Delphinapterus leucas (beluga whale): 111163908 Help Entry 111163908         CDS       T05885                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism dle  Delphinapterus leucas (beluga whale) Pathway dle04020   Calcium signaling pathway dle04024   cAMP signaling pathway dle04260   Cardiac muscle contraction dle04261   Adrenergic signaling in cardiomyocytes dle04371   Apelin signaling pathway dle04713   Circadian entrainment dle04911   Insulin secretion dle04921   Oxytocin signaling pathway dle04972   Pancreatic secretion dle05020   Prion disease dle05022   Pathways of neurodegeneration - multiple diseases dle05410   Hypertrophic cardiomyopathy dle05412   Arrhythmogenic right ventricular cardiomyopathy dle05414   Dilated cardiomyopathy dle05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:dle00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     111163908 (RYR2)    04020 Calcium signaling pathway     111163908 (RYR2)    04024 cAMP signaling pathway     111163908 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     111163908 (RYR2)    04921 Oxytocin signaling pathway     111163908 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     111163908 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     111163908 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     111163908 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     111163908 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     111163908 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     111163908 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     111163908 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     111163908 (RYR2)    05414 Dilated cardiomyopathy     111163908 (RYR2)    05415 Diabetic cardiomyopathy     111163908 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dle04040]     111163908 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:dle04990]     111163908 (RYR2) Ion channels [BR:dle04040]  Voltage-gated cation channels   Ryanodine receptor    111163908 (RYR2) Domain-containing proteins not elsewhere classified [BR:dle04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    111163908 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  111163908 NCBI-ProteinID:  XP_022408778 UniProt:  A0A2Y9LTZ5 LinkDB All DBs Position Unknown AA seq 4965 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSQGKFMMKTAQGGGHRTLLYGHAILLRHSYSG MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS LMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHIN TGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFN RFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS AQYRKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGF DGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYT RDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV RDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHTEEKVKKMKLP KNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRI FRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQ GSEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH IEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDLMFYRLSMPIECAEVFSKTAAGGIPGAGL FGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQR FLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWIT SDFQQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGLEI GCVVDTASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLS AGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCVEPLQF MSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLY AIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDENKKHG LPGIGLSTSLRPRMQFSSPSFVSINNEGYQYSPEFPLDILKAKTIQMLTEAVKEGSLHAR DPVGGTTEFLFVPLIKLFYTLLIMGIFHSEDLKHILQLIEPSVFKEAAGPEEEGESPEKE PCADDSKLEGAAEEENKGGKRSKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVA FSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECP CPEEIQDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKP VESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYT INGISVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSV GLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAM EEAIKIAEDPSRDGPSPTSGSSKTPDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMH LIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAA MVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPL LTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQH LLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWG IFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVD TSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKE KEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAID MSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKEKAKDRE KAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGS RSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSL FCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAED LEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQ VSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTK SSRERAALNLPTNVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVMEVILPMLCSYMS HWWEHGPENNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPII NKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEVRGDMSEAELLILDEFTTLARDLY AFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINN MSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQE LIALAKNRFSLKDTEDEVRDIIRSNIHLQGKVEDPAIRWQMALYKDLPNRTEDTSDPEKT VERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNL FLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEK CKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARL HDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQ SLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSASHFESHRLQTGEKVLQDDEFTCDLF RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCTETDENETLDY EGFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM QLAAQISESDLNERSANKEESGKEKPEEQGPRTGFFSIVTVTSALFALRYNILTLMRMLS LKSLKKQMKKVKKMTVKDMVTAFFMSYWGFFMSLLHFVASVFRGFSRIVGSLLLGGSLVE GAKKIKVAELLANMPDPTQDEVRGDGEDGERKAMEGALPSEDLTDLKELTEESDLLSDIF GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKAKEEKEEKEESKSEPEK AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYN MRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVSSPDSSPRIIAVHYVLE ESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPS EDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDA REKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMAMSVLGHYNNFFFAAH LLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTP DMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAII QGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFL MYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14898 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggatgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgtactgcaaccatccacaaagaacagcagaaactgtgtttggccgcagaa gggtttggcaacagactttgcttcttggagtccacttcgaattccaagaatgtcccccca gacctctccatctgcacctttgtgctggaacagtccctctctgtccgggccctgcaggag atgctggctaacactgtggagaagtcacaagggaaattcatgatgaagaccgctcaaggt ggtggccaccgaacgctcctctatggacatgccatattgctgcgtcattcctacagcggc atgtatctgtgctgcctgtccacctctcggtcttcaactgataaactggcctttgatgtt ggcttgcaagaggacacaacaggtgaagcttgttggtggaccatccatcctgcctccaag cagcgctcagaaggagaaaaagtacgggttggagatgacctcatcttagttagtgtgtcc tccgaaaggtacttgcacttgtcttatggcaacggcagcctgcacgtggacgccgctttc cagcagaccctctggagcgtggccccaatcagctcaggaagtgaagcagcccaagggtat ctgattggtggtgacgtcctcaggttgcttcatggacacatggatgaatgcctcacggtc ccttcgggagaacatggtgaagagcagcgaagaactgttcattacgaaggtggtgctgta tctgttcacgcacgctccctgtggagactagagacgctaagagttgcgtggagtggaagc cacataagatggggccagcctttccgactacgccatgtcacaacaggaaaatacttgagc ctcatggaagacaaaagccttctactcatggacaaagaaaaagctgatgtcaaatcaaca gcatttaccttccgatcttccaaggaaaaattggatgtaggggtgagaaaagaagttgat ggcatgggaacctctgaaataaaatatggagactcagtatgctatatacagcatatcaat acgggcttgtggctaacttaccagtctgtggatgtgaaatctgtgagaatgggatccata caacgtaaggctattatgcatcatgaaggtcacatggatgatggcctaaatttgtccaga tctcagcatgaagaatcacggacagcacgtgtcatccggagcacagtcttccttttcaat agatttattaggggccttgatgctctcagcaaaaaagcgaaggcttccactgtagactta cctatagagtctgtaagtctaagtctgcaggacctgattggctacttccacccaccagat gagcacttagagcatgaagataagcagaacagattacgagctctaaagaatcggcagaat ctcttccaggaagagggaatgatcaaccttgtgctcgagtgtatagacaggctgcacgtg tacagcagcgctgcacactttgcggatgtcgctgggagagaagcaggggaatcttggaaa tcgattctgaattctctgtatgagttgctggcggctctaattagaggaaatcgtaaaaac tgtgctcaattttctggctccctcgactggttaatcagccgattggaaagactggaagct tcttctggtattcttgaagttttacactgtgtgttagtagaaagtccagaagctctaaat attattaaagaaggccatattaaatccattatctcacttttagacaagcatggaagaaat cacaaggttctggacgtcttatgctccctctgtgtttgccatggggtagcagtccgttct aaccagcatctcatctgcgacaatcttctgccaggaagagacctgttactgcagacacgc cttgtgaaccacgtcagcagcatgaggcccaatatttttctgggtgtcagcgaagggtct gcgcaatataggaaatggtactatgagttgatggtggaccacaccgagccatttgtgacc gccgaagccactcacctgcgagtgggctgggcttcaacggaggggtactctccctaccct ggagggggcgaggagtggggtggaaatggtgtcggagatgacctcttctcctatggattt gatggccttcacctctggtcaggttgtattgcccgtactgtcagctcaccaaaccagcat ctgttgagaactgatgatgtcatcagttgctgtttagatctaagtgccccaagcatctcc ttccgaattaacgggcaacctgttcaaggcatgtttgagaatttcaacattgatggcctc ttctttccagttgtcagtttctctgcaggaatcaaggtacgctttctgcttggggggaga catggagaatttaagttccttcctccacccgggtatgctccttgttatgaagctgttctg ccaaaagaaaagttgaaagtggaacacagccgagagtacaagcaagaaaggacatataca cgggacctcctgggtcccacagtttccctgacacaagccgccttcacaccgatccccgtg gataccagccagattgtgttgcctccccacctggagaggataagagaaaagctggcagag aatatccatgaactctgggttatgaataaaattgaacttggctggcagtatggtccggtt