Drosophila ananassae: 6497948 Help Entry 6497948           CDS       T01059                                  Name (RefSeq) protein purity of essence   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism dan  Drosophila ananassae Brite KEGG Orthology (KO) [BR:dan00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dan04121]     6497948 Enzymes [BR:dan01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      6497948 Ubiquitin system [BR:dan04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     6497948 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR Htt_N-HEAT_1 Motif Other DBs NCBI-GeneID:  6497948 NCBI-ProteinID:  XP_001961779 UniProt:  B3MMX5 LinkDB All DBs Position Unknown AA seq 5344 aa AA seqDB search MSAHSGGTDWNSVVKVLLVNRTGALNKNEVVNLLKAINRCEHEFFDEESNYMQFYTAFAA LAADKLVQIKSICQTQICQLHDATAVLTSFILHRLPLVSVYETKWLLAALKMLCEGRESI ANSAAQFDYNAVASVLKSCKHPESSNKSIIGSSSTSAGGGNSNDKESPKSEIKRSRSDLS SVILQQLLAPLEPGKMTWVPLSEEVTDCTDQLQAVNLQCFQQMNGADTLLNVCVGLPILN RYRSKYMETINGGKPLYLPLTQVEATSVKSTMNHMLTDLSILSQAQGLIASQPLTPSRID KLSMCGITALYNAVLVSITTSVLSMSQASSSQKQQTASTSQGSAGGGGSSSGQTSKEHDD FEEQACSIVSKALEIYSSIGELFKSSARMHVYQNHLCYGSWLLISGIQGAMGASGSTGST TDSSSKSKPQAAKTTTTGSEPGTPIARVNLFKVQQGFGELNAAIANHSIKLLSELIEDLK IESACGQSSESGDIPEPAQFDILKNYTSLERIVRVLNTATLHQLFTFLATVAYRKACTLR RASAKDRTECDPISYSDSTTYFNDSLSCSDNSEEDDSESYLGHWFKETLSPETHDDNANT SAQERGNEQKSALVPKLDEPHEYLDLAADIFCFLDQFLANRHAYMQRYVKAGVSDQQMLL MANIIKDFDRDVMRSDSEQGSGNAAQPANAGSAGSAGASTKWQTSMIRFSGAAGRYIHNL ISTSLLSKQLQSNLLQHLAISPWSTDTNTWPLQVYPSTLSVLVQILLLKTTQEKEAACLS VWHRLINTLVEGVCTWNAASDSDYEDLNIEHAQMLLFLFHSLNLMQKKSILLLTAGGVIR CAEVCRGITAERPVKNSQMMLLSRLLLFLEYLMKHLYNAPPELLDQVRWNLFSVSSMPET QKITDLLNSRTKLNSYCRQDIEDKFRKSTGDYGSSIRPTFYSLVMGDPEKPYWAQEFKLD GLAWNFILCTPDKLKYPLLVDALTDILAIADMSAFSKEKEKDESMHNLCAMQYCFSIAWK LLLGLPPSTSHVESIKVDRVPNLHSLIWSIRYPLASSQYLVVNSLIKQGMYTQFAESLWT QVGDIAAEMKYSLKQTILGVEAFNTQMNGKGTPRLSDLILFDALVAHMQAVAWAHKEDYK LPRKECDDSSSEQSSITGASASGGSNEPEIYSSNESIDQQKSKQEDEGLMPVEVEERNQM VNELMLKLMSSYRLLSVIVRAQMLKQLSSSTPEQALNLIVPIVSDKPAIMLELHAAFLKV LPNEDKQLIANEWPKCLIVNDSAFDGKQHPVEPYTLNVIDAHITELTHGANYSTLHTVKH CLKTILNLFELLLPLCSNNAEVESQLKMLLIASMLDMRTDYLQGQSEQCLREILSGLTLE AQKLLLYEHMIGYCYRMLIDFAADLKQPQAGTASTGSGAVDQDRAMFNESMLFAVLKTMI KMLEKPTAVQAMRQFFKDQHLGSLTTLLLSFTGTSLPVSYARKMLQFVERLFQQSTQTDS QFQHEDLVECFAELATVDVARLKLWLTHIIYGPNVSADVSSSEAMDTTCRLLTSIMQPSS SSSSNAQTPTNMATVSAMPSISDQLDAMDIDYDCGGAGASGSGAAGTGAGGAATTGSQIL SLWQAAQPNLSEESSQACDAPGGERNGALLLSFVKSLVKDQQKAAQIAPPLFQALLQLGQ TLISPPQDGCDFADVLQIMITLADASPARGHVALFNTTLLWLELAKLQLPDKQLRHAENV SALLRYLSELLQSIGYRGSRQHIPPWDDEFQSDMDELYDELAEDGEQDSLLDDSDEDTLN NKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYGNFFCDCGA KEDGSCQALSRRLGSSEARDAVGVPGGYLPSHLPLLSCKKRSSPPVIQQIAARKDSVTSE RILLLSKLLEPYRETLQHQDQWLLVVRCILEYFDVLLPSIKENCTLYSIVGCHKRATVAL ERLHQLEQSFQVTDQLMFATLGSQEGAFENVRMNYSGDQGQTIKHLISSGVVRRVAFCCL