Drosophila hydei: 111598039 Help Entry 111598039         CDS       T05888                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism dhe  Drosophila hydei Brite KEGG Orthology (KO) [BR:dhe00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dhe04040]     111598039    04990 Domain-containing proteins not elsewhere classified [BR:dhe04990]     111598039 Ion channels [BR:dhe04040]  Voltage-gated cation channels   Ryanodine receptor    111598039 Domain-containing proteins not elsewhere classified [BR:dhe04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    111598039 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans TPR_TTI1_C EF-hand_7 Motif Other DBs NCBI-GeneID:  111598039 NCBI-ProteinID:  XP_023168837 UniProt:  A0A6J1LXT8 LinkDB All DBs Position Unknown AA seq 5125 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVTLSCTATGERVCLAAEGFGNRHCFLENIADKNVPPDLS QCVFVIEQALSVRALQELVTAAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTS SSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKE NEQSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWGREAG QNIVIYEGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNESNELIL VKKEEASIATTTFCLRQEKDDEKKVLEDKDLEIIGSPIIKYGDTTVIVQHCESSLWLSYK SYETKKKGVGKVEEKQAILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALE TLQSNRRHSIFFQKVNLNEMVMCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEE GVLNLILEAIDKINIITSQGFLASFLAGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQF ANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRD PKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTLLVDHVASIRPNIFVGRVDGS SMYQKWYFEVTMDHIEQTTHIMPHLRIGWANTSGYVPYPGGGKKWGGNGVGDDLYSFGFD GAHLWTGGRKTLVVDTLPEEPYIRKGDVIGVAIDLSVPVITFTFNGGKVRGCFRDFNLDG MFFPVMSCSSKLSCRFLFGGDHGRLKYAPPMGFSALVQCLMPHQILSLDPCFYFGNLSKN VLAGPWLIEDDTPFVPKPVDTTGVSLPSSVDQIKEKLAENIHEMWALNKIDAGWTWGEQR EDYHRIHPCLTQFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPARIRPVRLPNEI FMQANGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRS PHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAAFRT YRVERNYAVTSGKWYFEFEVLTAGPMRVGWARADCYPGAMLGSEDTSWAFDGHNVTKMHA GTIEHFGVRYEAGDVIGCFIDVKEQTISFSLNGELLMDALGGETTFADVTAEGVGFVPAC TLGVGQKARLIYGQDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTEEMP DCRIDVTRIPGGADTPPHLKISHNTFETMEKANWEFLRLSLPVTCMSDFISEQEKARRWE EIKLRQYRLMREAQEAAIQMQTQTAAHMDHMLKGGFNMNDIKGLTRNFDDHTEAEAEHMM RNPPRPPRKGSLTRNITFETDMTAALDEMQRSSSVLDMNGLGDDLDDKKKRGRSPFKFFS KKSRDQSREKNGSRTADTSLERRNTVAHGRNVVNQQMTTRTPTLRLNNAEIPPSPVPQGP KQLSATNLGQPPVESSGNEMFDAECLKLINEYFYGVRIFPGQDPTHVYVGWVTTQYHLHS REFNKNKVRRGSVYIEDYYEVPIERIDRQSCYVVRADELFNEVTQDASGKGASQGMFVGC FVDTATGIIRFTCEGKETSHRWMMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAA VLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTSLQVHALKLSDIRGWSMLCEDPVSMLA LHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHALCQHVDQKQLLYAI RSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELKELYAEDEMRHSLRSL VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPNIDQLYSPKFPLEVVREFVMEALKDAV EINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQKLLVMVDPETWDATFAREG KDEHRKGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESIIAFSHDFVGDLQTDQLRRYI EIKQSDLPSAVAAKKTKEFRCPPREQMNQILCFKNLESDDQDNCTCGLELRSRLSEFHDC LMQKVSLNALQEPDGTETNAIEEIKTGPITKIYNFINTVKELEEGPKEVEEPEKKTPEEV FRKVLIKTIVSWAEESQIENPKLVREMFSLLVRQYDTVGELVRALEKTYVINNRARDDVA EMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMAVMMN TLGRRAQAQSDAPAQTEGAEGVPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFD FLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSE LVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGEG EGLFRAIVEANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGEEDEDYIDTGAAILNFY CTLVDLLGRCAPDVSVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLTQTAPGEEKP KSDMPSGLLPNNKQSIVLFLERVYGIETQDLFYRLLEDAFLPDLRTATILDKSDGSESDM ALAMNRYIGNSILPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDF LVALTSQMQPAMLLKLLRKLTVDVSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGA SSDEEKRLTMLLFSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKNTDEDYYG RQMGAPDQPQYVPNPIDTNNVHLDNDLNSLVQKFSEHYHDAWASRRLEGSWTYGEIRSDN DRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIGWTVEHSEIDLPLNHRGSTRRQSKP QINEGSPFNYNPHPVDMSNLTLSREMQNMAERLAENSHDIWAKKKNEELNGCGGVIHPQL VPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAVEEGGATQAAVELRFSYSLL EKLIQYLDRATINMKLLKPSTTFSRRTSFKTASRDIKFFSKVVLPLMEKYFSTHRNYFIA IATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQVLVKGIDAKTL TKNCPEFIRTSMLTFFNQTSDDLGNTIMNLQDGKYSHLRGTHLKTSTSLGYVNQVVLPVL TAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDATLTHDRKYLKTEIERHRPALG SCLGAYSSCFPVAYLEPHLNKHNQYSLLNRIADHSLEAQDIMVKMESCMPNLEAILTEVD QFVESDKTYTDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNSLLRN VLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLHKEDS MRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEELY NHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISEGVPAVGGKVKKKK KNRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMNEYDVIEF ARNQLTLPDKLDPSDEMSWQHYLYSKLGKTEEPVDEQALEKVNANSNEKGKDKTTETVDR IVAMAKVLFGLHMIDHPQQQSKNVYRSVVSIQRKRAVIACFRQTSLHSLPRHRACNIFAR TYYEQWLQEENVGQEVMIEDLTQTFEESEKSKKDEEETDGKPDPLTQLVTTFCRGAMTER SGALQEDLLYMSYAQIAAKSCGEEEEEGGEEGEGGEGGEEGEGTSIHEQEMEKQKLLFHQ ARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKKDVG FFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCE GHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKANFFK AIGVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLL KELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLADLIE SPSFHEIDMKNEGWVIPKDFREKMEQSKNYTPEEMDFLLACCERNHEGKIDYRAFVERFH EPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGSSKRIERV YFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMA TDDGGGNVKRDTAYSSYMSEEEEERAARDPIRRTITAVKDGLKFGVHMLSPSNIKHQIGV MQTKSIPELIVGFFKIIFYMFYYTGYAHYCVVRYIFGILLNLMRGPAPEQEEEQTVVEEE TFGRALPPLPLEEPPGPVQAFGLDINKEENGMYKVVVHESPASSSVEEGGESSPEDGAAV AGELLEGDLHQDPISIVDMLGGEAAKKAAQERQEAQKAQEAAMASIEAEAKKSSSAPQET PAVHQIDFSQYTHRAVSFLARNFYNLKYVALVLAFSINFMLLFYKVTSFNDESEGSAEEE LILGSGSGAGADMGSGLGGSGDGSGDGDFEDDDIPELVHVDEDFFYMEHVLRIAALLHSL VSLAMLIAYYHLKVPLAIFKREKEIARRLEFDGLFIAEQPEDDDFKSHWDKLVISAKSFP VNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKSAFTAQESEETGILRYIMNIDWRYQVW KAGVTFTDNSFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLV LTVMLLTIIVYIYTVIAFNFFRKFYIQEEDEEVDKKCHDMLTCFVFHLYKGVRAGGGIGD EIGDPDGDDYEVYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQLESVKDNMESNCF ICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRSW DFFPVGDCFRKQYEDELSGGGGGGG NT seq 15378 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcggaaggtggctccgaacaggatgatgtttcattcctgcgtacggaagat atggtcacgctctcctgcacagcaactggcgaacgtgtctgcctggccgctgagggattc ggtaatcggcattgcttcctcgaaaacattgccgataaaaatgtgccgcccgatttgtcg caatgcgtgttcgtcatcgaacaagcgctatcggtgcgtgcgctccaggaactggtgaca gcagctggctcagagaccggcaagggcacaggatctggccatagaactctgctctatggc aatgccatactcctgaggcatcataacagcgacatgtatctggcctgtttgtcaacatcg tcgtcgaatgataagctctccttcgatgtgggcctgcaggagcatagccagggggaggcc tgttggtggaccgttcatccggcgagcaaacagcgttcggagggtgaaaaggtgcgtgtg ggcgatgatttgattttggtctccgttgccaccgaacggtatctgcacacaaccaaggag aacgaacagtccattgtgaacgccagcttccatgtgacccactggtccgtacagccctac ggcaccggcatctcacgcatgaaatatgttggctatgtgttcggtggcgatgtcttgcgt ttctttcatggcggcgacgagtgtctgaccatacccagcacctggggccgtgaggcaggt caaaacattgtcatatacgaaggaggcgtggtcatggctcaggcacgttctctgtggcgc ttggaactggcacggaccaaatggacgggcggcttcataaactggtatcatcccatgcgt atacgtcatataacgacgggacgctatctgggcgtcaacgagagcaacgagctaatcctc gttaaaaaggaggaagcatcgattgcaacgacgactttctgcctgaggcaagaaaaagac gacgaaaagaaagtactcgaggacaaagacttagaaataatcggttcgccgatcatcaaa tacggtgacaccaccgtcattgtgcagcactgcgagtctagcctgtggctcagctacaag agctacgaaacgaaaaagaagggcgtcggcaaggtggaagagaagcaagcgatactccac gaggagggtaaaatggacgattgcctcgacttttcgcgctcacaggaagaggaatcaaag acggcacgcgtcattcgaaagtgtagcagcctcttcacacagtttataaccgccttagaa accttacaatccaatcgtcgacattcaatatttttccaaaaagttaatctcaacgaaatg gtcatgtgcctggaagatttaatcaattacttctcgcagccagaagatgatatggaacac gaggagaagcaaaaccgttttcgtgccttgcgcaatcgtcaggatctgttccaggaggaa ggcgtgctcaatctcatattggaggccattgataagattaatataattacctctcaaggc tttttggccagcttcctggccggcgacgagaccggccagagttgggatctaatctccact tatctgtaccagctgctggccgccatcatcaagggcaatcacaccaattgcgcccagttt gcgaacagcaatcgcctgaattggcttttctctcgcctgggctcgcaggcatcaagcgaa ggatctggcatgttggatgtgcttcattgtgtgttaattgactctcccgaggcgctgaac