agagatgacaataagagacagcacccgtgtctggtggagttctgcaagctgcctgaacag gaacgcaattacaacttacagatgtcgcttgagaccctgaagactttgttggcattagga tgtcatgtgggtatatcagatgaacacaccgaagaaaaggtgaaaaaaatgaagctgccg aagaattaccagctgacaagtggatacaagcctgccccgatggacctgagctttatcaag ctcaccccatctcaggaagcgatggtggacaagttggcggaaaatgctcataacgtgtgg gcccgggatcgaatccggcagggctggacctatggcatccaacaggatgtaaagaacaga agaaaccctcgcctggttccctatgcccttctagatgaccgaactaagaaatccaacaag gacagcctccgtgaggccgtgcgcacactgctggggtatggctacaacctggaggcgccc gatcaagatcatgctgccagagctgaagtgtgcagcggcacaggagaaaggttccgaatc ttccgcgctgagaaaacttacgctgtgaaggcaggaaggtggtattttgaatttgaggct gtcactgctggagacatgagagttggctggagcagaccaggctgtcaacccgatcaggag cttggctcggatgaacgtgcctttgctttcgatggcttcaaggcccagcggtggcaccag ggcagtgagcactatgggcgctcttggcaagcaggagatgttgtggggtgtatggttgac atgacagaacataccatgatgttcacactgaacggcgaaatccttctggatgattcgggt tcagaattggctttcaaggactttgatgttggtgatggattcatacctgtatgtagcctt ggagtggctcaagtgggcaggatgaactttggaaaggatgtcagcaccttgaaatatttc accatctgtggcttacaagagggctatgaaccatttgccgttaacacgaacagggatatt accatgtggctaagcaagaggcttcctcagtttctccaagttccatcaaaccatgaacat attgaggtgaccagaattgacggcaccatcgacagttccccgtgtttaaaggtcactcag aagtcctttggctctcagaacagcagcacggatctcatgttttatcgtctgagcatgccc atcgagtgcgcggaggtcttctccaagactgcggctggagggatccctggcgccggtctc tttgggcccaagaatgatttggaggattatgatgtggattcggactttgaggttctcatg aagacagctcatggccatctggtgccagatcgagtggacaaagacaaagaagctacaaaa ccggagtttaacaaccacaaagattatgctcaggaaaagccctctcgtctgaaacaaaga tttttgcttagaaggacaaagccagattacagcaccagccactctgcaagactcacagaa gatgtcctggcagatgagagggacgactatgattacttgatgcaaacgtccacgtactat tactcagtgagaatctttcctggacaagaacctgccaacgtctgggtgggctggatcaca tccgatttccaacagtatgatacaggctttgacctggacagagttcgtacagtgaccgtg actctaggagatgaaaaaggaaaggtgcacgaaagcatcaaacgcagcaactgctatatg gtgtgtgcgggtgagagcctgagccccgggcaaggacgcaacaacaacggcctggagatt ggctgcgtggtggacaccgccagtgggctgctcaccttcacggccaacggcaaggagctg agcacatactatcaggtggaaccaagtacaaaattatttcctgcagtttttgcacaagct acaagtcccaacgtttttcagtttgagttgggaagaataaagaatgtgatgcctctctca gcgggattattcaagagcgagcacaaaaaccccgtgccgcagtgtccccctcgtctccat gtgcagttcctctcacatgtcctctggagcagaatgcccaaccagttcttgaaggtagac gtgtctcgaataagtgaacgccaaggctggctggtgcagtgtgtggaacctctgcagttc atgtctctccatatcccagaggagaacagatctgtggacatcctggaactgaccgagcag gaagaactgctgaaattccactaccatactctccggctttactcggccgtctgcgcgctt gggaatcaccgggtggcccacgccttgtgcagccacgtggacgaaccacagctgctctac gccatcgagaataagtacatgcccggcttgctgcgcgccggctactacgacctgctgatt gacatccacctcagctcctacgccaccgccaggctcatgatgaacaatgagttcatcgtc cccatgacggaggagacaaagagcatcaccctcttccccgatgagaacaaaaagcacggc ctcccgggcattggcctcagcacctccctcaggccacggatgcagttttcctccccgagt tttgtcagcattaacaacgagggttaccagtacagccctgagttcccgctggacatcctg aaggccaagaccatacagatgctgacggaggccgtgaaagagggcagccttcacgcccgg gaccctgtcggggggaccactgagttcctcttcgtccctctcatcaagttgttctatacc ctgctcatcatgggcatcttccacagcgaggacttgaaacacatcttgcagctgattgag cccagcgtgttcaaggaagctgccggtcccgaggaagagggagagtcgccagagaaggag ccctgtgcggacgactccaagctggaaggagccgctgaggaagaaaacaaaggcggtaag aggtccaaggaaggcctgctccaaatgaaactgcccgagccagttaaattgcagatgtgc ctgctacttcagtacctctgtgactgccaggtccggcaccggatagaagccattgtggcc