Drosophila arizonae: 108616347 Help Entry 108616347         CDS       T05886                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism daz  Drosophila arizonae Brite KEGG Orthology (KO) [BR:daz00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:daz04040]     108616347    04990 Domain-containing proteins not elsewhere classified [BR:daz04990]     108616347 Ion channels [BR:daz04040]  Voltage-gated cation channels   Ryanodine receptor    108616347 Domain-containing proteins not elsewhere classified [BR:daz04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    108616347 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans TPR_TTI1_C EF-hand_7 Motif Other DBs NCBI-GeneID:  108616347 NCBI-ProteinID:  XP_017866955 LinkDB All DBs Position 5 AA seq 5149 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVTLSCTATGERVCLAAEGFGNRHCFLENIADKNVPPDLS QCVFVIEQALSVRALQELVTAAGSETDSQVGKGTGSGHRTLLYGNAILLRHHNSDMYLAC LSTSSSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLH TTKENEQSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWG REAGQNIVIYEGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSN ELILVKKEEASIATTTFCLRQEKDDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCESSLW LSYKSYETKKKGVGKVEEKQAILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFI TALETLQSNRRHSIFFQKVNLNEMVMCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDL FQEEGVLNLILEAIDKINIITSQGFLASFLAGDETGQSWDLISTYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTLLVDHVASIRPNIFVGR VDGSSMYQKWYFEVTMDHIEQTTHIMPHLRIGWANTSGYVPYPGGGKKWGGNGVGDDLYS FGFDGAHLWTGGRKTLVADALPEEPYIRKGDVVGVAIDLSVPVITFTFNGNKVRGCFRDF NLDGMFFPVMSCSSKLSCRFLFGGDHGRLKYAPPAGFSALVQCLMPHQILSLDPCFYFGN LSKNVLAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIDAGWTW GEQRDDYHRIHPCLTQFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPARIRPVRL PNEIFMQANGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSE NHRSPHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFA AFRTYRVERNYAVTSGKWYFEFEVLTAGPMRVGWARADCYPGAMLGSEDTSWAFDGHNVT KMHAGTIEHFGVRYEAGDVIGCFIDVKEQTISFSLNGELLMDALGGETTFADVTAEGVGF VPACTLGVGQKARLIYGQDVDSLKFFTTCGLQEGYEPFCVNMQRPVTHWYTKDQPIFENT EEMPDCRIDVTRIPGGADTPPHLKISHNTFETMEKANWEFLRLSLPVTCMSDFISEQEKA RRWEEIKLRQYRLMREAQEAAIQMQTQNAAHMDHMLKSGFNMNDIKGLTRNFDDHTEAEA EHMMRGPPRPPRKGSLTRNITFETDMTAALDEMQRSTSVLDMNGLGDDLDDKKKRGRSPF KFFSKKSRDQSREKNGSRTADTSLERRNTVAHGRNVVNQQMTTRTPTLRLNNAEIPPSPV PQGPKQLSSTNLGQPSVESSGNEMFDAECLKLINEYFYGVRIFPGQDPTHVYVGWVTTQY HLHSREFNKNKVRRASVYIEDYYEVPIERIDRQSCYVVRADELFNEVTQDASGKGASQGM FVGCFVDTATGIIRFTCEGKETSHRWMMEPDTKLFPAIFVEATSKEILQIELGRTPTTLP LSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTSLQVHALKLSDIRGWSMLCEDPV SMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHALCQHVDQKQL LYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGPELKELYAEDEMRHS LRSLVTESVRPQLRMTEITPPVIATSSMPSVSSEPIPNIDQLYSPKFPLEVVREFVMEAL KDAVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQKLLVMVDPETWDPTF EREGKDEHRKGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESIIAFSHDFVGDLQTDQL RRYIEIKQSDLPSAVAAKKTKEFRCPPREQMNQILCFKNLEADDQDNCTCGLELRSRLSE FHDSLMQKVSLNALQEPDGTETNAIEEIKTGPITKIYNFINTVKELEEGPKEVEEPEKKT PEEVFRKVLIKTIVSWAEESQIENPKLVREMFSLLVRQYDTVGELVRALEKTYVINNRAR DDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMA VMMNTLGRRAQAQSDAPAQTEGAEGVPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMF DHFDFLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQ SNSELVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPAL RGEGEGLFRAIVEANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGDEDEDYIDTGAAI LNFYCTLVDLLGRCAPDVSVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLTQTAPG EEKPKSDMPSGLLPNNKQSIVLFLERVYGIETQDLFYRLLEDAFLPDLRTATILDKSDGS ESDMALAMNRYIGNSILPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREA VSDFLVALTSQMQPAMLLKLLRKLTVDVSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQG SYGASSDEEKRLTMLLFSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKNTDE DYYGRQMGAPDQPQYVPNPIDTNNVHLDNDLNSLVQKFSEHYHDAWASRRLEGGWTYGEI RSDIERKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIGWTVEHSEIDLPLNHRGSTRR QSKPQIHDFQNEGNPFNYNPHPVDMSNLTLSREMQNMAERLAENSHDIWAKKKNEELNGC GGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAVEEGGATQAAVE LRFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTASRDIKFFSKVVLPLMEKYFS THRNYFIAIATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQVLV KGIDAKTLTKNCPEFIRTSMLTFFNQTSDDLGNTIMNLQDGKYSHLRGTHLKTSTSLGYV NQVVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDATLTHDRKYLKTEI ERHRPALGSCLGAYSSCFPVAYLEPHLNKHNQYSLLNRIADHSLEAQDIMVKMESCMPNL EAILNEVDQFVESDKTYADAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTAD HMNSLLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTE NMLHKEDSMRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDN IPEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISEGVPAV GGKVKKKKKNRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKM NEYDVIEFARNQLTLPDKLDPSDEMSWQHYLYSKLGKTEDPVDEQALEKVNANSNEKGKD KTTETVDRIVAMAKVLFGLHMIDHPQQQSKNVYRSVVSIQRKRAVIACFRQTSLHSLPRH RACNIFARTYYEQWLQEENVGQEVMIEDLTQTFEESEKSKKDEEETDGKPDPLTQLVTTF CRGAMTERSGALQEDLLYMSYAQIAAKSCGEEEEEGGDEGEGGEGGEEGEGTSIHCRMSK LMEQEMEKQKLLFHQARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNIDI QMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEEYIPSAGAGLGVGSEGAA GEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESI MDFYWHYSSKEIIDPAGKANFFKAIGVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVG GFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVE SASNVELILKYFDMFLKLADLIESPSFHEIDMKNEGWVIPKDFRDKMEQSKNYTPEEMDF LLACCERNHEGKIDYRAFVERFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSV LNYFEPFLGRIEILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEK LEAFVNFCEDAIFEMTHASGLMATDDGGGNVKRDTAYSSYMSEEEEERAARDPIRRTITA VKDGLKFGVHMLSPSNIKHQIGVMQTKSIPELIVGFFKIIFYMFYYTGYAHYCVVRYIFG ILLNLMRGPAPEQEDEVAVVEEETFGRALPPLPLEEPPGPVQAFGLDINKEENGVYKVVV HESPASSSVEEGGESSPEDGAAPTGELVEGELHQEPISIVDMLGGEAAKKAAQERQEAQK AQEAAMASIEAEAKKSSAAPQETPAVHQIDFSQYTHRAVSFLARNFYNLKYVALVLAFSI NFMLLFYKVTSFNEESEGSAEEELILGSGSGAGADMAGSGLGGSGDGSGDGDFEDDDIPE LVHVDEDFFYMEHVLRIAALLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRLEFDGLFI AEQPEDDDFKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKSAF TAQESEETGILRYIMNIDWRYQVWKAGVTFTDNSFLYSLWYFSFSVMGNFNNFFFAAHLL DVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDEEVDKK CHDMLTCFVFHLYKGVRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIVILLAIIQGL IIDAFGELRDQLESVKDNMESNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHL INKPDTEYTGQETYVWNMYQQRSWDFFPVGDCFRKQYEDELSGGGGGGG NT seq 15450 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcggaaggtggctccgagcaggatgatgtttcattcttgcgtacggaagat atggtcacgctctcctgcacagcgacgggcgagcgtgtctgtctggccgccgagggattt ggtaatcggcattgttttctcgaaaacattgccgataagaatgtgccgcccgatttgtcg caatgcgtctttgttatcgaacaggcgctgtcggtgcgcgcgctccaggaactggtgact gcagctggatcagagaccgatagtcaagttggcaagggcacaggatccggccatagaacc ctgctctatggcaatgccatactcctgaggcatcacaacagcgacatgtatctggcctgt ttgtcaacatcgtcgtcgaacgataagctctccttcgatgtgggtctgcaggagcatagc cagggcgaggcctgttggtggaccgtacatccggcgagcaaacagcgctcggagggtgaa aaggttcgtgtgggtgatgatttgattttggtgtcggttgccaccgaacggtatctgcac acaaccaaggagaacgagcagtccattgtgaatgccagcttccatgtgacccactggtcc gtgcagccctacggcaccggcatctcacgcatgaaatacgttggctatgtgttcggcggc gatgtcttgcgtttctttcatggcggcgacgagtgcctgaccatacccagcacctggggc cgtgaggcaggtcaaaacattgtcatatacgagggcggcgtggtcatggctcaggcacgt tctctgtggcgcttggagttggcgcgcacgaagtggacgggcggcttcataaactggtat catcccatgcgtatacgtcatataacgacgggacgctatctgggcgtcaacgatagcaac gagctaatcctcgttaaaaaggaggaggcatcgattgcaacgacgactttctgcctgagg caagaaaaggacgacgaaaagaaagtactcgaggacaaagacttagaagtaatcggttcg ccgatcatcaaatacggtgacaccaccgtcatcgtgcagcactgcgagtcgagcctgtgg ctcagctacaagagctacgaaacgaaaaagaagggcgtcggcaaggtggaagagaaacag gccatactccacgaggagggtaaaatggacgattgcctggacttctcccgctcccaggaa gaggaatcgaagacggcgcgtgtcattcgaaagtgcagcagcctcttcacacagtttata accgccttagagaccctgcaatccaatcgtcgacattcaatatttttccaaaaagttaat ctcaacgaaatggtcatgtgcctggaggatttaatcaattacttttcgcagccagaagat gatatggaacacgaggagaagcagaatcgttttcgtgccttgcgcaatcgccaggatctg ttccaggaggagggcgtgctcaatctcattttggaggccattgacaaaattaatataatt acctcgcaaggcttcttggccagcttcctggccggcgacgagactggtcagagctgggat ctaatctcaacttatctctaccagctactggccgccatcatcaagggcaatcacaccaat tgtgcccaatttgcgaacagcaatcgcctcaattggctgttctcccgcctgggctcgcag gcatccagcgagggctccggcatgctggatgtgctccactgtgtgctcattgactcgccc gaggcgctgaacatgatgagggacgagcacattaaagtgattatatcgctgctcgagaaa