KEGG   Delphinus delphis (saddleback dolphin): 132434173
Entry
132434173         CDS       T11117                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
ddp  Delphinus delphis (saddleback dolphin)
Pathway
ddp01522  Endocrine resistance
ddp04010  MAPK signaling pathway
ddp04015  Rap1 signaling pathway
ddp04068  FoxO signaling pathway
ddp04071  Sphingolipid signaling pathway
ddp04114  Oocyte meiosis
ddp04148  Efferocytosis
ddp04218  Cellular senescence
ddp04261  Adrenergic signaling in cardiomyocytes
ddp04370  VEGF signaling pathway
ddp04380  Osteoclast differentiation
ddp04517  IgSF CAM signaling
ddp04550  Signaling pathways regulating pluripotency of stem cells
ddp04611  Platelet activation
ddp04613  Neutrophil extracellular trap formation
ddp04620  Toll-like receptor signaling pathway
ddp04621  NOD-like receptor signaling pathway
ddp04622  RIG-I-like receptor signaling pathway
ddp04625  C-type lectin receptor signaling pathway
ddp04657  IL-17 signaling pathway
ddp04658  Th1 and Th2 cell differentiation
ddp04659  Th17 cell differentiation
ddp04660  T cell receptor signaling pathway
ddp04664  Fc epsilon RI signaling pathway
ddp04668  TNF signaling pathway
ddp04670  Leukocyte transendothelial migration
ddp04714  Thermogenesis
ddp04722  Neurotrophin signaling pathway
ddp04723  Retrograde endocannabinoid signaling
ddp04728  Dopaminergic synapse
ddp04750  Inflammatory mediator regulation of TRP channels
ddp04912  GnRH signaling pathway
ddp04914  Progesterone-mediated oocyte maturation
ddp04917  Prolactin signaling pathway
ddp04926  Relaxin signaling pathway
ddp04932  Non-alcoholic fatty liver disease
ddp04933  AGE-RAGE signaling pathway in diabetic complications
ddp04935  Growth hormone synthesis, secretion and action
ddp04936  Alcoholic liver disease
ddp05014  Amyotrophic lateral sclerosis
ddp05020  Prion disease
ddp05022  Pathways of neurodegeneration - multiple diseases
ddp05132  Salmonella infection
ddp05133  Pertussis
ddp05135  Yersinia infection
ddp05140  Leishmaniasis
ddp05142  Chagas disease
ddp05145  Toxoplasmosis
ddp05152  Tuberculosis
ddp05161  Hepatitis B
ddp05163  Human cytomegalovirus infection
ddp05167  Kaposi sarcoma-associated herpesvirus infection
ddp05169  Epstein-Barr virus infection
ddp05170  Human immunodeficiency virus 1 infection
ddp05171  Coronavirus disease - COVID-19
ddp05205  Proteoglycans in cancer
ddp05208  Chemical carcinogenesis - reactive oxygen species
ddp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ddp05415  Diabetic cardiomyopathy
ddp05417  Lipid and atherosclerosis
ddp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ddp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    132434173 (MAPK12)
   04015 Rap1 signaling pathway
    132434173 (MAPK12)
   04370 VEGF signaling pathway
    132434173 (MAPK12)
   04668 TNF signaling pathway
    132434173 (MAPK12)
   04068 FoxO signaling pathway
    132434173 (MAPK12)
   04071 Sphingolipid signaling pathway
    132434173 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    132434173 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    132434173 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    132434173 (MAPK12)
   04218 Cellular senescence
    132434173 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    132434173 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132434173 (MAPK12)
   04613 Neutrophil extracellular trap formation
    132434173 (MAPK12)
   04620 Toll-like receptor signaling pathway
    132434173 (MAPK12)
   04621 NOD-like receptor signaling pathway
    132434173 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    132434173 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    132434173 (MAPK12)
   04660 T cell receptor signaling pathway
    132434173 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    132434173 (MAPK12)
   04659 Th17 cell differentiation
    132434173 (MAPK12)
   04657 IL-17 signaling pathway
    132434173 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    132434173 (MAPK12)
   04670 Leukocyte transendothelial migration
    132434173 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    132434173 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    132434173 (MAPK12)
   04917 Prolactin signaling pathway
    132434173 (MAPK12)
   04926 Relaxin signaling pathway
    132434173 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    132434173 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    132434173 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    132434173 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    132434173 (MAPK12)
   04722 Neurotrophin signaling pathway
    132434173 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    132434173 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    132434173 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    132434173 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    132434173 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    132434173 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    132434173 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    132434173 (MAPK12)
   05161 Hepatitis B
    132434173 (MAPK12)
   05171 Coronavirus disease - COVID-19
    132434173 (MAPK12)
   05163 Human cytomegalovirus infection
    132434173 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    132434173 (MAPK12)
   05169 Epstein-Barr virus infection
    132434173 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    132434173 (MAPK12)
   05135 Yersinia infection
    132434173 (MAPK12)
   05133 Pertussis
    132434173 (MAPK12)
   05152 Tuberculosis
    132434173 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    132434173 (MAPK12)
   05140 Leishmaniasis
    132434173 (MAPK12)
   05142 Chagas disease
    132434173 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    132434173 (MAPK12)
   05020 Prion disease
    132434173 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    132434173 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132434173 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    132434173 (MAPK12)
   05415 Diabetic cardiomyopathy
    132434173 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    132434173 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    132434173 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    132434173 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    132434173 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ddp01001]
    132434173 (MAPK12)
Enzymes [BR:ddp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     132434173 (MAPK12)
Protein kinases [BR:ddp01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   132434173 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo CENP-F_C_Rb_bdg Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 132434173
NCBI-ProteinID: XP_059881848
LinkDB
Position
11:complement(101805534..101814091)
AA seq 367 aa
MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPHETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGETLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSAEAQNYMNGLPELEKKDFADILTNASPLAVNLLEKMLVLDAERRV
TAAKALTHPYFESLHDTEDEPKAQKYDESFDDVDRTLEEWKRVTYREVLSFKPPRQLGAK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcccgcccgcaagggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtaggctcgggcgcctatggcgcc
gtgtgctcggcggtggacagccgcacgggcgccaaggtggccataaagaagctgtaccgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccatgagaacgtgattgggctgctcgatgtgttcacgccccatgagaccctggat
gatttcacagacttttacctggtgatgccgttcatgggcaccgacctggggaagctcatg
aagcacgagaagctgagtgaggaccgaatccagttcctcgtctaccagatgctcaagggg
ctgaagtacatccatgctgctggcatcatccacagggacctgaagcccggcaacctggcc
gtgaacgaggactgtgagctcaagatcctggacttcggcctggcccggcaggcagatagc
gagatgactgggtacgtggtgacccgctggtaccgggcgcctgaggtcatcttgaattgg
atgcactacacacagacggtggacatctggtcagtgggctgcatcatggctgagatgatc
acaggggagacgctcttcaaaggcagcgaccacctggaccagctgaaggagatcatgaag
gtgacggggacgcctcccgccgagttcgtgcagaggctgcagagtgccgaggctcagaac
tacatgaacggcctccccgagctagagaaaaaggattttgccgacatcctgaccaacgca
agccctctggccgtgaacctcctggagaagatgctggtgctggatgcggagcggcgggtg
acggcggccaaggcgctgacccacccctacttcgagtcgctccacgacacggaggacgag
cccaaagcccaaaagtacgatgaatcctttgatgacgtggaccgcacgctggaagagtgg
aagcgtgtcacatacagagaggtgctcagcttcaagcctccccgacagctgggggccaag
gtctccaaggagacggccctgtga

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