Delphinapterus leucas (beluga whale): 111177745
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Entry
111177745 CDS
T05885
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
dle
Delphinapterus leucas (beluga whale)
Pathway
dle01521
EGFR tyrosine kinase inhibitor resistance
dle01522
Endocrine resistance
dle04010
MAPK signaling pathway
dle04012
ErbB signaling pathway
dle04014
Ras signaling pathway
dle04015
Rap1 signaling pathway
dle04022
cGMP-PKG signaling pathway
dle04024
cAMP signaling pathway
dle04062
Chemokine signaling pathway
dle04066
HIF-1 signaling pathway
dle04068
FoxO signaling pathway
dle04071
Sphingolipid signaling pathway
dle04072
Phospholipase D signaling pathway
dle04114
Oocyte meiosis
dle04140
Autophagy - animal
dle04148
Efferocytosis
dle04150
mTOR signaling pathway
dle04151
PI3K-Akt signaling pathway
dle04210
Apoptosis
dle04218
Cellular senescence
dle04270
Vascular smooth muscle contraction
dle04370
VEGF signaling pathway
dle04371
Apelin signaling pathway
dle04380
Osteoclast differentiation
dle04510
Focal adhesion
dle04540
Gap junction
dle04550
Signaling pathways regulating pluripotency of stem cells
dle04613
Neutrophil extracellular trap formation
dle04620
Toll-like receptor signaling pathway
dle04650
Natural killer cell mediated cytotoxicity
dle04660
T cell receptor signaling pathway
dle04662
B cell receptor signaling pathway
dle04664
Fc epsilon RI signaling pathway
dle04666
Fc gamma R-mediated phagocytosis
dle04668
TNF signaling pathway
dle04720
Long-term potentiation
dle04722
Neurotrophin signaling pathway
dle04725
Cholinergic synapse
dle04726
Serotonergic synapse
dle04730
Long-term depression
dle04810
Regulation of actin cytoskeleton
dle04910
Insulin signaling pathway
dle04912
GnRH signaling pathway
dle04914
Progesterone-mediated oocyte maturation
dle04915
Estrogen signaling pathway
dle04916
Melanogenesis
dle04917
Prolactin signaling pathway
dle04919
Thyroid hormone signaling pathway
dle04921
Oxytocin signaling pathway
dle04926
Relaxin signaling pathway
dle04928
Parathyroid hormone synthesis, secretion and action
dle04929
GnRH secretion
dle04934
Cushing syndrome
dle04935
Growth hormone synthesis, secretion and action
dle05010
Alzheimer disease
dle05022
Pathways of neurodegeneration - multiple diseases
dle05034
Alcoholism
dle05132
Salmonella infection
dle05135
Yersinia infection
dle05160
Hepatitis C
dle05161
Hepatitis B
dle05163
Human cytomegalovirus infection
dle05164
Influenza A
dle05165
Human papillomavirus infection
dle05166
Human T-cell leukemia virus 1 infection
dle05167
Kaposi sarcoma-associated herpesvirus infection
dle05170
Human immunodeficiency virus 1 infection
dle05200
Pathways in cancer
dle05205
Proteoglycans in cancer
dle05206
MicroRNAs in cancer
dle05207
Chemical carcinogenesis - receptor activation
dle05208
Chemical carcinogenesis - reactive oxygen species
dle05210
Colorectal cancer
dle05211
Renal cell carcinoma
dle05212
Pancreatic cancer
dle05213
Endometrial cancer
dle05214
Glioma
dle05215
Prostate cancer
dle05216
Thyroid cancer
dle05218
Melanoma
dle05219
Bladder cancer
dle05220
Chronic myeloid leukemia
dle05221
Acute myeloid leukemia
dle05223
Non-small cell lung cancer
dle05224
Breast cancer
dle05225
Hepatocellular carcinoma
dle05226
Gastric cancer
dle05230
Central carbon metabolism in cancer
dle05231
Choline metabolism in cancer
dle05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
dle00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
111177745 (MAP2K1)
04012 ErbB signaling pathway
111177745 (MAP2K1)
04014 Ras signaling pathway
111177745 (MAP2K1)
04015 Rap1 signaling pathway
111177745 (MAP2K1)
04370 VEGF signaling pathway
111177745 (MAP2K1)
04371 Apelin signaling pathway
111177745 (MAP2K1)
04668 TNF signaling pathway
111177745 (MAP2K1)
04066 HIF-1 signaling pathway
111177745 (MAP2K1)
04068 FoxO signaling pathway
111177745 (MAP2K1)
04072 Phospholipase D signaling pathway
111177745 (MAP2K1)
04071 Sphingolipid signaling pathway
111177745 (MAP2K1)
04024 cAMP signaling pathway
111177745 (MAP2K1)
04022 cGMP-PKG signaling pathway
111177745 (MAP2K1)
04151 PI3K-Akt signaling pathway
111177745 (MAP2K1)
04150 mTOR signaling pathway
111177745 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
111177745 (MAP2K1)
04148 Efferocytosis
111177745 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
111177745 (MAP2K1)
04210 Apoptosis
111177745 (MAP2K1)
04218 Cellular senescence
111177745 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
111177745 (MAP2K1)
04540 Gap junction
111177745 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
111177745 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
111177745 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
111177745 (MAP2K1)
