KEGG   Dipodomys merriami (Merriam's kangaroo rat): 138823550
Entry
138823550         CDS       T11079                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
dmer  Dipodomys merriami (Merriam's kangaroo rat)
Pathway
dmer00562  Inositol phosphate metabolism
dmer01100  Metabolic pathways
dmer01521  EGFR tyrosine kinase inhibitor resistance
dmer04012  ErbB signaling pathway
dmer04014  Ras signaling pathway
dmer04020  Calcium signaling pathway
dmer04062  Chemokine signaling pathway
dmer04064  NF-kappa B signaling pathway
dmer04066  HIF-1 signaling pathway
dmer04070  Phosphatidylinositol signaling system
dmer04072  Phospholipase D signaling pathway
dmer04360  Axon guidance
dmer04370  VEGF signaling pathway
dmer04380  Osteoclast differentiation
dmer04611  Platelet activation
dmer04613  Neutrophil extracellular trap formation
dmer04625  C-type lectin receptor signaling pathway
dmer04650  Natural killer cell mediated cytotoxicity
dmer04662  B cell receptor signaling pathway
dmer04664  Fc epsilon RI signaling pathway
dmer04666  Fc gamma R-mediated phagocytosis
dmer04670  Leukocyte transendothelial migration
dmer04722  Neurotrophin signaling pathway
dmer04750  Inflammatory mediator regulation of TRP channels
dmer04919  Thyroid hormone signaling pathway
dmer04933  AGE-RAGE signaling pathway in diabetic complications
dmer04935  Growth hormone synthesis, secretion and action
dmer05167  Kaposi sarcoma-associated herpesvirus infection
dmer05169  Epstein-Barr virus infection
dmer05170  Human immunodeficiency virus 1 infection
dmer05171  Coronavirus disease - COVID-19
dmer05200  Pathways in cancer
dmer05205  Proteoglycans in cancer
dmer05206  MicroRNAs in cancer
dmer05214  Glioma
dmer05223  Non-small cell lung cancer
dmer05225  Hepatocellular carcinoma
Module
dmer_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dmer00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    138823550
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    138823550
   04014 Ras signaling pathway
    138823550
   04370 VEGF signaling pathway
    138823550
   04064 NF-kappa B signaling pathway
    138823550
   04066 HIF-1 signaling pathway
    138823550
   04020 Calcium signaling pathway
    138823550
   04070 Phosphatidylinositol signaling system
    138823550
   04072 Phospholipase D signaling pathway
    138823550
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    138823550
   04613 Neutrophil extracellular trap formation
    138823550
   04625 C-type lectin receptor signaling pathway
    138823550
   04650 Natural killer cell mediated cytotoxicity
    138823550
   04662 B cell receptor signaling pathway
    138823550
   04664 Fc epsilon RI signaling pathway
    138823550
   04666 Fc gamma R-mediated phagocytosis
    138823550
   04670 Leukocyte transendothelial migration
    138823550
   04062 Chemokine signaling pathway
    138823550
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    138823550
   04919 Thyroid hormone signaling pathway
    138823550
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    138823550
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    138823550
  09158 Development and regeneration
   04360 Axon guidance
    138823550
   04380 Osteoclast differentiation
    138823550
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138823550
   05206 MicroRNAs in cancer
    138823550
   05205 Proteoglycans in cancer
    138823550
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    138823550
   05214 Glioma
    138823550
   05223 Non-small cell lung cancer
    138823550
