Charadrius vociferus (killdeer): 104294087 Help Entry 104294087         CDS       T08577                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism cvf  Charadrius vociferus (killdeer) Pathway cvf04020   Calcium signaling pathway cvf04260   Cardiac muscle contraction cvf04261   Adrenergic signaling in cardiomyocytes cvf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cvf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     104294087 (RYR2)    04020 Calcium signaling pathway     104294087 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     104294087 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     104294087 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cvf04040]     104294087 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:cvf04990]     104294087 (RYR2) Ion channels [BR:cvf04040]  Voltage-gated cation channels   Ryanodine receptor    104294087 (RYR2) Domain-containing proteins not elsewhere classified [BR:cvf04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    104294087 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  104294087 NCBI-ProteinID:  XP_009891954 LinkDB All DBs Position Unknown AA seq 4983 aa AA seqDB search MCCWQSRELGQLFWEKTGFTARHTLFFWSCVHWHKWDDEVVLQCTATVHKEQQKLCLAAE GFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKF MMKSAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWW TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSG SEVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETL RVAWSGSHIRWGQPFRLRHITTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDI GTRKEVDGMGAPEIKYGDSICFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMD DGLTLSRSQNEESRTARVIRSTVFLFNRFIRGLDALSKKVKSSTVDLPIESVSLSLQDLI GYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGK EAGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLV ESPEALNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGR DLLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWAST EGYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLD LSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYA PCFEAVLPKEKLKVEHSREYKQDRSYTRDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLER IREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETL KTLLALGCHVGIADEHAEEKVKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLA ENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGY GYNLEAPDQDHAMRLDVCSGIMEKFRIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRP GCLPDQELGSDEEAFVFDGFKAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGE ILLDDSGSELAFKDFEVGDGFLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFA VNTNRDITIWLSKRLPQFLPVPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVM FFRLSMPIECAEVFSRSAAGGLPGSGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTE REKDATKPELNNHKDYVQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYL MQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESI KRSNCYMVCAGESMSPGQGRNNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLF PAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVP NHFLKVDVSRISERQGWMIQCLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRL YSAVCALGNNRVAHAMCSHVDESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLM MNNEFIVPMTDETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSP EFPLEILKTKTIEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLK HILQLIEPRVFKEAMSQEDDIDFSEKELSSDELKSEEGEEETRGDQVPKEGLLQMKLPEP VKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARK TKEFRSPPQEQINMLLNFKDDKNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNS DLTIRGRLLYLMEKVTYLKKKQAEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELV RAMFVLLHRQYDGIGGLVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKL MIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLC YFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPD LEKVVRYLAGCGLQSCPLLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVV RLLIRRPECFGPALRGEGGNGLLAAMEEAIQISEDPTRDGPSPSNGSSKTLEMEEQEDDT IHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFH MPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAAS LDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSL TKAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYY CLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYM ESNYVNMMEKQSSMDSDGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGW TYGETYSESAKVQPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALY NRTRRISQTSQISVDTAHGYTPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELE AKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRF AYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLY FLSAASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLD ARTVMKTGLESVKMALRAFLDNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVAL LPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAA FSGAFPVAFLETHLNKHNIYSIYNTKNARDRAVLNLPTSVEEVCPNIPSLVKLMEEIVEL AESGIRYTQMPHIMEVILPMLCSYMSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNIL KIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLR AEGRGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAE VFIYWSKSHNFKREEQNFVVQNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSM QTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDTIRSNLHLQGKLED PAIRWQMALYKDLPNRTEDSSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPE EDESLKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEDDDDSEEEVKS FEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAI LXXXXXXXQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS GEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESI SDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVV GFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVE SSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEF LLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESV LNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEK MELFVNFCEDTIFEMQLAAQISESDLNGRSANKEENEKDKPEEQDPRMGFFSLVTMKSAL VALKYNFMTLMKMLSVKSLKKQMKKVKKMTMKDMVMALFSSYWSILMGLLHFACSVIRGF FRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPTEAALPTEDLTD LTTLSDESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLPPMPEVQEKVQEQV KEDEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVQESAFWKKI IAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEQEVPVVSAGESTKL NSLESDNQKVIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREK EVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRD RISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAW YMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRI IFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHG FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYED QLN NT seq 14952 nt NT seq  +upstreamnt  +downstreamnt atgtgctgctggcagagccgagagcttgggcagcttttctgggagaagactggttttaca gccagacatactctgttcttctggagctgtgtgcattggcataaatgggatgatgaagtg gttctgcagtgcactgcaacggttcacaaggagcaacagaaattgtgtcttgctgcagaa ggatttggcaacaggctttgctttttggaatctacatcaaattctaagaatgttccacct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgggccctccaggaa atgctggctaacacagaagaaaaggcagaagggctagttgatgtggaaaaatggaaattt atgatgaagtctgcacaaggtggcggtcatcgaacactactctatgggcatgcaatcctg ctgcgccattcctacagcggcatgtatctatgctgcctctctacatctcgatcttcaatg gataagctggcatttgatgtaggattgcaagaggacacaacaggtgaggcatgctggtgg accatccatcctgcttccaagcaacgatcagaaggagaaaaagtgcgtgttggagatgat cttattttagtcagtgtctcttcagaaaggtatttgcatctctcttatggcaatggtagc ttacatgttgatgcagccttccagcaaacgctctggagtgtagctccaatcagttcagga agtgaagttgcccaaggatatctgataggaggggatgttctgagattattgcatggtcac atggacgaatgtttgacagtcccttcaggtgaacacggagaagaacaaagaagaactgtc cattatgaaggtggtgccgtgtcaattcatgctcgttccctttggcgactagagactcta agagttgcgtggagtggcagccacattagatggggacagccattcagactaagacatata acaacaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagacaaagag aaagcggatgtaaaatctacagcattctgttttcgatcttccaaggaaaagttggacata gggacaagaaaagaggtggatggaatgggagcccctgaaataaaatacggggattcaata tgcttcatacaacatgtagatacaggcctatggctcacataccagtccgctgatgcaaag tctgtaagaatgggttctgtgcagcggaaggcaataatgcaccatgaaggtcacatggat gatggtttaacgttgtccagatctcagaatgaagaatcccgtacagcacgtgtcatccgt agtacagtcttccttttcaacaggtttataaggggccttgatgctctcagcaagaaagtg aagtcttccactgtcgatttgcctattgagtcagtcagtctgagccttcaggacttgatt ggctactttcatccccctgatgaacatttggagcatgaagacaaacaaaacaggctccga gcactgaagaatcgccagaacctcttccaggaagagggtatgatcaaccttgttcttgaa tgtattgatcgcttgaatgtatacagcagtgcagctcattttgcagacgtagctgggaag gaagctggagaagcatggaaatctattctgaattctttgtatgaattgctagcggctctg attcgaggaaatcgtaaaaactgtgctcaattttctggatctcttgactggttgatcagc agattagaaagactggaagcctcttctggaattctagaggttttacattgtgtgttggtg gaaagcccagaagctctaaacattattaaggaaggacatattaaatcaattatctgtctt ttggacaaacatggaagaaaccataaggttttggatgttttgtgttctctctgtgtttgt catggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgccaggaaga gatctgctcttacagacacgtcttgtcaaccatgtgagcagcatgcgacccaacatcttc ttgggaattagtgaaggctctgcccaatacagaaaatggtactatgaacttatggtggac catctcgagccctttgtgaccgcagaatcaactcatctacgagtgggctgggcttcaaca gagggctactcaccatatccaggaggaggagcagaatggggaggaaatggtgttggtgat gacttgtattcctatggctttgatggtctgcatctgtggtcaggttgtgtagcacgaaca gtaaattctcccaaccaacatctcttaagaactgatgatgttattagctgctgtttggac ctgagtgcccccagcatctctttccggataaatggtcagccagttcaaggaatgtttgag aatttcaacatagatggcctcttcttcccagttgtgagcttctctgcaggaataaaggta cgtttcttgcttggaggtcgccatggagaattcaagttccttcctccacctggatatgcc ccttgctttgaagctgtcctaccgaaagagaagctgaaagtggagcatagccgagagtac aagcaggatcgtagctacacaagagacctgctgggtcccaccgtctctctgtcacaagca gctttcactcccgttcctgtagatactagccagattgttttgcctccccacctggaaagg