Delphinapterus leucas (beluga whale): 111166419 Help Entry 111166419         CDS       T05885                                  Symbol TOP2A Name (RefSeq) DNA topoisomerase 2-alpha   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism dle  Delphinapterus leucas (beluga whale) Pathway dle01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:dle00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     111166419 (TOP2A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:dle03032]     111166419 (TOP2A)    03036 Chromosome and associated proteins [BR:dle03036]     111166419 (TOP2A) Enzymes [BR:dle01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      111166419 (TOP2A) DNA replication proteins [BR:dle03032]  Eukaryotic type   DNA Topoisomerases    111166419 (TOP2A) Chromosome and associated proteins [BR:dle03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     111166419 (TOP2A)   Centrosome formation proteins    Centriole proteins     111166419 (TOP2A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim Microp_apicomplexa_20 Motif Other DBs NCBI-GeneID:  111166419 NCBI-ProteinID:  XP_022413801 UniProt:  A0A2Y9LYD0 LinkDB All DBs Position Unknown AA seq 1533 aa AA seqDB search MEMSPLQPVSDNMQVNKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVESVTQQ MWVYDEDIGINCREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTVDPENNLISIWN NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWRDNMGRAGEMELKPFSGEDYTCITFHPDLSKFKMQSLDKDIVALMV RRAYDIAGSTKDVKVFLNGNKLPIKGFRSYVDMYLKDKVDETGNPLKIIHEQVNPRWEVC LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK YGVFPLRGKMLNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT DQDQDGSHIKGLLINFIHHNWPSLLHHRFLEEFITPIVKVSKNKQEVAFYSLPEFEEWKS STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEW YIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLMDGEEPLPMLPSYKNFKGTIE ELAPNQYVISGEMSILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK KDELCKLRNEKEQELETLKRKSPSDLWKEDLAAFIEELEAVEAKEKQDEQIGLPGKGGKA KGKKTQRAEVLPSPCGKRVIPQVTIEMKAEAEKKIKKKIKNENTEGSPREDGMEIEGLKQ RLEKKQKREPGTKTKKQTTLPFKPVKKAKKRNPWSDSESDIGSNESNFDVPPREKEPRRA ATKTKFTMDLDSDEDFSDFDENTQDEDCVPSDASPPGTTTSPKHTNKELKPQKSATSVTD LHADDAKGNAPPPPSAPAADFPAVTKTINPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAP KGTKKDPDLDSDVSKKPNPPKTKSHRKRKPSTSDDSDSNFEKMISKAVTSKKPKEDSDDF HLDLDSAVASRAKSGRTKKPIKYLEESDEDDLF NT seq 4602 nt NT seq  +upstreamnt  +downstreamnt atggagatgtcgccactgcagcctgtaagtgacaatatgcaagtcaacaaaacaaagaaa aatgaagatgctaagaaaagactgtctattgaaagaatctaccaaaagaaaacacaactg gaacatattctgctccgcccagacacctacattggctctgtggaatcagtgacccagcaa atgtgggtttacgatgaagatattggcattaactgtagggaagtcacttttgttcctggt ttgtacaaaatctttgatgagattctagtcaatgctgcagacaacaaacaaagggaccca aaaatgtcttgtattagagtcacagttgacccggagaataatttaattagtatatggaat aatggaaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagctctc atctttggacagctcctaacttctagtaactatgatgatgaagaaaagaaagtaacgggt ggtcgaaatggctatggagccaaattgtgtaacatattcagtaccaaatttactgtggaa acagccagtagagaatacaagaaaatgttcaaacagacatggagggataacatggggaga gctggtgagatggaactcaagccctttagtggagaagattatacatgtattaccttccac cctgatttgtctaagtttaaaatgcaaagcctagacaaagatattgttgcactgatggtt agaagagcatatgatattgctggatccactaaagatgtcaaggtctttctcaatggaaat aagcttccaataaaaggattccgtagctatgtagatatgtatctgaaggataaggtagat gaaactggcaatccactgaaaattatccatgaacaagtaaaccccaggtgggaagtgtgt ttaacaatgagtgaaaaaggctttcagcaaatcagctttgtcaacagcattgctacttcc aagggtggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtg gtgaagaaaaagaacaagggtggtgttgcagtaaaagcacatcaggtaaaaaatcacatg tggatttttgtgaatgccttaattgaaaacccaaccttcgactcccagacaaaagagaac