Drosophila melanogaster (fruit fly): Dmel_CG14472 Help Entry Dmel_CG14472      CDS       T00030                                  Symbol poe Name (RefSeq) purity of essence, isoform B   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism dme  Drosophila melanogaster (fruit fly) Brite KEGG Orthology (KO) [BR:dme00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dme04121]     Dmel_CG14472 (poe) Enzymes [BR:dme01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      Dmel_CG14472 (poe) Ubiquitin system [BR:dme04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     Dmel_CG14472 (poe) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR Htt_N-HEAT_1 Motif Other DBs NCBI-GeneID:  46243 NCBI-ProteinID:  NP_001260222 FlyBase:  FBgn0011230 UniProt:  Q9VLT5 M9PB68 LinkDB All DBs Position 2L:complement(8054322..8071624) Genome browser AA seq 5322 aa AA seqDB search MSAHSGGTDWNSVVKALILNRTGALNKNEVVNLLKAITRCEHDFFEEESNFTQFYTAFAA LAADKLMQIKTICQTQICQLHDATAVLIRFIIYRLPRVSVYETKWLLGALKMLCEGRECP ASASSSMFDYNAVANVLKSCKHPESTTKSIMPSSSSSGSGASNDKESPKSEIKRSRSDLS SVILQQLIAPLEPGKMTWVPLSEEVTDCTEQILAANVEYFQEQNGVDTLLDVCVSLPILN RYRSKYMETINGGKSLYLPLTQVEATAVKSSMNHMLTDLTILSQAQALIEMQPLTPSRIE RLSMCGIAALYNAVLTSIATSVLGMSQASSSQKQTASTSQGSGVGGSSGGQSNKDHDDFE DQACSIVNKALEIYSNIGHMFKTSARIHVYQNHLCYGSWLLISGIQGAMGASGSGGSSSD SASKSASKATKSGSEAGTAPTTPIARVNLFKVQQGFGELNAAIANHSIKLLSELIEDLKV EAACGQSLESTELPEPAQFDILQNYSSLERIVRVLNTATLHQLFTFLATVAYRKACTLKR ASAKDRTECEPISYSDSTTYFNDSLSCSDNSEEDDSESYLGHWFKETLSPETHDDNANTS TQERAEQKSALVPKLDEPHEYLDLAADIFCFLDQFLANRHAYMQRYVKAGVSDQQMLLMA NIIKDFDRDVMRNESDQGSGNAPAASAGAGTSAGASTKWQTSMIRFSGAAGRYIHNLIST SLLSEQLQSNLLQHLSISPWSTDTNTWPLQVYPSTLSVLVQILLLKPTQEKEAACLSVWH RLINTLVEGVCSSNTASDSDYEDLNIEHAQLLLFLFHSLNLMQKKSILLLTAGGVIRCAE VCRGISEDRPVKNSQIMLLSRLLLFLEYLMKHLYNAPPELLDQVRWNLFSVSSMPDTQKI TDLLNCRTKLNSYCRHDIEENFRKSAGEYGSSIRPTFYSLVMGDPEISYWAQEFKLDGLA WNFILCTPDKLKYPLLVDALTDILSITDMSMYSKEKDKEASMHNLCAIQYCFTIAWKLNL GLPPSTSHVESLKAERSPNLHSLMWSIRLPLASSHYLVVSSLIKQGMYTQYAETLWTHVG DIGADIKYSLKQTILGVEAFNSQMNGNGTPRLSDLILFDSLVAHMQAVAWANKEGLKWPR KESEDAAGEQSAGTSLTSSSNDPELYSSNESIDDQKLKQDDDGKLSSDLQKYNQLVNELM VKLMNSYQLLSVIVRGQMLKQLSSSTPEKALNLIVPIVSDKPAIMLELHAAFLKLLPNED KQLIANEWPKCLMVNDFAFNGKQHPVEPYILNVIDAHIIELTRGSNYSTLHTLKHCLKSI LQLFELLLPHRTANAEVETQLKQLLISSMLDMRTDYLQGHSEHCLREILSGLTQEAQKLL LYEHMVGYCYRMLKEFAADLRQPQSAGPSGGAPLDQDRAMFNESMLFAVLKTMFKMLEKP VAVQAMRQFFKDQRSGSLTTLLLSFTGTSLPVSYARKMLQFVNRLFQLSLQADSQFQHED LVECFSELATVDVARLKQWLGHIIYGPNVSTDVSTSEALDTTCRMLTSILQPSSSSSSNA QTPTNMATVSAMPSISDQLDPMEIEYDCGTAAGGGESNPGTGGAAANTSQILSLWQAAQP NPSEESSQACDHSDSERNGALLLSFVKSLVKDQSKASQIAPPLFQALLQLGQTLISPPQE GCDFADVLQIMITLADASPARGHVALFNTTLLWLELAKLQLPDKHLKHAENVSAQLRYLS ELLQSIGFRGSRQHNPPWDDELQTDIDELYDELAEEGEQDSLLDDSDEDTLNNKLCTFSQ TQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYGNFFCDCGAKEDGSCQA LSRRIGSNEVRDSAGIGSYLPSHMSLLAGKKRSSLPVGQPVLTRKDSLTNERIAVLTKLL