SSPHGRRQQLAVSHEKGKVTILQLSALLKQADASKRKLTLTQLSSAPIACTVLSLAANPC NEDCLAVCGLKECHVLTFSSGGSTNEHIVVSPQLENGNYIKKAVWLPGSQTLLAIVTSDY VKIYDLAVDTYSPKYYYLVAVGKIRDCTFMYQDGNYYMLSFASSGYIYTQQLDQQSLAVH GDFYVTNTLELSHQHIKDINGQVGGGGVSVYYSHALQLLFYSYSSGRSFFSPLTNVNEGV RGIYHLDTNSASKSASKGPLQPLVQWTEVAGHPGLVYASMQTSNNPIILMLTPERIYMQE IKAQSAKSRIMDVVGIRHAVAGVEKTTLLLLCEDGSLRIFSAQPEHTSFWLSPQVQPFGN QLYSSTLMAKGSGGGGSASAKSKTGAGAGGGKPKQKMQKQLTAGGQHVFPIDFFEHCNML ADVEFGGNDLLQIYNKQKLKTRLFSTGMFVASTRANGFTLEVINNDPNVVIVGIRVLIGT QDVQRAPLAVTILGRTVTTPVRRARWFDIPLTRDEMLQSDKLLKVVFATSLDPEHVTLLD SIEVYGKSKELVGWPDDSEEVTAPGSSVPPVASSQTSSANFGEGFNCITQLDRMVNHLLE VMDCALHLLGAGVPAPLRQKAVKTASALLLLPTPNPVQTQARYVLATLYGSRPSYHMYKD GVLLQFVNGELQAMQPKLEKLESLQDIDPEAFYRLILLVRGIANARPQSLAKICQENNYD IVPSLLAIVLELHKVTPNLDEPTNIVRRGLCQAETIVHCLVEIMYGFALADLGQVGRMTK YFIDLLKHDASVISHSAKEALILLLSPRLKRRKVAIVTPPACSTPTPSTSAIQALQAVAG SAASDIIEEAAAAAVEAAVGVGGAGAGAAALPPDPHPEVELVGVAGVAGAAGLAGHQQLL NLEAFMGGGFPRLLGLPEDADDEAIMDIAIALSLQQHGGDANALQSLQQGLANLQGIRQA AAMAAAANVTASVSAGGSDDDEGSNVATDGSTLRTSPAEPAGSGGSESGGSGVESIGGTS ARSSNFGDHANSSPPRQSSAKDDQEQPGPSGASGVSALSAMSSSEDNEINEDEKLSKLHD LRLAVLESIINHLSTFDLCNGLQAIPLIQVILMLTTDLNGNNERDQQVLQDLLTALVEYV EIGKRGAASRMETKCPGNEVRLALLSLFGVMMGKTKSKQTGTTSPPHQFKDNSSFVASTT ANVLSKSGAFVYALEALNTLLAHWKTVLGDPYAAGGAAALPAQPSSGSGVQLLKPIKHGP KPDISILIPHNYLKNYPDIFESYDALLTEIIVRLPYQILRLSSAHPDNYDSGFCEAMTFT LCEYMMLNLNTLLRRQVRKLLMYICGSKEKFRMYRDGHSLDAHFRVVKRVCSIVSSKTGA PYNANPPLLSYDALVELTEHLRTCQEISQLRTGNWQKFCVVHEDALAMLMEIACYQLDDG VSPIIIQLLQAAVCNLPAPNGSKQVQPLPAASTSSSGKVRSEREKSEDTDAYYSKFDPSQ CGTFVHQIFRYACDPLITRFVRIFLLENNISQLRWQAHSFMTGLFEHANDRHREKLLNIF WNLWPLVPTYGRRTAQFVDLLGYLTLSTRTITERLPELVSRAVDVLRQQNELLCKHPNAP IYTTLESILQVNGYYLESEPCLVCNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTI SKLIVRIADLKRTKMVRTINVYYNNRSVQAVVELKNRPALWHKARSVSLQSAQTELKIDF PLPITACNLMIEFADFFETVSGSSENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAIN YDEKDPFLCHSCGFCKYAKFDFSMHARVCCAVDPIESAEDRAKTVSLIHSSLERADRIYR QLLTNKQMLELLIQKVAEHRSSDRLVEDNMASVHSTSQVNKIIQLLAQKYCVESRTSFEE LSKIVQKVKACRSELVAYDRQQQDQPPTNPGVGSGAENTTTNRCYGCALASTEQCLTLLR AMAYNYDCRVGLYSQGLVSELAEHNLRRGTPQIQEEVRNLLVVLTKDNAEACMHLLQLVT TRVKNALMGAIPLISMEAAVHQEMTLLEVLLSQDDVCWEYKLKVIFELFISNCRLPRGPV TSVLHPCLRIMQNLICPVLPARKPNDKAAAHQDLCSMKVLEGNTVDYRAWLNSDRNHEYA AWCSRMPVNNVQPLAQTKQKSSKEQAATGTGPAPETPPKSKREVRAFYLSEKYGKRWRER VLDKQRVVKPLVFNAKWIQPLLFNPNSRFGRQLACSLLSSLSRTNERRQQALNMLTSFLK HVGDAGEASAEYLMLYKSMATERPWLQYLVLRGVLGQISQLLAVEISKVHRMEEHSLSSD LSLGYALRQYVELLWLLLECPNIRRTYKTRMLGPVLESYLALRSLVVQRTRLIDDAQEKL LEMLEDMTSGTEEETRAFMEILIDTVEKTRMNDIKTPVFIFERLYSIIHPEEHDESEFYM TLEKDPQQEDFLQGRMLGNPYPSGEMGLGPLMRDVKNKICTDCELIALLEDDNGMELLVN NKIISLDLPVKDVYKKVWLAEGGDRDAMRIVYRMRGLLGDATEEFVETLNNKSQEQVDTE QLYRMANVLADCNGLRVMLDRIGSLQRISRNRELIQVLLKLFLICVKVRRCQEVLCQPEI GAINTLLKVLQMCLQSENDSIQSAVTEQLLEIMETILSKAASDTLDSFLQFSLTFGGPEY VSALISCTDCPNVRNNPSVLRHLIRVLAALVYGNEVKMALLCEHFKDTLNFKRFDIERTP