cacggtcgcgatcccaaggttctcgatgtcctctgctccctgtgtgtgggtaatggagtc gcggtgcgctcctcgcaaaacaacatttgtgatttcctgctgcccggcaaaaatctgttg ctgcagaccttgctggtggatcatgtggcgagcatacgtcccaacatctttgtgggacgc gtggatggctcgtccatgtaccagaagtggtactttgaggtgaccatggatcacatcgag cagaccacacacataatgccgcatctacgcattggctgggccaacacctccggctacgtg ccttatccgggcggaggcaagaagtggggcggcaatggcgtcggcgatgacctctactcg tttggctttgatggcgctcatctgtggacaggaggacgcaagacgcttgtagcggacgct ttgcccgaggagccatacatacgcaagggcgacgtcgttggtgtggccattgatctgtcc gtgccggtcattacgttcacctttaacggcaacaaggtgcgcggctgcttcagggacttc aatctggacggcatgttcttcccggtgatgagttgctcctccaagctcagctgtcgcttt ctgtttggcggcgatcacggccgtctgaagtatgccccacccgcgggcttctcggcgctc gtacagtgcctgatgccgcatcagatcctaagcttggatccctgcttttactttggcaat ctgagcaaaaatgtgctggccggtccctggctcatcgaggacgacacagcgtttgtgccg aagccagtggacacgacaggcgtgaccctgcccagctccgtggatcagattaaggagaag ctcgccgagaacatacacgagatgtgggctctgaacaagatcgacgccggctggacctgg ggagagcagcgcgacgactaccatcgcatacatccctgtctcacacagttcgagaagctg ccagctgctgagaagcgttacgacaatcaactagcggtccaaacattgaaaactatcatc tctttgggctactatataaccatggataagccgccagcacgcatacgacccgtgcgcctg cccaacgagatatttatgcaggccaacggctacaagccggcaccgctcgacctgagcgct gtgaccctgacgcccaagctggaggagctcgtcgatcagctggccgagaacacacacaat ctctgggcacgcgagcgcatccaacagggctggacctacggcctaaacgaggactctgaa aatcaccgcagtccccacctggtgccctatgccaaggtcgatgaggccatcaagaaagcg aatcgtgacactgcctccgagacagtgcgcaccctgctggtctacggctatgtgctggat ccgcccaccggcgaaggcaccgaagctctgctagccgaggcacaacgcctgaagttcgcc gcctttcgcacatatcgcgtggaacgcaactacgccgtcacctctggcaaatggtatttc gaattcgaggtgctgacagcgggtccaatgcgcgtgggctgggcacgggccgattgctat ccgggcgccatgttgggcagcgaggacaccagctgggcgtttgatggccacaatgtaacg aaaatgcatgccggaacgatcgagcactttggtgttcgctatgaggctggtgacgtcatt ggttgtttcatcgatgttaaggagcaaaccatcagcttctcgttgaacggagaactactt atggatgccttgggtggcgagacaacgttcgccgatgtcaccgctgagggcgtgggcttt gtgcccgcctgcaccttgggagtgggtcagaaggcgcgcttgatttatggccaagatgtg gactccctcaagttctttaccacctgcggtctgcaagagggctacgagcccttctgtgtc aatatgcaacgccctgttacgcattggtataccaaggatcagccgatttttgagaatacc gaggaaatgcccgattgccgcattgatgtgacgcgcatacctggcggagctgatactccg ccccatttgaagatctcgcataatacgttcgagaccatggagaaggcaaattgggaattc ctgcgtctctccctgcctgtcacctgcatgagcgacttcatcagtgagcaggagaaggcg agacgctgggaggagatcaagctacgccaatatcgcttgatgcgcgaggcacaagaggca gccatccagatgcagacccaaaatgctgcacacatggatcacatgctcaagtccggcttc aatatgaacgacattaagggcttgacgcgcaatttcgatgatcacaccgaggcagaggcc gagcatatgatgcgcggtccaccacgaccaccacgcaaaggttcgctcacccggaatata acatttgagaccgacatgacggctgccttggacgagatgcagcgttcgacctccgtattg gacatgaatggcctgggcgatgatctagatgacaaaaagaaacgtggccgcagtccgttc aagttcttttcgaagaagtcacgcgaccagagccgtgagaagaatggctcgagaaccgca gacacatcgctggagcgcagaaacacggtggcccatggccgaaacgtggttaaccagcag atgacaacaagaacgccaacgttacgtctaaataatgccgaaataccgcccagtccagtg