atgatgagggacgagcatattaaagtaattatatcgctgctggagaaacacggccgagac cccaaagttctcgacgtcctctgctctctgtgtgtgggcaatggcgttgcggtgcgctcc tcgcaaaataacatttgtgatttcctgctgcctggcaagaacctgctgctgcagacactg cttgtggatcatgtggccagcatacgtcccaacatctttgttggacgcgtcgatggctca tccatgtaccaaaagtggtactttgaggtgaccatggatcacatcgagcaaaccacccac ataatgccacatctacgcattggctgggccaacacctccggctatgtaccctatccgggc ggtggcaagaagtggggcggcaatggcgttggcgatgacctctattcgtttggcttcgat ggcgctcacttgtggacgggaggacgcaagacacttgtggtggacacactgcccgaagag ccatacattcgcaagggcgatgtcattggcgttgccatcgatctgtccgtgccggtcata acgttcacatttaatggcggcaaggtacgcggctgcttcagagactttaatctggatggg atgttcttcccagtgatgagttgctcgtcgaagctcagttgtcgctttttgtttggcggc gaccacggccgcttgaagtacgccccacccatgggcttctcggcgctcgtacagtgcctc atgccgcatcagatcttaagcttggatccctgcttttactttggtaatctgagcaaaaat gtattggccggtccctggctcatcgaggacgatacaccatttgtgcccaagcccgtggat acgacaggcgtatcgctgcccagctctgtggatcagattaaggagaagctggcagaaaat atacacgaaatgtgggctttgaataagatcgacgctggctggacctggggagagcaacga gaggattatcatcgcatacatccctgcctcacgcagttcgagaaactgccagctgccgag aagcggtacgacaatcaactagcggtccaaacactaaaaactatcatttcattgggttac tacataaccatggacaagccaccagcacgcatacgacctgttcgactgcccaatgagata tttatgcaggccaatggctacaagccggcgccgctcgacctgagcgctgtcaccctaacg ccaaagctggaagagctcgtggatcagctggccgagaacacgcacaatttgtgggcacgc gagcgtattcagcagggctggacctacggcctaaacgaggactccgaaaatcatcgcagc cctcatctggtgccctatgccaaggtcgatgaggcaatcaagaaagcgaatcgcgacact gcctccgagacagtgcgcactctgttggtctatggctatgtcctggatccgcccactggc gagggcaccgaagcattgctagccgaggcacaacgtctgaagttcgcagcctttcgaacg tatcgagtggaacgcaactatgccgtcacctctggcaaatggtatttcgagtttgaggtg ctaacagcgggtcccatgcgcgttggctgggcccgcgccgattgctatccgggcgccatg ttgggcagcgaagacaccagctgggcatttgatggacacaatgtaacgaaaatgcatgcc ggaacgatcgagcacttcggtgttcgctatgaggctggcgacgtcattggttgtttcatc gacgtcaaggagcaaaccatcagcttctcattgaatggagagctacttatggatgccttg ggtggcgagacaacttttgccgatgtaaccgctgagggcgtgggctttgtgcccgcctgc accttgggcgtgggccagaaggcgcgtttgatttatggtcaagacgtggactccctaaag ttctttaccacatgtggtctgcaagagggctacgagccattctgtgtcaatatgcgacgc cctgtcacgcactggtataccaaggatcagcccatttttgaaaataccgaggaaatgccc gattgtcgcatcgatgtgacgcgcatacctggtggagctgacactccgccgcatttgaag atctcgcataacacgttcgagaccatggagaaggcgaattgggaattcctgcgtctctcc ctgcctgtcacctgcatgagcgacttcatcagtgagcaggaaaaggcgagacgctgggag gagatcaaattacgccaatatcgcttaatgcgcgaagcacaagaggcagctatccaaatg caaacccaaaccgcagcacatatggatcacatgctcaagggcggcttcaatatgaacgat attaagggcttgacacgcaatttcgatgatcacaccgaggcagaagccgagcacatgatg cgtaatcccccacggccaccacgcaaaggttccctgacccgcaatataacgtttgaaacc gatatgacggctgcattggatgagatgcagcgttcgtcttccgtattggatatgaatggc ctgggcgatgacctagatgacaaaaagaaacgtggccgcagcccgttcaagttcttctcg aagaaatcacgtgatcagagtcgtgagaaaaatggttctagaactgcggacacctcgctg gagcgcagaaataccgtagcacatggcagaaacgtggttaaccagcagatgacaacacga acaccaactttgcgactaaacaatgccgaaataccgcccagtccagtgcctcagggacct