EEEFKMELFCVLTNQIEHNCIGGTLKDYIVSMGIVERSLAYITEHAPCVKPTLLRTDSDE LKEFISRPSLKYILRFLTGLSNHHEATQVAISKDIIPIIHRLEQVSSDEHVGSLAENLLE ALSTDAATAARVQQVRDFTRAEKKRLAMATREKQLDALGMRTNEKGQVTAKGSILQKIEK LRDETGLTCFICREGYACQPEKVLGIYTFTKRCNVEEFELKSRKSVGYTTVTHFNVVHVD CHTSAIRLTRGRDEWERASLQNANTRCNGLLPLWGPAVGEAAFSGCMTRHSSYMQESTQR CDISYPSSIHDLKLLLLRFAWERSFHDDAGGGGPQSNMHFVPYLLFYAVYLLLSSRTAAR DSKTLLTYLQAPPSEKWLECAYEVDGPLYMSTMSLSLHSRDLWNKHKVAHLKRLIAVAQA RHISPSVLCKALLSPADRQEKEYSVYKPFLMMWALIDLCYNNLFKTVSTPKEEDWPMSLF DYLRKNDEAMLKSTDSILQTLTDEFLPCTSFGEFCDVAGLLHLIEQPDSFIQDILTSLPS TSSS NT seq 16035 nt NT seq  +upstreamnt  +downstreamnt atgtcggcccacagcggcggaacggactggaactccgtggttaaagttttgctagtgaac cgcaccggagctctcaataagaacgaggtggttaacctgctgaaggcgatcaatcgatgc gaacatgaatttttcgacgaggaaagcaattacatgcaattctacacggcctttgcggct ctggcggcggataagcttgtccaaatcaagtcgatttgccagacacagatttgtcagctg cacgatgccaccgccgtgctcacctcctttatcctccaccggctgcctctggtctcggtg tacgagaccaaatggctgctggcggctcttaaaatgctttgcgaaggccgggagagcatc gccaattcggcggcgcaattcgactacaatgccgtggccagtgtactgaagagctgcaag caccccgagtcgagcaacaagagcatcattgggagcagtagtacatcggcaggcggtgga aacagcaatgacaaggaatcgccaaagtcggagatcaagcgatcgcgctcggacctctcc tcggttattcttcagcagttgttggcgccattggagccgggaaagatgacctgggtgccg cttagcgaggaggtcaccgattgcacagaccaacttcaggccgtgaacttgcagtgcttc cagcagatgaacggcgccgataccttgctgaacgtgtgcgtaggcctgcccatcttgaac cgataccgctccaagtacatggagaccataaacggcggcaagccactgtatctgccactc acgcaagtggaggccacatcagtgaagtcgaccatgaatcacatgctgacggatctatct attctgagtcaggcccagggcttgatcgcatctcagcccttgacgccgagtcgcatcgac aagctctcaatgtgcggcatcaccgctctgtacaatgcagtgctcgtttcgatcaccacc agtgtgctgagcatgtcccaggcgagcagttcccagaagcagcagactgcgtccaccagc cagggcagtgccggaggcggcggatccagcagtggacagacgtcgaaggagcacgacgat ttcgaggaacaggcttgcagcattgtcagcaaggccctggagatctactcgagcattggt gaactgttcaagagctcggcccggatgcatgtctaccagaatcacctctgctacggcagc tggttgctcatcagcggcattcagggagccatgggtgcttcaggcagcactggaagtacc acggactcctcatccaaatcgaagccacaagctgcaaagactacaacaacggggagtgaa cccggcacacccatcgctagagtaaatcttttcaaagtccaacagggattcggagaactc aacgcggctattgccaaccacagtatcaagcttttgtcagagctaatcgaggacctgaag atcgagtccgcctgcgggcagagctccgaatccggggacatcccagagccggcccagttt gatattctgaagaactacacttcgctggagcgaattgtgagggttctcaacacggccacc ctgcatcaactgtttactttcttggccaccgtagcatatcgcaaggcctgcactctgcga cgagcttcggccaaggatcgcactgaatgcgatccgatcagctactcggactcaaccaca tacttcaacgattcgctctcctgctccgacaactcggaggaggacgacagcgagagctat ctggggcactggttcaaggagaccctctcgccggaaacccatgacgataatgcgaacaca tctgcccaagaacgaggaaacgagcagaagagtgctctagtgccgaagctggatgagcca cacgagtatctggatctggcggcggacatcttctgtttcttggaccagtttctggccaac cggcatgcctacatgcagcgctacgtgaaggccggcgtcagtgaccaacagatgctcctg atggccaacataatcaaggactttgaccgggatgtgatgcgcagtgatagcgagcagggg tctggaaacgctgctcagccggccaatgccggttcggccggttccgctggggcctccacc aagtggcagacttcgatgattcgcttctcgggagctgctggacgctacatccacaatctg