ttttcagatgactttgtagccaagctccaagacaatcaacgattccgctataacgaagtt atgcaagccttgaacatgtcggctgcactcacagccaggaaaaccaaggaattcagatca ccgcctcaagagcagatcaatatgcttctcaattttaaggatgacaaaagcgaatgtcca tgtcccgaagaaatccaagaccaactcttagattttcatgaagatttgatgacacattgt gggattgagctggatgaagatgggtctctggatggaaacagtgatttaacaattagagga cgcctgctgtccttggtagaaaaggtgacatacctaaagaagaagcaagctgaaaagccc gttgagagtgactccaagaagtcgtccactcttcagcagttgatttctgagaccatggtc cgatgggcccaagagtctgttattgaagaccctgagttggtgagggccatgttcgtgttg ctccatcgacagtacgatggcattgggggtctggtccgggctctgccaaagacctacact ataaatggtatttccgtggaggataccatcaacctgctggcatctcttggtcagattcgt tctctgctgagtgtgagaatgggcaaagaagaagagaaacttatgatccgtggattaggg gatatcatgaataataaagtgttttaccagcaccctaatctcatgagggcacttgggatg cacgagacagtgatggaggtcatggtgaatgtccttggaggtggggagtccaaggaaatc acttttcccaagatggtggccaactgttgccgttttctctgttacttctgtcgtataagt aggcagaatcagaaagcaatgttcgatcatctcagttatttactggaaaacagcagtgtt ggtcttgcctcaccagctatgagaggttcaacgccactggacgtggcagcagcctcggtg atggataataatgaactagccttagctttgcgggagccagatctggaaaaggtagtgcga tatttggctggttgtggactgcaaagttgtcagatgctggtgtcgaagggttatccagac attgggtggaatccagttgaaggagagagatatcttgactttctcagatttgctgtcttc tgtaatggggaaagcgtggaggagaatgcaaatgtcgtggtgagattgctcatccggagg cctgagtgtttcggtcctgccttgaggggggaaggtgggaatggtctgctcgcagccatg gaagaagccataaaaatagctgaggatccttctcgagatggtccctcaccaactagtgga tccagcaaaacccctgatacagaagaggaggaagatgataccatccacatggggaatgcc atcatgacattttatgcagctttgattgacctgttaggacgctgtgctcccgaaatgcat ttgattcatgctgctaagggagaagccatcagaatcaggtctattttgagatccctgatt ccactgggagatttggtgggagtaatcagcattgcttttcagatgccaacgatagccaaa gatgggaatgtggtggagcctgacatgtctgcggggttttgcccagatcacaaggcagcc atggttttgttccttgacagggtctatggaattgaggttcaagatttcctcctccatctt ctcgaggttggctttctgccagatctgcgggctgctgcttctttagatacggctgctttg agcgctacagacatggccctggccctcaatcggtacctttgcacggccgtgttgcctttg ttaacaagatgtgctcctctttttgctggcactgagcaccatgcttccctcattgactca ttacttcacaccgtgtacagactttctaagggctgctcacttaccaaagctcaacgagat tccatagaagtgtgtttactctccatttgtggccaattgagaccttctatgatgcagcac ttactcagaagattagtatttgatgtcccattattaaatgaacatgcaaagatgcctctt aagctgctgacaaatcattatgaaagatgctggaaatactactgcctgcctggagggtgg ggaaactttggagctgcctcagaagaagaacttcatttatcaagaaagttgttctggggc atttttgatgccctgtctcaaaagaaatatgaacaagaacttttcaaactggcactgcct tgcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtcagt atgatggaaaaacagtcatcaatggattctgaagggaactttaacccacaacctgttgat acctcaaatattacaattcctgagaagttggaatacttcattaacaaatatgcagaacat tcccatgacaagtggtcaatggacaagttggcaaatggatggatttatggagaaatatat tcagactcgtctaaagttcaaccattaatgaagccatataaactattatctgaaaaggaa aaagaaatttatcgctggccaatcaaagaatctttaaaaactatgctggcctgggggtgg agaattgaaaggacacgggagggagacagcatggccctttataaccggactcgtcgtatt tcccagacaagccaggtttctgtagatgccgcccatggttatagcccccgagccattgac atgagcaatgttacactatccagagatctgcatgctatggcagaaatgatggctgaaaac taccataatatatgggcaaagaaaaagaaactggaactggagtccaaaggaggtggaaac catcccctgctggtaccctatgatacactgacggccaaagagaaagccaaggatagggaa aaagcacaggacatcctcaagttcctgcagatcaatggctatgctgtatccagaggattc aaggacctggaattggacactccttctattgagaaacgatttgcctatagtttccttcag caactcattcgctatgtggacgaagcccaccagtatatcctggagtttgatggtggcagc