Drosophila hydei: 111594932 Help Entry 111594932         CDS       T05888                                  Name (RefSeq) protein purity of essence   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism dhe  Drosophila hydei Brite KEGG Orthology (KO) [BR:dhe00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dhe04121]     111594932 Enzymes [BR:dhe01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      111594932 Ubiquitin system [BR:dhe04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     111594932 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR LEDGF Htt_N-HEAT_1 Motif Other DBs NCBI-GeneID:  111594932 NCBI-ProteinID:  XP_023164192 UniProt:  A0A6J1LDG4 LinkDB All DBs Position Unknown AA seq 5358 aa AA seqDB search MSAHSGGTDWNSVVKPLLSNRTSALNKNEISNLLKAITRCEHEFFDDESNYTQYYTAFAA LAADKIMQIKSICQTQISQLHDASAVLIRFILFRLPKVSVYEIKWLLVALKMLCEGRESV TQGSGSSTQFDYNAVAAVLKSAKHPESNIKSISSSSCSSVASGATGNEKESPKSEIKRSR SDLSTVILQQLLAPLEPGKMTWVPLSEEINDCTEQLLAANVEYFQEQNGVDTLLDVGVCL PILNRYRSKYQETIVGGKALYLPLTQVEASTVKSAMAHMLTDLSILGQAHSLIALQPLTP SRIEKLSMCGIAALYNAVLTSIAASVLSMCQASGGSQKQQPAAATTSQGSGNNSNVSTGA KDHDDFEEQACTIVNKALEIYTSIGEMFKASARMHVYQNHLCYGSWLLISGIQGAMGASG SSSSSSGTSTGKSATSTAESNVAPSTPIARVNLFKVQQGFGELNAAIANHSIKLLSELID DLKIESACGSTSSSGSTSCLDIEPAQFDILQNYTALQRIVRVLNTATLHQLFTFLATVAY RKACTLKRANTKDRTECEPISYSDSTTYFNDSLSCSDNSEEDDSESYLGHWFKETLSPET HDDNANACTQERSGEQKSALVPRLDEPHEYLDLAADIFCFLDQFLANRHAYMQRYVKAGV SDQQMLLMANIIKDFDRDVMRQEAGGNSSGGGDGNCSNWQSAMIRFSGAAGRYIHNLIST SLLSEQLQSNLLQHLAISPWSTDTNSWPLQVYPSTLSVLVQILLLKPTQEKEAACLSVWH RLINTLVEGVCSSANASDTDYEDLNIEHAQLLLFLFHSLNLMQKKSILLLTAGGVIRCAD VCRGISSERPVRNSQMMLLSRLLLFLEYLMKHLYNAPPELLDQVRWNLFSVSSMPDTQKI TDLLNSRTKLTSYCRQDIEEKFRNCTVGDLSSSIRPTFYSLVTADSSKPHWAQEFKLDGL AWNFILCTPDKLKYPLLVDALIDILAITDMSAFTKDKDNLHNLCAMQYCFSITWKLLLGL PPSTSHVESLKTERVPNLHSLLWSIRCPLAYSHYLVVNSLIKQGMYTQYAESLWAQVGDR TADIRYSLKQTVLGVEAFNKQLSKASPNPRLSDLILFDALIAHMQAVAWADKEGYKVQRK ESDSDSITSESRERENSSAATDPEVYSSSESIDEQQSKLTEDSILTPGELLERTQLSNEL LVKLMESYTLISNIVCAQMLKQLSSTTPEQALNLIVPVVSDKPAIMLELHAAFLKLLPNE DKQLIANEWPKCLLVNDEAFNGKQHPVEPYTLNVIDAHITELTKSSTYTTLHTLKHCLKS ILNLLELLLSFCTTIGDVEAQLKPMLIASMMDMRTDYLQSQSEQCLREILHGLTNEAHKQ LLFEHMIGHCYQMLIDFAAELKQQPTEAVVAEQEQRALFNESMLFAVLKTMIKMLDVPTA VQAMRQFFKEQRAGSLTTLLLSFTGTTLPLSYARKMLQFVERLFEHAAGPDAHFLHEELV ECFAELASVDVARLKLWLAHIIYGPNVAPNNSSCEASCKLLTSIMQPSSSSSSNAQTPTN MATVSAMPSISDQLDAMDIDHDCAGSGNAAPNTSQILSLWQGNNQPNNQSEDSSQACDQQ NNGTQPRNGALLLSFVKSLVREQPAAAQLAPPLFQALLQLGQTLITPPQDGCDFADVLQI MITLADAAPARGHVALFNTTLLWLELAKLELAKLQLRHAENVSALLRYLSELLQGIGYRG SRQHMPPWDDELQSDIDELYDELVDEQQEQDSLLDDSDEDTLNNKLCTFSQTQKEFMNQH WYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYGNFFCDCGAKEDGSCQALSRRLPTSG CDTRDGYVSAHMSLLAAGKKRQSPPTQIRKDSLSNERIALLGKLLEPHREALQHPDQWLL VVRCILEYFDVLLPSIRENCTLYSIVGCHKRATVALERLHQLDQSFQITDQLMFATLGSQ EGAFENVRMNYSGDQGQTIKHLISSGVVRRVAFCCLSSPHGRRQQLAVSYEKGKVTILQL