EPYRETLQHQDQWLLVVRCILEYFDLLLPSINENCMLYSIVGCHKRATAALERLHLLEQS FQVTDQLMFATLGSQEGAFENVRMNYSGDQGQTIKHLLSSGVVRRVAFCCLSSPHGRRQQ LAVSHEKGKVTILQLSALLKQADASKRKLTLTQLSSAPIACTVISLAANPCNEDCLAVCG LKECHILTFSSSGSTNEHIVVNPQLENGNYIKKAVWLPGSQTLLAVVTSDYVKIYDLAVD TYSPKYYYLVAVGKIRDCTFVYQDGNYNMLTFASSGYIYTQQLDQQSLAVHGDFYVTNTL ELSHQHIKDIAGHIGGGGVSIYYSHTLQLLFYSYSCGRSFFSPLTNVSEGVKGIYHLDTN SASKSASKGPLQPLVQWTEVTGHPGLVYASMQTSNNPIILMITPERIYLQEIKAQSAKSR IMDVVGIRHAVAGVEKTTLLLLCEDGSLRIFSAQPEYTSFWLSPQVQPFGNQLYSSTLMA KGGGSGSTSKSKSNTASGKMTSRKASQQQKQPTAGGQPVFPIDFFEHCNMLADVEFGGND LLQIYNKQKLKTRLFSTGMFVASTRSNGFTLEVINNDPNVVIVGIRVLIGTQDVQRAPQS VTILGRTIPTPVRRARWFDIPLTREEMLQSDKLLKVVFAKAPDPEHVTLLDCIEVYGKSK ELVGWPDESEDVTVPGSSAPAVSSSQASSANFGEGFNCITQLDRMANHLLEVMDCALHLL GSGVPASMRQKAVKTASALLLLPTPNPVQTQARYVLATLYGTRALYHNYKDGVLLQFVNR ELQSMQPKLEKLETLREIDPEAFYRLVLMVRGIANARPQSLAKICVENNYDIVPTLMGIV LELHKVTPTLDEPVNIVKRGLCQPETIVHCLVEIMYGFALADPGQVGRMTKYFIDLLKHD ASVISHSAKEALILLLSPRMKRRKVAIVTPPACSTPTPSTSTMQALQAAASSAASDIIEE AAGVVVDGSVGGGGLPEPNADAEGAAVGVGGVGQQQMLNLEAFMGGGFPRLLGLPEDADD EAIMDIAIALSLQQHGGDANALQSLQQGLANLQGIRQATAMAAAVNAAANVSLGGSDDDE GSNVATDGSTLRTSPAEPAGSGGSESGGSGVESIGGTSARSSNFGDHANASPPRQGSTKD DQEQPGPSGVAGSGGVAVLSAMSSSEDNEANEDDKLSKLHDLRIAVLESIIQHLGTFDLC NGLQAIPLIQVILMLTTDLNGNNERDQQVLHDLLTALVDYVEIGKRGAAARMETKCPGNE VRLALLSLFGVLMGKTKSKQTGTTSPPHQFKDNSSFVASTTANVLSKSGAFVYALEALNT LLVHWKNVLGDPYAAGGGLASQSAQASGGASGPGVQLLKPIKHGPKPDISILIPHNYLKN YPDIFESYDGLLTEIIVRLPYQILRLSSAHPDNYDSGFCEAMTFTLCEYMMLNLNTLLRR QVRKLLMYICGSKEKFRMYRDGHSLDAHFRVVKRVCNIVSSKTGAPYNANPPMLSYDALV ELTEHLRTCQEISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVSPIIIQLLQAAVCN LPPPSGSKQAQPQPSTSSASGKLRTDREKSEDTDAYYSKFDPAQCGTFVHQIFRYACDAL IIRFVRIFLLENNITQLRWQAHSFMTGLFEHANERQREKLLNIFWNLWPLVPTYGRRTAQ FVDLLGYLTLSTRSITERLPEFVSRAVDVLRQQNELLCKHPNAPIYTTLESILQVNGYYL ESEPCLVCNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTISKLIVRIADLKRTKMV RTINVYYNNRSVQAVVELKNRPALWHKARSVSLQSAQTELKIDFPLPITACNLMIEFADF FETVSGSSENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCK YAKFDFSMYARVCCAVDPIESAEDRVKTVSLIHSSLERADRNYRQLLTNKQMLELLIQKV AEHRSSDRMVEDNMASVHSTSQVNKIIQLLAQKYCVESRTSFEELSKIVQKVKACRSELV AYDRQQQDQPPVNPGSTTGAENPTTNRCYGCALASTEQCLTLLRAMAYNYDCRVCLYSQG LVSELAEHNLRRGTPLIQEEVRNLLVVLTKDNAEACMHLLQLVTTRVKNALMGSIPLISL EAAVHQEMTLLEVLLGQDDICWEYKLKVIFELFISNCRLPRGPVTAVLHPCLRIMQNLIC PVLPGSKPNQKVATTDLCSMKMFEGNTVDYRAWLNSDRNHEYAAWSKRMPSNNQAKLKNA KDQNVAASGGSDAPPKSRREVRVAFLSEKYGKRWRERVLDKQRVIKPLVFNAKWIQPLLF NANSRFGRQLACSLLSSLSRTNERRQQALNMLTSFLKHVGEAGEASAEYLMLYKNMATEQ PWLQYLVLKGVLSQISQLLAIEISKVHRMEEYSLSSDLSLGYALRQYVELLWLLLECPNI RRTYKTRMLGPVLESYLALRSLVVQRTRLIDDAQEKLLEMLEDMTSGTEEETRAFMEILI DTVEKTRMNDIKTPVFVFERLYSIIHPEEHDESEFYMTLEKDPQQEDFLQGRMLGNPYPS SEMGLGPLMRDVKNKICTDCELIALLEDDNGMELLVNNKIISLDLPVKDVYKKVWLAEGG DRDAMRIVYRMRGLLGDATEEFVETLNNKSQEQVDTEQLYRMANVLADCNGLRVMLERIG SLQRISRNRELIQVLLKLFLICVKVRRCQEVLCQPEIGAINTLLKVLQMCLQSENDSIQS