aaacaattgagcgctacgaatttgggccagccccctgtcgaatcatctggcaacgagatg ttcgatgccgagtgccttaagttgatcaacgagtatttctatggtgtgcgcatattcccc ggtcaggatcccacccacgtgtacgtgggctgggtaacgactcagtaccatttgcatagt cgcgaattcaataagaacaaagtgcgacgcggctcggtctacattgaggattattatgaa gtgcccattgaacgcatagatcgtcagagctgctacgtggtacgcgccgacgagctattc aacgaggtaacacaagatgcctctggcaaaggtgcatcgcagggtatgttcgtcggttgc ttcgtggatacagctacgggcataatacgcttcacgtgcgagggcaaggagacatcgcat cgctggatgatggaaccggataccaaactatttccagcaattttcgtcgaagccaccagc aaagagatcctacaaattgaattgggccgcacacccactacgctgccattgtcagcagcc gtgctgcccaccagcgacaagcacataaacccgcagtcaccgccccgtttgaaggtgcag tgcctgcgaccgcaccaatgggcacgagtgcccaacacctcactgcaggtgcatgcgctg aagctgtccgatatacgtggctggtcaatgctctgcgaagatccagtctcaatgctggcc ctacacatacccgaagaagatcgctgcatcgatatattggagctaattgaaatggataaa ctactctccttccatgcccacacgcttacactctatgctgcgctgtgctatcaatccaat tatcgtgccgcgcatgcgctctgccagcatgtcgatcagaagcaactgctctatgccatc cggtccgagtatatgagtggaccattgcgtcagggattctatgatctgctgatagcgctg catctggaatcgcatgccaccacaatggaggtatgcaaaaatgaatacattacaccgttg ggcgcggaactgaaggagctctacgccgaggatgagatgcgccactcactgcgttcgctt gtcacggagtctgtgcgcccgcagttgcgtatgacggaaatcactccccctgtgattgca acatctagtatgccaagtgtttccagcgaaccgatacccaacatcgatcagttgtattcc ccgaagttcccattagaagtagtcagagaatttgtaatggaagcacttaaagatgctgtg gaaataaatcaagtgcataaccgtgatcccatcggttggaccaacgagaatctattcttg ccactcattaagctaacggatcgcctactgttagttggcgtccttactgatgaggacgtt caaaagctattagtaatggtggatccagagacttgggatgccactttcgcgagagagggc aaagatgaacatcgcaagggtttgctcaccatgaaaatggccgagggagccaagttgcaa atgtgctatctattgcatcatctgtacgacacacagctacgccatcgggtggagagcata atagcgttctcccacgattttgtgggcgatctgcaaaccgatcagttgcgccgttatatt gagattaagcaatccgatttgccaagtgctgttgcggccaaaaagactaaggaattccgt tgtccacccagagaacaaatgaatcagattctttgctttaagaatctagagtctgacgat caggataattgcacctgtggtcttgagttgcgcagtcgcttaagcgaattccacgactgt ctaatgcaaaaggtatcgctgaatgcgctgcaggagccggatggtactgagactaatgca atcgaagagatcaaaacgggacccataacaaaaatctacaatttcatcaataccgtcaag gaactagaggagggacccaaagaagtggaggagcctgagaaaaagacacctgaagaggtt ttccgcaaggtcctaatcaaaaccatcgtcagctgggctgaagaatcacaaatcgagaat ccaaaattagttcgcgaaatgtttagcttactggtacggcaatacgatacggtcggtgag ctggtacgtgctcttgaaaagacatatgtgatcaacaaccgtgcacgggatgatgtagct gagatgtgggttggcttaagccaaatacgtgcattgctgcccgtccaaatgagccaggaa gaggaggagctgatgcgtaagcgtctgtggaaactggtaaacaacgccacattcttccag catccagatttgatacgcatcttacgtgtgcacgaaaacgtaatggccgtcatgatgaat actctaggccgtcgtgctcaggcacaaagcgatgcccccgcacaaaccgagggtgccgag ggtgtgccctcaaaggagaaagacacctcgcacgaaatggttgtggcttgttgtcgcttt ctatgttacttttgccgtaccggacgccagaatcagaaggccatgttcgatcattttgac tttttactggacaatgcgaacatattgttagccagacccagtctgcgtggttccacccca ttggatgtggcatattcgagtttaatggagaacacagaattagctctggcacttagggaa cattatttggagaagattgcagtgtacctgtccagatgtggattgcaaagcaattcagag