SALLKQADASKRKLTLTQLSSAPIACTVLSLAANPCNEDCLAVCGLKECHVLTFSSSGST NEHIVVTPQLDNGNYIKKAVWLPGSQTLLALVTSDYVKIYDLALDAYSPKYYYLVAVGKI RDCTFIYQEGEYYMLTFASSGYIYYQTLDEQSLAVHGDFYVTNTLELSHHHIKDVNGQVG GGGVSIYYSHALQLLFYSYASGRSFVSPLTNVNHGVKGIYHLDTNSAVSKSSSKGPLQPL VQWTEVAGHPGLIYAHMQTSNNPIILMLTPELIYMQEIKAQSAKSRIMDVVGIRHSVAGT EKTTLLLLCEDGSLRIFSPQPELTSFWLSPRVQPLGNQLYSATLLAKSGTTLSAGSPKSG KPSKLPRKSGAGGVAVGVAGSQQKQLTSGGVPVFPIDFFEHCNMLADVEFGGNDLLQIYN KQKLKTRLFSTGMFVASTRANGFTLEVLNNDPNVVMVGIRVLLGTQDTQRAPQSVSILGR TIATPVRRARWFDIPLTREEMLQSDKLLKVCFAKSQDPEHVTLLDCIEVYGKSKELVGWP DDSEEMPATAGGASAATAVASPASSANFGEGFNCITQLDRMCTHLLEVLDCALHLLGNGG AVAVAMRQKAVKTASALLLLPTPNPVQTQARYVLATLYGSRGSYHAYKDSVLLQFVHSEL QAMQPKLTQLDTLQDIDPEAFYRLILLVRGIANARPQSLAKICAECNYDIVPALMAIVLE LHKVTPALDEPTNIVRRGLCQPETIVHCLVEIMYGFALADASQVGRMTKYFIELLKHDAS VISHSAKEALILLLSPRIKRRKVAIVTTPPACSTPTPSASAISSSNLSALQGAASQAASD IIEEAAAAAVDASAVVSADANALLEADPAGVNQQQQQQQLLNLEAFMGGGFPRLLGLPED ADDEAIMDIAIALSLQQHGGDANALQSLQQGLANLQGIRLAAAATANVAASGDAAGSDDD EGSNVATDGSTLRTSPAEPAGSGGSESGGSGVESIGGTSARSSNFGDHANASPPRQSKDQ EQEQPGTSSGCVAALSAMSSSEDNEINEDEKLSKLHDLRIAVLESIIEHLSTFDLCNGLQ AIPLIQVILMLTTDLNGNNERDQQVLQDLLAALVDYVEIGKRGVATKMETKCPGNEVRLA LLSLFGVMMGKTKSKQTGTTSPPHQFKDNSSFVASTTANVLSKRGAFVYALEALNTLLVH WKQVLGDPYAAGGSGITQPAGGNVGGTGTAGQLLKPIMHGPKPDISILIPHNYLKNYPDI FESYDALLTEIIVRLPYQILRLSSAHPDNYDSGFCEAMTFTLCEYMMLNLNALLRRQVRK LLMYICGSKEKFRMYRDGHSLDAHFRVVKRVCSIVSTKNGAPYNANPPMLSYDALVELTE HLRTCQEISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVSPIIIQLLQAAVCNIPQP MTGIKQQQQQQQSQPISTSSKLRGEREKSEDTDTAYYSKFDPAQCSTFVHQIFRYASDAL IIRFVRIFLLENNVSQLRWQAHSFMTGLFEHANERQREKLLSIFWNLWPLVPSYGRRTAQ FVDLLGYLTLSTRSITDRLPEFVSRAVEVLRQQNELLCKHPNAPIYTTLESILQVNGYYL ESEPCLVCNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTISKLIVRIADLKRSKMV RTINVYYNNRSVQAVVELKNRPALWHKARSVSLQSGQTELKIDFPLPITACNLMIEFADF YETVSGSSENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCK YAKFDFSMYARVCCAVDPIESAEDRAKTVQLIHSSLERADRIYRQLLTNKQMLELLIQKV AEHRSSDRLVEDNMGSVHSTSQVNKIIQLLAQKYCVESRTSFEELSKIVQKVKACRSELV AYDRQQQDQPSASMPSGIETNLTTNRCYGCALASTEQCLTLLRAMAYNYDCRVGLYSQGL VSELAEHNLRRGTPQIQEEVRNLLVVLTKDNAEACMHLLQLVTTRVKNALMGAIPLISLE AAVHQEMTLLEVLLGQDDVCWEYKLKVIFELFISNCRLPRGPVTSVLHPCLRIMQNLICP ALPSAGKNNNNNQPQQQQQQQQQQQQQQQQQQPQQQLGPTELCSIKLLDGNTIDYRAWLS SDRNHDYSAWSSRMPTNKYQRQEGGKQQQRSNSNNISNKQQTQVGDAPLKGGRRAEVRAA FLSEKYGHRWRQQVLDKEKVIKPLVFNAKWIQPLLFNANSRFGRQLACSLLSGLCRTSER KQQALNMLTGFLRHVGEAGEASAEYLTLYRSVATETPWLQYLVLRGVLGEISQLLAVEIG KIHRMEEHSLSSDLSLGYALRQYVELLWLFLECPNIRRTYKTRLLGPVLESYLALRSLVV QRTRLIDDAQEKLLEMLEEMTSGTEEETRAFMEILIDTVEKTRMNDIKTPVFIFERLYSI IHPEEHDESEFYMTLEKDPQQEDFLQGRMLGNPYPSSEVGLGPLMRDVKNKICTDCELIA LLEDDNGMELLVNNKIISLDLPVKDVYKKVWLAEGGDRDAMRIVYRMRGLLGDATEEFVE TLNNKSQEQVDTEQLYRMANVLADCNGLRVMLERIGSLQRISRQRELIQVLLKLFLICVK VRRCQEVLCQPEVGAINTLLKVLQMCLQSENDSIQSAVTEQLLEIMETILSKAASDTLDS FLQFSLTFGGPEYVSALISCTDCPNVRNNPSVLRHLIRVLAALVYGNEVKMALLCEHFKH