AVTEQLLEIMETILSKAASDTLDSFLQFSLTFGGPEYVSALISCTDCPNVRNNPSVLRHL IRVLAALVYGNEVKMALLCEHFKDTLNFNRFDNERTPEEEFKLELFCVLTNQIEHNCIGG TLKDYIVSLGIVERSLAYITEHAPCVKPTLLRTDSDELKEFISRPSLKYILRFLTGLSNH HEATQVAISKDIIPIIHRLEQVSSDEHVGSLAENLLEALSTDSATAARVQQVRDFTRAEK KRLAMATREKQLDALGMRTNEKGQVTAKGSILQKIEKLRDETGLTCFICREGYACQPDKV LGIYTFTKRCNVEEFELKSRKTIGYTTVTHFNVVHVDCHTSAIRLTRGRDEWERASLQNA NTRCNGLLPLWGPAVGEAAFSACMTRHSSYMQESTQRCDISYTSSVHDLKLLLVRFAWER SFHDDAGGGGPQSNMHFVPYLLFYSVYLLLSSRSAARDSKTLLTYLQAPPSEKWLECGYE VDGPLFMATISLSLHSRELWNKHKLAHLKRMIAVAQGRHVSPAVLCKALLAPADRQVKDY TVYKPFLMMWALVDLIYDNLFKTVSTPKEEDWPISLFDYLRKNDEALLKSTDSILQTLTE EFLPCTSFVEFCDVAGLLHLIEHPDNFIEEILAALPSTSSSN NT seq 15969 nt NT seq  +upstreamnt  +downstreamnt atgtcggcccacagcggcggaacggattggaattccgttgttaaagccctgatacttaac cgtacaggagccttaaacaagaacgaagttgttaatttgctcaaagctatcacgcgatgc gaacatgactttttcgaggaggaaagcaatttcacgcagttttacacggcctttgcggcc ctggcggcggacaaacttatgcaaatcaagacaatttgccagacgcagatttgtcagttg cacgatgccaccgccgtgcttatccggtttattatctatagactgcccagggtgtccgtc tacgagaccaagtggctcctgggcgccctcaagatgctctgcgagggccgggagtgccca gcatcagcgtcgtcatccatgttcgactacaatgcggtggctaatgttcttaaaagctgc aaacatcccgagtcgaccaccaagagcattatgcccagcagcagttcctccggaagtggg gccagcaacgacaaggagtcgcccaagtcggagattaagcgatcccggtcggacctgtcc tcggttattctgcagcaactgattgctcctttagagcccggcaagatgacttgggttcca ctcagcgaggaggtcaccgactgcactgaacaaatcctggcggccaatgtggagtacttc caggagcaaaacggagtggataccctgctggatgtgtgtgtgagcctgcccatactcaat cgataccgatccaaatatatggagaccatcaacggcggtaaatcgctttatttgccactg acccaagtggaggccactgcagtgaaatcgagcatgaatcacatgcttactgatctgact attttgagtcaggcccaagccctgatcgagatgcagccactgactcccagtagaattgaa cgactatcaatgtgtggtattgctgcgctatacaatgctgtgttgacctcaatagccacc agtgttctcggtatgagccaggccagcagctctcagaaacagactgcatccactagtcaa ggaagcggagtaggaggttctagtggtgggcaatccaacaaagaccatgacgactttgag gatcaggcctgtagcatagtgaacaaagctttagagatctactccaatattggtcacatg ttcaaaacttcggccaggattcatgtatatcagaaccatctctgctatggcagctggctg ctaattagcggtatacaaggagcaatgggcgcctctggaagcggtggatctagctcggat tcggcatcgaagtcggcgtcaaaagcgaccaagtctggtagtgaggctggaaccgcacct actacacctattgccagagtcaaccttttcaaggtacagcaaggatttggagaactcaat gcagctattgctaaccacagcattaaattgctctcagagctaatagaagatctaaaggtt gaagccgcatgcggacagagtctcgaatccacagagctcccggagcctgcacagttcgat attttgcagaactacagttcgctggagcggattgtccgcgtgctgaatacagccactctg catcaacttttcacttttctagccactgtggcttatcgcaaggcatgcaccttaaagcgc gcttccgccaaggatcgtacggaatgcgaacccataagctactcagattctacgacttat ttcaacgattctctctcctgttcggacaactccgaggaggacgatagtgagagttacctg ggccactggtttaaggaaactctttctccagaaacccatgatgataatgcaaacacatcc acacaagagcgtgctgaacagaagagcgcccttgtccccaagctagatgagccacatgag tatttagacttggccgcagacatattctgtttcctggatcaatttttggccaatcgacat gcctacatgcagcgctatgtaaaggcaggcgttagtgatcagcaaatgctgttaatggca aatataatcaaagattttgaccgcgacgtgatgcgaaatgagagcgatcaggggtcggga aatgccccagctgccagtgcaggagcaggaacctctgcaggagcttctaccaagtggcag