KEGG   Delphinus delphis (saddleback dolphin): 132437791
Entry
132437791         CDS       T11117                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ddp  Delphinus delphis (saddleback dolphin)
Pathway
ddp00562  Inositol phosphate metabolism
ddp01100  Metabolic pathways
ddp04015  Rap1 signaling pathway
ddp04020  Calcium signaling pathway
ddp04022  cGMP-PKG signaling pathway
ddp04062  Chemokine signaling pathway
ddp04070  Phosphatidylinositol signaling system
ddp04071  Sphingolipid signaling pathway
ddp04072  Phospholipase D signaling pathway
ddp04081  Hormone signaling
ddp04082  Neuroactive ligand signaling
ddp04261  Adrenergic signaling in cardiomyocytes
ddp04270  Vascular smooth muscle contraction
ddp04310  Wnt signaling pathway
ddp04371  Apelin signaling pathway
ddp04540  Gap junction
ddp04611  Platelet activation
ddp04613  Neutrophil extracellular trap formation
ddp04621  NOD-like receptor signaling pathway
ddp04713  Circadian entrainment
ddp04720  Long-term potentiation
ddp04723  Retrograde endocannabinoid signaling
ddp04724  Glutamatergic synapse
ddp04725  Cholinergic synapse
ddp04726  Serotonergic synapse
ddp04728  Dopaminergic synapse
ddp04730  Long-term depression
ddp04742  Taste transduction
ddp04750  Inflammatory mediator regulation of TRP channels
ddp04911  Insulin secretion
ddp04912  GnRH signaling pathway
ddp04915  Estrogen signaling pathway
ddp04916  Melanogenesis
ddp04918  Thyroid hormone synthesis
ddp04919  Thyroid hormone signaling pathway
ddp04921  Oxytocin signaling pathway
ddp04922  Glucagon signaling pathway
ddp04924  Renin secretion
ddp04925  Aldosterone synthesis and secretion
ddp04926  Relaxin signaling pathway
ddp04927  Cortisol synthesis and secretion
ddp04928  Parathyroid hormone synthesis, secretion and action
ddp04929  GnRH secretion
ddp04933  AGE-RAGE signaling pathway in diabetic complications
ddp04934  Cushing syndrome
ddp04935  Growth hormone synthesis, secretion and action
ddp04961  Endocrine and other factor-regulated calcium reabsorption
ddp04970  Salivary secretion
ddp04971  Gastric acid secretion
ddp04972  Pancreatic secretion
ddp04973  Carbohydrate digestion and absorption
ddp05010  Alzheimer disease
ddp05016  Huntington disease
ddp05017  Spinocerebellar ataxia
ddp05022  Pathways of neurodegeneration - multiple diseases
ddp05142  Chagas disease
ddp05143  African trypanosomiasis
ddp05146  Amoebiasis
ddp05163  Human cytomegalovirus infection
ddp05200  Pathways in cancer
ddp05415  Diabetic cardiomyopathy
ddp05417  Lipid and atherosclerosis
Module
ddp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ddp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    132437791 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    132437791 (PLCB4)
   04310 Wnt signaling pathway
    132437791 (PLCB4)
   04371 Apelin signaling pathway
    132437791 (PLCB4)
   04020 Calcium signaling pathway
    132437791 (PLCB4)
   04070 Phosphatidylinositol signaling system
    132437791 (PLCB4)
   04072 Phospholipase D signaling pathway
    132437791 (PLCB4)
   04071 Sphingolipid signaling pathway
    132437791 (PLCB4)
   04022 cGMP-PKG signaling pathway
    132437791 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    132437791 (PLCB4)
   04081 Hormone signaling
    132437791 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    132437791 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132437791 (PLCB4)
   04613 Neutrophil extracellular trap formation
    132437791 (PLCB4)
   04621 NOD-like receptor signaling pathway
    132437791 (PLCB4)
   04062 Chemokine signaling pathway
    132437791 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    132437791 (PLCB4)
   04922 Glucagon signaling pathway
    132437791 (PLCB4)
   04929 GnRH secretion
    132437791 (PLCB4)
   04912 GnRH signaling pathway
    132437791 (PLCB4)
   04915 Estrogen signaling pathway
    132437791 (PLCB4)
   04921 Oxytocin signaling pathway
    132437791 (PLCB4)