TLDFNRFDNERTTEEEFKLELFCVLTNQIEHNCIGGTLKDYIVSLGIVESALAYITEHAP CVKPTLLRTDSDELKEFISRPSLKYILRFLTGLANHHEATQLAISKDIIPIIHRLEQVSS DEHVGSLAENLLEALSTDAATASRVQQVRDFTRAEKKRLAMATREKQLDALGMRTNEKGQ VTAKGSILQKIEKLRDETGLTCFICREGYACQPEKVLGIYTFTKRCNVEEFELKSRKTIG YTTVTHFNVVHVDCHTSAIRLTRGRDEWERASLQNANTRCNGLLPLWGPAVGEAAFSGCM TRHSSYMQESTQRCDISYTSSVHDLKLLLVRFAWERSFHDDAGGGGPQSNMHFVPYLLFY AVYLLLSSRSAARDSKTLLNYLTAAPSDKWLECGYEVDGPLYMLTISLSLHSRELWNKHK LAHLKRLVAVAQARHVSPSVLCKALLSPADRQAKDYSVYKPFLMMWALVDLIYNTLFKTV STVKEEDWPASLFEYIRKNDEAMLKSTDSILQTLTDEFLPCTSFGEFCDVAGLLNLIEQP ESFIEDVLGALPTTTSSS NT seq 16077 nt NT seq  +upstreamnt  +downstreamnt atgtcggcgcacagtggaggtacggattggaactcggttgtaaaaccacttttatcaaac cgtacaagcgctttaaataaaaatgaaatatcaaatttactaaaagcgattaccagatgt gaacatgagtttttcgatgatgaaagcaactatacacaatattacacagcctttgcggct ctggcggccgataagataatgcaaattaagtcgatatgccagacgcaaatttcacaactg cacgatgccagtgcagtgcttatacgtttcatacttttccgattgccgaaggtgtcagtg tatgagatcaaatggctgttggtcgcactgaaaatgttgtgcgagggtcgcgaaagcgtt acccaaggttcgggctcgtccacacagtttgattataatgctgtggctgctgtattgaag agcgcgaagcatccagaatcaaatatcaaaagcattagtagtagcagctgcagcagcgtt gccagcggcgcaactggaaacgaaaaggaatcgccgaaatcggagattaaacggtcgcgt tcagatctttcgacagttatactgcaacagctattggcgcctttagagcctggcaaaatg acatgggtgccattgagtgaggagatcaacgactgcactgaacaactgctggccgccaat gttgaatactttcaagaacaaaacggcgtggacactttgctcgacgtaggcgtttgtttg cccatactcaatcgctatcggtcgaaataccaggagacaattgtgggcggcaaagcgttg tatttgccgcttacgcaagtggaggctagcaccgtcaaatcggcaatggcacatatgcta accgatttatccatattggggcaagcacattcgttgattgcacttcagccgctcacgccg agtcgcatcgagaagctttcaatgtgcggcattgcagcgttgtacaatgcagtgctgacc tctatagcggctagtgtgctgagcatgtgccaggccagtggaggatcacagaaacaacag ccagcagctgcgacaactagccagggcagtggcaacaacagtaatgtttcgactggtgcc aaggaccacgatgatttcgaggaacaggcctgcaccatcgtaaataaagcgcttgagatc tacacgagcataggagagatgtttaaagcctccgcacgtatgcatgtatatcagaatcat ttgtgttatggttcttggttacttattagtggcatacaaggcgccatgggagcttctggg agtagcagcagcagcagtggcacatcaactggcaaatctgcaaccagcacagcggaatca aatgtcgcgcctagcacgcccatagcgcgtgttaatctgtttaaggtgcaacaaggattt ggcgagctaaatgcagccattgccaatcatagcattaaacttctctcggagctcatcgat gatctaaaaattgaatctgcttgcggctcgaccagcagcagtggaagtaccagctgcctg gatatagagccagcgcaatttgatatattgcaaaattacactgctctacagcgtattgtg cgcgttttaaacacagccacattgcatcaactcttcaccttcttggccactgtggcatat cgcaaggcgtgcactttgaaacgtgccaatacgaaggatcgcaccgaatgtgaaccaatt agctactcggattcaacaacatattttaatgattcactctcctgttcagacaattcggaa gaggatgacagcgaaagctatttgggccattggtttaaggagactctgtctccagagacg catgatgataatgccaatgcttgcactcaggagcgcagcggagagcagaaatccgcacta gtgcccagactggatgaaccacatgaatatcttgacttggctgcagatatattctgtttc ctggatcaatttttggctaatcgacatgcctatatgcagcgctatgttaaggcgggcgtt agtgatcagcaaatgttgctcatggcgaatattattaaagactttgatcgggatgttatg cgtcaggaggcaggtggtaattctagtggtggtggcgatggcaactgttccaattggcaa tcggcaatgattcgcttttcgggcgctgccggacgttatatacacaatttgatctcgaca