KEGG   Dipodomys merriami (Merriam's kangaroo rat): 138808865
Entry
138808865         CDS       T11079                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
dmer  Dipodomys merriami (Merriam's kangaroo rat)
Pathway
dmer01521  EGFR tyrosine kinase inhibitor resistance
dmer01522  Endocrine resistance
dmer04010  MAPK signaling pathway
dmer04012  ErbB signaling pathway
dmer04014  Ras signaling pathway
dmer04015  Rap1 signaling pathway
dmer04022  cGMP-PKG signaling pathway
dmer04024  cAMP signaling pathway
dmer04062  Chemokine signaling pathway
dmer04066  HIF-1 signaling pathway
dmer04068  FoxO signaling pathway
dmer04071  Sphingolipid signaling pathway
dmer04072  Phospholipase D signaling pathway
dmer04114  Oocyte meiosis
dmer04140  Autophagy - animal
dmer04148  Efferocytosis
dmer04150  mTOR signaling pathway
dmer04151  PI3K-Akt signaling pathway
dmer04210  Apoptosis
dmer04218  Cellular senescence
dmer04270  Vascular smooth muscle contraction
dmer04370  VEGF signaling pathway
dmer04371  Apelin signaling pathway
dmer04380  Osteoclast differentiation
dmer04510  Focal adhesion
dmer04540  Gap junction
dmer04550  Signaling pathways regulating pluripotency of stem cells
dmer04613  Neutrophil extracellular trap formation
dmer04620  Toll-like receptor signaling pathway
dmer04650  Natural killer cell mediated cytotoxicity
dmer04660  T cell receptor signaling pathway
dmer04662  B cell receptor signaling pathway
dmer04664  Fc epsilon RI signaling pathway
dmer04666  Fc gamma R-mediated phagocytosis
dmer04668  TNF signaling pathway
dmer04720  Long-term potentiation
dmer04722  Neurotrophin signaling pathway
dmer04725  Cholinergic synapse
dmer04726  Serotonergic synapse
dmer04730  Long-term depression
dmer04810  Regulation of actin cytoskeleton
dmer04910  Insulin signaling pathway
dmer04912  GnRH signaling pathway
dmer04914  Progesterone-mediated oocyte maturation
dmer04915  Estrogen signaling pathway
dmer04916  Melanogenesis
dmer04917  Prolactin signaling pathway
dmer04919  Thyroid hormone signaling pathway
dmer04921  Oxytocin signaling pathway
dmer04926  Relaxin signaling pathway
dmer04928  Parathyroid hormone synthesis, secretion and action
dmer04929  GnRH secretion
dmer04934  Cushing syndrome
dmer04935  Growth hormone synthesis, secretion and action
dmer05010  Alzheimer disease
dmer05022  Pathways of neurodegeneration - multiple diseases
dmer05034  Alcoholism
dmer05132  Salmonella infection
dmer05135  Yersinia infection
dmer05160  Hepatitis C
dmer05161  Hepatitis B
dmer05163  Human cytomegalovirus infection
dmer05164  Influenza A
dmer05165  Human papillomavirus infection
dmer05166  Human T-cell leukemia virus 1 infection
dmer05167  Kaposi sarcoma-associated herpesvirus infection
dmer05170  Human immunodeficiency virus 1 infection
dmer05200  Pathways in cancer
dmer05205  Proteoglycans in cancer
dmer05206  MicroRNAs in cancer
dmer05207  Chemical carcinogenesis - receptor activation
dmer05208  Chemical carcinogenesis - reactive oxygen species
dmer05210  Colorectal cancer
dmer05211  Renal cell carcinoma
dmer05212  Pancreatic cancer
dmer05213  Endometrial cancer
dmer05214  Glioma
dmer05215  Prostate cancer
dmer05216  Thyroid cancer
dmer05218  Melanoma
dmer05219  Bladder cancer
dmer05220  Chronic myeloid leukemia
dmer05221  Acute myeloid leukemia
dmer05223  Non-small cell lung cancer
dmer05224  Breast cancer
dmer05225  Hepatocellular carcinoma
dmer05226  Gastric cancer
dmer05230  Central carbon metabolism in cancer
dmer05231  Choline metabolism in cancer
dmer05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:dmer00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    138808865 (Map2k1)
   04012 ErbB signaling pathway
    138808865 (Map2k1)
   04014 Ras signaling pathway
    138808865 (Map2k1)
   04015 Rap1 signaling pathway
    138808865 (Map2k1)
   04370 VEGF signaling pathway
    138808865 (Map2k1)
   04371 Apelin signaling pathway
    138808865 (Map2k1)
   04668 TNF signaling pathway
    138808865 (Map2k1)
   04066 HIF-1 signaling pathway
    138808865 (Map2k1)
   04068 FoxO signaling pathway
    138808865 (Map2k1)
   04072 Phospholipase D signaling pathway
    138808865 (Map2k1)
   04071 Sphingolipid signaling pathway
    138808865 (Map2k1)
   04024 cAMP signaling pathway
    138808865 (Map2k1)
   04022 cGMP-PKG signaling pathway
    138808865 (Map2k1)
   04151 PI3K-Akt signaling pathway
    138808865 (Map2k1)
   04150 mTOR signaling pathway
    138808865 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    138808865 (Map2k1)
   04148 Efferocytosis
    138808865 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    138808865 (Map2k1)
   04210 Apoptosis
    138808865 (Map2k1)
   04218 Cellular senescence
    138808865 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    138808865 (Map2k1)
   04540 Gap junction
    138808865 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    138808865 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    138808865 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    138808865 (Map2k1)
   04620 Toll-like receptor signaling pathway
    138808865 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    138808865 (Map2k1)
   04660 T cell receptor signaling pathway
    138808865 (Map2k1)
   04662 B cell receptor signaling pathway