attagagaaaaattagcagagaacatccatgaactttgggttatgaataagattgaactt ggctggcagtatggaccagttagagatgacaataaaagacaacacccatgcttagtggag ttctcaaaattgccggagcaggaaagaaattataacttgcaaatgtcacttgaaacactg aaaaccctgctggcattaggctgccatgttggaattgctgatgaacatgctgaagaaaaa gtgaaaaaaatgaaacttccaaagaactaccagttgttgagtggatataagcctgctccc atggatctgagttttatcaaactgaccccctctcaagaagctatggtggataaactagca gagaatgctcataatgtgtgggcaagggaccgtataaggcaaggctggacatacggtatc cagcaggatgtgaaaaatcgacgaaatcctcgcctggtaccttatgctcttttggatgat cggacaaagaagtcaaacaaagacagtcttcgggaagcagtccgcacccttctcggctat ggttacaacctggaagctcctgatcaagatcatgcgatgagactggatgtgtgcagtggg ataatggaaaaattcaggatcttccgtacagaaaagacttacgcagtgaaggctgggaag tggtactttgagtttgaggcagttactgcaggagacatgagagttggctggaccaggccg ggttgtctgccggatcaggaacttggctcagatgaagaagcttttgtttttgatggcttt aaggcacagcggtggcatcaaggtaatgagcattttggccgctcttggttggcaggagat gttgttggatgtatggttgacatgaatgagcacactatgatgttcaccttaaatggtgaa atcctgcttgatgactcaggttcagaacttgcattcaaagacttcgaggttggtgatgga tttctacctgtgtgcagcctgggcccatctcaagtgggaagaatgaactttggaaaagat gtcagcactctaaaatatttcactatctgtggcttacaggaagggtatgaaccctttgct gttaacacaaacagggacatcaccatttggctgagtaaaaggctccctcagtttctacca gtgccacaaaatcatgaacatattgaggtgatgagaattgatggcaccatagacagctgc ccctgcctgaaggtcacacagaagtcctttggttcacagaacagtaaaacagacgtcatg ttttttcgattaagcatgcccattgaatgtgctgaggtgttctccagatcagctgcagga gggttaccaggctctggtctttttggcccgaagaatgacttggaggattatgatgctgat tcggattttgaggttctaatgaaaactgctcatggtcatctagttcccgaccggacagaa agagaaaaagatgccacaaaaccagagttaaacaaccataaagattatgttcaagaaaag ccttcacgtcttaaacaaagatttatgctcaggaggacaaagccagattatagcacaagt cactctgcacggcttactgaggatgtgctagcagatgatagggatgactatgattatttg atgcaaacttccacgtactattattcagtgcgaatatttccgggtcaagaacctgctaat gtctgggttggctggattacatctgactttcatcagtatgacacgagctttgacttggac agagtgcgtactgtcacagtgacactgggagatgaaaaagggaaggttcatgagagtata aaacgcagcaactgctatatggtgtgcgcaggagagagcatgagccctggacaaggacgt aataataatggtctggagattggttgcttggttgatgctgccagtggcctgctgaccttc acagctaatgggaaggaactaggcacatactatcaggttgaaccaagtacaaagttattt cctgctgtatttgctcaagctacaagccccaatgttttccagtttgaattgggaagaata aagaatgtgatgccattatctgctggcttattcaagagtgaacacaaaaacccagtgtct caatgtcctccacgtctccatgttcaatttctgactcatgtgctttggagcagagtgcca aaccacttcttgaaggttgatgtgtctcggatcagtgaacgtcaaggctggatgatacag tgcctgaatcctttgcagttcatggcccttcatattcctgaagaaaacagaacaattgat attttagagctgacagaacaagaagaactgctgaaatttcactaccataccctccgatta tattcagctgtctgtgctttaggcaacaaccgagtggcccatgctatgtgtagccacgtg gatgaatctcaactcttgtatgctattgagaataaatatatgccaggattgttacgtgca ggatattatgacttactcattgacatccatctcaatacctatgcaactgccaggttaatg atgaataatgaatttatagttccaatgacagatgagaccaagagtattactttgtttcct gatgaaaacaaaaaacatggcctccctggtataggacttagcacttcgttaaggccaaga atgcagttctcctctccaagttttgtaagcattagcagtgaatgctttcagttcagtcct gaattccctcttgaaatcttaaagacgaaaactatagagatgctgactgaagctgttcag gagggcagcctccacgtcagagatccagttggaggttctaccgaatttctgtttgtccct ctcatcaaactcttctataccctcctaattatgggaatcttccacaatggggatctgaaa cacatcttgcagttgattgagcctcgggttttcaaagaagcaatgagccaggaggatgat attgatttctcagagaaggagctgagttcagatgagctcaagtcagaagaaggagaggaa gaaaccagaggggatcaagtgccaaaggaaggactccttcagatgaaacttccagaacct