tcgttgctctcggagcagctgcaatctaatctgctgcaacatttggccatttcaccgtgg tccacagataccaatagttggccactgcaagtctatcccagcactctatccgtgctggtg cagattttgttgctgaagccgacgcaggaaaaggaggcagcctgtttgtccgtatggcat cgtcttattaacacgctggttgagggcgtttgctcgtctgctaatgccagtgatacggac tacgaggacttgaatattgaacacgctcagctattgctcttcttgtttcactcacttaat ctgatgcagaagaaatcaatattattgctcactgctggcggtgtcatacgctgtgccgat gtctgccgcggtatcagttcggagcgtcctgtacgcaatagccaaatgatgttgctctcg cgccttttgctcttcctcgagtatctaatgaagcatctgtacaatgcgccacctgagttg ctcgatcaggttcgctggaatctgtttagtgtcagcagtatgccagatacgcaaaagatt acagacttacttaatagtcgaaccaaattgacgtcctattgccgccaggatattgaggaa aagtttcgcaattgcactgtgggcgatctcagctcaagcattcgtcccactttttattcc ttggtcactgcggattcttcaaaaccccattgggcccaggaattcaaattagatggctta gcctggaattttatattgtgcacgccagataaactaaagtatcctttgctagtggatgca cttattgatatactagctattacggatatgtctgcttttactaaggataaggacaatctg cataatctatgtgccatgcagtattgctttagcatcacatggaagcttcttcttggcctt ccaccttctacatcacatgtggagtcacttaaaacggaacgtgtacccaatttacattca ttgctttggagcatacgctgtcctttagcctactcgcattatctggtcgtcaacagtctc atcaagcagggcatgtacacacagtacgcagagtcattgtgggcacaggtgggcgatcgc actgcagatatacgctacagcctaaagcagacagtgctgggtgtggaggccttcaataag caacttagcaaagcttcaccaaatcctcgtctttctgatttaattctgttcgatgcactg attgcacacatgcaggctgtggcttgggctgataaggaaggctacaaggtgcagcgcaag gaaagtgatagcgacagcatcacatctgagagtcgcgaacgggaaaattcaagcgctgcc accgacccggaggtttactcctcgagtgagtccattgatgagcaacaatcgaagctaaca gaggacagtatactcacaccaggtgaactgctcgagcgtacacagttaagcaatgagctg ttagttaaactaatggaatcctacacactcatatcgaatattgtatgcgctcagatgctt aaacaactatcgagcactactccggagcaggcactcaatctcatagtgcctgtggtgagc gataagccagcaattatgttggagctgcatgcagctttccttaagcttctgcccaatgag gataaacagttaatagctaatgaatggcccaagtgtctgttggtcaacgacgaagccttc aatggcaaacagcatccggtcgaaccgtacacattgaatgtcatagatgctcacatcaca gagttaaccaaatcctcgacttataccacgctccatacgctaaagcattgcttgaaatcc attttaaatctattggagctgctgttgtccttctgtacgacaattggggatgtggaggcg cagttgaaaccaatgcttattgcatcaatgatggatatgcgcaccgattatctgcagagc cagagtgagcaatgtctgcgggaaattcttcatggcctgaccaacgaggcgcataaacaa ctgctcttcgagcacatgatcggacactgttatcaaatgttgattgactttgctgccgaa ctgaaacagcagccaactgaagctgttgttgctgaacaggaacaacgtgctttattcaac gagtccatgttgtttgctgttctcaagacaatgatcaaaatgctggatgtaccaaccgct gtacaggcaatgcggcagttctttaaggaacagcgcgcaggtagcttaaccacattgttg ctttccttcacgggtactacattgcctttaagctatgcacgcaagatgctgcagtttgtg gagcgtctgtttgagcatgcagctggaccagacgcgcattttctgcatgaggaattggtt gaatgctttgccgagttggctagcgtggatgtggcacgtctcaagctgtggctggcccac ataatctatggtcccaatgtcgcgcctaataatagcagctgcgaggcatcgtgtaagttg ctgaccagtataatgcagccgtcgagcagctcgagcagcaatgcacaaactccaacgaat atggccactgtatcggccatgcccagcatatcggatcagctggatgccatggatattgat catgattgcgcgggctccggcaatgcagcgcctaatacgtcccaaatcttgagtctctgg cagggcaataatcagcccaataatcaatccgaggattcttcacaggcatgtgatcaacag aataacggcactcaaccacgcaatggagccttattacttagttttgttaagtcgttggtg cgagagcagccagcagctgcacagctggctccgccattattccaggccttgctgcagctg