    138808865 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    138808865 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    138808865 (Map2k1)
   04062 Chemokine signaling pathway
    138808865 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    138808865 (Map2k1)
   04929 GnRH secretion
    138808865 (Map2k1)
   04912 GnRH signaling pathway
    138808865 (Map2k1)
   04915 Estrogen signaling pathway
    138808865 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    138808865 (Map2k1)
   04917 Prolactin signaling pathway
    138808865 (Map2k1)
   04921 Oxytocin signaling pathway
    138808865 (Map2k1)
   04926 Relaxin signaling pathway
    138808865 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    138808865 (Map2k1)
   04919 Thyroid hormone signaling pathway
    138808865 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    138808865 (Map2k1)
   04916 Melanogenesis
    138808865 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    138808865 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    138808865 (Map2k1)
   04726 Serotonergic synapse
    138808865 (Map2k1)
   04720 Long-term potentiation
    138808865 (Map2k1)
   04730 Long-term depression
    138808865 (Map2k1)
   04722 Neurotrophin signaling pathway
    138808865 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    138808865 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138808865 (Map2k1)
   05206 MicroRNAs in cancer
    138808865 (Map2k1)
   05205 Proteoglycans in cancer
    138808865 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    138808865 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    138808865 (Map2k1)
   05230 Central carbon metabolism in cancer
    138808865 (Map2k1)
   05231 Choline metabolism in cancer
    138808865 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    138808865 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    138808865 (Map2k1)
   05212 Pancreatic cancer
    138808865 (Map2k1)
   05225 Hepatocellular carcinoma
    138808865 (Map2k1)
   05226 Gastric cancer
    138808865 (Map2k1)
   05214 Glioma
    138808865 (Map2k1)
   05216 Thyroid cancer
    138808865 (Map2k1)
   05221 Acute myeloid leukemia
    138808865 (Map2k1)
   05220 Chronic myeloid leukemia
    138808865 (Map2k1)
   05218 Melanoma
    138808865 (Map2k1)
   05211 Renal cell carcinoma
    138808865 (Map2k1)
   05219 Bladder cancer
    138808865 (Map2k1)
   05215 Prostate cancer
    138808865 (Map2k1)
   05213 Endometrial cancer
    138808865 (Map2k1)
   05224 Breast cancer
    138808865 (Map2k1)
   05223 Non-small cell lung cancer
    138808865 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    138808865 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    138808865 (Map2k1)
   05161 Hepatitis B
    138808865 (Map2k1)
   05160 Hepatitis C
    138808865 (Map2k1)
   05164 Influenza A
    138808865 (Map2k1)
   05163 Human cytomegalovirus infection
    138808865 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    138808865 (Map2k1)
   05165 Human papillomavirus infection
    138808865 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    138808865 (Map2k1)
   05135 Yersinia infection
    138808865 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    138808865 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    138808865 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    138808865 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    138808865 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138808865 (Map2k1)
   01522 Endocrine resistance
    138808865 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dmer01001]
    138808865 (Map2k1)
Enzymes [BR:dmer01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     138808865 (Map2k1)
Protein kinases [BR:dmer01001]
 Serine/threonine kinases: STE group
  STE7 family
   138808865 (Map2k1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 138808865
NCBI-ProteinID: XP_069851184
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDGKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMAHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaaaaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtg
aacgggaccagctcggcggagacgaacctggaagccttgcagaagaagctggaggagctg
gagcttgacgagcagcagcggaagcgccttgaggcctttctgacccagaaacagaaggtt
ggagagctgaaggatgacgacttcgagaagatcagcgagctgggtgctggcaatggcggg
gtggtattcaaggtttcccacaagccatctggcttggtcatggccaggaagctaattcac
ctggagatcaaacctgccatccgcaaccagatcatcagggagcttcaggttctgcatgaa
tgcaactccccatatattgtgggcttctatggtgcattctacagtgatggcgagatcagc
atctgcatggagcacatggatggtggttccttggatcaagttctgaagaaagctggaaga
attcctgaacagattttaggaaaagtgagcattgctgtgataaaaggcctaacatatctt
agagagaagcacaagattatgcacagagatgtcaagccctctaacatcctggtcaattcc
cgaggggagatcaagctgtgtgactttggggtcagtgggcagctcattgactccatggcc
aactccttcgtgggcacaaggtcctatatgtcgccagagagactgcagggcacccactac
tccgtccagtcagacatctggagcatgggactgtctctggtggaaatggcggtcgggagg
tatcccatccctcctccagatggcaaggagctggagctgatgttcgggtgccaggtggag
ggagatgcggctgagacaccacccaggccaaggaccccagggaggcccctgagctcatat
ggaatggacagccgacctcccatggcaatatttgagttgttggactacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagacttcgtgaataaa
tgtttaataaaaaaccctgctgagagagcagatttgaaacaactcatggctcatgctttc
atcaagagatctgatgctgaggaggtggattttgctggctggctctgctccaccattggc
ctcaaccagcccagcacaccaacacacgcagccagcatctaa

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