KEGG   Delphinus delphis (saddleback dolphin): 132430028
Entry
132430028         CDS       T11117                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ddp  Delphinus delphis (saddleback dolphin)
Pathway
ddp00562  Inositol phosphate metabolism
ddp01100  Metabolic pathways
ddp04015  Rap1 signaling pathway
ddp04020  Calcium signaling pathway
ddp04022  cGMP-PKG signaling pathway
ddp04062  Chemokine signaling pathway
ddp04070  Phosphatidylinositol signaling system
ddp04071  Sphingolipid signaling pathway
ddp04072  Phospholipase D signaling pathway
ddp04081  Hormone signaling
ddp04082  Neuroactive ligand signaling
ddp04261  Adrenergic signaling in cardiomyocytes
ddp04270  Vascular smooth muscle contraction
ddp04310  Wnt signaling pathway
ddp04371  Apelin signaling pathway
ddp04540  Gap junction
ddp04611  Platelet activation
ddp04613  Neutrophil extracellular trap formation
ddp04621  NOD-like receptor signaling pathway
ddp04713  Circadian entrainment
ddp04720  Long-term potentiation
ddp04723  Retrograde endocannabinoid signaling
ddp04724  Glutamatergic synapse
ddp04725  Cholinergic synapse
ddp04726  Serotonergic synapse
ddp04728  Dopaminergic synapse
ddp04730  Long-term depression
ddp04742  Taste transduction
ddp04750  Inflammatory mediator regulation of TRP channels
ddp04911  Insulin secretion
ddp04912  GnRH signaling pathway
ddp04915  Estrogen signaling pathway
ddp04916  Melanogenesis
ddp04918  Thyroid hormone synthesis
ddp04919  Thyroid hormone signaling pathway
ddp04921  Oxytocin signaling pathway
ddp04922  Glucagon signaling pathway
ddp04924  Renin secretion
ddp04925  Aldosterone synthesis and secretion
ddp04926  Relaxin signaling pathway
ddp04927  Cortisol synthesis and secretion
ddp04928  Parathyroid hormone synthesis, secretion and action
ddp04929  GnRH secretion
ddp04933  AGE-RAGE signaling pathway in diabetic complications
ddp04934  Cushing syndrome
ddp04935  Growth hormone synthesis, secretion and action
ddp04961  Endocrine and other factor-regulated calcium reabsorption
ddp04970  Salivary secretion
ddp04971  Gastric acid secretion
ddp04972  Pancreatic secretion
ddp04973  Carbohydrate digestion and absorption
ddp05010  Alzheimer disease
ddp05016  Huntington disease
ddp05017  Spinocerebellar ataxia
ddp05022  Pathways of neurodegeneration - multiple diseases
ddp05142  Chagas disease
ddp05143  African trypanosomiasis
ddp05146  Amoebiasis
ddp05163  Human cytomegalovirus infection
ddp05200  Pathways in cancer
ddp05415  Diabetic cardiomyopathy
ddp05417  Lipid and atherosclerosis
Module
ddp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ddp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    132430028 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    132430028 (PLCB3)
   04310 Wnt signaling pathway
    132430028 (PLCB3)
   04371 Apelin signaling pathway
    132430028 (PLCB3)
   04020 Calcium signaling pathway
    132430028 (PLCB3)
   04070 Phosphatidylinositol signaling system
    132430028 (PLCB3)
   04072 Phospholipase D signaling pathway
    132430028 (PLCB3)
   04071 Sphingolipid signaling pathway
    132430028 (PLCB3)
   04022 cGMP-PKG signaling pathway
    132430028 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    132430028 (PLCB3)
   04081 Hormone signaling
    132430028 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    132430028 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132430028 (PLCB3)
   04613 Neutrophil extracellular trap formation
    132430028 (PLCB3)
   04621 NOD-like receptor signaling pathway
    132430028 (PLCB3)
   04062 Chemokine signaling pathway
    132430028 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    132430028 (PLCB3)
   04922 Glucagon signaling pathway
    132430028 (PLCB3)
   04929 GnRH secretion
    132430028 (PLCB3)