acgtcgatgattcgattttcgggagctgcaggccgatatattcacaatttgatttccact tcattgctgtccgagcaattgcagtcaaatctgctgcagcacttgtctatatcgccatgg tctactgatacaaacacctggcctttacaagtttatccgagtactctgtctgtactggtg caaattcttttgctgaagccaacacaagagaaggaagccgcctgcctgtccgtgtggcac cgccttattaacacgttggtggaaggagtttgttcttcgaataccgccagtgattctgac tatgaagaccttaacattgagcacgcccaactgctgcttttcctatttcattcgctcaat ctgatgcaaaagaaatccattctgcttttaacggctggcggtgttatccgttgcgcagaa gtttgtcgtggaatcagcgaggatagacccgtaaaaaacagccaaattatgctgctgtct cgcttgctgctctttttggagtatcttatgaagcacttgtacaatgcgcctccggaattg ctagaccaggtgcgctggaatctttttagtgtgagcagcatgccggacacccaaaagatc acggatctgctaaactgccgaaccaaactgaattcctattgccgccatgatattgaagag aatttccgcaagtcggccggcgaatatggctcatcaattcgcccaactttttactctctg gtaatgggtgatcccgagatatcctactgggctcaggaatttaagctggatggtttggct tggaactttattctctgcacaccggataagcttaaatatccgctactggtggatgcattg actgacatactatccatcaccgacatgtcaatgtattccaaggaaaaggacaaggaagcg agcatgcataatctttgcgctatacagtattgctttacgattgcctggaagctgaatttg ggtttgccgccctctacttctcacgtagagtcgctgaaggcagagcgatcacccaatctg cactcactgatgtggagtatacgtctacccctggccagttctcactacctagtcgttagc agcctaatcaagcagggaatgtatacccagtacgctgagacgttgtggactcatgtgggc gacataggtgccgatataaaatatagtctcaagcaaacaattcttggtgtggaggcgttc aatagtcaaatgaatggaaatggaactccccgcctctccgatctcatcctttttgattct ttggtggcgcacatgcaggcggtagcctgggcaaacaaggagggcctcaagtggccgcga aaagagagcgaagatgccgctggcgagcagtccgctggtacatccttaacttcatcgtca aacgatccggaactttattcttccaacgaatcaattgatgatcaaaaattgaaacaagac gacgacggtaagctgtcaagtgatttgcaaaagtataatcaacttgtaaacgagctaatg gtaaagctcatgaattcttaccaattgctttcggtgatcgtgcgtggccaaatgctaaag cagttgtcaagttcaacaccggagaaggcactgaatttgattgtgcccattgtaagcgat aagccagcaattatgttagaactccatgcagcttttctaaaactcctgcccaacgaggac aaacaactaatagcaaacgaatggccaaagtgcctaatggtcaatgattttgcattcaat ggaaagcaacatccggtggaaccatatattttgaacgttattgatgctcacattattgag ctgacacgaggatccaattactctaccctgcacactctgaaacactgcttaaagtctatc ctgcaattgtttgagttgctgctaccacatcgcaccgcgaacgcagaagtagagactcag ctaaagcaattgcttatctcctcaatgctggacatgcgaacggattacttgcaaggacac agcgagcattgtctgcgcgagatcctcagtggtctgacacaagaggcacaaaagctgctg ctttacgagcacatggttggatattgctatcgcatgctcaaagagtttgctgccgatctt cgtcagccccagtctgcggggcctagtggcggagctcctcttgatcaggatcgtgctatg tttaacgagtccatgctgtttgccgtgcttaaaactatgttcaaaatgctggaaaagccg gtggcagttcaggccatgcgccagtttttcaaagatcagcgctctgggagtcttaccaca cttttgctatcgttcactggcaccagtctgcctgttagctatgcgcgcaagatgctgcaa tttgttaaccgacttttccagctatccttacaagcggattcacagttccagcatgaagat ctggttgagtgtttctcggaactggccacagttgacgtagctcgtttaaagcaatggttg ggccacattatctacggccctaatgtgagtaccgatgtaagcacctccgaggcattagac accacctgccggatgctcaccagcattttgcagccgtcgagtagctccagcagcaatgct cagacgccaacaaatatggccaccgtttcggctatgccaagtatctcagaccagttggat cccatggaaattgaatacgattgcggaactgcagcgggaggcggagaaagtaacccagga accggaggagctgcagccaatacctcgcagattctgagtttgtggcaggctgcgcagcca