KEGG   Dipodomys merriami (Merriam's kangaroo rat): 138823137
Entry
138823137         CDS       T11079                                 
Symbol
Ikbkb
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
dmer  Dipodomys merriami (Merriam's kangaroo rat)
Pathway
dmer01523  Antifolate resistance
dmer04010  MAPK signaling pathway
dmer04014  Ras signaling pathway
dmer04062  Chemokine signaling pathway
dmer04064  NF-kappa B signaling pathway
dmer04068  FoxO signaling pathway
dmer04150  mTOR signaling pathway
dmer04151  PI3K-Akt signaling pathway
dmer04210  Apoptosis
dmer04380  Osteoclast differentiation
dmer04620  Toll-like receptor signaling pathway
dmer04621  NOD-like receptor signaling pathway
dmer04622  RIG-I-like receptor signaling pathway
dmer04623  Cytosolic DNA-sensing pathway
dmer04625  C-type lectin receptor signaling pathway
dmer04657  IL-17 signaling pathway
dmer04658  Th1 and Th2 cell differentiation
dmer04659  Th17 cell differentiation
dmer04660  T cell receptor signaling pathway
dmer04662  B cell receptor signaling pathway
dmer04668  TNF signaling pathway
dmer04722  Neurotrophin signaling pathway
dmer04910  Insulin signaling pathway
dmer04920  Adipocytokine signaling pathway
dmer04930  Type II diabetes mellitus
dmer04931  Insulin resistance
dmer04932  Non-alcoholic fatty liver disease
dmer04936  Alcoholic liver disease
dmer05010  Alzheimer disease
dmer05132  Salmonella infection
dmer05135  Yersinia infection
dmer05142  Chagas disease
dmer05145  Toxoplasmosis
dmer05160  Hepatitis C
dmer05161  Hepatitis B
dmer05162  Measles
dmer05163  Human cytomegalovirus infection
dmer05164  Influenza A
dmer05165  Human papillomavirus infection
dmer05166  Human T-cell leukemia virus 1 infection
dmer05167  Kaposi sarcoma-associated herpesvirus infection
dmer05168  Herpes simplex virus 1 infection
dmer05169  Epstein-Barr virus infection
dmer05170  Human immunodeficiency virus 1 infection
dmer05171  Coronavirus disease - COVID-19
dmer05200  Pathways in cancer
dmer05206  MicroRNAs in cancer
dmer05208  Chemical carcinogenesis - reactive oxygen species
dmer05212  Pancreatic cancer
dmer05215  Prostate cancer
dmer05220  Chronic myeloid leukemia
dmer05221  Acute myeloid leukemia
dmer05222  Small cell lung cancer
dmer05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
dmer05417  Lipid and atherosclerosis
dmer05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dmer00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    138823137 (Ikbkb)
   04014 Ras signaling pathway
    138823137 (Ikbkb)
   04064 NF-kappa B signaling pathway
    138823137 (Ikbkb)
   04668 TNF signaling pathway
    138823137 (Ikbkb)
   04068 FoxO signaling pathway
    138823137 (Ikbkb)
   04151 PI3K-Akt signaling pathway
    138823137 (Ikbkb)
   04150 mTOR signaling pathway
    138823137 (Ikbkb)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    138823137 (Ikbkb)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    138823137 (Ikbkb)
   04621 NOD-like receptor signaling pathway
    138823137 (Ikbkb)
   04622 RIG-I-like receptor signaling pathway
    138823137 (Ikbkb)
   04623 Cytosolic DNA-sensing pathway
    138823137 (Ikbkb)
   04625 C-type lectin receptor signaling pathway
    138823137 (Ikbkb)
   04660 T cell receptor signaling pathway
    138823137 (Ikbkb)
   04658 Th1 and Th2 cell differentiation
    138823137 (Ikbkb)
   04659 Th17 cell differentiation
    138823137 (Ikbkb)
   04657 IL-17 signaling pathway
    138823137 (Ikbkb)
   04662 B cell receptor signaling pathway
    138823137 (Ikbkb)
   04062 Chemokine signaling pathway
    138823137 (Ikbkb)
  09152 Endocrine system
   04910 Insulin signaling pathway
    138823137 (Ikbkb)
   04920 Adipocytokine signaling pathway
    138823137 (Ikbkb)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    138823137 (Ikbkb)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    138823137 (Ikbkb)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138823137 (Ikbkb)
   05206 MicroRNAs in cancer
    138823137 (Ikbkb)
   05208 Chemical carcinogenesis - reactive oxygen species
    138823137 (Ikbkb)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    138823137 (Ikbkb)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    138823137 (Ikbkb)
   05221 Acute myeloid leukemia
    138823137 (Ikbkb)
   05220 Chronic myeloid leukemia
    138823137 (Ikbkb)
   05215 Prostate cancer
    138823137 (Ikbkb)
   05222 Small cell lung cancer
    138823137 (Ikbkb)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    138823137 (Ikbkb)
   05170 Human immunodeficiency virus 1 infection
    138823137 (Ikbkb)
   05161 Hepatitis B
    138823137 (Ikbkb)
   05160 Hepatitis C
    138823137 (Ikbkb)
   05171 Coronavirus disease - COVID-19
    138823137 (Ikbkb)
   05164 Influenza A
