KEGG   Delphinapterus leucas (beluga whale): 111165617
Entry
111165617         CDS       T05885                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
dle  Delphinapterus leucas (beluga whale)
Pathway
dle00562  Inositol phosphate metabolism
dle01100  Metabolic pathways
dle04015  Rap1 signaling pathway
dle04020  Calcium signaling pathway
dle04022  cGMP-PKG signaling pathway
dle04062  Chemokine signaling pathway
dle04070  Phosphatidylinositol signaling system
dle04071  Sphingolipid signaling pathway
dle04072  Phospholipase D signaling pathway
dle04081  Hormone signaling
dle04082  Neuroactive ligand signaling
dle04261  Adrenergic signaling in cardiomyocytes
dle04270  Vascular smooth muscle contraction
dle04310  Wnt signaling pathway
dle04371  Apelin signaling pathway
dle04540  Gap junction
dle04611  Platelet activation
dle04613  Neutrophil extracellular trap formation
dle04621  NOD-like receptor signaling pathway
dle04713  Circadian entrainment
dle04720  Long-term potentiation
dle04723  Retrograde endocannabinoid signaling
dle04724  Glutamatergic synapse
dle04725  Cholinergic synapse
dle04726  Serotonergic synapse
dle04728  Dopaminergic synapse
dle04730  Long-term depression
dle04742  Taste transduction
dle04750  Inflammatory mediator regulation of TRP channels
dle04911  Insulin secretion
dle04912  GnRH signaling pathway
dle04915  Estrogen signaling pathway
dle04916  Melanogenesis
dle04918  Thyroid hormone synthesis
dle04919  Thyroid hormone signaling pathway
dle04921  Oxytocin signaling pathway
dle04922  Glucagon signaling pathway
dle04924  Renin secretion
dle04925  Aldosterone synthesis and secretion
dle04926  Relaxin signaling pathway
dle04927  Cortisol synthesis and secretion
dle04928  Parathyroid hormone synthesis, secretion and action
dle04929  GnRH secretion
dle04933  AGE-RAGE signaling pathway in diabetic complications
dle04934  Cushing syndrome
dle04935  Growth hormone synthesis, secretion and action
dle04961  Endocrine and other factor-regulated calcium reabsorption
dle04970  Salivary secretion
dle04971  Gastric acid secretion
dle04972  Pancreatic secretion
dle04973  Carbohydrate digestion and absorption
dle05010  Alzheimer disease
dle05016  Huntington disease
dle05017  Spinocerebellar ataxia
dle05022  Pathways of neurodegeneration - multiple diseases
dle05142  Chagas disease
dle05143  African trypanosomiasis
dle05146  Amoebiasis
dle05163  Human cytomegalovirus infection
dle05200  Pathways in cancer
dle05415  Diabetic cardiomyopathy
dle05417  Lipid and atherosclerosis
Module
dle_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dle00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    111165617 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    111165617 (PLCB4)
   04310 Wnt signaling pathway
    111165617 (PLCB4)
   04371 Apelin signaling pathway
    111165617 (PLCB4)
   04020 Calcium signaling pathway
    111165617 (PLCB4)
   04070 Phosphatidylinositol signaling system
    111165617 (PLCB4)
   04072 Phospholipase D signaling pathway
    111165617 (PLCB4)
   04071 Sphingolipid signaling pathway
    111165617 (PLCB4)
   04022 cGMP-PKG signaling pathway
    111165617 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    111165617 (PLCB4)
   04081 Hormone signaling
    111165617 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    111165617 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    111165617 (PLCB4)
   04613 Neutrophil extracellular trap formation
    111165617 (PLCB4)
   04621 NOD-like receptor signaling pathway
    111165617 (PLCB4)
   04062 Chemokine signaling pathway
    111165617 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    111165617 (PLCB4)
   04922 Glucagon signaling pathway
    111165617 (PLCB4)
   04929 GnRH secretion
    111165617 (PLCB4)
   04912 GnRH signaling pathway
    111165617 (PLCB4)
   04915 Estrogen signaling pathway
    111165617 (PLCB4)
   04921 Oxytocin signaling pathway
    111165617 (PLCB4)
   04926 Relaxin signaling pathway
    111165617 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    111165617 (PLCB4)
   04918 Thyroid hormone synthesis
    111165617 (PLCB4)
   04919 Thyroid hormone signaling pathway
    111165617 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    111165617 (PLCB4)
   04916 Melanogenesis
    111165617 (PLCB4)
   04924 Renin secretion
    111165617 (PLCB4)
   04925 Aldosterone synthesis and secretion
    111165617 (PLCB4)
   04927 Cortisol synthesis and secretion
    111165617 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    111165617 (PLCB4)
   04270 Vascular smooth muscle contraction
    111165617 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    111165617 (PLCB4)
   04971 Gastric acid secretion
    111165617 (PLCB4)
   04972 Pancreatic secretion
    111165617 (PLCB4)
   04973 Carbohydrate digestion and absorption
    111165617 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    111165617 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    111165617 (PLCB4)
   04725 Cholinergic synapse
    111165617 (PLCB4)
   04728 Dopaminergic synapse
    111165617 (PLCB4)
   04726 Serotonergic synapse
    111165617 (PLCB4)