aatccgtcggaagaatcttcacaggcttgcgatcatagtgatagcgaacgaaatggcgcg ttgctcttaagcttcgtgaagtcattggtgaaagatcaaagcaaagcatcgcagatagct ccaccactgttccaagctttgcttcagctcggacaaacattaatttcaccaccccaggaa ggctgcgattttgcagatgtactacagataatgattactctagctgacgccagtccagca cgcggccatgtcgccttgttcaataccaccctcctttggctggaactggccaaattgcaa ttaccggacaaacacttgaaacatgcagagaacgtaagtgcccagttgcgctatttaagc gaacttcttcagagcattggcttccgaggcagtaggcaacataacccgccgtgggatgat gaactacagaccgatattgatgagctatatgacgagctagccgaggaaggtgagcaagac tcgttgcttgacgattccgacgaggacacgttgaacaacaagctgtgtaccttctcgcag acccaaaaggagttcatgaaccaacattggtatcattgtcatacttgcaacatgataaac acagttggcgtctgttctgtgtgcgcaagggtttgccataagggacatgatgtcagttac gccaaatatggaaatttcttctgtgactgcggagccaaggaggacggatcctgtcaggca ttgagtaggcgtatcggcagcaatgaggttagagattcagctggaattggcagctatcta ccgtcccacatgagcttactcgctggaaagaagaggagcagcttaccagttggccagcca gtacttacgcgaaaggattcattgactaatgaacggatcgcagtacttaccaaactgttg gaaccttacagagagacacttcagcaccaggatcagtggctgctggtcgtaagatgcatc ctagagtattttgacctgctgctaccatcaataaacgaaaattgtatgctatactccatt gtcggctgccacaagagagcaactgcggccttggagagactccacctgcttgaacagagc ttccaggtaaccgatcaactgatgtttgcaactttgggctcacaagagggagcttttgag aatgttcgaatgaactattctggcgaccaaggtcagactataaagcacctactatcatcc ggagttgtccgccgtgttgccttctgctgtttgtcctcgccacatggacgtcgtcaacag ttggctgtatcccatgagaagggaaaggtgaccatcctccagctgtcggcactgttgaag caagcagatgcctccaagagaaagttaactctaacgcaattgagttctgcacccattgcc tgcacggttatctccctagctgctaatccgtgcaatgaggattgccttgcagtttgtggc ctaaaagagtgtcacattctcaccttctcaagcagtggcagtactaacgaacacatagta gtgaacccccaactggaaaatggaaactacatcaagaaagctgtgtggctgcctggctca cagactcttcttgccgttgtaacttcggattatgtaaagatttacgatttggcagtggat acatatagcccaaagtactattacctagtggccgttggcaaaattagagattgcacgttt gtgtaccaggatggcaactacaatatgctgacctttgcaagcagcggatacatctatact cagcagttggatcaacagagtctagcggttcatggagatttctatgtaaccaacactttg gagctgagccaccaacatatcaaggatattgccggtcatatcggaggcggtggagtatcc atctactattcgcataccctacagctgctcttctacagttattcttgcggaaggagcttc ttttcaccactcaccaatgtaagtgaaggcgtgaagggaatatatcacctggacacaaat tcggctagtaagtcagcttcgaagggaccactacagcctctcgtgcagtggacagaggtt acagggcatccaggattggtttacgccagcatgcagacatcgaataatccgattatattg atgataacccctgaacggatttacctgcaagagatcaaggcacaatcggccaagtcacga atcatggacgttgttggcattcgtcatgcggttgccggagtggaaaaaactacgcttttg ctcctctgcgaggatggaagcttgaggatcttttccgctcaaccagaatacactagcttc tggctatcgccacaggttcagccatttggtaatcagttgtactcgtccaccttgatggct aagggaggtggatctggttcgacttcaaagtccaaatcaaatacagcatctggaaagatg accagcagaaaggcaagccaacaacagaagcaacccacagctggaggtcagcccgttttc ccaattgactttttcgagcactgcaacatgctagccgatgtggaatttggaggcaacgat ctgctccagatttacaacaaacaaaaactaaagacgcgtctgttctcaacgggaatgttt gtggccagcacccgatcgaatggctttactctggaggtgatcaataatgatcccaatgtt gtaatcgtgggaataagagtgttaattggaactcaggacgtacagcgtgctccccaatct gtgactattctgggacgtactatacccacaccggtcaggagggcacgttggttcgatatc cccctgacccgggaagaaatgctccagtccgacaagttattgaaagtcgtgtttgctaaa