agaagcaaaggagaacatttcccttatgaacaagaaatcaagttctttgctaaagttgtt cttcctttaattgatcagtatttcaaaaaccatcgtttatacttcttatctgcagcaagc agacctctctgttctggaggacatgcatcaaacaaagagaaagaaatggtgactagccta ttctgcaaacttggagttcttgtcaggcataggatttcactatttggaaatgatgcaaca tcaattgtcaactgtcttcatattttgggtcagactttggatgcaaggactgtgatgaag actggcctggaaagtgttaaaagtgcactcagagctttcctggacaatgccgcagaggat ctggagaagacgatggaaaatcttaagcagggccagttcacccacacccgaaaccaaccc aaaggtgttactcagattatcaattataccacggtggcactgttgccaatgctgtcatca ttatttgagcatattggccagcatcagttcggagaagatctaatattggaagatgtacag gtatcatgttatagaattctgactagcttgtatgcattgggaaccagcaagagtatttat gtggaaaggcaacgttctgcattaggagagtgtctggctgcctttgctggtgcctttcct gtagcatttttggaaactcatctcgacaaacacaatatttactccatctacaatactaag tcttctcgagagagagcagctcttaatttgccaactaatgtcgaagatgtttgtccaaat ataccatctttggagaaactcatggaagaaattgtggatttagctgagtccggtattcgc tacacacaaatgccacatgtgatggaagttatcctgcccatgctgtgtagctacatgtct cattggtgggagcacggacccgagaataatccaggaagggctgagatgtgctgcacggct ctgaactcagagcacatgaacacgctgctgggaaatatcctgaaaatcatatataataac ttgggaattgatgagggagcctggatgaaaaggttagcagtattttcccagcctattata aataaagtgaaacctcagctcttgaaaactcatttcttgccattaatggagaaactcaag aaaaaggcagctatggtggtatcagaggaagaccatctgaaatccgaggtcaggggggat atgtccgaggctgaacttctcattctagacgagttcaccacgctggccagagatctctat gccttctacccgctcttgattagatttgtggactataacagggcaaagtggctaaaagag cctaacccagaagcagaagaccttttccgcatggttgcagaggtgtttatctactggtca aaatcccacaatttcaaaagagaagagcagaacttcgtggtacaaaatgaaatcaacaat atgtctttccttattacggacaccaagtcaaagatgtccaaggcagctgtttctgatcag gaaaggaagaaaatgaagcgcaaaggagaccggtattccatgcagacctctcttatcgtg gcagctctgaagcgattactgcccattggcttgaacatctgtgcccctggggaccaggag ctcattgctctggccaaaaatcgatttagtctgaaagacactgaggatgaagttcgagat ataatccgcagtaatattcacttacaaggcaaggtggaggatcctgctattagatggcag atggctctttacaaagatttacccaacaggacagaagacacttcagatcctgagaagaca gtggaaagggtcttggatatagcaaatgtgctttttcatcttgaacaggtcgagcatcct cagagatcgaaaaaggctgtgtggcacaaactgctctctaagcagaggaaacgggcagtg gttgcctgctttcggatggctcctttgtataacctgccaaggcatcgggctgtcaatctc tttcttcagggatatgaaaaatcttggattgagacagaagaacattactttgaagataaa ctgatagaagatttagcgaaacctggagcagaacctccggaagaagatgaaggaactaag cgggttgatcctctccatcagctgatacttctgttcagtcgaacggctttaacggagaaa tgcaaactggaggaagattttttatatatggcttatgcagatattatggcaaagagttgt catgatgaggaagacgatgatggggaagaggaagtgaagagttttgaagtcacaggatcc caacgcagcaaggaaaaagaaatggaaaagcaaaagcttctgtaccaacaagccaggctc cacgaccgcggtgcagctgagatggtgctgcagaccatcagtgccagcaaaggtgaaact ggacccatggtggctgctactttgaaactcggaattgctatcttaaatggcgggaactct acagtacagcagaaaatgcttgactatctcaaggagaaaaaggatgtgggcttctttcag agccttgctggcctgatgcagtcatgcagtgtccttgacctaaacgcatttgagcgacaa aacaaagctgaaggacttgggatggtgaccgaggaaggatcagcctctcactttgaaagt cacagactgcagactggagaaaaggttctgcaggatgacgaattcacctgtgacctcttc cgcttcttgcaactgctttgtgagggacacaactcagattttcaaaattatctgagaact cagactggcaataatacgactgtcaacataatcatctctaccgtagactacctactgaga gttcaggaatcaatcagtgacttctattggtattactctgggaaagatgtcattgatgaa cagggacaaaggaatttctccaaagccattcaagtagcaaaacaagtctttaacacgctt acagagtatattcagggtccttgcactggcaaccagcagagtttggctcatagcaggctc tgggatgcggtggtgggttttcttcatgtgtttgcccacatgcagatgaagctgtctcag