ggacagacgttgataacgccgccgcaggatggttgtgattttgctgatgtcctacagata atgataacactagcggatgcagctccagcacgtggtcatgttgcgctgttcaataccacg ttactctggctggagttggctaagctggagcttgcaaaactacagctacgtcatgcggag aatgtgagcgctttgttacgttaccttagcgaactgctgcagggaattggctatcggggc agtcggcagcatatgccaccatgggacgatgagctacaatcggacattgatgaactatac gatgagttggtcgatgagcaacaagaacaggactcattgctggatgactctgatgaagat acgctcaataataaactgtgtacgttctcgcaaactcagaaagagtttatgaatcaacat tggtatcattgccacacttgcaacatgatcaacactgttggcgtttgctctgtttgcgct cgcgtctgtcacaaaggtcacgatgtcagctatgctaagtacggcaatttcttttgtgac tgtggcgccaaagaggatggctcttgccaagctcttagtcgtcgtctgcccaccagcggt tgcgatactcgtgacggttacgtctcggctcatatgagccttttggctgccggcaagaag cgtcagtcgccgcccacgcagatacgcaaagattcgctaagcaatgagcgcattgcgcta cttggcaagttgctggagccgcaccgtgaagcattgcagcatccagatcaatggctgctt gtcgtgcgctgcattctcgagtatttcgatgtgctactaccttcaatacgggagaattgc actctatactcaattgttggttgtcacaaacgtgcaacagtcgcgctcgagcgcctacat caacttgatcagagtttccagatcacagatcagttaatgtttgccacactgggctcgcag gaaggcgcctttgaaaatgtgcgcatgaactactccggcgaccagggtcagacaattaaa catctcatatcgtcaggtgtagtgagacgcgtcgcattttgctgtctgtcttcgccacat ggaagacgtcaacagctggcggtatcctatgagaaaggaaaggtaaccatattgcagctg tctgcgctacttaagcaagcggatgcctccaagcgtaagctaacgctgacacagctcagt tcagcgcccatagcgtgcaccgttctctcgctggctgccaatccctgcaacgaagattgc ttggctgtatgtggcttgaaggaatgccatgtgttgaccttctccagcagcggcagcacc aatgagcacattgtagtcacacctcaattggacaatggcaattacattaagaaggctgtc tggctgccgggttcccaaacgcttctagctttggttacctccgattatgtgaagatctat gatctggcattggatgcatacagtccgaagtactattatcttgtggcggtgggcaagata cgtgactgcacctttatttaccaggagggcgaatattatatgttgaccttcgccagtagc ggttatatatattaccagacgctggacgaacagagtctagccgtgcatggagatttttat gtgacaaatacgcttgagctgagtcatcatcatatcaaggatgtgaacggacaggttggc ggtggcggtgtctctatttactactcacacgcgctgcaattgctcttctatagctacgca tcgggtcgaagctttgtctcccccctaacaaatgtgaatcacggcgttaagggcatttac catctggatacgaattcggctgttagcaaatcttcgtcgaaaggcccactccaaccactg gttcaatggaccgaggtggctggacatccaggactcatttacgcccatatgcaaacctca aacaatccaattatattgatgctcacaccggaattgatatacatgcaggagatcaaggct caatcggccaagtcacgtatcatggatgtggtgggcatacgtcactctgtagccggcacg gaaaaaacaacactgcttctgctctgcgaggatggtagcctgcgcatattttcaccccag cctgagttaactagcttctggttatcaccacgcgtccaaccattgggcaatcaactttac tctgccactttgctggccaagagtggcaccactttgtctgctggtagtccaaagtcgggc aagcctagcaagttgccacgaaaatccggtgctggtggtgtcgctgttggcgttgctggt agccagcaaaagcagttgacatcgggcggagtacccgtttttcccattgactttttcgag cattgcaatatgttggccgatgtggaattcggtggcaatgatttgcttcagatatacaat aagcaaaagttaaagacacgtctcttctcaacgggcatgtttgtggccagcacaagagct aatggattcactctagaggtgctgaacaacgatccaaatgtggttatggttggcatacgc gttctactgggcacgcaggacacacaacgtgctcctcagtcagtgagcatattgggtagg acaattgcaacgcctgtgcgacgtgctcgctggtttgatatacccctgacgcgtgaggag atgctacagtcggataagttgctgaaggtatgctttgccaagtcgcaagatccggaacat gtgacactgctcgattgcattgaggtttatggcaagtcgaaggagcttgtcggctggcca