atgactttacaagtcaagagttttggatcaacgtgccagttgagtgaaaaattcatcaaa gctgcaattggctgtggtattgtagaaagcatactaaactgggtgaaatttaaggcccaa gtccagttaaacaagaagtgttcagctgtaaaacataacagaatcaaaggaattcccaaa cttgatgatgccaatgatgcaggaggtcgaaactccactgagtgtacacttatcctgaca gagggagactcagctaaaactttggctgtttcaggccttggtgtggttgggagagacaag tacggggttttccctcttagaggaaaaatgcttaatgttcgagaagcttctcataaacag ataatggaaaatgctgaaattaacaatataatcaagattgtgggtcttcagtacaagaaa aactatgaagatgaagattcattgaagactctgcgttatgggaagataatgattatgaca gatcaggaccaagacggttcccatatcaaaggcttgctgattaatttcatccatcataac tggccctctcttctgcaccatcgttttctggaggaatttatcactcccattgtaaaggtg tctaaaaacaagcaagaagtggcattctatagccttcctgagtttgaagaatggaagagt tctacaccaaatcataaaaaatggaaagtcaagtattacaaaggtttgggcaccagcaca tcaaaagaagctaaagagtactttgcagatatgaaaagacatcgtatccaattcaaatat tcaggtcctgaagatgatgctgcaatcagcctggcctttagcaaaaaacagatagatgat cgaaaggaatggttaactcatttcatggaagatagaaggcaacgaaagttacttggcctt cctgaggattacttatatgggcaaactaccacatatctgacatataatgacttcataaat aaggaacttatcctgttctcaaattctgataatgagaggtctatcccatctatggtggat ggtttgaagccaggtcagagaaaggttttgtttacatgtttcaaacggaatgacaagcga gaggtgaaggttgcccagttagctgggtcagtagctgagatgtcctcttatcatcatggt gagatgtcactaatgatgaccattatcaatttggctcagaactttgtgggtagcaataat ctgaacctcttgcagcccattggtcagtttggtaccaggctgcatggtggcaaggattct gctagtcctcgatacatcttcacaatgctcagccctttggctcggttgttatttccacca aaagatgatcacacgttaaagtttttatatgatgacaaccaacgtgttgagcctgaatgg tacattcctattatacccatggtgctgataaatggcgctgaaggaattggtactgggtgg tcctgcaaaatccccaactttgatgttcgtgaagttgtgaataacatcagacgtttgatg gatggagaagaacctttgccaatgcttccaagttacaagaacttcaagggtactattgaa gagctggctccaaatcaatatgtgattagtggtgaaatgtctattcttaattctacaacc attgaaatctcagagcttcccgtcagaacatggacccagacatataaagaacaggttcta gaacccatgttgaatggcactgagaagacaccccctctgataacagattacagggaatac cacacagacaccactgtgaagtttgttgtgaagatgactgaagaaaaactggcagaggca gagagagttggactacacaaagtcttcaaactccaaactagtctcacatgcaactctatg gtgctttttgaccacgtaggctgtttaaagaaatacgacacagtgttggatattctaaga gacttctttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatg cttggcgctgaatctgctaaactgaataatcaggctcgctttatcttagagaaaatagat ggcaaaataatcattgaaaacaagcctaagaaagaattaattaaagttctgattcaaaga ggttatgattcggatcctgtgaaggcttggaaagaagcccagcaaaaggttccagatgaa gaagaaaatgaagagagtgacaatgaaaaggaaactgaaaagagtgactctgtaacagat tctggaccaaccttcaactaccttcttgatatgcctctttggtatctaaccaaggaaaag aaagatgaactgtgcaaactaagaaatgaaaaagagcaagagctagaaacattaaagaga aagagtccatcagatttgtggaaagaagacttggctgcttttattgaagagctggaggct gttgaagcaaaggagaaacaagatgaacaaataggacttcctgggaaaggtgggaaagca aaggggaaaaaaacacaaagggcagaagttctgccttctccatgtggaaaaagagtcatc ccccaagtgaccatagagatgaaagcagaggcagaaaagaaaattaaaaaaaaaattaag aatgaaaatactgaaggaagccctcgagaggatgggatggaaatagaaggcctaaaacag agattagaaaagaaacagaaaagagaaccaggtaccaagacaaagaaacaaactacattg ccatttaaaccagtcaagaaagccaaaaagagaaacccctggtctgattcggaatcagat ataggcagtaacgaaagtaattttgatgtccctccccgagaaaaagagccacggagagca gcaacaaaaaccaaattcacaatggatttggattcagatgaagatttctcagattttgat gaaaacactcaagatgaagattgtgtcccatcagatgctagtccacctgggaccacaacc tccccaaaacatactaacaaagaactgaagccacagaaaagtgccacatcagtaacggac cttcacgctgatgatgccaagggtaatgcaccacctcctccaagcgctcctgctgctgat ttcccagctgtaactaaaaccataaaccctgttcctaaaaagaatgtgaccgtgaagaag acggcagcaaaaagtcagtcttccacctctactacaggggccaaaaaaagggctgcacca aaaggaaccaaaaaggatccagacttggattctgatgtctctaaaaagcctaatcccccc aagaccaagagtcaccgcaaaaggaagccgtccacttctgatgattccgactctaatttt gagaaaatgatttctaaagcagtcacaagcaagaaacccaaggaggacagcgatgacttc catctggacttagactcagctgtggcttctcgggcaaaatcgggacggacaaagaaacct ataaagtacctcgaagaatcagatgaagatgatctgttttaa

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