atctccacatcgctgctctcgaagcaactgcagtcgaatctgctgcagcacctggccatc tcgccctggtccaccgataccaacacctggccgttgcaagtctatcccagcacgctgtca gtgctcgttcagatcctgctgctgaagaccacgcaggagaaggaagcggcctgcttgtcc gtgtggcaccgcctcatcaacactttggtggagggggtatgcacttggaacgctgccagt gactctgactacgaggacctgaacattgagcatgcccagatgctgctcttcctgttccac tccctcaatctcatgcagaagaagtcgatcttgctgctcacagccggaggggtaatccgc tgtgcggaggtctgtcgcggcatcactgccgagcgacccgtgaagaacagccagatgatg ttgctctcgcgactgctcctcttcctggagtacctcatgaagcacctgtacaacgcccca ccagagctgctggatcaggtgcgctggaacctgttcagtgtcagcagcatgcctgaaact caaaagatcacagatctccttaacagccgcaccaagttgaactcctattgccggcaggat atcgaggacaagttccgcaaatcaacgggtgattatggatcatcaattcgccccaccttc tactccctggtcatgggagatccggaaaagccctattgggcgcaagagttcaagttggat ggcctggcatggaactttattctgtgcacgccggacaagttgaagtatcccttgctggtg gatgccctgaccgatatcctggccatcgcggacatgtcagccttctcgaaggaaaaggag aaggacgagagcatgcacaacctgtgcgccatgcagtactgcttcagcattgcctggaag ctgctcctcggtctgccgccctccacctcgcacgtggagtcgatcaaggtggatcgagtg cccaatctccactcgctgatctggagcattcgctacccgctggccagctcccagtacttg gtggtgaacagcctcatcaagcagggaatgtacacccagttcgccgagtccttgtggacc caagtgggcgacatagccgccgaaatgaagtacagcctgaagcagaccatcctgggggtg gaggccttcaacacccagatgaacggaaaaggcacaccgcgtctctccgacctcatcctg ttcgatgctctggtagctcacatgcaggccgtggcctgggcccacaaggaggactacaag ctgccgcgcaaggagtgcgatgactcctccagtgaacaatcctccatcacaggagcctcg gcgtctggcggctcaaacgagcccgaaatatactcctcgaacgagtccatagatcagcag aagtccaagcaggaggatgagggtctgatgcccgtagaagtggaggaacgcaaccaaatg gtgaatgagctgatgctcaagttgatgtcctcctaccgactcctgtctgtgattgtgcgc gcccagatgctgaagcagttgtccagctccaccccggagcaggctctcaacctgattgtg ccgatagtgagtgacaagccggcgatcatgctggagctgcacgccgctttcctgaaggtc ctgccgaacgaggacaagcagcttatagccaacgagtggcccaagtgcctgatagtcaac gactcagccttcgacggcaagcagcatcccgtggagccctacaccctcaacgtgattgat gcccacatcacggagctgacgcatggagccaactactccaccctgcacaccgtgaagcac tgcctgaaaacgatcctgaatctctttgagttgctgctaccactctgctccaacaatgcc gaggtggagtcgcagctgaagatgctgctgatcgcgtccatgctggacatgcgaaccgac tacctgcagggccagagcgagcagtgcctgcgggagattctcagcggcctgacgctggag gcccagaaactgctcctctacgagcacatgatcggctactgctaccgaatgctcatcgac tttgcggccgacctgaagcagccgcaggctgggacagccagcactggaagcggagccgtg gaccaagatcgcgccatgttcaatgagtcgatgctgttcgcggtgctcaagacgatgatc aagatgctggagaagccgacggcggtgcaggccatgcgccagttcttcaaggaccagcac ctgggcagcctcaccaccctgctgctctccttcaccggcaccagcctgcccgtcagctac gcccgcaagatgctgcagtttgtggagcgcctcttccagcaatcgacccagaccgactcc cagttccagcacgaggacctggtcgagtgctttgccgaactggccacggtggacgtggct cgcctgaagctctggctgacgcacatcatctacggcccgaacgtgagtgccgatgtgagc agctccgaggccatggacaccacctgccgcctcctcaccagcatcatgcagccgtcgagc agctccagcagcaatgcccagacgccgacgaacatggccactgtttcggccatgccgagc atctccgatcaactggatgccatggacatagactacgactgtggtggcgccggagcaagt ggctctggagcggcgggaaccggcgctggaggagctgccactaccggatcacagatcctc agtctctggcaagctgcccagccgaatctctcggaagagtcctcgcaggcctgtgacgcc cctggaggggaacgaaatggcgcactgctgctcagcttcgtgaaatctctagtcaaggat