gctccagatccggagcatgtgacattactggattgcattgaggtatatggaaaatcgaaa gagctggtgggctggcccgacgaaagcgaggatgttactgtcccaggatccagtgcgcca gcagtatcttcctcccaggcaagtagcgctaactttggagaaggattcaattgcattact cagctggatcgaatggctaatcaccttttggaagtaatggattgtgcactgcatttgttg ggatctggagtacctgcttctatgcgtcaaaaggcagttaaaacagcgagtgccctattg ctactgccaacgcccaatcctgttcagacccaggcgcgctacgtgctggccactctatac ggaactagagcattgtaccataactacaaggatggagtgcttcttcagtttgtaaataga gaactacagtcaatgcagccgaagcttgaaaaacttgaaactctgcgggagatcgaccct gaggctttctaccgcctagttctgatggtccgtggcattgccaacgcacgaccccaatcg ctagcgaagatctgcgtggagaacaactatgatattgttccaaccctcatgggaattgtc ttggagttgcataaggttacaccgacgctagacgaacccgtgaatattgtgaagcgaggc ttgtgccagccggagaccattgtccattgtctggtagagataatgtacggatttgccttg gccgatcccggacaggttggtcgcatgaccaagtacttcattgatttgctgaagcatgat gctagcgtgattagccacagcgccaaagaggccctgatccttttgcttagtccaagaatg aagcgcagaaaggtggccatagttacacccccagcatgttcaacaccgactccctcaacg tctaccatgcaggcactgcaagcagcggcttcttcagctgcaagtgatatcatcgaggaa gcagctggcgttgttgttgatgggtcagttggaggaggtggattacccgaaccgaatgcg gacgcggaaggtgctgcagttggagtaggaggagtcggtcagcagcaaatgctcaatctg gaggcattcatgggtggcggtttccctcgcttactcggcctacccgaagatgccgacgat gaggccatcatggatattgccatcgcattgagtctccaacagcacggtggggatgcaaac gccttgcagtctcttcagcaaggattggccaatcttcagggcatccgtcaagctactgcc atggcagcagctgtgaacgcagctgccaatgtctccctaggtggatccgatgatgatgaa ggttccaatgtggcaaccgatggatcaacattgcgtacttctccagcagagcctgctggc agcggtggatcagagagtggaggcagtggagtagagagtattggtggaacatccgccagg agcagcaactttggcgaccacgcgaatgcctcgccgccgcgtcagggatccaccaaggac gatcaagagcagccaggtcccagtggcgttgctggctccggtggtgttgctgttttgagt gccatgagcagcagtgaggataatgaagcaaacgaggacgataagctcagcaagctacat gaccttagaattgctgtgctggagagcattatccaacatctaggaacattcgacttgtgc aatggcctgcaggcaatcccactgatccaggttatactcatgttgactaccgatctcaat ggaaacaacgaaagggatcaacaagtgcttcacgatctgcttactgctctagtggactat gtggaaattggaaagcgaggagctgccgcaaggatggagacaaagtgtcctggcaatgag gtgcgcctcgcattgctttccctgttcggagttctgatgggcaaaacaaagtcaaagcaa actggaacaacatcgccgccgcatcaatttaaggacaatagctcctttgtggccagtacc acagcaaatgttctcagtaagagtggagcattcgtttacgccctagaagcactaaacacg ctactggtgcactggaagaatgtgctaggagatccttatgcagccggtggcggattagcc tcacagtcggcacaagccagtggcggagcttcaggtcccggagttcagctactgaagccc attaaacatggtcctaaacctgacatatccatacttataccgcacaactatctgaaaaac tacccggatattttcgagtcctacgatggactcctaactgaaattatcgtgcgattgcca tatcaaattctgcgcttaagtagcgcccatccggataactacgatagtggattctgcgaa gcgatgacctttacactttgtgagtacatgatgctaaatttgaacacactgcttcgtcgg caagtgcgaaagctcctgatgtacatttgcggcagcaaggaaaagttccgcatgtatcgc gacggtcactccctcgacgctcatttccgggtggtcaagcgggtgtgcaacattgtcagc agcaagactggtgctccttacaacgctaatcctcctatgctttcatacgatgcactggta gagttgacggaacacctacgtacttgccaggagataagccaaatgcgcacgggcaactgg cagaagttctgcgtcgtccatgaagatgcgttggccatgctgatggaaatcgcctgttat cagttggatgatggcgtgtcgcctattattatacaattgctacaggcggccgtttgcaac