cttgttgaaaagggttaccccgatttgggctgggacccggtcgagggtgagcgatatctg gactttttgcgctattgcgtttgggtcaatggcgagagtgtcgaggagaatgccaacctt gtcattcgtcttcttatccgtcgtccagaatgtttgggaccggctctaagaggagaaggg gaaggtctcttccgtgcaatcgtcgaggccaatcgtatgtcggagcgcatatcggatcgt tgtaaaatgcaagacgaagccgaaggcaccatagctggactcaattttacacatcccctt ccggaaggcgaagaagacgaagactatattgatacaggtgctgccatattgaatttctat tgtacacttgttgacctgctgggaagatgcgccccggacgtgtctgttatcgagcaaggc aagaacgaatcactgagagctagagctattttgagatctcttgtgccactggaagacctt caaggtgtgcttagcctaaagtttacgctcacacaaactgctcctggcgaggagaaaccg aaatcggatatgccatctggcctcttacccaataacaaacagagtattgtcctatttttg gaacgtgtctatggtatagagacacaagatctcttctatcggctgctagaagacgctttt ctgccagatctgcgtacagccacaattttagataagagcgatggctcggagagcgatatg gccttagccatgaatcgctacatcggcaactctattttgccactgctcatcaagcactca aagttctataacgaggctgagaactatgcaagtctcttggatgccacactgcacacggtc tacaggttatccaagaaccgtatgctaaccaaggggcagcgagaggcagtatccgatttt ctagtggcgttaacatcacaaatgcaacctgccatgctcttaaagctattgcgcaagttg actgttgatgtctccaaactatccgaatacacgacagtcgcactcaggctactcacacta cacttcgatcgctgcgctaagtactatggctcgactcaaggccagggctcgtatggagct tcgtcagatgaggagaagcgtctaacgatgcttctgttctcaaatatttttgactcgctg agcaacatggactatgacccggaactgttcggtaaagctttgccctgtctaattgctatt ggctgtgccttgccaccagattatagtttatcaaagaacaccgacgaggactattatggc agacaaatgggtgcaccggatcaaccacaatatgtgccaaatccaatcgatacgaacaat gtacatttggacaatgatttaaattcgttggttcaaaagttcagcgaacactatcacgat gcttgggccagtcgccgcttggaaggtagctggacatatggcgaaattcgatcagataac gatcgcaagcacccacgtctaaagccctacaatatgctcagtgaatatgagcgtgaacgc taccgggatccggtgcgtgaatgcctcaaaggtctcctggccattggctggaccgttgag cactctgaaatcgatttgccactcaatcatcgtggctcgacgcgtcgtcaatcgaagccc caaattaatgagggcagtcccttcaactataatccacatcctgtggacatgagcaacctg acgctgagcagagaaatgcagaacatggccgagcgtctggccgaaaactctcatgatata tgggcgaagaagaagaacgaagagttgaatggatgcggtggtgttatacatccacagttg gtgccctatgacttgcttacggataaggagaagaaaaaggaccgcgagcgttcacaggag ttcctcaaatacatgcagtaccagggatacaaattgcataagccctcaaagggtggcgct gttgaggaaggaggtgccacacaagctgccgttgagctgcgcttctcctattcactacta gagaagcttatccaatatctggaccgcgccaccatcaacatgaagctattgaagccatcc accacgttcagtcgacgaacatcattcaagacggcatcgcgtgacatcaagttcttctca aaggtagtcttgcctttaatggagaagtacttctcgacgcatcgcaattattttattgcc attgccacggctacgaacaacataggtgccgcttcgctaaaggagaaggaaatggttgca tccatattctgtaagttggcagctcttttgcgcaatcgtctcagcgcctttggacctgat gtgcgcatcactgtgcgctgcctacaagttcttgtcaagggcattgatgccaagactttg accaaaaactgtcccgaattcatacgcacatcgatgctgacgttcttcaatcaaacttcc gatgatctcggcaatacgataatgaatctacaggatggcaagtacagccatttgcgtggc acgcatcttaagacctccacatcattgggctatgtaaatcaggtggtgctgccggtgctg actgcgatgtttgaccacctggctgcctgtgattatggcagtgatttgctactcgacgag attcaagtggcgtcttataagatattagctgccttgtatcacttgggcaccgatgcgaca ttgacacacgatcgcaaatacctgaaaacggaaattgagagacaccgacctgcgttgggc tcttgcttgggcgcctacagctcgtgctttccagttgcctatctggagccgcatctcaat