cctcagggaccaaaacaattgagctccacgaatttgggccagccatcagtcgaatcgtct ggcaatgagatgttcgatgccgagtgcctcaagctgattaacgaatatttctatggtgtg cgcatattccctggccaggatcccacccacgtctacgtcggctgggttaccacccaatac catttgcatagtcgcgaattcaataagaataaggtgcgacgcgcctcggtctacattgag gactattatgaagtgcccattgagcgcatcgatcgtcagagctgttatgtggtgcgcgcc gacgagctgttcaatgaggtaacccaagacgcctctggcaaaggtgcatcgcagggtatg tttgtcggttgctttgtggacacggcgacgggcataatacgcttcacctgcgagggcaag gaaacctcgcatcgctggatgatggaaccggacaccaaactgtttccggccattttcgtc gaagccaccagcaaggagatcctgcaaattgagctgggacgcacaccaaccacgctccca ctgtcggcagccgtgctgcccaccagtgacaagcacatcaatccccagtccccgcctcgc ttgaaggtgcagtgcctgcgtccgcatcaatgggcgcgtgtgcccaacacctcactacag gtgcatgcgctgaagctgtccgatattcggggctggtcaatgctctgcgaggatcctgta tcaatgctggccctgcacatacccgaagaggatcgctgcatcgatatattggagctgatt gagatggataaactgctgtccttccatgctcacactctcacgctctacgctgcgctgtgt tatcaatcaaattatcgtgccgcgcacgcgctctgccagcatgtcgatcagaagcaactg ctctatgccatacgctcggagtatatgagtggaccactgcgtcagggattctatgatctg ctgatagcgctgcatctggaatcgcatgccaccacaatggaggtatgcaaaaatgaatat attacaccgttgggccccgagctgaaggaactttatgctgaggatgagatgcgtcactca cttcgttcccttgtcacggagtctgtgcgtccgcagttgcgtatgacggaaatcactccc cctgtgattgcaacatctagtatgccaagtgtttccagcgaaccgatacccaacatcgat cagttgtattccccgaagttcccattagaagtagtcagagaatttgtaatggaggcactc aaagatgctgtggaaataaatcaagtgcataaccgtgatcccatcggttggaccaacgag aatctattcttgccactcatcaagctaacggatcgcctactgttagttggcgtccttact gatgaggacgtacaaaaactattagtaatggtggatccagaaacttgggaccccactttc gaaagagagggaaaagatgagcaccgcaagggtttgctcaccatgaaaatggctgaagga gccaagctacaaatgtgctacctattgcatcatctatacgacacacagctccggcatcgg gtggagagcattatagcattctctcacgattttgtgggcgatctgcaaaccgatcagttg cgccgttatattgagattaaacaatccgatttgccaagtgctgttgcggccaaaaagact aaggaattccgttgtccacccagagaacaaatgaatcagattctttgcttcaagaatctc gaagctgacgatcaggacaattgcacctgtggtcttgagttgcgcagtcgcttaagcgaa ttccacgactctctaatgcaaaaggtatcgctgaatgcgctgcaggagccggatggtact gagacaaatgcaatcgaagagatcaaaacgggacccataacaaagatctacaatttcatc aataccgtcaaggagctagaggagggacccaaagaagtggaggagcctgagaaaaagaca cctgaagaggttttccgcaaagttctaatcaaaaccatcgtcagctgggctgaggaatca caaatcgagaatccaaaattagttcgcgaaatgttcagcttactggtacggcaatacgat acggtcggtgagctggtacgtgctctggagaagacctacgtgatcaacaatcgcgcacga gatgatgtggctgagatgtgggttggcttaagccagattcgtgcattgctgcccgtacaa atgagccaggaagaagaggagctgatgcgtaagcgcttatggaaactggtaaacaatgcc acattcttccagcatccggatttgatacgcatcttacgtgtgcacgaaaacgtaatggcc gtcatgatgaatactctaggccgtcgtgcgcaggcacaaagcgatgctcccgcccagacc gagggagctgagggcgtgccctcaaaggagaaggacacctcgcacgaaatggttgtggct tgttgtcgcttcctatgctacttttgccgtaccggacgtcagaatcagaaggccatgttc gatcactttgactttttgctggacaatgcgaacatattgttagccaggcccagtctgcgt ggttccaccccattggatgtggcatattcgagtttaatggagaacacagaattagctctg gcacttagggaacactatttggagaagattgcagtttacctgtccagatgtggattgcag agcaattctgagctggtcgagaagggctatcccgatttgggctgggacccggtcgagggt