cagcagaaggcggcgcagatagctcctccgctgttccaggctctgctccagctgggccag accctcatctcgccaccccaggacggctgtgactttgccgatgtcctgcagataatgatc accctggcggatgccagtccagcgcgcggccatgtggcgctgttcaacaccacgctcctc tggctggaactggccaagctgcagcttccggacaagcagctccggcacgccgagaacgtg agtgccctgctccggtatctgagcgaactcctgcagagcatcgggtatcggggcagtcgc cagcacatcccgccgtgggatgacgagttccagagcgacatggacgagttgtacgacgag ctggccgaggacggggagcaggactcgctcctggacgactctgacgaagatacgctgaac aacaagctgtgcaccttctcgcagacccagaaggagttcatgaaccagcactggtaccac tgccacacctgcaacatgatcaacacggtgggagtgtgctccgtgtgcgcccgcgtctgc cacaagggccacgacgtcagctacgccaagtacggcaatttcttctgcgactgcggcgca aaggaggacggatcctgccaggcactgagccgccggctgggcagcagcgaggccagggat gcagtgggtgtgcctggtggctacctgccgtcgcacctgcccctgctctcttgcaagaag cgctccagtccgccggtgatccaacagattgccgcccgcaaggactcagtgaccagcgag cgcatcctgctgctgagtaaactattggagccctaccgtgagacccttcagcaccaggat cagtggctgctagtggtgcgctgcattctggagtacttcgatgtgctgctgccttcgatc aaggagaactgcaccctctactccatcgtgggctgccacaagagagccaccgttgccctg gagcgactgcatcagctggagcagagcttccaggtgacggatcaactgatgtttgccacg ctgggctcccaggagggcgccttcgagaacgtgcgtatgaactactccggcgaccagggc caaaccatcaagcacctgatatcctccggcgtggtccgccgcgtcgccttctgctgcctg tcctcgccgcacggtcgtcgccagcagctggccgtgtcccatgagaagggcaaggtgacc atcctgcagctgtcggcgctgctcaagcaggcagatgcctccaagcggaagctgactctg acccagctcagctccgcaccgatcgcctgcacggtgctctccctggccgccaatccgtgc aacgaggactgcctggctgtgtgcggactgaaggagtgccacgtgctcaccttctccagc ggcggcagcaccaacgagcacattgtggtgagcccccagctggagaacggcaactacatc aagaaggccgtctggctgccgggatctcagaccctgctggccattgttacctcggactac gtcaagatctacgacctggccgtggacacctacagccccaagtactactacctggtggcc gtcggaaagataagggactgcaccttcatgtaccaggacggcaactactacatgctgagc ttcgccagttccggctacatatacacccagcagctggaccagcagagcctggccgtgcac ggtgacttctacgtgaccaacactctggagctgagccatcagcacatcaaggatataaac ggacaggtgggcggcggcggagtctccgtctactactcgcacgccctccagttgctcttc tacagctactcctccggccggagcttcttctcgccgctgaccaacgtcaacgagggcgtc aggggcatctaccacctggacacgaactcggccagcaaatcggcctctaaaggcccgctc cagcccctcgtccagtggacagaggtggcagggcatccgggattggtgtacgccagcatg cagacgtcgaacaacccgatcatactgatgctcaccccggaacggatctacatgcaggag atcaaggcccagtcggccaagtcacgcattatggacgtggtgggaattcggcatgcggtc gctggagtggagaagaccacgttgctgctcctctgcgaggacggaagcctgcgaatcttc tcggcccagccagagcacaccagcttctggctctcgccacaggtgcagcccttcggcaat cagctgtactcctccaccctcatggccaagggaagcggcggtggaggcagtgcctcagcc aagtccaagaccggcgcaggagctggaggcggcaagccgaagcagaagatgcagaagcaa ctcacggctggcggacagcacgttttccccatcgacttcttcgagcactgcaacatgtta gcggacgtggagttcggcggcaacgatctcctccagatctacaacaaacagaagctcaag acgcgcctcttctccaccggcatgttcgtggccagcaccagggcgaatggcttcaccctg gaggtgatcaacaacgacccgaatgtggtaattgtgggcattcgtgtgctgatcggcacc caggacgtgcagcgcgctccgctggcggtgaccatcttgggacgcacggtgaccactccc gtgaggcgagcccgatggttcgacatacccctaacccgcgacgagatgttgcagtcggac aagctgctcaaggtggtgtttgccacctccctagacccggagcacgtaactctgttggac