gttaaattacagatgtgccatctactccagtacctgtgtgattgccaagtacgacaccga atagaagccattgtagcattttcggatgattttgtggccaagcttcaagagaatcaacgc ttccggtacaatgaagtgatgcaggccttgaatatgtctgctgctctgacagctagaaaa acaaaagagtttcgatccccacctcaggagcagattaacatgctgctgaactttaaagat gataaaaatgattgtccttgccccgaagaaattcgggatcaactcttggatttccatgaa gacctaatgacacactgtggaattgaattagatgaagatggaaccttggatggaaatagt gatttaaccattaggggtcgcctcctataccttatggaaaaagttacatatctgaagaag aagcaagctgagaagccagttgatgatgatgccaagacatcctctactcttcagcagttg atttcagacactatggtacgctgggcccaggaatcagtgatagaagacccggagttagtg agggccatgtttgtattgctgcatcgccaatatgatggtattggtggcctggttcgagcc ctgccaaagacctacaccataaatagtgtgtctgtggaagacacaatcaatcttctggca tccctcggccaaatccgttccttgcttagtgtcagaatggggaaggaggaagagaaactt atgattcgtggattaggagacatcatgaataataaagtattttaccaacatccaaatctc atgagagctttaggcatgcatgaaactgtcatggaagtgatggtaaatgtgcttggtgga ggagaatccaaggaaatcactttccctaagatggtggcaaactgctgtcgttttctgtgt tatttttgccgcatcagcagacagaatcaaaaagctatgtttgatcatcttagctattta ttggaaaacagcagtgttggccttgcctctccttctatgcgaggatcaactcctttagat gttgcagcagcctctgtgatggataacaatgaacttgcactagctttaagggagcctgat ctggagaaggtggttcgctacttggctggatgtggactgcagagttgtcctttgttgata tctaaaggctacccagacattggatggaatccagttgaaggagagcgatatttagatttt cttcgttttgctgttttttgcaatggagagagtgtggaggagaatgctaatgttgtagtc agactgcttatccgtcgacctgaatgttttggtccagctctaagaggagaaggaggcaat gggttacttgctgccatggaggaagcgatacaaatatcagaagatccaacaagagatgga ccttccccaagtaatggatctagtaaaacccttgaaatggaagagcaagaagatgacact attcacatgggaaatgcaatcatgaccttttatgctgctttgattgatctcttaggacgt tgtgcccctgaaatgcatctaatccatgctggtaaaggggaagccattagaatcagatca attctacggtctttgattccactggaagatttggtgggagtgattagtattcctttccac atgccaaccatagctaaagatggtactgtggtggaacctgacatgtctgcggggttttgc ccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggaccag gattttcttctacatcttcttgaagttggctttctgccagatcttcgtgctgctgcttct ttagatacggctgctttaagtgctacggatatggctttggctctgaatcgatacctttgc acagcagtcttgcctctgttgaccagatgtgctcctctttttgctggcacagagcaccac gcttccctcattgattccttgttacatactgtgtacagactctcaaagggatgctctctt accaaagctcagcgagattctattgaagagtgtttgctctctatctgtgggcagttgcgg ccttccatgatgcaacatttgctgagaagattagtatttgatgttcctctgttaaatgaa catgcaaagatgcctctcaagttgctgacaaatcattatgaaaggtgctggaagtattat tgtttgccaggtggatggggtaactttggtgctgcctcagaagaagaacttcatttatcc agaaagttgttctggggtatttttgatgctttgtctcaaaagaagtatgaacaagaactg ttcaaattggctttgccttgtttgagtgcagttgcaggggccttgcctccagactatatg gaatcaaattatgtcaatatgatggaaaaacagtcttcaatggattcagatgggaacttt aatcctcaaccagttgatacatcaaacattacaatccctgaaaagctagaatatttcatt aacaaatatgcagaacactctcacgacaaatggtcaatggaaaagtttgccaatggatgg acatatggtgaaacgtattctgaatctgcaaaagtgcaaccattaatgaagcaatataag ttactatctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcactaaaaact atgctggcatggggatggcgaattgaaagaacacgggagggagattccatggcactgtac aatcggacacgccgcatatctcaaaccagtcaaatctctgtagatacagcccatggttac actcctcgagcaattgacatgagcaatgtcaccctctccagagacttacatgctatggct gagatgatggccgaaaactaccataacatatgggcaaagaaaaagaaaatggagcttgaa gcaaaaggaggaggcaaccatcctcttcttgttccttacgatacactcacagccaaagaa aaagccaaggacagagaaaaagcacaggatattctgaaatttctacagattaatggatat gttgtctccagaggacttaaggacctggaattagacacaccttccattgagaaacgcttt