gaacgatatctggactttttgcgctattgcgtttgggtcaatggcgagagtgtcgaggag aatgccaaccttgtcattcgtcttcttatccgtcgtccagaatgtttgggaccggctcta agaggagaaggggaaggtctcttccgtgcaatcgtcgaggccaatcgtatgtcggagcgc atatcggatcgttgcaaaatgcaagacgaggccgaaggcaccatagctggacttaatttt acccatcccctaccagaaggcgacgaagatgaggactatatcgatacaggtgccgccata ttgaatttctattgcacacttgttgacctgctgggcagatgcgcccccgacgtgtctgtc atcgagcaaggcaagaacgaatcactgagagctagagctattttgagatctcttgtgcca ctggaagaccttcaaggtgtgcttagcctaaagtttacactcacccaaactgctcccggt gaggagaaaccaaaatcggatatgccatctggcctcttacccaataacaaacagagtatt gtcctctttttggaacgtgtttacggcatagagacacaagatctattctatcggctgctc gaagacgcttttctcccagatctgcgtacagccacaattttggataagagtgatggctca gagagcgatatggcattggccatgaatcgctatattggcaactccattttgccactgctt atcaagcactcaaagttctataacgaagctgagaactatgcaagtctcttggatgccacg ctgcacacggtctataggttatccaagaaccgtatgctaaccaagggacagcgagaggca gtatccgattttctagtagcgctgacgtcacaaatgcaacctgccatgctcttaaagcta ttgcgcaagttgactgttgatgtatccaagctatccgaatatacgaccgtcgcactcagg ctgctcacactacacttcgatcgctgcgctaagtactatggctcgactcaaggccaaggc tcatatggagcttcgtcagatgaggagaagcgtctaacgatgcttctcttctcaaatatt tttgactcgctgagcaacatggactatgacccggaactgttcggtaaagcattgccctgc ctaattgccatcggctgtgccctgccaccagactacagcttatcgaagaataccgatgag gactattatggcagacaaatgggcgcaccagatcagccacaatatgtgccaaatccaatt gatacgaacaatgtacatttggacaatgatttgaattcgttggttcaaaagttcagcgag cattatcacgatgcttgggccagtcgccgtttggagggaggctggacatatggtgaaatt cgatccgatatcgaacgcaagcacccacgcctaaagccttacaatatgctcagtgaatat gagcgtgaacgctaccgagatccggtgcgtgaatgcctcaaaggtcttttggccattggc tggaccgttgagcactctgaaatcgatttgccactcaatcatcgtggctcgacgcgtcgt caatcgaagccccaaattcatgattttcagaatgaaggcaaccccttcaactataatcca catcctgtggacatgagcaacctgacgctcagcagagaaatgcaaaatatggccgaacgt ctggccgaaaactctcatgatatttgggcgaagaagaagaacgaggagttaaatggatgc ggcggagttatacatccacaattggtgccctatgacctgctcaccgacaaggagaagaag aaggatcgcgagcgctcccaagagttcctcaaatacatgcagtatcagggatacaagttg cacaagccctcgaagggtggcgctgttgaggaaggcggtgccacacaagctgccgttgag ttgcgcttctcctattcactgctagagaagctcatccaatatctggaccgtgccaccatc aacatgaagctactgaagccatcgaccacgttcagccgacgcagctccttcaagacggca tcgcgggacatcaagttcttctcaaaggtcgtgttgcctctaatggagaagtatttctcg acgcatcgcaattattttatcgctattgccacggcaacgaacaacataggcgccgcatcg ctaaaggagaaggaaatggttgcctccatattctgtaaattggctgctctgttgcgcaat cgcctgagcgcctttgggcctgatgtgcgcatcaccgtgcgctgcctgcaagtactggtc aagggcatcgatgccaagactttgaccaagaattgccccgaattcatacgcacatcgatg ctgacgttcttcaatcaaacttctgatgatctgggcaacacgatcatgaatctacaggat ggcaagtacagccatttgcgtggtacacatctaaagacctccacgtcactgggctatgta aatcaggtggtgctaccggtgctaactgcaatgtttgatcacctggctgcctgtgattac ggtagtgatctgctgctcgacgagattcaagtggcctcatataagattttagctgcccta tatcacttgggcaccgatgcgacactgacacacgatcgcaaatatttgaaaacggaaatc gagaggcatcgacctgccttgggctcctgcttgggcgcctacagctcgtgcttcccagtt gcctatttggagccgcatctcaataagcacaatcagtactccttgctcaatcgcattgca