ttaccccctcctagtggatctaagcaggcccagccgcagccatcgacctcgtctgcctcc ggaaaacttcgaacagatcgtgagaagagcgaggatacagacgcctactactccaagttt gatccagcccagtgtggtacatttgtgcaccagatctttagatacgcatgcgatgcgctg ataatcagatttgtgcgaatattcctgttggagaacaacattactcagctgagatggcag gcccactcatttatgaccggactttttgagcatgccaatgaacggcagcgtgagaaactt ctcaacatattttggaacctgtggccattggtgcccacctacggtcgtaggacagcgcag tttgtcgacctattggggtatctaaccctaagtaccagaagtataacagaacgactgcca gagttcgtttcccgcgctgtggatgttctcaggcagcagaacgaactgctttgcaagcat ccaaatgccccaatatacaccaccttggagtctatacttcaagtaaatggttactaccta gaatcggaaccttgtttagtgtgcaacaatccagaggtgccgatggctaatataaagttg ccatcagttaaatcagactctaagtacaccacaaccacaatgatttataagctagtccaa tgccatactatttccaagttgatcgtgcggattgccgacttaaagcggacaaagatggtg agaaccattaatgtttactacaacaaccgcagtgtccaggcggtagtggagctaaaaaat cgcccagctctgtggcacaaagctcgctcagtatccctgcaatcggcacagaccgaactg aagatcgattttccactaccaatcaccgcatgcaatttgatgatcgagtttgctgatttc tttgaaactgtgagtggatccagtgagaatttacaatgtccacgttgtagtgcagcagtg ccggcttatccgggagtctgcggaaattgcggtgagaacgtgttccagtgccacaaatgt cgggccattaactacgatgagaaggacccgttcctgtgccactcctgtggcttctgcaaa tatgccaaatttgatttcagcatgtatgcccgtgtttgctgcgctgttgatcctatagaa tcggcagaggatagggtcaagactgtttcactgattcacagctccctagaacgagccgat agaaattaccgccagctgctgaccaacaagcaaatgctggagcttcttattcaaaaggtg gccgagcatcgtagcagtgatcgaatggtcgaggacaacatggccagcgtgcacagcact tctcaagtaaacaagattatacagctgctcgcccagaaatactgtgtggaatcgcgcacc agtttcgaggagctaagcaagatcgttcagaaggtcaaggcatgtcgaagcgaactagtg gcctacgatcgtcaacagcaggaccagccgccggttaatcccggctcaacaaccggtgcc gaaaatcccaccacaaatcgctgctacggctgtgcactggcatctaccgagcagtgtctg acgcttctgcgagccatggcttacaattacgattgtcgcgtgtgcttgtatagtcaggga ctcgtcagtgaactggctgagcacaacctgcgacgaggcactcccctaattcaggaggaa gtgcgcaacctgttggtcgtactgactaaggataatgccgaggcatgcatgcatctgttg cagttggtgaccacaagggtgaagaatgctctgatgggatcgattcctctgataagttta gaggcagctgtgcaccaagaaatgacacttttggaggtgctcttgggccaggacgacatc tgctgggaatacaagctaaaggtcatctttgagctgttcattagcaactgccgtttgcct cgtggtccggtaacagcagtactacacccctgtctgcgcatcatgcagaatctcatctgc ccggttctgcccggcagcaagcccaatcagaaggtggccactacagatttgtgtagcatg aagatgtttgagggcaacacggtggactatagggcctggctgaactcagaccgtaatcat gaatacgcagcgtggagcaagcggatgccgtcaaacaaccaggctaagctaaagaatgcc aaggatcagaatgtggcggcatccggcggatcagatgcaccgccgaagagcaggagggag gtgcgagtcgcattccttagcgaaaagtacggaaaacgctggcgggaacgtgtgctggac aagcaacgagtgattaaacctcttgtattcaacgccaagtggatacaaccgttgctattt aatgcaaactccagattcggtcgccagctggcctgctccttgctgagcagcttgagccga actaacgaacggcggcaacaggctctgaatatgctgacatcgttcttgaaacatgtaggc gaagcaggggaagccagtgcagagtacttaatgctgtacaagaacatggccacagagcaa ccctggctgcagtatttggtcctgaaaggagtattaagtcaaatctcacagcttctggct attgaaatcagcaaggtgcaccgcatggaggagtactcgctttcttcagatttatcctta ggatatgcactgcgccagtatgtggaattgttgtggctactcctagagtgtccaaatatc cgcagaacctacaagactcgcatgctaggaccagttctggaaagctatcttgccctaaga agcttagtcgtgcagcgtacgcgactcattgacgacgcacaggagaagctgttagagatg