KEGG   Delphinapterus leucas (beluga whale): 111186018
Entry
111186018         CDS       T05885                                 
Symbol
MAP2K4
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 4 isoform X1
  KO
K04430  mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Organism
dle  Delphinapterus leucas (beluga whale)
Pathway
dle04010  MAPK signaling pathway
dle04012  ErbB signaling pathway
dle04620  Toll-like receptor signaling pathway
dle04664  Fc epsilon RI signaling pathway
dle04668  TNF signaling pathway
dle04912  GnRH signaling pathway
dle04926  Relaxin signaling pathway
dle04935  Growth hormone synthesis, secretion and action
dle04936  Alcoholic liver disease
dle05132  Salmonella infection
dle05135  Yersinia infection
dle05142  Chagas disease
dle05161  Hepatitis B
dle05166  Human T-cell leukemia virus 1 infection
dle05167  Kaposi sarcoma-associated herpesvirus infection
dle05169  Epstein-Barr virus infection
dle05208  Chemical carcinogenesis - reactive oxygen species
dle05417  Lipid and atherosclerosis
dle05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    111186018 (MAP2K4)
   04012 ErbB signaling pathway
    111186018 (MAP2K4)
   04668 TNF signaling pathway
    111186018 (MAP2K4)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    111186018 (MAP2K4)
   04664 Fc epsilon RI signaling pathway
    111186018 (MAP2K4)
  09152 Endocrine system
   04912 GnRH signaling pathway
    111186018 (MAP2K4)
   04926 Relaxin signaling pathway
    111186018 (MAP2K4)
   04935 Growth hormone synthesis, secretion and action
    111186018 (MAP2K4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    111186018 (MAP2K4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    111186018 (MAP2K4)
   05161 Hepatitis B
    111186018 (MAP2K4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    111186018 (MAP2K4)
   05169 Epstein-Barr virus infection
    111186018 (MAP2K4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    111186018 (MAP2K4)
   05135 Yersinia infection
    111186018 (MAP2K4)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    111186018 (MAP2K4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111186018 (MAP2K4)
   05418 Fluid shear stress and atherosclerosis
    111186018 (MAP2K4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    111186018 (MAP2K4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dle01001]
    111186018 (MAP2K4)
Enzymes [BR:dle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     111186018 (MAP2K4)
Protein kinases [BR:dle01001]
 Serine/threonine kinases: STE group
  STE7 family
   111186018 (MAP2K4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Seadorna_VP7 Pkinase_fungal Haspin_kinase Choline_kinase APH
Other DBs
NCBI-GeneID: 111186018
NCBI-ProteinID: XP_022451931
UniProt: A0A2Y9Q357
LinkDB
Position
Unknown
AA seq 399 aa
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPAGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
NT seq 1200 nt   +upstreamnt  +downstreamnt
atggcggctccgagcccgagcggcggcggcggctccgggggcggcagcggcagcggcacc
ccgggccccgtggggtctccggcgcccggccacccggccgtcagcagcatgcagggtaaa
cgcaaagcactgaagttgaattttgcaaatccacctttcaaatctacagcaaggtttact
ctgaatcccaatcctgcaggagttcaaaacccacacatagagagactgagaacacacagc
attgaatcgtcaggaaaactgaagatctcccctgagcagcactgggatttcactgcagag
gacttgaaagaccttggagaaattggacgaggagcttatggttctgtcaacaaaatggtc
cacaaaccaagtgggcaaataatggcggttaaaagaattcggtcaacagtggatgagaaa
gagcaaaaacaacttctcatggatttggatgtagtgatgcgaagtagtgattgcccgtac
attgttcagttttatggtgcactcttcagagagggtgactgttggatctgtatggaactc
atgtctacctcgtttgataagttttacaaatatgtatatagtgtattagatgatgttatt
ccagaagaaattttaggcaaaatcactttagcaactgtgaaagcactaaaccacttaaaa
gaaaacttgaaaatcattcacagagatatcaaaccttccaatattcttctggatagaagt
ggaaatattaaactctgcgactttggcatcagtggacagcttgtggactccattgccaag
acaagagatgctggatgcaggccatacatggcacctgaaagaatagacccaagtgcgtca
cgacaaggatatgacgtccgctctgatgtctggagtttggggatcacattgtacgaattg
gccacaggccgatttccttatccaaagtggaatagtgtgtttgatcaactaacacaagtt
gtgaaaggagacccaccacagttgagtaattctgaggaaagggaattttccccaagtttc
atcaactttgtcaacttgtgccttaccaaggatgaatccaaaaggccaaagtataaagaa
cttctgaaacatccctttattttgatgtatgaagagcgcgctgtcgaggtcgcatgctat
gtttgtaaaatcctggatcaaatgccagctactcccagctctcccatgtatgtcgactga

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