gaccattcgctggaggcccaggacattatggtcaaaatggaaagctgtatgcccaatttg gaagcgatcctcaatgaagtggatcagtttgttgagtcggataagacttatgccgatgca ccgcacatcatcgatgttatattgccgctgctctgcgcctatttgccattctggtggtcc cagggtccggataacgtgagtccaactagtggcaaccatgtgaccatggtcaccgcggat cacatgaattcgctgctgcgcaatgtgctcaagatgatcaagaagaacattggcaatgat aacgcgccctggatgacacgcattgcggcctacacccagcagataatcatcaatacatca gaggagctgctcaaggatccattcctgccactggcggagcgtgtcaagaagcgtaccgag aacatgctgcacaaggaggacagcatgcgaggatttataaaatcggccacagatgatact tcgcaagtggagacgcaactacaagaggattggaatttgcttgtgcgagacatatactca ttttatccgctactcatcaaatacgtggatctgcagcgcaatcattggctaaaggataac atccctgaggccgaagagctgtacaatcatgttgccgagatcttcaatatctggtcaaag agtcaatacttcttgaaggaggagcaaaactttatatcggccaatgaaattgataatatg gctctgataatgccaacggcgacgcgacgatcggccatatccgagggcgtgccggcagtg ggtggcaaggtcaagaagaagaagaagaacagagacaagaaacgtgacaaggacaaggag gtgcaagccagtttaatggttgcctgtctgaagcgtctactgcccgtaggcctcaatcta ttcgctggtcgcgaacaggagctggtgcagcattgcaaggatagatacttgaagaagatg aacgaatacgatgtcatagaattcgcacgcaatcagttgacattgcctgacaaactggac ccatccgatgagatgtcgtggcagcattacctctactcgaaactgggcaagactgaggat ccagtcgatgaacaggccttggagaaggtgaatgccaattcgaatgagaagggtaaagac aagacgacagagaccgttgatcgaattgtggccatggctaaggttctgtttggcctgcat atgatcgaccatccacaacagcagagcaaaaatgtctacaggagcgttgtgtcaatacaa aggaagcgtgccgtaatcgcatgtttccgtcagacatcgctacattctctacccagacat cgtgcttgcaatatttttgctcgcacctactacgagcaatggctgcaggaggagaacgtc ggccaggaggtgatgatcgaggatctgacgcagacatttgaagagtcggagaaatctaag aaggatgaagaggaaacggacggcaagccagatccgttgactcagctggtgaccaccttc tgtcgtggtgccatgacagaacgcagtggcgcacttcaggaggatttactgtacatgtcc tatgcacaaatcgcagccaagtcttgcggcgaagaggaagaggaaggtggtgacgagggc gaagggggcgagggcggcgaagagggcgaaggcacaagtattcattgccgcatgtcaaaa ctaatggaacaagaaatggagaaacagaagctactgttccatcaagcgcgtctgtcgaat cgtggcgttgccgaaatggtgctgttgcacatatccgcctccaaaggtataccttcggag atggtcatgacgacactcaatttgggcatcgccatactgcgtggcggcaacatcgacatt caaatgggtatgttgaatcacttgaaggagaagaaggatgtgggcttcttcacttccata gccgggctgatgaactcgtgcagtgtgctcgatctggatgcattcgagcgcaacacaaag gccgaggagtatattccaagtgcgggtgcaggtcttggtgtcggctcggaaggcgctgcg ggtgagaagaatatgcacgatgcggagttcacgtgtgctctattccgattcattcagcta acctgcgagggtcacaacttggaatggcaaaactatttacgtacccaggcgggcaatacg actacggtgaatgtggtcatctgtacggtggattatttgctgcgtctgcaggaatcgatt atggacttctattggcactactccagcaaggagatcattgacccagctggcaaggcgaac ttctttaaagccatcggcgtggctagccaagtgttcaataccctcactgaggtcatccag ggtccgtgtaccttgaatcagcaagccttggcccattccagattgtgggatgcggtcggc ggctttctatttctattttcgcatatgcaagacaaactctcgaagcattcgagtcaggtg gatctgctaaaggagctgctcaatctacaaaaggatatgatcaccatgatgttgtccatg ctggaaggcaatgttgtgaatggcacaattggcaagcagatggtggacacccttgttgag tcggctagcaatgttgagctgattctcaagtatttcgatatgttcctgaaattggccgac ttgattgagtcgcccagtttccatgagattgatatgaagaacgagggctgggtaataccc aaggatttcagagacaaaatggagcagtccaagaactacacaccggaggaaatggatttc