   04912 GnRH signaling pathway
    132430028 (PLCB3)
   04915 Estrogen signaling pathway
    132430028 (PLCB3)
   04921 Oxytocin signaling pathway
    132430028 (PLCB3)
   04926 Relaxin signaling pathway
    132430028 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    132430028 (PLCB3)
   04918 Thyroid hormone synthesis
    132430028 (PLCB3)
   04919 Thyroid hormone signaling pathway
    132430028 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    132430028 (PLCB3)
   04916 Melanogenesis
    132430028 (PLCB3)
   04924 Renin secretion
    132430028 (PLCB3)
   04925 Aldosterone synthesis and secretion
    132430028 (PLCB3)
   04927 Cortisol synthesis and secretion
    132430028 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    132430028 (PLCB3)
   04270 Vascular smooth muscle contraction
    132430028 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    132430028 (PLCB3)
   04971 Gastric acid secretion
    132430028 (PLCB3)
   04972 Pancreatic secretion
    132430028 (PLCB3)
   04973 Carbohydrate digestion and absorption
    132430028 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    132430028 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    132430028 (PLCB3)
   04725 Cholinergic synapse
    132430028 (PLCB3)
   04728 Dopaminergic synapse
    132430028 (PLCB3)
   04726 Serotonergic synapse
    132430028 (PLCB3)
   04720 Long-term potentiation
    132430028 (PLCB3)
   04730 Long-term depression
    132430028 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    132430028 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    132430028 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    132430028 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    132430028 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132430028 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    132430028 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    132430028 (PLCB3)
   05142 Chagas disease
    132430028 (PLCB3)
   05143 African trypanosomiasis
    132430028 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132430028 (PLCB3)
   05016 Huntington disease
    132430028 (PLCB3)
   05017 Spinocerebellar ataxia
    132430028 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    132430028 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132430028 (PLCB3)
   05415 Diabetic cardiomyopathy
    132430028 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    132430028 (PLCB3)
   04934 Cushing syndrome
    132430028 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ddp04131]
    132430028 (PLCB3)
Enzymes [BR:ddp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     132430028 (PLCB3)
Membrane trafficking [BR:ddp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    132430028 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    132430028 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 132430028
NCBI-ProteinID: XP_059875120
LinkDB
Position
8:102548607..102565873
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPSGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLITVVAGPDPVNTSFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPEDLMGRILVKNKKRHRPSTGVPDS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEAGLEKPSLEPQKSLGE
ESLQRGPDALGSAYREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANAVRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLALLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLV
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGLETSQETQSQQP
GSQLTPNPTPSPLDASPRRAPGPITSSTSTSLSSPGQRDDLIASVLSEVAPVPLDELRGH
KALLKLQSRQERDFRELHKKHQRKAVALTRRLLDNLAQAQAESRCRHRPGVLGGEDEREE
EEEVKRYQEFQKKQVQCLLELREAQADTEAERRLEHLRQAQQRLREIVMDAHTTQCKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLVAAQQQILQQLTEEEPKLLAQLAQECQEQRERLPQEIRRSLLGETPEGLGDGHL