   04720 Long-term potentiation
    111165617 (PLCB4)
   04730 Long-term depression
    111165617 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    111165617 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    111165617 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    111165617 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    111165617 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111165617 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    111165617 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    111165617 (PLCB4)
   05142 Chagas disease
    111165617 (PLCB4)
   05143 African trypanosomiasis
    111165617 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    111165617 (PLCB4)
   05016 Huntington disease
    111165617 (PLCB4)
   05017 Spinocerebellar ataxia
    111165617 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    111165617 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111165617 (PLCB4)
   05415 Diabetic cardiomyopathy
    111165617 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    111165617 (PLCB4)
   04934 Cushing syndrome
    111165617 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dle04131]
    111165617 (PLCB4)
Enzymes [BR:dle01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     111165617 (PLCB4)
Membrane trafficking [BR:dle04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    111165617 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    111165617 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 111165617
NCBI-ProteinID: XP_022412178
UniProt: A0A2Y9LTY4
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAIGKSENDLEGRVVCVCSGTDLVNISFTYMVAENSE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDVKKKGQISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKASD
DLEHENNKKGLVTIEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRLAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKASVTPQ
SSSELRPTTTATLGAGLEVKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELSSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTLQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCV
KLQDAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcgtttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttttttctgacctggagaagtgaaggcaaggaaggacaagttcta
gaatgttctctcatcaacagtgttcgactgggagccacaccaaaggatcccaaaattttg
gctgctcttgaagctattggaaagtcagaaaatgacctggaagggcgggtagtttgtgtc
tgcagtggtacagatctggtgaacatcagtttcacatacatggtggctgaaaattcagaa
gtaactaagcaatgggtcgaaggcctgagatccatcatacacaacttcagggccaacaat
gtcagtcccatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattaccagaacctttgcatcggggaagacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgaa
cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattc
ccattttatgatactaaaagggcaatgcagatcattgagatgtatgagcctgatgaagac
gtgaagaaaaaaggccaaatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctagatcgcctagagctttaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtgggaag
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaagaaccaataataactcatggaaaagcaatgtgc
acagatatactttttaaggatgtcattcaagccatcaaggaaactgcatttgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcccttgaatcacat
ccactggaaccaggcagacctttgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagcttgaagctttgaaaagtatg
atggaagcaggagaatccgctgccccagtgaacatcttagaggatgataatgaagaggaa
atagaaagtgctgagcaagaggaagaagctcaccctgaatacaaatatggaaatgaactt
tctgcagacgacttgggtcacaaggaagctattgccaatagtgttaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactatagaagatgagcaggcatgg
atggcatcttataaatatgtaggcgccaccactaatatccatccatatttgtccacaatg
atcaactatgcacagcccgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcttttaatgagtcagttggtctaggctacttgaagacacatgcg
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgagacggcctgatcgaacatttgat
cccttctctgaaacgcctgttgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagttcttatcagataaaaaaattggcacatatgtagaagtggatatgtatggg
ttgcccaccgacactatccggaaggaattccgaacacgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtatttcggaaggtgatcctccccgacctggca
gtcttgagacttgcagtgtatgatgacaacaacaagctgattggccagaggattctgcca
ctggatggcctccaagcaggctatcgacacatttctcttcgaaatgagggaaataaacct
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaaccagtgacatcgccgacgtgcccagtgac
acatcaaagaatgacaagaaagggaaagccaacacagcaaaagcaagtgtgacccctcag
agcagctcagagctcaggcccaccaccacagccaccctgggagctggcctggaggtcaag
aaaggtattgaactgatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctcagttctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagctacattgcacacaagttgacaaaattgtggcgcagtat
gacaaggagaagtcaactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaagaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaggagatcgtggcgcagcacacaaaagagtggtcagacatgatc
aacactcacagtgcagaggagcaggagatccgggatctgcacctcagccagcagtgcgag
ctactcaaaaagctcctgatcaacgcccacgagcagcagaccctgcagttgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgggtcagg
gaattaaacagcagcaacactaaaaagtttctggaagaaagaaagcgactcgcaatgaag
cagtccaaagaaatggaccagttgaaaaaagtccagcttgagcacctcgaattcctagag
aaacagaacgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagttgtgtg
aaactccaggacgcaaactga

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