tcgattgaagtgtacggtaagtccaaggagctggtgggttggccggacgacagtgaggag gttactgccccaggatcgagtgtaccgccggtggcctcgtcccagactagcagtgccaac ttcggcgagggattcaactgcatcacgcaactggacaggatggtcaaccatctcctggag gtcatggactgtgctctgcacctgctcggagccggagtccctgctccgctgcgccagaaa gcggtgaagacggcgagtgccctgctgctgctgcccacacccaatcctgtccagacgcag gcgcggtatgtgctggccaccctctacggcagccggccatcctatcacatgtacaaggac ggagtcctcctgcagttcgtcaacggagagctgcaggccatgcagccgaagctggagaag ttagagtctctgcaggacattgatccggaggccttctaccgactgattctcctggttcgg ggcattgccaacgcgcgcccccagtcgctggccaagatctgccaggagaacaactacgac attgtcccgtcgcttttggccattgtgctggagctgcacaaggtcacccctaatctggac gagccaaccaacatcgtgcgacgaggcctctgccaggcggagaccatagtccattgcctg gtggagataatgtacggctttgccctcgccgatctcggccaggtcggccgcatgaccaag tactttatcgatcttctcaagcacgacgccagcgtgatcagtcacagcgccaaggaggcg cttatcctgctactcagtcccagactgaagaggcgcaaagtggccattgtcacgccccca gcctgttccactcccacgccctccacatccgccatccaggccctccaggcggtggccgga tcagcagccagcgacatcatcgaggaggctgcagccgcagctgtggaagctgctgtagga gtgggaggagcaggtgctggagcagctgcgttgcccccagatccacacccggaagtagag ctcgttggagtggctggagtggcaggagccgccggcttggcgggccaccagcagctcctc aacctagaggccttcatgggcggcggctttccccgactgctggggcttccggaagacgcc gacgatgaagccatcatggacatagccatcgcgttgagtctccagcagcacggcggcgac gccaatgcgctgcagagcctccagcagggtttggccaacttgcagggcatccgccaggct gcggcaatggcagcagcggctaatgttacggccagcgtgtccgccggcggctcggatgac gacgaaggctcgaacgtggccaccgatggctctacactgcgaacttcccctgccgagccg gcaggaagcggaggttccgagagcggcggcagcggagttgagagcatcggcggcacttcg gcgaggagcagcaactttggcgaccacgccaactcctcgccgccgcgccagagctcggct aaggacgaccaggaacagccgggccccagtggcgccagcggggtgtccgccttgagtgcc atgagcagcagcgaggataacgagatcaacgaggacgagaagctcagcaagctgcacgac ctaagacttgctgtgctggaaagtatcatcaatcacctgagcaccttcgacctgtgcaac ggcctccaggctataccactcatccaggtgatccttatgctgaccacagacctgaatggc aacaatgagcgggatcagcaagtgctgcaggatctgctgaccgccctggtggagtacgtg gaaatagggaaacgaggagcagcctccaggatggaaaccaagtgtcctggcaacgaggtg cgcctcgccttgctctccctcttcggcgtgatgatgggcaagaccaagtccaagcagacg ggcaccacctcgcccccgcaccagttcaaggacaacagctcctttgtggccagcactacg gcgaatgtgcttagtaagagcggagccttcgtatatgccctggaggcactgaacacgcta ctggcccactggaagactgtactgggagatccctatgcggccggtggagctgctgccctg ccagcgcagccgtcatccggctcgggagttcaactgctgaagcccatcaagcacggcccg aaaccagacatttctatcctaataccgcacaactacctgaagaactacccggacattttt gagtcctatgacgccctcctcacagagattattgtgcgactgccgtaccagatcctgcgc ctgagcagcgcccatccggacaactatgacagcggcttctgcgaggccatgaccttcacc ctctgcgagtacatgatgctcaacctgaacaccctgctccggaggcaggtgcgcaagctg ctgatgtacatctgcggcagcaaggagaagttccgcatgtaccgcgacggtcactccctg gacgcccacttccgagtggtcaagcgggtgtgcagcatcgtaagcagcaagacgggagct ccgtacaacgccaatcctccgctgttgagctacgacgcactggttgagctcaccgagcac ctgcgcacctgccaggagatcagccagctgcgcaccggcaactggcaaaagttctgcgtg gtccacgaagacgccctggccatgctgatggagattgcctgctaccagctggacgacggg gtgtctcccattataatccaactgctgcaggctgccgtgtgcaatcttcccgctccgaac