gcctacagtttccttcagcaacttataagatacgtggatgaagcccatcagtacattctg gagtttgatggtggcagcagaggcaaaggagaacacttcccatatgaacaagaaatcaag ttttttgccaaagttgtgctccctttgattgatcagtactttaaaaatcaccgcctgtat ttcttatctgcagcaagtaggcctctcagcagtggaggccatgcctctaataaagagaaa gaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaatgatgcaacatcaatagtcaactgtcttcacatactgggccagaccttggat gcaaggactgtgatgaaaactggtctggaatctgttaagatggcattgagagcatttctg gacaatgctgctgaggatctggagaaaacaatggaaaaccttaagcaaggccagtttaca cacagcagaaaccagccaaagggagtcacacaaatcattaattataccacagttgctctc ctgccagtgctatcttcattatttgagcatattggacagcaccagtttggggaagatttg atattggaagacgttcaggtctcctgttacagaatattggcgagtttatatgctctggga accagcaagagtatctatgtagagcggcaacgatcagcactaggagaatgcttggccgct ttctcaggtgcctttccagtggcttttttggaaactcacttgaacaaacataatatctac tcgatttacaataccaagaatgcaagagacagagcagttctcaatttgcctactagtgta gaagaggtttgcccaaatattccttccttagtgaagttaatggaagaaattgtggaactg gcagagtctggcattcgttacacacaaatgccacatatcatggaagtaatactacctatg ctatgtagttacatgtcacactggtgggagcatggaccagaaaacaaccctgacaaggct gagatgtgttgcacagccttgacgtcagagcacatgaacactctgttgggtaacatattg aaaatcatctataacaaccttggtattgatgaaggagcctggatgaagagattagcagtg ttttcccagcccatcataagcaaagcgaagccacagctcttaaagacacacttcctgcca ctgatggataagctaaagaaaaaagcagcagtggttgtatcggatgaagaacatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagg gccaaatggctgaaagagcccaaccctgaagcggaagaattgttccgcatggtggctgag gtcttcatttactggtcaaagtctcataatttcaaaagggaagagcagaactttgtggta caaaatgaaatcaacaacatgtctttccttatcagtgacaccaaatctaagatgtccaag gcagcggtttctgaccaggagaggaagaagatgaagagaaaaggtgaccggtactctatg cagacctctctcattgtggcagcactgaagagattacttcccattggcctaaatatttgt gctcctggggaccaagagctaattgcactggccaaaaatcgattcagcatgaaagatact gaagatgaagtacgagatacaatccgcagtaatcttcatctccagggcaagcttgaggat cctgccattaggtggcagatggcactttacaaggatctaccaaacaggactgaagattcc tcagatccagagaagactgtggaaagagtccttgatatagctaatgtactatttcacctg gaacaggttgagcatcctcagcggtccaaaaaagcagtgtggcataagctgctatctaaa cagaggaaaagagcagtggttgcctgctttagaatggcaccattgtataatcttccaagg caccgagccgtgaatctctttcttcaaggctatgataaatcatggattgaaacagaagaa cactattttgaagacaaactgatagaagacttagcaaaacctggggaggaaccaccggaa gaagatgaaagccttaaaagagttgatcctttacatcaacttattctgctattcagtcga acagccttaactgaaaaatgcaaattggaagaagatttcctgtatatggcatatgctgac attatggcaaagagctgccatgatgaagatgatgatgatagtgaagaagaagtgaagagt tttgaagtgacaggatcacaacgcagcaaggaaaaagaaatggaaaagcaaaaacttctg taccaacaagccagactgcatgaccggggtgctgctgagatggttttgcagacaatcagt gctagtaaaggtgagatggggccaatggttgcagctaccctaaagctagggattgccatc ttaaannnnnnnnnnnnnnnnnntcagcagaaaatgcttgactacctcaaggataaaaag gatgtgggattctttcagagtcttgctggtcttatgcagtcctgtagtgttcttgaccta aatgcatttgaacgtcagaacaaagcagaaggccttggcatggtgactgaagagggatca ggagaaaaggtgatgcaagatgatgagttcacctgtgacctcttccgcttccttcagttg ctttgtgaaggacataactcagattttcagaattacctgagaactcagactggtaacaac acaactgttaatattataatttccactgtggattacttattaagagttcaggaatccatt agtgatttctattggtattattctgggaaggatgttattgatgagcaaggacaacgaaac ttttccaaagccatccaggttgcaaaacaagttttcaatactctcacagagtatatccag gggccatgtactgggaatcagcaaagtctggcacacagcaggctatgggatgctgtagtt ggttttcttcatgtgtttgcccacatgcagatgaagctgtctcaggattccagtcaaatt