctggacatcgctcacgtc ctctttcacctggaccaggttgaacaccctcagcgcagtaagaaggcagtgtggcacaaa cttctgtcgaaacagaggaagagagcagtggtggcttgtttcaggatggctcctctctac aacctgcccagacaccgagcggtgaatctgttcctgcagggctatgagaagctgtggatc gaggcagaggaacactactttgaggacaagctgatcgaagaccttgctaaaccaggggac gaggaggcgtgtgaggaagaggaggggacaaagcacatcgatcctctacatcaactcatc cagctgttcagccgaactgccctcaccgagaaatgtaaactggatgaagataacctgtac atggcgtacgctgacattatgggaaagagctgccatgatgaggaggacgaggatggagag gaagtcaagagctttgaggagaaggagatggagaagcagaagcttttataccagcaggct cgtctgcatgaccgaggagcagcagagatggttctacagaccattagcgcaagcaaaggt gagatgggtctgatggtggcatcaacgctgaagctaggcatcgcaatcctgaatggagga aactccacagtacagcagaaaatgttggactacctgaaggataagaaggacgttggcttc tttcagagtcttgccggtctcatgcagtcctgcagcgttctggacctgaatgcgtttgag cgtcagaacaaggctgaaggtctgggcatggtgacagaggagggatcagtcatcactcat gagcgtggtgagaaggtcatgcaggatgatgagttcacctgtgaccttttccgcttcctg cagctgctctgtgaaggacacaactcagactttcagaactacctgaggactcagacagga aacaacacaacagtgaacatcatcatctccacagtggactatctcctcagagtgcaggag tctatcagtgatttttactggtattattccggtaaggacgtcattgatgagcagggtcag aggaatttctccaaggccatcaacgtggctaaacaggtgtttaacactctgacggagtac atccagggtccatgcacagggaaccagcagtctttggctcacagtcgtctttgggacgcc gtggtcggttttctccacgtttttgctcatatgcagatgaaactctcacaggactcgagt cagatcgaattactgaaggaactgatggacctgcagaaggacatggtggttatgctgctc tccatgctggagggtaacgtggtgaatgggacgattgggaagcagatggtggacatgttg gtggagtcgtccaacaacgtggagatgatcctgaagttcttcgacatgttcctcaaactg aaggacttgacatcttctgatgccttcaaggaatatgacccagacgggaaaggggtcatc tcaaagagggacttccacaaagccatggagagccacaaacactacacccaatcagaaacc gacttcctgctgtcctgtgccgagactgacgagaacgagctgcttgactacgaagagttc gttaagaggtttcatgagccagccaaggacattggctttaacgtggcggttctgctgaca aacctgtcggagcacatgcctcatgacactcgtctgcagacgtttctggagctggccgac agcgtcctgaattactttcagccctaccttggacgcatcgagatcatgggcagcgccaaa cgcatcgagagggtttactttgagatcagcgagtcaagtcggacacagtgggagaaacct caggttaaggaatcaaagcgtcagttcatctttgacgttgtgaatgaaggaggagagaag gagaagatggagctctttgtgaacttctgtgaggacaccatctttgagatgcagctggca gctcagatgtcagacgctggcgagcgattggccaacaaggaggagagtgagcgagagaaa ccagacgaggagagtccagatatgggcttcttctccatcaccaccgtccgcatggcactg ctagcactacgctacaatgtcatgatgctcatcaaggttctgtcaatgaagagtgtgaag aagcagatgaagaagatgaagaacatgacgctgaaggacctgctgaccacgctgatggct ttctattggtctgttctgctggctctgctccacatggccttcagcgtggcccgaggtttc tgcaggatcttctacaacaccttcatgggtgggaacctggtggagggggccaagaccatc aaggtgtccgagctgctggccaacatgcctgaccccacccaggacgaggttaggggtgag ggagaggagcgtgaaaagaggccgtcccctcaagaggacctggccgacctggcggtgaac accagcgagacggagctgctgtcagacatctttggactggacctaaggagggaggggggc cagtacaagatcaccccccacaaccccaacgccagcctcactgagctgctcaactcccct gtaccctctcccacacctccagccccacccactgcggcctcctccacagcgccccctcct gagctcagacggaggcatcagtccaaaagttcttccagtgaggagaaggaggtgacagca gacacgcaaacggaacctgaaaaaacagaagttgtagagaaagaggagaaacagcagaag aaggagaagctgaagcccaaagtgaggaggcatcacatgtcaaagtctgatgagcccgac ctgcaggagtcagccgtcctcaagaagatcatcgcctaccagaggaagctgctgaactac tttgctagaaacttctacaacatgaggatgctcgctctttttgtggccttcgccatcaac ttcattctcctcttctataaggtgtccacttcctcatcgtccttggtggaggagaagcag gttgtgttgagcaacagccaatcagaaagcagtgttcagtgggaggctctgggaggagaa ggggcagagctaaaggaggaggttcaggaagaggcaggggaggtactgaagccagtaaca gtgcgttttgtcctagaggagagcagcggctacatggagccgatgctacgaatcctcgcc atccttcacaccgtcatcgccttcttctgcatcattggatactactgccttaaagttcct ctggtcatctttaagagagagaaggaagtggcgaggaaactggagtttgacggtttgtac atcacagagcaaccatcagaggacgacatcaagggacagtgggacagactggtcatcaac acacaatctttccccaataactactgggataagtttgtgaagaggaaggtgatggataaa tatggagagttttatggacatgatcggatcagcgagctgctggggttggataaagctgct ctggacttcagcgactctcataagaagaggaaacctcgcagagacagctcgctgactgcc gtgctgaactccattgatgtcaaatatcagatctggaagctcggagtcgtttttaccgac aacagcttcctgtacctagcctggtatatgaccatgtccatcctcggtcactacaacaac ttcttctttgctgctcacctgctcgacatcgccatgggtttcaagactctgaggaccatc ctgtcatctgtcacacacaacggcaaacagctggtcctgactgtgggtctgttggcggtg gttgtgtatctgtacacggtggtggcctttaacttctttagaaagttctacaacaaagga gaggacggagagctgcccgacatgaagtgtgacgacatgctgacatgttacatgttccac atgtatgtgggggtgagggcggggggaggtatcggggaccagatcgaggatcctgcagga gatgagtatgagatctaccggatcatctttgacatcaccttcttcttctttgtcatcgtc atcctgctggctatcatacaaggtctgatcatcgatgcgtttggagaactgagagatcag caggaacaagtcaaagaagacatggagaccaaatgttttatctgtgggatcggcaatgat tacttcgacaccgttcctcatggctttgagacgcacacgctgcaggagcacaacttagcc aactacctattctttgttatgtatctaatcaacaaagatgaaactgagcacactggacag gaatcatacgtgtggaaaatgtaccaggagcgttgttgggagtttttccccgctggcgac tgcttccggaaacaatatgaggatcagctgaactga

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