gggtctaagcaggtgcaaccactgcccgcagcatcgacttcgtcgtcggggaaagtacgc agcgaacgagagaagagcgaggacaccgacgcctactactccaagttcgatccctcgcag tgcggcacgttcgtgcaccagatcttcagatacgcctgcgatccgctgatcactcgcttc gtcaggatcttcctgctggagaacaacatcagccagttgcgctggcaggcgcactcgttc atgaccggcctcttcgagcacgccaacgaccgccaccgcgagaagcttctcaacatcttc tggaacctgtggcccctggtgcccacctatggacggcgcacggcccagtttgtggatctg ctgggctacctaaccctgagcacccgcaccattacggagcgtctgcccgagctggtttcc agagcggtggacgtcctccggcagcagaatgagctgctctgtaagcatcccaatgcgccc atttacaccactctggagtccatactgcaggtgaacggctactacctggaatcggagccg tgtctggtgtgcaacaacccggaggttcccatggctaacatcaagctgccatccgtcaag tcggattccaagtacacgaccaccacaatgatctacaagctggtgcagtgccacaccata tccaagctgattgtgcggatcgccgacctgaagagaaccaagatggtgcgcaccatcaat gtctactacaacaaccgtagtgtccaggcggtggtggagctgaagaatcgcccagccttg tggcacaaggcccgctccgtgtccctgcaatcggcccagaccgagctgaagatcgacttc ccgctgccgatcaccgcctgcaacttgatgatcgagtttgcggacttcttcgagactgtt agcggttctagtgagaacctgcagtgcccgcgatgcagtgcagccgtgccggcctatccg ggtgtttgcggcaactgtggagagaacgtgtttcagtgtcacaagtgccgagccatcaac tacgacgagaaggatcccttcttgtgtcactcgtgcggcttctgcaagtacgccaagttc gacttcagcatgcacgcccgtgtctgctgcgccgtggatcccatcgagtcggccgaggat cgggccaagaccgtctccctcatacacagttccttggagagagccgatcggatctaccgc cagctgctgaccaacaagcagatgctggagctgcttatccagaaggtggccgagcaccga agcagcgaccgactggtggaggacaacatggccagtgtgcacagcacctcgcaggtgaac aagatcatccagctgctggcccagaagtactgcgtggagtcgcgtaccagtttcgaggag ctgagcaagatcgtacagaaggtgaaggcctgtcgcagtgagctagtggcctacgatcgt cagcagcaggaccagccccctaccaaccctggagttggatcgggggccgagaacaccacc acgaaccggtgctatggctgcgcccttgcctccaccgagcagtgcctgacccttttgcgg gccatggcctacaactacgactgccgggtgggcctgtacagccagggcctagtcagcgag ctagccgagcacaatctgcgccgcggcactccccagatccaggaggaggtgcgcaacctg ctcgtagtgctgaccaaggacaatgccgaggcctgtatgcatctgctccagttggtgacc acgcgcgtcaagaacgctctcatgggcgccataccattgatcagcatggaggcagcagtg caccaggagatgacgctgctggaggttctgttgagccaggacgacgtctgctgggagtac aagctgaaggtcatctttgaactcttcatcagcaattgcagactccctcgcggaccagtg acgtcggtgctgcatccctgtttgcgcatcatgcagaatctgatttgtcccgttctacca gcccggaagcccaacgataaagcagcggctcaccaggacctgtgcagcatgaaggtcctt gagggcaacactgtcgactatagggcctggcttaactcggatcgaaaccacgagtacgcg gcctggtgtagtcgtatgccggtaaacaacgtacagccactggcccagaccaagcagaag agctccaaggagcaggctgccaccggaacaggaccggcgccggaaaccccgcccaagagc aagcgagaggtgagggccttctacctcagcgagaagtacgggaaacggtggcgcgaacga gtgctggacaagcaacgggtggtcaagcctctggtattcaacgccaagtggatccagccg ctgctcttcaacccgaactccaggttcggacgccagctggcctgttccttgctgagcagc ctgagccggacgaacgagaggcgccagcaggcactcaacatgcttacctcgttcctgaag cacgtgggcgatgccggagaggccagcgccgagtacttgatgctctacaagagcatggcc accgaacgcccctggttgcagtacctcgtgttgaggggagtccttggacaaatatcccag ctgctggccgttgagatcagcaaggtgcatcgcatggaagagcactcgctgtcgtcggac ttgtcgctgggctatgccttgaggcagtacgtggagctcctgtggctcttgctcgagtgt ccgaacatacgccggacctacaagaccaggatgctgggccccgtactggagagctacttg gccttaagaagcctggtggtgcaacgcacccgactgatcgacgacgcccaggagaaactg