Delphinapterus leucas (beluga whale): 111174651 Help Entry 111174651         CDS       T05885                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism dle  Delphinapterus leucas (beluga whale) Pathway dle01521   EGFR tyrosine kinase inhibitor resistance dle04062   Chemokine signaling pathway dle04081   Hormone signaling dle04148   Efferocytosis dle04151   PI3K-Akt signaling pathway dle04217   Necroptosis dle04550   Signaling pathways regulating pluripotency of stem cells dle04630   JAK-STAT signaling pathway dle04658   Th1 and Th2 cell differentiation dle04659   Th17 cell differentiation dle04725   Cholinergic synapse dle04917   Prolactin signaling pathway dle04920   Adipocytokine signaling pathway dle04933   AGE-RAGE signaling pathway in diabetic complications dle04935   Growth hormone synthesis, secretion and action dle05140   Leishmaniasis dle05145   Toxoplasmosis dle05152   Tuberculosis dle05161   Hepatitis B dle05164   Influenza A dle05167   Kaposi sarcoma-associated herpesvirus infection dle05168   Herpes simplex virus 1 infection dle05200   Pathways in cancer dle05207   Chemical carcinogenesis - receptor activation dle05235   PD-L1 expression and PD-1 checkpoint pathway in cancer dle05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:dle00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     111174651 (JAK2)    04151 PI3K-Akt signaling pathway     111174651 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     111174651 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     111174651 (JAK2)   09143 Cell growth and death    04217 Necroptosis     111174651 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     111174651 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     111174651 (JAK2)    04659 Th17 cell differentiation     111174651 (JAK2)    04062 Chemokine signaling pathway     111174651 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     111174651 (JAK2)    04917 Prolactin signaling pathway     111174651 (JAK2)    04935 Growth hormone synthesis, secretion and action     111174651 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     111174651 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     111174651 (JAK2)    05207 Chemical carcinogenesis - receptor activation     111174651 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     111174651 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     111174651 (JAK2)    05164 Influenza A     111174651 (JAK2)    05168 Herpes simplex virus 1 infection     111174651 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     111174651 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     111174651 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     111174651 (JAK2)    05140 Leishmaniasis     111174651 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     111174651 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     111174651 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     111174651 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:dle01001]     111174651 (JAK2) Enzymes [BR:dle01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      111174651 (JAK2) Protein kinases [BR:dle01001]  Non-receptor tyrosine kinases   JAK family [OT]    111174651 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  111174651 NCBI-ProteinID:  XP_022429344 UniProt:  A0A2Y9N3T7 LinkDB All DBs Position Unknown AA seq 1132 aa AA seqDB search MRMACLTMTEMEGTSSSPVHQNGDIPGNANSVKQIDPVLQVYLYHSLGKAEGDYLKFPTG EYVAEEICVAASKACGVTPVYHSMFALMNETERIWYPPNHVFHIDESTRHNVLYRVRFYF PYWYCNGSNRTYRHGISRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG MAVLDMMRIAKEKDQTPLDIYSSVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDVSIKQANQEGSNESRIVTIHKQDGKSLEIELRSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLTGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI RNEDLIFHESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDIYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLIHGNVCTKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYENRHQLPAPKWTEL ANLIHNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQGKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLALRVDQIRDSMAG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgcgaatggcatgccttacaatgacagaaatggaaggaacatcctcatctcctgtacat cagaatggtgatattcctggaaatgctaattctgtgaagcaaatagatccagtcctacag gtctatctttatcattcccttggaaaagctgagggggattatctgaagtttccaactggg gagtatgttgcagaagagatttgtgttgctgcttctaaagcttgtggagtcacacctgtg tatcatagtatgtttgctttaatgaatgaaacagaaaggatctggtatccacccaaccac gtcttccatatagatgaatcaaccaggcacaatgtactctacagagtcagattttacttt ccttactggtattgtaatggcagcaacagaacctataggcatggaatatctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggaggcatgat tttttgcatggatggataaaagtacctgttactcatgaaacacaggaagaatgtcttggg atggcggtgttagatatgatgagaatagccaaagaaaaggatcagacccccctggacatc tatagctctgtcagctacaagacatttttaccaaaatgtgttcgagcaaagatccaagac tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgatttt cctgatattattgatgtcagtattaaacaagcaaaccaagaaggctcaaatgaaagcaga attgtaactattcataagcaagatggtaaaagtctagagattgaacttaggtcattaaga gaagctttgtcttttgtgtcattaattgatggatattacaggttaactgcagatgcacat cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgccatcagtaaattgaagaaaactggtaatcagact ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct gttgagagagaaaacgtcattgaatataagcactgtttgattacaaaaaatgagaatgga gaatacaacctcactggtactaagaagaacttcagtaatcttaaagatcttttgaattgc tatcagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc ccaaagccaaaagataaatcaaaccttctagtcttcagaaccaatggtatttctgatgta ccaacctcaccaacattacagaggcataataatgtgaaccaaatggtgttccacaaaatc agaaatgaagatttgatatttcatgaaagccttggccaaggaacttttaccaaaattttt aaaggtgtaagaagagaagtaggagactatggtcaactgcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaaacatctggttttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggagtttgtaaaatttggatcactagatatatatctgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagctggcatgggcc atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcaccaaaaatattctt cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaggacattctgcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt accactttgtgggaaatctgcagtggaggagataagcccctgagtgctttggattctcaa agaaaactacagttttatgaaaataggcaccagcttcctgcaccaaagtggacagaatta gcaaatcttattcataattgtatggattacgaaccagattttagaccttctttcagagcc atcatacgagatcttaatagtttgtttactccagattacgaactattaacagaaaatgac atgttacctaatatgagaataggtgccctagggttttctggtgcttttgaagaccgagac cctacacaatttgaagagagacacttgaaatttctacagcaacttggcaagggtaatttt ggcagtgtggagatgtgccggtatgaccctctacaagacaacactggagaggtggtggct gtgaagaagctccagcacagtactgaagagcacctcagagactttgaaagggaaattgaa atccttaaatccttgcaacatgacaacattgtaaagtacaagggagtgtgctacagtgct ggccggcgtaatctaagattaattatggaatatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcataaaaaacttcttcagtacacatctcagata tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacgagg aatatattggtggagaatgaaaacagagttaaaataggagattttggcttaaccaaagtg ttgccacaaggcaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctgg tatgcgccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagcttt ggagtggttctgtatgaacttttcacatatattgagaagagtaaaagcccaccagcggaa tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaa ctcctgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatgta atcatgacagaatgctggaacaataatgtaaaccaacgcccctctttcagagacctagct cttcgagttgatcaaataagagacagcatggctggatga

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