gatgatagtgaggagatgcctgctacagcgggcggcgccagtgcagccacagctgttgct tcaccagctagttcagcaaactttggcgagggcttcaattgcatcacccaactcgatcgc atgtgtactcatctgctggaggtactggattgtgcgcttcatttgcttggcaatggaggc gccgtggcagttgccatgcgtcaaaaggcggtgaagacagccagcgctttgttgctttta ccaacaccgaatcccgtgcagacccaagcacgttatgtgctggcgacattgtatggcagt cgtggctcttatcatgcctacaaggatagcgttttactgcaatttgtgcacagtgaactg caggcaatgcagccgaagttaacccaattggacactttacaggacatagatccggaggca ttttatcgtctgatattgctcgttcgtggaattgccaatgctcggccacaatcgctggcc aagatttgtgccgagtgcaactacgatattgtgcccgctctaatggccattgtcttggag cttcataaggtaacccctgcgctggatgaaccaacgaatattgtgcgccgcggtctttgc cagccagagacgattgtccactgtctagtggagattatgtatggatttgcattggccgat gcgagccaagtggggcgcatgacaaagtatttcattgagctgctgaagcatgacgcgagc gtaattagccatagtgccaaggaagcgctcattttgttacttagtccgcgaatcaagcga aggaaggtggctattgtgacaacaccgccagcttgttcgacacccacgccgtcggcttcg gccattagcagcagcaatttgagcgctttgcagggtgctgcatctcaggcggccagcgat ataattgaggaagcggccgcagcggctgtggatgcatctgctgtcgttagcgccgacgcc aacgcactccttgaagcagatccagcgggcgttaatcagcaacaacagcagcagcagctg ctcaatctggaagcgtttatgggcggcggttttcctcgcttgcttggcttgccggaagat gccgacgatgaggccattatggacattgccatagcgttgagtctgcagcagcatggcggc gatgcgaatgcattgcaatccctgcaacagggtttggctaacctacagggaatacggctg gcagcagcagctacagcaaatgtggcggccagcggcgatgcagccggttccgatgatgat gaaggctctaatgtggccaccgatggctccacgctgcgcacatcacccgctgaaccagcg ggcagcggcggctctgaaagcggtggcagcggtgtcgaaagtattggtggcacttcggcg cgtagcagtaactttggcgatcatgcgaatgcctcgcccccacgccaaagcaaagatcag gaacaagagcagccgggcacaagcagtggctgcgttgcagcgctcagcgccatgagcagt agcgaagacaatgagataaacgaggatgagaagctgagtaaactacatgatttgaggatt gctgtgttggagagcattattgaacatttgagtacatttgacctgtgcaatggcctgcaa gctataccgctcattcaggtgatactgatgctgaccacagatttgaatggcaacaatgaa agggaccagcaagtgctgcaggatctgctcgccgcccttgtggactacgtggagattggc aagcgaggcgtagccaccaagatggaaaccaagtgtcctggtaatgaggtgcgactcgcg ctactttcgctatttggcgtcatgatgggcaagactaaatcgaagcaaacgggcaccact tcgccgccacatcagttcaaggataacagttcttttgtggccagcactacggcgaatgta ttaagcaaaagaggtgcgtttgtttacgctctcgaagcactcaatacgctactggtccat tggaagcaagtgctgggagatccctatgctgctggtggctctggcattactcaaccggca ggtggaaacgtgggtggaacgggcacagcgggacagctattgaagcccattatgcatgga cccaagccggatatatcgattttgataccacataactatttgaagaactatccggacatc tttgagtcgtatgatgcactgctcacagagattattgtgcgtctgccatatcagatattg cgtctgagcagcgctcatccggacaactatgatagcggtttctgcgaggcgatgaccttt acgctctgcgagtatatgatgcttaatctgaatgcgctgctgcgtcgccaggtacgcaaa ctactgatgtacatctgtggaagcaaggagaagttccgcatgtatcgtgacggacattcg ttggatgcccacttccgggtggttaaacgtgtatgcagcattgtcagcaccaagaacggt gctccttataatgctaatccaccaatgctcagctatgacgctttggtggagctaaccgaa catttgcgcacctgtcaagagattagtcaaatgcgaaccggcaattggcaaaagttttgt gtggttcatgaggatgctttggccatgctaatggagatcgcctgctatcaactggacgat ggcgtctcacccattatcattcagcttcttcaagcagccgtttgcaatataccacagccc atgacaggcatcaagcagcaacaacagcagcagcaatcgcagccaatctcaaccagcagt aagctgcgtggtgagcgtgagaagagcgaggatacggatactgcatactattcaaaattc