    138823137 (Ikbkb)
   05162 Measles
    138823137 (Ikbkb)
   05168 Herpes simplex virus 1 infection
    138823137 (Ikbkb)
   05163 Human cytomegalovirus infection
    138823137 (Ikbkb)
   05167 Kaposi sarcoma-associated herpesvirus infection
    138823137 (Ikbkb)
   05169 Epstein-Barr virus infection
    138823137 (Ikbkb)
   05165 Human papillomavirus infection
    138823137 (Ikbkb)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    138823137 (Ikbkb)
   05135 Yersinia infection
    138823137 (Ikbkb)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    138823137 (Ikbkb)
   05142 Chagas disease
    138823137 (Ikbkb)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    138823137 (Ikbkb)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    138823137 (Ikbkb)
   05418 Fluid shear stress and atherosclerosis
    138823137 (Ikbkb)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    138823137 (Ikbkb)
   04936 Alcoholic liver disease
    138823137 (Ikbkb)
   04932 Non-alcoholic fatty liver disease
    138823137 (Ikbkb)
   04931 Insulin resistance
    138823137 (Ikbkb)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    138823137 (Ikbkb)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dmer01001]
    138823137 (Ikbkb)
Enzymes [BR:dmer01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     138823137 (Ikbkb)
Protein kinases [BR:dmer01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   138823137 (Ikbkb)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH GTSE1_N Med30 Glyco_hydro_65m
Other DBs
NCBI-GeneID: 138823137
NCBI-ProteinID: XP_069872178
LinkDB
Position
Unknown
AA seq 772 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPKNRDRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGAVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF
KALDNILNLKLVHILNMVTGTIYTYPVTEDESLQSLKARIQEDTGILEKDQELLQEAGLA
LIPDKPAIQCISDGKLNEGRTLDMDLVFLFDNSKITYETQISPRPQPECVSCILQEPKRS
LSFFQLRKVWGQVWHCIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMAQQLK
AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWKEMEQAVELRGRVGDASYVSVLLDFF
HQENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTD
GDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVV
RLQEKRQKELWNLLKIACSKVRGPVSGSPDSISTSRVSHSGQLMSQPSSACDSLPEPNKK
SEELVAEAHTLCAQLENAMQNTVKAQDQSFMSLDWSWLQMEDEDQSGMEQAL
NT seq 2319 nt   +upstreamnt  +downstreamnt
atgagctggtcaccctccctgccaacccagacatgtggggcctgggaaatgaaagaaagg
cttgggaccgggggatttggaaatgtcattcgatggcacaatcaggagacaggtgagcag
attgcaattaagcagtgccgacaggagctcagcccaaagaaccgagatcgctggtgcctg
gagatccagatcatgaggaggctaaaccaccccaatgtggtggctgcccgggatgtcccc
gaggggatgcagaatttggcacccaatgacttgcccctgctggccatggagtactgtcaa
ggaggagatctccgaaagtacctaaaccagtttgagaactgctgtggcctacgggaagga
gccatcctcaccctgctgagtgacattgcctctgcacttagataccttcatgaaaacaga
atcatccatcgggatctaaagccagaaaacattgttctacagcaaggagaacaaagatta
atacacaaaattattgacctaggatatgccaaggaactggatcaaggcagtctttgtaca
tcctttgtgggaaccctacagtacttggccccagagctactggagcagcagaagtacaca
gtaacggttgactattggagctttggcaccttggccttcgaatgcatcacaggtttcagg
ccttttctccccaactggcagcctgtgcaatggcattccaaagtccggcagaagagtgag
gtggacatcgttgttagtgaagacttgaatggagcagtgaaattttcaagctctttacca
taccccaataatcttaacagcgtactggccgagcgactagagaagtggctgcagctgatg
ctcatgtggcaccccagacaaaggggcacagacccccagtatgggcccaatggctgtttt
aaggccctggataacatcttaaacttgaagctggttcatatcttgaacatggtcacaggc
accatttatacttatcctgtgacagaagatgagagcctgcagagcttaaaggccagaatc
caggaagacacaggaatcctggagaaggatcaagagctgctgcaagaggcaggtctggca
ttgatccctgacaagcctgccatccagtgtatttcagatggcaagctgaatgagggtcgc
acattggacatggatcttgtttttctctttgacaacagtaaaattacctatgagacacaa
atctctccacggccacaaccagaatgtgtcagctgtatccttcaggagccaaagaggagc
ctctctttcttccagctgagaaaagtgtggggccaggtctggcactgcatccaaaccctg
aaggaggactgtaaccggcttcagcagggacagcgagctgccatgatgaatctccttcgg
aataacagttgcctttccaaaatgaagaattccatggcctccatggctcagcagctcaaa
gctaagttggatttctttaaaaccagtatccagattgacctggagaagtacagagagcaa
actgagtttgggatcacatcagataaactgctgctggcctggaaggaaatggaacaggct
gtggagctccgtgggcgggtaggagatgcatcttatgtttctgtacttttggattttttt
catcaggagaatgatgtgaagcatttggtggaacgaatgatggcactgcaaacggacatt
gtggacttacaaaggagcccaatgggccggaagcaggggggcacactggatgacttagag
gaacaagcaagggagctctacaggagacttagggagaagccaagagaccagcggacagat
ggtgacagtcaagaaatggtacggctcctccttcaggcaattcaaagctttgagaagaaa
gtgcgagtgatttacacacagctcagcaaaactgtggtttgcaagcagaaggcattggaa
ttgctgcccaaggtggaagaggtggttagtctaatgaatgaggatgagaagacggttgtc
cggcttcaggaaaagcggcagaaggagctctggaaccttctgaagatcgcatgtagcaaa
gtccgaggtcctgtcagtggaagcccagatagcatcagtacttctcgagtcagtcactct
ggtcagctaatgtcccagccttcctctgcctgtgacagtttacctgagccaaacaagaaa
agtgaagaactggtagctgaagcacatactctctgtgcccaactagaaaatgccatgcag
aacaccgtgaaggcgcaggaccagagttttatgagtctagactggagctggttacagatg
gaggatgaagaccagagtggcatggaacaggccttgtga

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