   04926 Relaxin signaling pathway
    132437791 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    132437791 (PLCB4)
   04918 Thyroid hormone synthesis
    132437791 (PLCB4)
   04919 Thyroid hormone signaling pathway
    132437791 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    132437791 (PLCB4)
   04916 Melanogenesis
    132437791 (PLCB4)
   04924 Renin secretion
    132437791 (PLCB4)
   04925 Aldosterone synthesis and secretion
    132437791 (PLCB4)
   04927 Cortisol synthesis and secretion
    132437791 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    132437791 (PLCB4)
   04270 Vascular smooth muscle contraction
    132437791 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    132437791 (PLCB4)
   04971 Gastric acid secretion
    132437791 (PLCB4)
   04972 Pancreatic secretion
    132437791 (PLCB4)
   04973 Carbohydrate digestion and absorption
    132437791 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    132437791 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    132437791 (PLCB4)
   04725 Cholinergic synapse
    132437791 (PLCB4)
   04728 Dopaminergic synapse
    132437791 (PLCB4)
   04726 Serotonergic synapse
    132437791 (PLCB4)
   04720 Long-term potentiation
    132437791 (PLCB4)
   04730 Long-term depression
    132437791 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    132437791 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    132437791 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    132437791 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    132437791 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132437791 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    132437791 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    132437791 (PLCB4)
   05142 Chagas disease
    132437791 (PLCB4)
   05143 African trypanosomiasis
    132437791 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132437791 (PLCB4)
   05016 Huntington disease
    132437791 (PLCB4)
   05017 Spinocerebellar ataxia
    132437791 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    132437791 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132437791 (PLCB4)
   05415 Diabetic cardiomyopathy
    132437791 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    132437791 (PLCB4)
   04934 Cushing syndrome
    132437791 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ddp04131]
    132437791 (PLCB4)
Enzymes [BR:ddp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     132437791 (PLCB4)
Membrane trafficking [BR:ddp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    132437791 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    132437791 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 132437791
NCBI-ProteinID: XP_059887209
LinkDB
Position
15:35932784..36352253
AA seq 1209 aa
MCMKKSFCKHVLNIIMAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFG
FFLTWRSEGKEGQVLECSLINSVRLGATPKDPKILAALEAIGKSENDLEGRVVCVCSGTD
LVNISFTYMVAENSEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIP
VRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDL
FKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKKKG
QISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEM
YRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVI
LSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRL
KSEVEKKQLEALKSMMEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDL
GHKEAIANSVKKGLVTIEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEE
RNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQ
MVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSV
QVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILP
DLAVLRLAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVP
DGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKASV
TPQSSSELRPTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKK
HAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTL
TSDHKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTLQL
KLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRL
AMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSN
SCVKLQDAN
NT seq 3630 nt   +upstreamnt  +downstreamnt
atgtgtatgaagaaaagcttttgcaaacacgtcttaaatataatcatggccaaaccttat
gaatttaattggcagaaggaagttccttcgtttttgcaagaaggagcagtttttgacaga
tatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaagtggatgaatttggc
ttctttctgacctggagaagtgaaggcaaggaaggacaagttctagaatgttctctcatc
aacagtgttcgactgggagccacaccaaaggatcccaaaattttggctgctcttgaagct
attggaaaatcagaaaatgacctggaagggcgggtagtttgtgtctgcagtggtacagat
ctggtgaacatcagtttcacatacatggtggctgaaaattcagaagtaactaagcaatgg
gtcgaaggcctgaggtccatcatacacaacttcagggccaacaatgtcagtcccatgaca
tgcctcaagaaacactggatgaaattggcatttatgaccaacacaaatgggaaaattcca
gttaggagtattaccagaacctttgcatcagggaagacagaaaaggtgatctttcaagca
ctcaaggagctaggtcttcccagtggaaagaatgatgaaattgaacctgcagcatttact
tatgaaaagttctatgaactgacacaaaagatttgtcctcggacagatatagaggatctt
tttaaaaaaatcaatggagacaaaactgattatttaacggtagaccaattagtgagcttt
ctaaatgaacatcaacgagatcctcgattgaatgaaattttattcccattttatgatact
aaaagggcaatgcagatcattgagatgtatgagcctgatgaagacttgaagaaaaaaggc
caaatatctagtgatgggttttgcagatacctgatgtcagatgaaaatgccccagtcttc
ctagatcgcctagagctttaccaagaaatggaccaccctctggctcactacttcatcagc
tcttcccacaacacctatctcactggcagacagtttggtgggaagtcttcagtagaaatg
tacagacaggtcctcctggctggttgcagatgtgttgaacttgactgttgggatggaaaa
ggtgaggaccaagaaccaataataactcatggaaaagcaatgtgcacagatatccttttt
aaggatgttattcaagccatcaaggaaactgcatttgtcacatctgaatatcctgtaatt
ctctcctttgaaaatcactgcagcaaatatcaacagtacaagatgtccaaatattgcgaa
gatctatttggagatctcctgttgaaacaagcacttgaatcacatccactggaaccaggc
aggcctttgccatccccaaatgacctcaaaagaaaaatactcatcaaaaataaacggctg
aaatctgaggttgaaaaaaaacagcttgaagctttgaaaagtatgatggaagcaggagaa
tccgctgccccagtgaacatcttagaggacgacaatgaagaggaaatagaaagtgctgag
caagaggaagaagctcaccctgaatacaaatatggaaatgaactttctgcagacgacttg
ggtcacaaggaagctattgccaatagtgttaagaagggcctggtaactatagaagatgag
caggcgtggatggcatcttataaatatgtaggcgccaccactaatatccatccgtatttg
tccacaatgatcaactatgcacagcccgtaaagtttcaaggtttccatgtggctgaagaa
cgcaatattcattataacatgtcttcttttaatgagtcagttggtctgggctacttgaag
acacatgcgattgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaag
ggaggccgagtcgattccagtaattacatgcctcagattttctggaacgctggctgccag
atggtttcgctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaattt
gagtataatggatcgtgcgggtaccttctcaaaccagatttcatgagacggcctgatcga
acatttgatcccttctctgaaacgcctgttgatggggttattgcagccacttgctcagtg
caggtcatatcaggtcagttcttatcagataaaaaaattggcacatatgtagaagtggat
atgtatgggttgcccaccgacactatccggaaggaattccgaacacgcatggtgatgaac
aatggactcaatccagtttacaatgaagaatcatttgtatttcggaaggtgatcctccct
gacctggcagtcttgagacttgcagtgtatgatgacaacaacaaactgattggccagagg
attctgccactggatggcctccaagcaggctatcgacacatttctcttcgaaacgaggga
aataaacctttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcct
gatggatttggagatattgtggatgctttatcagatccaaagaaatttctttccattacg
gaaaagagagcagaccaaatgagagctatgggcattgaaaccagtgacatcgccgacgtg
cccagtgacacatcaaagaatgacaagaaagggaaagccaacacagcgaaagcaagtgtg
acccctcagagcagctcagagctcaggcccaccaccacggccgccctgggagctggcctg
gaggccaagaaaggtattgaactgatccctcaagtgaggatagaagatttaaagcagatg
aaggcttacttgaagcatttaaagaaacaacagaaggagctcaattctttaaagaagaaa
catgcaaaggagcacagcaccatgcagaagctacattgcacacaagttgacaaaattgtg
gcgcagtatgacaaggagaagtcaactcatgagaaaatcctagagaaggcaatgaagaag
aaggggggaagtaattgtctcgaaatgaagaaagaaacagaaattaaaattcagacgctg
acatcagatcacaaatctaaggtcaaggagatcgtggcacagcacacaaaagagtggtca
gacatgatcaacactcacagtgcagaggagcaggagatccgggatctgcacctcagccag
cagtgtgagctactcagaaagctcctgatcaacgcccacgagcagcagaccctgcagttg
aaactgtctcatgacagggaaagcaaggaaatgcgagcgcaccaggctaagatttctatg
gaaaatagcaaagccatcagccaagataaatctatcaagaataaagcagaacgggaaagg
cgggtcagggagttaaacagcagcaacactaaaaagtttctggaagaaagaaagcgactc
gcaatgaagcagtccaaagaaatggaccagttgaaaaaagtccagcttgagcacctcgaa
ttcctagagaaacagaacgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaa
ggcgaaggagatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaac
agttgtgtgaaactccaggacgcaaactga

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