VACASNGHAPGSSGHLSGADSESQEETTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtcgtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaactctgcgcgtggaccccagtggcttcttcctgtactggacggggcccaacatggag
gtggacacactggacatcagttccatcagggacacgaggacaggccgttatgcccgccta
cccaaggaccccaagattcgggaggtgttgggctttgggggccctgatgcccggttggag
gagaagttgataacagtggtggctgggccagacccggtgaatacatcgtttttgaacttc
atggccgtgcaggatgacacagccaaggtctggtccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcttgcgcaaagcgtacacgaagctg
aaactgcaggtgaaccaggatggacggatcccggtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtagaaactgcgctggaatcctgtggcctcaatttcaaccggagc
gagtccatccggcctgacgagttttccttggaaatcttcgagcggttcttgaacaagctt
tgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaaaccatac
ctgacactggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaat
gaagtgctgtacccgcctctgcggccctcccaggcccggctgcttatcgagaagtatgag
cccaaccagcaattcctggagagagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaacggcatcctgcccctagaggctctggatctgagcgcagacatgacc
cagccgctcagtgcctacttcatcaactcctcacacaacacctatctcactgcggggcag
ctggcgggaacctcgtcggtggagatgtaccggcaggcactgctgtggggctgccgctgc
gtggagctggacgtgtggaaaggacggccgcctgaggaggagcccttcatcacccacggc
ttcaccatgaccacggaggtgccgctgcgagatgtgctggaggccattgcggagaccgcc
ttcaagacctcgccctaccctgtcatcctctcctttgagaaccatgtggactcggcaaag
cagcaggccaagatggctgagtactgccgctccatctttggggacgcgctgctcatcgac
cccctggacaagtacccgctggccccgggcgtccccctgcccagccccgaggacctgatg
ggccgcatcctggtgaagaacaagaagcggcaccggcccagcactggcgttcccgacagc
tccgtgcgcaagcggccactagagcagagcaactcggccctgagtgagagctccgctgcc
accgagccctcctcgccccagctcgggtcccccagctctgacagctgcccaggcctgagc
aatggggaggaggcgggccttgagaagcccagcctggagcctcagaagtctctgggtgag
gagagtttgcagcggggccctgatgcccttggatctgcctaccgtgaggatgaggaagag
gatgaggaagaggaggaacagacggaccccaaaaagccgaccaccgatgagggcactgcc
agcagtgaggtcaatgccactgaggaaatgtcgacgcttgtcaactacatcgagcccgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaagtgctttgagatgtcatccttt
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacacgcgtggactcgtccaactacatg
ccccagctcttctggaatgtgggctgccagctcgtcgcgctcaacttccagaccctggac
gtggccatgcagctcaacgcgggcgtgttcgagtacaatgggcgcagtggctacctactc
aagcccgagttcatgcggcggccggacaagtcctttgaccccttcaccgaggtcatcgtg
gatggcatcgtggccaatgccgtgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggatatgttcggcctccctgtcgacacgcggcgc
aagtaccgcactcggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
ttcgacttccccaaagtggtactgcccacgctggctttgctgcgcatcgcggcctttgag
gagggtggcaagttcgtggggcaccggatcctgcctgtctctgccatccgctcagggtac
cactacatctgcctgcggaacgaggccaaccagccgctgtgcctgccggccctgcttgtc
tacactgaggcctctgactacattcccgatgaccaccaagactacgcagaggccctgatc
aatcccatcaagcacgtcagcctgatggaccagagggccaagcagctggctgccctcatt
ggggagagtgaggctcaggctggcctagagacaagccaggagacccagtctcagcagcca
gggtcccaactgaccccaaaccccacacccagcccactggacgcctccccccgccgggcc
ccaggccccatcacctcctccaccagcacctccctcagcagcccaggtcagcgtgatgac
ctcattgccagcgtcctctcagaggtggccccggtcccgctggatgagctccgaggccac
aaggccctgttgaagctccagagccggcaagagcgagactttcgagagctgcacaagaag
catcagcggaaggcggttgccctcacacgccggttgctcgacaacctggcccaggcccag
gccgagagcaggtgccggcaccggccgggtgtcctaggcggggaggacgagagggaggag
gaggaagaggtgaagaggtatcaagagttccagaagaagcaggtgcagtgtctgctggag
ctgagggaggcccaggcggacacagaggccgagcggaggctggagcacctgagacaggct
cagcagaggctcagggagattgtcatggatgctcacaccactcagtgcaagagactgaag
gagatgaacgagagggagaagaaggaactgcagaagatactggacaggaagcgccacaac
agtatctcagaggcaaagaccagggagaaacataagaaggaggcggaactgacagagatt
aaccgtcgacacatcactgagtcggtcaactccatccgtcggctggaggaggcccaaaag
cagcggcaggaacgccttgtggccgcgcagcagcagattctccaacagctgacagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggagaggctgccc
caggagatccgccggagcctgctgggcgagacaccggagggactgggggacgggcatctg
gtggcctgtgccagcaatggtcacgcgcctgggagcagtgggcacctgtccggcgctgat
tcggagagccaagaggagactacgaagctctga

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