aagcacaatcagtactcgttgctaaatcgcattgcagaccattcgctagaggcacaggac attatggtcaaaatggaaagctgtatgcccaatttggaagcgatcctcactgaagtggat cagttcgttgagtcagataagacttataccgatgcaccgcacatcattgacgttatattg ccactgctatgcgcctatttgcccttctggtggtcccagggtccggataacgtgagtccg accagcggcaatcatgtgaccatggtcacagccgatcacatgaattcgctactacgcaat gtgctcaagatgatcaagaaaaatatcggcaatgataatgcaccctggatgacacgcatt gcggcctacactcagcagatcatcatcaatacgtcggaggagctgctcaaggatccattc ctgccattggccgagcgggtcaagaaacgtactgagaatatgctacacaaggaggacagc atgcgaggatttataaaatcggcaacagacgatacttcgcaagtggagacgcagcttcaa gaggattggaatttgcttgtgcgagatatatactcgttttatcctctactcatcaaatat gtggatctgcagcgcaatcattggctaaaggataatattccagaggccgaagagctctac aatcatgttgcagagatcttcaatatctggtcgaagagtcaatacttcttgaaggaggaa caaaactttatatcagccaatgaaattgataatatggctctgataatgccaacggctacg cgacgatcggccatatcagagggcgtgccggcagtgggtggcaaggtgaagaagaagaag aagaacagggacaagaaacgtgacaaggacaaggaagtgcaggccagcttaatggttgcc tgtctgaagcgtctactgcccgttggtctaaatctattcgcgggtcgcgaacaggagctg gtgcagcattgcaaggatagatacttgaagaaaatgaacgaatacgatgtcatagaattt gcacgcaatcagttgacattgcccgacaaactagatccatcggatgagatgtcgtggcag cattatctctactcgaagctgggcaaaactgaagagccagtcgatgagcaggctttggag aaggtgaatgccaattcgaatgagaagggtaaagacaagacgacagagaccgttgatcga attgtggctatggctaaggttctatttggcctgcatatgatcgaccatccacaacagcag agcaaaaatgtctacaggagcgttgtgtcaatacaaaggaagcgtgccgttatcgcatgt ttccgtcagacatcgctacattctctacccagacatcgtgcttgcaatatctttgcacgc acctattacgaacaatggctgcaggaggagaacgttggccaggaagtaatgatcgaggat ctgacccagacatttgaagagtcagaaaaatcgaagaaggacgaagaggaaactgacggc aaaccggatcctttgacacagctggttaccaccttctgccgcggtgccatgacagagcgc agtggcgcacttcaagaggacttactgtacatgtcctatgcccaaatagcagccaagtct tgtggcgaagaggaagaggaaggcggcgaggaaggtgaagggggcgagggcggcgaagag ggcgaaggcacaagtattcatgaacaagaaatggagaagcagaagctgctgttccatcaa gcgcgtctgtcgaatcgtggcgttgccgaaatggtgctgttgcacatatccgcctccaaa ggtataccttcggagatggtcatgacgacactcaatttgggcatcgccatattgcgtggc ggtaatattgacattcaaatgggtatgttgaatcacttgaaggagaaaaaggatgtgggc ttcttcacctccatagccggactgatgaactcgtgcagcgtgctcgatctggatgcattc gagcgcaacacaaaggccgagggtcttggtgtcggctcggagggcgctgcgggtgagaag aatatgcacgatgcggagtttacgtgtgctctgttccgtttcattcagctaacctgcgag ggtcacaacttggaatggcaaaactatttgcgaacacaggctggaaatacaaccactgtg aacgtggtcatatgtacagtggattatttgctgcgtctgcaggaatcgattatggacttc tattggcactactccagcaaggagatcattgatccggctggcaaggctaacttcttcaag gccatcggcgtggctagccaagtgttcaatacactcactgaggtcatccagggtccatgt actttgaatcagcaggccttggcccattccagattgtgggatgcggtcggcggttttcta tttctattttcgcatatgcaggacaagctctcgaagcattcgagtcaagtggatctgcta aaggagctgctcaatctacaaaaggatatgatcaccatgatgttgtccatgctggaaggc aatgttgtgaatggcactattggcaagcagatggtggatactcttgtggagtcggctagc aatgttgaattgattcttaagtatttcgatatgttcctgaagttggccgacttgatcgag tcgcccagtttccatgagatcgatatgaagaacgagggctgggtaatacccaaggacttc agagagaaaatggagcagtccaagaactacacaccggaggaaatggatttccttttggcc