gattccagtcagattgagctgctgaaagaattgatggatcttcagaaggacatggtggtc atgttgctgtccatgttggaaggcaatgtcgttaatggcaccatcggcaaacagatggtt gatatgctcgtggaatcttccaacaacgtggagatgattctcaaattttttgacatgttc ttaaaactcaaggacttgacgtcttctgatacctttaaagagtatgacccagacggtaag ggagtcatttccaagagggacttccacaaagcgatggagagccataagcactacacccag tctgagactgaatttctgctgtcctgcacagagacggatgaaaacgaaactctggactac gagggatttgtcaagcggttccacgagcctgccaaggacatcggcttcaacgtggcagtg cttctgacaaacctttctgaacacatgcccaacgacacccggctgcagaccttcctggaa ttggccgagagcgtcctgaattacttccagccctttctgggccgcatcgagatcatgggc agtgccaagcgcatcgagagggtttactttgaaatcagtgagtccagccgaacccagtgg gagaagccccaggtcaaggagtccaaaaggcaatttatatttgatgtggtcaacgaaggg ggagaaaaagagaagatggagctcttcgtgaacttctgtgaggacaccatatttgagatg cagctcgcagctcagatctcagagtcggacttgaacgagaggtcagcgaataaagaggag agcgggaaggagaagccagaggagcaggggccgaggacgggtttcttttccatcgtgacg gtcacgtcggccctgtttgccctcaggtataatatcttgacccttatgcggatgctcagc ttaaagagcctgaagaagcagatgaagaaggtgaagaagatgacggtgaaggacatggtc acggccttctttatgtcctactgggggttttttatgagcctcctgcacttcgtagcgagc gttttcagaggcttctcccgcatcgtcggcagcctcctgctaggaggaagcctggtggaa ggtgcgaagaagatcaaggtggcggagctcttggccaacatgccggaccccacgcaggat gaggttcgaggagacggggaggacggagagaggaaagccatggaaggcgccctgcccagc gaagatctgacggacttaaaggaactgacagaggagagtgacctgctttccgacatcttt ggcctggacctgaagcgagaaggcgggcagtacaaactgattcctcataatcccaatgct ggcctgagcgacctcatgagcaaccccgtccctatccccgaggtgcaagaaaagttccag gaacagaaggcaaaagaagaaaaggaagaaaaagaagaaagcaaatccgaacctgagaaa gccgagggagaagatggagaaaaagaagaaaaagccaaagaagataagggtaaacaaaaa ttgaggcagctccacacacacagatatggagagccagaagttcctgagtcagcattctgg aagaaaatcatagcctatcaacagaagcttctaaactattttgctcgcaacttttacaac atgagaatgttagccttatttgtcgcgtttgcaatcaatttcatcttgctcttttataag gtctccacttcttctgtggttgaaggaaaggagctccccactcgcagttcaagtgaaaat gccaaagttagcagcccggacagctcgcctagaatcattgcagttcactatgtgctggag gagagcagcggctacatggagcccacgctgcgtatcttagccattttgcacacggttatc tctttcttctgcatcattggatactactgcttgaaagtcccactggttatttttaagcga gaaaaagaagtagctcgaaaactggaatttgatgggctttatattacagaacagccttca gaagatgatattaaaggccagtgggatagactcgtaatcaacacacagtcatttcccaac aactactgggacaaatttgttaaaagaaaggttatggataaatatggagagttctatggc cgagacagaatcagcgagttacttggcatggacaaagctgccctggacttcagcgatgcc cgggaaaagaagaagccaaagaaagacagctccctgtcggccgtgctgaactctattgat gtgaagtatcagatgtggaaactaggagtcgttttcactgacaattccttcctctacctt gcctggtatatggccatgtccgttctcggacactataacaactttttttttgccgctcat cttcttgacattgctatgggattcaagacgttaagaaccatcttgtcatcagtaacacac aatggcaaacagcttgtattaaccgttggcttattagctgttgttgtatacctatatact gtcgtggcattcaattttttccgaaaattctacaataaaagtgaagatggcgatacaccg gacatgaaatgtgatgacatgctaacgtgctatatgttccacatgtatgttggggtacgt gccggagggggtatcggtgatgaaatcgaagacccagccggcgatgagtatgagatctat cgaatcatctttgatatcaccttcttcttctttgtaattgtcattctcttggccataata caaggtttaattatcgatgcttttggggaactaagagaccaacaggaacaggtcaaagaa gacatggagaccaagtgcttcatctgtgggataggcaatgattacttcgacaccgtgccc catggctttgaaacccacactttacaggaacacaacttggccaattatctgttttttctg atgtatctcataaacaaagatgaaacagagcacacaggacaggaatcttatgtttggaag atgtatcaagaaaggtgctgggaatttttccccgctggggattgtttccggaaacagtat gaagaccagctaaattaa

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