gatccggctcagtgcagcacctttgtccaccaaatctttcgctatgccagcgatgcgctc ataatacgctttgtgcgcatctttttgctagaaaacaatgtgagtcaactgcgctggcaa gcgcactcctttatgacaggccttttcgagcatgcgaacgagcgtcagcgtgagaagttg cttagcatcttctggaatttgtggcctttggtgcccagctatggccgccgcacagcgcag tttgtagatctgcttggttatctaacgctaagcacgaggagcattacggatcgcttgccg gagttcgtttctcgagcagttgaggtgttacgtcagcaaaatgagctgctctgcaagcat ccaaatgcgcccatctataccactctggagtccatattgcaggttaatggttactacctg gaatcagagccttgtctggtgtgtaacaacccggaggtgcccatggccaatattaagctg ccctcggtcaagtcggactccaaatatacaaccactaccatgatctataaactggtgcag tgccacaccatctcgaagctaattgtgcgcatcgccgatctcaagcgctccaaaatggtg cgcaccataaacgtctactacaacaatcgcagtgtacaggccgttgtggagcttaagaat cgtccagcgctgtggcataaagcacgttccgtctcgttgcaatcggggcaaacggagctc aaaattgatttccctctaccgattactgcttgtaatctaatgatcgaatttgcggacttc tacgagacggtcagcggttccagtgagaatttgcaatgtccacgctgcagtgcagcggtg ccagcgtatcctggtgtttgcggcaactgtggcgaaaatgtgttccaatgccacaaatgt cgtgccatcaactacgatgagaaagatccgttcttgtgccactcgtgcggcttctgcaag tatgccaaatttgattttagcatgtatgcacgggtctgttgtgcagtggatccgattgag tcggccgaggatcgagcgaagacggtacaactaatacatagctcgctggagcgtgccgat cgcatctatcgccaactgttgaccaacaaacaaatgctcgagctgctcatccaaaaggtc gcggagcatcgtagcagcgatcgccttgtcgaggataatatgggcagcgtacatagcacc tcgcaagtgaacaagatcatccagctactcgcccagaaatattgcgtagagtcgcgcacc agcttcgaggaactcagcaagattgtgcaaaaggttaaggcttgtcgcagtgaactggtt gcttatgatcgccagcagcaggatcagccgtcagcgagcatgccttctggcattgaaacg aatcttacaacaaatcggtgctacggttgcgctttggcttccacggagcagtgccttacg ctgctgcgagccatggcatataactacgattgccgtgtgggtctgtacagtcagggcttg gtcagtgaacttgccgagcataatttgcgtcgcggcacacctcaaattcaagaggaggta cgcaatctgctcgttgtgctgactaaagataatgccgaagcgtgcatgcatctgctgcaa ctggttacgacacgtgtcaagaatgcgttaatgggcgcaatacccttaattagtttggag gctgctgtgcatcaggaaatgacgttgctagaggtgctgctcggacaagatgatgtttgc tgggaatacaagctgaaggttatctttgagctattcatcagcaattgtcggttgccccgt ggtcctgtgacatcggtactccatccttgcctgcgcatcatgcagaatttgatttgtcct gccttacccagcgctggcaagaacaacaacaacaatcaaccacagcagcagcagcagcag caacaacaacaacaacaacaacaacaacagcaacagccgcaacagcaactgggccccacg gagctgtgtagcattaaattgcttgatggcaacacaattgattatcgtgcctggctaagt tccgatcgtaatcacgattatagtgcttggagcagtcgcatgccaaccaataaatatcaa cggcaagaaggaggcaaacagcagcagcgtagcaacagcaacaacatcagcaacaagcaa caaacgcaggttggtgatgcaccactaaagggcgggcgacgtgctgaagtccgtgctgcc tttttgtcagagaagtatggacatcgctggcgtcaacaggtgctggacaaggaaaaagtg attaagccgctcgtattcaatgctaaatggatacagccgctgctatttaacgcgaactct cgtttcggtcgccagttggcatgttcgctgctcagcggcttgtgccgtaccagtgaacgg aaacagcaagcgcttaatatgctcaccggcttcctgcggcatgtgggcgaggcaggagag gcaagtgccgagtacttaactctgtatcgcagtgtagccacagaaacgccttggctgcag tatctggttttgcgtggagttctaggcgaaatctcgcagctcttggcggtggagattggt aaaattcatcgcatggaggaacattcattgtcctcggatctctcactgggctatgctcta cgccagtatgtggagctgctgtggctgttccttgagtgtcccaacatcaggcgcacctac aagacgcgtctgttgggtcccgtgctggagagctatttggctttgcgtagtcttgttgtg