04620 Toll-like receptor signaling pathway
111177745 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
111177745 (MAP2K1)
04660 T cell receptor signaling pathway
111177745 (MAP2K1)
04662 B cell receptor signaling pathway
111177745 (MAP2K1)
04664 Fc epsilon RI signaling pathway
111177745 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
111177745 (MAP2K1)
04062 Chemokine signaling pathway
111177745 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
111177745 (MAP2K1)
04929 GnRH secretion
111177745 (MAP2K1)
04912 GnRH signaling pathway
111177745 (MAP2K1)
04915 Estrogen signaling pathway
111177745 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
111177745 (MAP2K1)
04917 Prolactin signaling pathway
111177745 (MAP2K1)
04921 Oxytocin signaling pathway
111177745 (MAP2K1)
04926 Relaxin signaling pathway
111177745 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
111177745 (MAP2K1)
04919 Thyroid hormone signaling pathway
111177745 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
111177745 (MAP2K1)
04916 Melanogenesis
111177745 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
111177745 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
111177745 (MAP2K1)
04726 Serotonergic synapse
111177745 (MAP2K1)
04720 Long-term potentiation
111177745 (MAP2K1)
04730 Long-term depression
111177745 (MAP2K1)
04722 Neurotrophin signaling pathway
111177745 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
111177745 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
111177745 (MAP2K1)
05206 MicroRNAs in cancer
111177745 (MAP2K1)
05205 Proteoglycans in cancer
111177745 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
111177745 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
111177745 (MAP2K1)
05230 Central carbon metabolism in cancer
111177745 (MAP2K1)
05231 Choline metabolism in cancer
111177745 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
111177745 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
111177745 (MAP2K1)
05212 Pancreatic cancer
111177745 (MAP2K1)
05225 Hepatocellular carcinoma
111177745 (MAP2K1)
05226 Gastric cancer
111177745 (MAP2K1)
05214 Glioma
111177745 (MAP2K1)
05216 Thyroid cancer
111177745 (MAP2K1)
05221 Acute myeloid leukemia
111177745 (MAP2K1)
05220 Chronic myeloid leukemia
111177745 (MAP2K1)
05218 Melanoma
111177745 (MAP2K1)
05211 Renal cell carcinoma
111177745 (MAP2K1)
05219 Bladder cancer
111177745 (MAP2K1)
05215 Prostate cancer
111177745 (MAP2K1)
05213 Endometrial cancer
111177745 (MAP2K1)
05224 Breast cancer
111177745 (MAP2K1)
05223 Non-small cell lung cancer
111177745 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
111177745 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
111177745 (MAP2K1)
05161 Hepatitis B
111177745 (MAP2K1)
05160 Hepatitis C
111177745 (MAP2K1)
05164 Influenza A
111177745 (MAP2K1)
05163 Human cytomegalovirus infection
111177745 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
111177745 (MAP2K1)
05165 Human papillomavirus infection
111177745 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
111177745 (MAP2K1)
05135 Yersinia infection
111177745 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
111177745 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
111177745 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
111177745 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
111177745 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
111177745 (MAP2K1)
01522 Endocrine resistance
111177745 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
dle01001
]
111177745 (MAP2K1)
Enzymes [BR:
dle01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
111177745 (MAP2K1)
Protein kinases [BR:
dle01001
]
Serine/threonine kinases: STE group
STE7 family
111177745 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
Motif
Other DBs
NCBI-GeneID:
111177745
NCBI-ProteinID:
XP_022435548
UniProt:
A0A2Y9P0A4
LinkDB
All DBs
Position
Unknown
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELVFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHVAGI
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcaaaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgccttgaggccttccttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggaggt
gtggtgttcaaggtctcccacaagccatccggtctggttatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctgcaggttctacatgag
tgcaactccccttacattgtgggcttctacggtgcattctacagtgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactcctttgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctggtgtttgggtgccaggtggag
ggagatgcggctgagacaccgccccggccaaggactcccggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaattgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccacgtggctggcatctaa
DBGET
integrated database retrieval system