tgctgtgaacgcaatcacgaaggcaaaattgattatagagcctttgtcgaacgtttccac gagccatcaaaggagatcggtttcaacctggctgtgctgctgaccaacctaagtgaacac atgcccaacgagccgcgcttggcgcgtttcctggagacagcgggctctgtgctgaactat tttgagccgttcctgggtcgcatcgaaatcttgggcagctcgaagcgcattgagcgtgtt tacttcgagatcaaggactcgaacatcgaacagtgggagaagccacagattcgtgaatcg aagcgcgccttcttctactcgattgtcacggagggcggcgacaaggagaagctggaagca tttgttaacttctgtgaggatgcgatctttgagatgacccacgcctctggtctcatggcc acggacgatggtggcggcaatgtgaagcgggatacggcctacagttcctatatgagtgaa gaagaggaagagcgcgcagctcgggatccgattaggcgcacaataactgctgtcaaggac ggtctgaagttcggagttcacatgctgagtccatcgaatatcaagcatcaaattggagtt atgcaaacgaaatcgatacctgaactaattgttggcttctttaagataatattctatatg ttctactacacgggctatgcacactactgtgtggtgcgctatatctttggcattctattg aatctgatgcgtggccccgcacccgagcaggaggaggaacaaactgtagttgaggaggaa acatttggacgtgcgctgccgccgttgccgttggaagagccgccgggtccggttcaagca tttggcctggacataaacaaggaagaaaatggcatgtataaggtggtggtgcacgagtcg ccagcgagctcttctgtggaagagggcggtgaatctagcccagaagacggcgcagctgtt gctggagaactactcgaaggcgatcttcatcaggatccaatttcaatagttgatatgctc ggtggtgaggcggctaagaaggcagctcaagagcgccaggaggcacaaaaggctcaagaa gctgccatggcatccattgaggcggaggccaagaagtcatcatcggcaccacaagagact ccagcagtgcaccagatcgacttctcgcagtacacgcaccgcgccgttagcttcttggct cgtaacttctacaatttgaaatatgtggcgctcgtcttggcattcagcattaactttatg ttgctcttctataaggtcacctcatttaacgatgaatcggaaggatcggctgaggaggaa ctcattctaggctcgggttcgggtgccggtgcggatatgggctctggcctgggtggttca ggcgatgggtcgggcgatggcgatttcgaagacgatgatataccggagcttgtgcatgtg gacgaggacttcttctatatggaacatgtgctacgcatagctgccctactccactccttg gtatcgctggccatgctgatcgcgtattatcatctgaaggtgccactggctatattcaag cgggaaaaggagatcgcccgtcgtctggaattcgatggtctcttcatagccgagcagccc gaggacgatgactttaagtcccattgggataagctggtcatctcggccaagagtttccct gtcaactattgggataaatttgtcaagaagaaggtcaggcaaaagtacagtgagacctac gactttgattccatctctaatttgctgggcatggagaagagcgcatttaccgcacaggag agcgaagagacgggcattctgcgttacatcatgaacatcgactggcgctatcaggtgtgg aaagcgggcgtcacctttacggacaactccttcctctactccctgtggtatttcagcttc tcggtgatgggcaactttaataacttcttctttgcggcccatttgttggatgtggctgtc ggcttcaagacactgcgcacgattctgcaatccgtaacacacaatggcaaacagctcgtc ttgaccgtgatgctccttacgattattgtgtacatatatacggtgattgcgttcaatttc ttccgcaagttctatatacaggaggaggatgaggaggtggacaagaagtgccatgacatg ttgacgtgcttcgtcttccatttgtacaagggcgttagagcaggcggtggcataggtgat gaaattggagatccggatggagatgactatgaagtctatcgcatcatcttcgacattaca ttcttctttttcgtcattgtcatcctgttggccatcatccagggtttgattatcgacgcc ttcggcgagttgcgtgatcaattggaatcggtcaaggataatatggaatcgaattgcttc atttgtggcatgggcaaggacttctttgatatagttccgcatggcttcgatacacacgtg cagaaggagcacaatctggccaactatatgttcttcctgatgcatttgatcaataagccg gatacagaatataccggccaggagacgtacgtgtggaatatgtaccaacagcgcagctgg gacttcttcccagtgggcgactgcttccgcaagcagtacgaggacgagctctctggcggc ggcggtggcggtggctga

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