cagcggacacgtctgatcgatgatgcgcaggagaagctgttggaaatgctggaggagatg actagcggcactgaagaagagacgcgcgcctttatggaaattctgatcgatactgtggaa aagacgcggatgaatgatatcaaaacgccggtattcatatttgaacgtctctactcgata atacatcccgaggagcatgatgagagtgaattctacatgacactggagaaggatccacag caggaagatttcctacagggacgcatgcttggtaatccatatccttccagcgaagtaggc ttgggtccgctgatgcgtgatgtgaaaaataaaatctgcactgactgcgaactgattgcg ctactggaggatgataatggcatggagctgctagtgaataacaagataattagcttagat ctgcctgtgaaagatgtctataaaaaggtctggttagccgaaggcggagatcgtgatgcc atgcgcattgtgtatcgaatgcgcggtctgttgggcgatgccaccgaggaattcgtggag acgttgaataacaagagccaggagcaggtggacaccgagcagttgtatcgtatggccaat gttctggccgattgcaatggcctgagggtcatgctcgagcggattggcagcctacagcgc atctcacgccagcgtgaactaatccaagtgctactcaagctattcctcatctgcgttaag gtgcgccgctgtcaggaggttctgtgccagcctgaagtgggagctatcaatacactgcta aaggtgcttcagatgtgtttgcaatcggaaaacgattcaatacaatctgctgtaacggag caactgctcgagattatggaaacgatactgtccaaggctgccagcgatacgctcgactct tttctgcaattctcgctaacctttggtgggccagaatatgtgagcgctcttatctcctgc accgattgtccaaatgtgcgcaataatccatctgtgttgcgccatctcatacgcgtcctt gcggcgctcgtctacggcaacgaggtgaaaatggcgctgctctgcgaacacttcaagcat actcttgattttaatcgttttgacaacgagcgcaccaccgaggaggaatttaagttggag ctattctgcgtactaacgaatcaaattgagcacaattgcattggcggtactctgaaggat tatatcgttagtctgggtattgtggagagcgcattggcttatattacggaacatgcgcca tgtgttaagcccacactactgcgcacggattccgatgaactgaaggagtttatttcgcga ccaagcctgaagtacattttgcgctttctaactggcctggctaatcatcatgaggccacc cagttggccataagcaaggacataatacccattatacatcgcctggagcaggtgtccagt gacgaacatgttgggagtctggccgagaatttgctcgaggcactcagcacagatgcggcg acggcatcgcgtgtccaacaggtgcgagactttacacgtgccgagaaaaaacggctagcg atggctacgcgtgagaagcagttggatgcgctgggcatgcgaactaatgaaaagggtcag gtcacggctaagggctccatactgcaaaaaatcgagaaactgcgcgacgagacgggactt acctgtttcatttgtcgtgagggctatgcgtgtcaaccggagaaggtgctgggcatctat acgttcaccaaacgctgcaatgtcgaggaatttgaactgaagtcgcgcaaaacgattggg tacaccaccgtgacacacttcaatgtggtgcatgtggattgtcacacgtcggccatacgc ttaacgcgcggccgcgatgaatgggaacgtgccagcctgcagaatgccaacactcgctgc aatggcctgcttccactctggggtccagctgtcggggaggctgccttctctggctgcatg actcgacacagcagctacatgcaggagagcactcagcgatgcgacatctcgtacacgagc agtgtgcatgatctgaagctgttgttggtgcgtttcgcttgggaacgcagcttccatgat gacgctggcggcggtggtccacaatcaaatatgcactttgtgccctacctgctcttctat gcggtctatttgctgctctcctcacgatccgctgcacgggatagcaaaacattgcttaac tatttgacagctgcgccatcagataaatggttggaatgtggttatgaggtggacggacca ctctacatgttaaccatatcgctgtcactgcacagtcgtgaattgtggaataagcataag ttggcgcacttgaagcgtctggtggctgtggctcaggcacgacacgtatcaccgtcggtg ttgtgcaaagcgctgctgtcgccggcagatcgacaggccaaagattatagcgtatataag ccgttccttatgatgtgggcacttgttgatttgatctacaatacgctcttcaagacggtg agcaccgtcaaggaggaggactggcccgcatccctatttgaatacatacgcaagaatgat gaggccatgcttaagtcaacggatagcatactgcaaacattgacggatgagttcttgccg tgcacctcatttggcgagttctgcgatgtggcgggtcttctcaatctaatcgagcagccg gagagcttcattgaagatgtgctcggcgccctgcccaccaccaccagctctagttaa

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