ctagaggatatgaccagcggaaccgaggaggagacacgtgcctttatggaaatccttatt gacaccgtagagaagacccgcatgaatgacattaaaacaccggtgtttgtcttcgagcgc ttatattccattattcatcccgaggagcatgacgaaagcgagttctatatgacattagag aaagatccccagcaggaggactttctgcaaggtcgcatgctgggtaatccttacccctcg agtgaaatgggattgggtccattgatgcgggatgtgaagaataagatttgtacggattgt gaactaatcgccctgttggaagatgataacggcatggaattgctggtcaacaacaaaata ataagcttggatctgcccgttaaggatgtttacaagaaagtttggttagctgaaggaggc gaccgagatgccatgagaattgtatatcgcatgcgcggtctcctgggagacgccacagag gaatttgtggaaacgctgaacaacaaaagccaggagcaggtggacaccgagcagctgtat cgcatggccaatgtgctggctgattgcaacggcctacgcgtaatgttggaaagaattggc agcctgcagcgcatatcgcgcaaccgagaacttatccaggtactgcttaagctattcctt atttgtgtgaaagtgcgccgttgccaagaggtgctttgccaacccgagatcggagccatc aacacgctgcttaaggtgctacaaatgtgtctccagtcggagaacgattcgattcaatcg gcggttaccgagcagttattggagatcatggaaacaatactatcgaaggcggccagcgat acgttggactcgttcctgcagttctccttgacattcggtggaccggagtatgtaagcgca ctaatatcgtgcacagactgtcccaatgttagaaacaatccttcggtgctccgccatctt attcgtgtcctagccgctttggtctatggcaacgaggtgaagatggctctactttgcgag catttcaaggacactttgaactttaatcgctttgacaacgagcgcacacctgaagaagag ttcaagctggaactcttctgcgtgctgactaaccaaattgagcacaactgcattggcggc actctcaaggactacatagtaagtctcggcatcgttgagcgatcgctagcctacatcacc gagcatgcgccttgtgtcaagcccactctcctgcgaaccgactccgatgagctgaaagaa ttcatctcgcggccaagcttgaagtatattcttcgtttcctcaccggcctctcaaatcat catgaggcaactcaggtggctattagcaaggacattatacccattattcatcgcctggaa caagtatccagcgatgagcatgtgggcagtctggccgagaaccttttggaagctctctcc accgattcggcgacagcagcgagggtgcagcaagtgcgtgacttcacaagggcagagaag aagcggctggcaatggccacgcgcgagaaacagttggatgcattgggaatgcgcacgaat gaaaagggccaggtgacggccaagggctccatcctgcagaagatcgaaaaactgcgcgac gaaacaggactaacttgctttatttgtcgcgaaggctacgcctgccagccagacaaggtg cttggtatctacaccttcaccaagcgctgcaatgtcgaggagtttgagctgaagtcgaga aaaaccattggctataccaccgtcacacacttcaatgtggtccatgtggactgccacaca tcagccataagattgacacgtggcagggatgaatgggagcgtgctagtttgcaaaatgcc aacaccagatgtaatggactgctgcccctttggggacccgccgttggagaggcggccttc tccgcttgcatgacccgccacagcagttatatgcaggagagtacccagcgctgtgacatc tcctacaccagcagtgtgcatgacttgaagctgctgttggtacgatttgcttgggaacgc agcttccatgacgatgccggcggaggtggtccgcaatcgaacatgcacttcgtaccctac ctgctcttctactccgtctatctgttgctttcgtcgcgatcagcggctagagacagcaag actctgctgacgtatttgcaggcgccgcccagcgagaagtggttggaatgcggatatgag gtggatggtccgcttttcatggcaaccatttcgctgtcactgcacagccgagagctatgg aataagcataagctagcacatctgaagaggatgattgcagtggcccagggtcgccacgtc tcacccgccgtgctgtgcaaagccttgttggctcctgcagaccgccaggtcaaggattac actgtttacaagcccttccttatgatgtgggcattggtggacttgatctacgacaatctg ttcaagacggtaagcacgcccaaggaggaggattggccgatttccctgttcgactatctt cgtaagaacgatgaggctttgctcaagtccacggatagcatcctgcagaccctaacggag gagttcctgccctgcacttcctttgtcgaattctgtgatgttgcaggtctcctgcatctc atcgagcacccggacaacttcatcgaagaaatcctcgctgccctgccttcaacatcgagc tctaattaa

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