gaattactgaaggaattaatggatcttcagaaggatatggttgtcatgttgctgtctatg ctggaaggtaatgttgtgaatggaactattggcaagcagatggtcgatatgcttgtggaa tcgtccaacaacgtggagatgattctgaagttttttgatatgttcttaaaattgaaggat ttgacttcctctgatgcattcaaagaatatgaccctgatggtaaagggataatttcaaag agggattttcacaaggcaatggaaagccataagcattacacccagtctgaaactgagttt ctgctatcatgtgctgaaacagatgagaatgagactctggactatgaggagtttgtgaaa cgattccatgaacctgccaaagacattggtttcaatgtcgctgttctcctgaccaaccta tcagaacacatgccccatgatacccgcttgcaaacttttcttgaactgtcagagagtgtg ctgaattactttcagcctttccttggacgcatagaaatcatgggcagtgcaaagcgcatt gaacgagtgtattttgaaataagtgagtcaagtcggactcagtgggagaaacctcaggta aaagagtcaaagagacaatttatatttgatgttgtaaatgaaggaggggagaaagaaaag atggagctgtttgttaatttctgtgaggataccatctttgaaatgcaactggctgcccag atctctgagtcagatctaaatggaagatcggcaaataaagaggagaatgagaaagataag cctgaggaacaggatcctagaatgggtttcttctctctcgtgaccatgaagtcagcatta gtagctctcaagtataatttcatgactcttatgaaaatgctcagcgtgaaaagcctgaag aaacagatgaaaaaagtgaagaaaatgaccatgaaggacatggtcatggctttattttct tcctattggagcattttgatgggcttactacattttgcttgtagtgtcatccggggcttc tttcgcatcatatgcagtttgctgcttggaggaagcctagtagaaggagcaaagaaaatc aaggtggctgaactattagctaatatgccagatcccactcaggatgaggtgcgtggggaa ggagaagagggggagcggaagcccacagaagctgcattgcctacagaagatttgacagat ctgacaactttatcagatgagagtgatctactctcagatatatttggtttggatttgaaa cgagaaggtggacagtataaattgatccctcacaatccaaatgctggtttgagtgattta ttgagcactccctccttacctccaatgcctgaggtgcaggaaaaagtccaggagcaggtg aaagaagatgaaaaggaagagaaggaggaaacaaaatctgaacctgaaaaagcagaagga gaagatggagaaaaagaagagaaagccaaggaagacaaagggaagcagaaattaagacaa cttcatactcacagatatggagaaccagaagttcaggagtcagctttctggaagaaaatc attgcataccaacagaagcttcttaattattttgcacgaaacttttacaacatgaggatg ttggcattgtttgttgcttttgccatcaactttatcctgcttttctataaggtctccacc tccgctgtgacagaagaacaggaagttcctgtggtatctgctggtgaaagtactaagttg aacagcctggaaagtgacaaccagaaggtcattgcagtgcattatgtcctggaagaaagc agtggctacatggagcccacactgcggattttggccatcctacacacagtcatctcattc ttctgcattatagggtattattgtttgaaggttccactggttatttttaagagagaaaag gaagtagcaaggaaattggaatttgatgggctgtatatcactgaacagccatcagaagat gatattaagggacagtgggatagacttgtaatcaacacacagtcttttccaaataactat tgggacaaatttgtgaaaagaaaggtcatggataaatatggtgagttctatggccgtgac aggatcagtgagttactaggaatggacaaagctgctctcgattttagtgatgctcgagaa aagaagaaaccaaagaaggatagctccttatctgctgtgctaaattccattgatgttaag tatcagatgtggaaattaggagttgttttcactgataattctttcctttacctagcttgg tacatgaccatgtcagtccttggccattacaacaattttttctttgctgctcatcttctt gacattgcaatgggattcaagacattacgaactatcctgtcatcagtgacccacaatggt aaacagcttgtcctaacagtgggattactggcagtagtagtatacttgtacacggtagtg gcattcaattttttccgcaagttctacaacaagagtgaagatggtgatatgccagacatg aaatgtgatgatatgctaacatgctacatgtttcacatgtacgttggagtacgtgcaggt ggaggcattggtgatgaaatagaggatccagcaggagatgaatatgaaatctatcggatt atctttgacatcactttcttcttctttgtaattgtcatcctgcttgcaatcattcaaggt ttaattattgatgcttttggtgagttaagagatcagcaagagcaagttaaggaagacatg gagacgaagtgctttatctgtggaataggaaatgactactttgatacagtgccccatggc tttgaaacacacacattacaggagcacaacttggccaattatttgttttttctgatgtat cttattaacaaagatgaaacagagcatacaggacaggaatcctatgtatggaaaatgtat caagaacggtgctgggagtttttccctgctggtgattgcttccgaaaacagtatgaagac cagctcaactaa

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