ctggagatgctcgaggatatgaccagtggcaccgaggaggagacgcgtgccttcatggag atcctcatcgatacggtcgagaagacccgcatgaacgacatcaagacgccggtcttcata ttcgagcgcctgtactccattatccatccggaggagcacgacgagagcgagttctatatg acccttgagaaggatccgcagcaggaagacttcctccaaggccgcatgcttggcaatccc tacccgtccggcgaaatgggtctggggcccctgatgcgcgatgtcaagaacaagatctgc acggactgcgagctgatagctcttctggaggacgacaacggcatggagctgttggtcaac aacaagatcatcagccttgatctgcctgtcaaggatgtgtacaagaaggtctggctggcc gagggcggcgatcgggatgccatgcggattgtgtatcgcatgcgcggtctccttggcgat gccaccgaggagtttgtggagacgctgaacaacaagagccaagagcaggtggacaccgag cagctgtatcgcatggccaacgttctggccgactgcaatgggttgcgcgtcatgctggac aggattggcagcctgcagcgcatctcccgcaatcgtgaactcatccaggtgctgctcaag ctcttcctcatctgcgtcaaggtgcgtcgctgtcaagaggtgctctgccagccggaaatt ggagccatcaacacactgctgaaggtgctgcagatgtgtctgcagtctgagaacgattcc atacagtcggcggtgaccgagcagttgctggaaataatggagaccatcctatccaaggca gccagcgatacgttggactcgttcctgcagttctccctcaccttcggtggcccagagtat gtgagcgccctgatctcctgcacggattgtcccaatgtgagaaataacccatccgtgctc cgtcatctgattcgcgtcctagccgccctggtgtacggaaatgaggtgaagatggccctg ttgtgcgagcacttcaaggacactctgaacttcaagcgattcgacattgaacgtactccg gaggaggagttcaagatggaactcttctgcgtcctgaccaaccaaatcgaacacaactgc atcggcggcaccctcaaggactacatcgtcagcatgggaattgtggagcgatcgctggcc tacatcaccgagcatgctccgtgcgtcaagccgaccctcctgcgcactgactccgacgag ctcaaggagttcatctctcgccccagcttgaagtacatcctgcgcttcctcaccggtctc tccaatcaccacgaggccacgcaggtcgctatcagcaaggatataataccgattatacat cgcctggagcaggtgtcaagcgacgaacacgtcggcagcctggccgagaacctcctggag gctttgtcgaccgatgctgctacggcggcacgggtccagcaagttcgcgactttacgcgc gcggagaagaagcgcctggcgatggccacccgagagaagcagttggacgccctgggcatg cgtacgaacgagaagggacaggtgacggccaagggctcgatcctccagaagatcgagaag ctgcgagatgagaccggactgacgtgcttcatctgccgcgagggctatgcctgccaaccg gagaaggtccttggcatctacacctttacgaagcgctgcaacgtggaggagttcgagctg aagtcgcgcaagagcgtaggatacaccacggtgacgcacttcaatgtggtgcacgtggac tgccacacctcggccatacggctgacccgcggacgtgatgagtgggagcgggccagtctg cagaacgccaacaccaggtgcaatggattgctgcccctctggggtccggctgtgggcgag gcggccttctccgggtgcatgacccgtcacagtagctacatgcaggagagcacccagcgc tgtgatatctcgtatcccagcagcattcacgacctgaagctgctgctgctgcgattcgcc tgggagcgcagcttccacgacgacgccggaggcggcggtccccagtccaatatgcacttt gtgccatatctgctcttctacgccgtgtacctcctactgtcctcccggacagcggccaga gacagcaagaccctgctcacctacctgcaggcaccgcccagcgagaagtggctcgagtgc gcctacgaagtggacgggccactctacatgagcaccatgtcgctctccctgcacagccgc gatctgtggaacaagcataaggtggcgcatctgaagcgcctgattgccgtggcccaggcc cgacacatttccccctcggttctgtgcaaggctctcctctccccggccgatcggcaggag aaggagtacagtgtgtacaagccgttccttatgatgtgggcgctgatcgatctgtgctat aataatctcttcaagacggtcagcacgcccaaggaggaggactggccgatgtcgctgttc gactatctgcgcaagaacgacgaggccatgctgaagtccactgacagtatcctgcaaacc ctaacggatgagttcctgccgtgcacctccttcggtgaattctgcgatgtggcaggtctt ctacatctcatcgaacagccggacagcttcatccaggacatcctcacatccctgccttca accagctctagttaa

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