cttttggcctgctgtgaacgcaatcacgaaggcaaaatagattatagagcctttgtcgaa cgtttccacgagccatcaaaggagatcggtttcaacctggctgtgctgctgaccaatctc agtgaacacatgcccaatgagccgcgcctggcgcgcttcctggagaccgctggctctgtg ctgaactatttcgagccgttcctgggtcgcatcgaaatcttgggcagctcgaagcgtatt gagcgtgtttactttgagatcaaggactcgaacatcgagcaatgggagaagccacagatt cgcgaatcgaaacgcgccttcttctactcgattgtcacggagggcggcgacaaggaaaag ctggaagcatttgttaacttctgtgaggatgcgatctttgagatgacccacgcctctggc ctgatggccacggacgatggcggcggcaatgtgaaacgggatacggcctacagttcctac atgagcgaagaggaggaagagcgcgccgctcgcgatccgattagacgcacaataactgct gtcaaggatggcctgaagttcggagttcacatgctaagtccctcaaacatcaagcaccaa attggagttatgcaaacaaaatcgatacctgaactgattgttggattctttaagataatc ttctatatgttctactacacgggttacgcccactactgtgtggtgcgctatatctttggc atactgttgaatctgatgcgtggtcccgcacccgagcaggaggatgaagtggctgtagtt gaggaggagacatttggacgtgcgctgccgccgttgccgctggaggagccaccgggcccg gttcaagcattcggcttggacataaacaaagaggaaaacggcgtgtacaaggtggtggtc cacgagtcgccagccagctcatctgtggaggagggcggtgagtctagcccagaagatggc gcagctccaaccggagaactagtcgaaggcgaactgcatcaggaacccatttcaattgtc gatatgctcggtggtgaggcggctaagaaggcagctcaggagcgtcaggaggcgcagaag gcccaagaggcagccatggcatccattgaagcggaggccaagaagtcatcggcagcacca caagagacaccagcggtgcaccagatcgacttctcgcagtacacgcaccgcgccgtcagc ttcttggctcgcaacttttacaatttgaaatatgtggcgctcgtcttggctttcagcatt aactttatgttgctcttctacaaggtgacctcattcaacgaggaatcagaaggatcggcc gaagaggagcttattctgggctctggctcgggtgctggtgctgacatggctggctctggt ctgggtggctcgggcgatgggtcgggcgatggcgatttcgaagacgatgacataccggaa ctggtgcacgtggatgaggacttcttctatatggagcatgtgctgcgcattgccgcactg ctccactccctagtatcgctggccatgctcatcgcttactatcatctaaaggtgccgctg gccatattcaagcgagaaaaggaaattgcacgtcgtctggaattcgatggtctcttcata gccgagcagccggaggatgatgacttcaagtcccactgggataagctggtcatatcggcc aagagtttccctgtcaattactgggataaatttgtcaagaagaaggtcaggcaaaagtac agtgagacctacgactttgactcaatctcgaatctgctgggcatggagaagagcgccttt acggcacaggagagcgaggagacgggcattctgcgctacatcatgaacatcgattggcgc tatcaggtgtggaaggctggagtcacctttacggacaactccttcctctactcactgtgg tacttcagcttctcggtgatgggcaactttaacaacttcttctttgccgcccatttgctg gatgtggccgttggctttaagacactgcgcacgattctgcagtccgtaacccacaatggc aaacagctcgttctgaccgtgatgctcctgacgattatcgtttatatatacacggtgatt gcgttcaacttcttccgcaagttctacatacaggaggaggatgaggaggtggacaagaag tgccatgacatgttgacctgtttcgtcttccatttgtacaagggcgttagagcaggcggt ggcattggcgacgaaatcggggatccggatggagatgattatgaggtctatcgcatcatc ttcgacatcacattcttcttcttcgtcattgtcatcctgttggccatcatccagggtttg attatcgacgctttcggcgagctgcgtgatcaattggaatcggtcaaggataatatggaa tcgaattgctttatttgtggcatgggtaaggacttctttgatatagtcccgcatggcttc gatacgcacgtgcagaaggagcacaatctggccaactatatgttcttcctgatgcatttg atcaataaaccggataccgagtacaccggccaggagacgtacgtgtggaatatgtatcaa cagcgcagctgggacttcttcccagtgggcgactgcttccgcaagcagtacgaggacgaa ctctctggcggcggcggtggcggaggctga

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