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    138823550
   05171 Coronavirus disease - COVID-19
    138823550
   05167 Kaposi sarcoma-associated herpesvirus infection
    138823550
   05169 Epstein-Barr virus infection
    138823550
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    138823550
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138823550
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dmer04131]
    138823550
Enzymes [BR:dmer01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     138823550
Membrane trafficking [BR:dmer04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    138823550
 Endocytosis
  Macropinocytosis
   Phospholipase C
    138823550
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14
Other DBs
NCBI-GeneID: 138823550
NCBI-ProteinID: XP_069873042
LinkDB
Position
Unknown
AA seq 1265 aa
MTTVGNVDTLPEHEKSQLKRALELGTVMTVFSFRKCTPERRTVQVIMETRQVAWSKTADK
MEGFLDIMEIKEIRPGKNSKDFERAKAVRHKEDCCFTILYGTQFVLSTLSLATDSKEEAV
KWLSGLKILHQEALSASTPSMIESWLRKQVYSVDQTRRNSIGLREMKAILPTVNFKVNSV
KLLKDKFMEISAHKDELSFEQLHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRLEASV
VYLQDFQRFLLHEQQEPWAQDINKVRERMTRFIDDTMRETVEPFLFVDEFLTYLFSRENS
IWDDKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYVRCLRLGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFEDVVQAIRDHAFVASSFPVILSIEEHCSVEQQRHMAKV
FKEVLGDLLLTRPTEVSADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHRQQGE
LCMWDSIDQKWTRHYCAIADAKLSFSDDIEQNVEEEPPQDTPPTELHLGEKWFHKKVEKR
TSAEKLMQEYCLETGAKDGTFLVRESETYPDNYTLSFWRSGRVQHCLIRSTVEGGAKKYY
LTDNLTFPSIYALVQHYREAHLRCAEFELRLTDAVPNPNPHESKPWYYGQLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRISRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYSVERDVNSLYDVSRMYVDPSEISPSMPQRTVKALYDY
KAKRADELTFCRGALIHNVCKEPGGWWKGDYGTRVQQYFPSNYVEDVSAGDPEGLEKQIM
EDNPLGSLCRGILDLNNYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFAADSVEELFEWF
QSIRQITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSMVRQKPRELLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGAQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRGEKYDPLPPESQRRVVMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPSLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGHSEDIELASLLVFCEMRPVLECEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQDRCNRRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccaccgtgggcaacgtggacacccttcccgagcatgagaagagtcagctcaagagg
gctctggagctgggcaccgtcatgaccgtgtttagtttccgcaagtgcacccccgagcgg
aggaccgtgcaggtgatcatggagacgcggcaagtggcgtggagtaagacggcggacaag
atggaaggcttcttggacatcatggagataaaggagatccgcccggggaagaactccaag
gattttgaacgtgcgaaagctgtgcgccacaaggaggattgctgcttcaccattctgtac
ggcacccagttcgtcctcagcacgctcagcttggcaaccgactccaaggaagaagcggtg
aagtggctgtctggcctgaaaatcctacaccaagaagcgctgagcgcatcgaccccaagc
atgatcgagagttggctgagaaaacaggtttattctgtggatcaaaccagaagaaacagc
attggcctccgagagatgaaggccattctgcccacggtgaacttcaaggtgaacagcgtg
aaactcctcaaggacaagttcatggaaatcagcgcccacaaagatgagctcagcttcgaa
cagctgcatctcttctacaaaaagctgatgttcgaacagcagaaatcgatacttgatgaa
ttcaagaaggattcctccgtgttcattctggggaacacggaccggctggaggcctctgtg
gtgtacctgcaggacttccagaggttcctcctgcacgaacagcaggagccctgggctcag
gatataaacaaagtccgggagcggatgaccaggttcatcgatgacaccatgagagagact
gtggagcccttcctgtttgtggatgagttcctcacctacctgttctcccgggagaacagc
atctgggacgacaagtacgacgcggtggacatgcaggacatgaacaaccccctgtcccat
tactggatctcctcctcccacaacacgtacctcaccggggaccagcttcgcagcgagtcg
tccaccgaggcctacgtgcgctgcctgcgtctgggctgccgctgcatcgagctggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggaccaggaccaccaagatc
aagttcgaggacgtcgtgcaggccatcagggaccacgcctttgtggcatccagcttcccg
gtgatcctgtccattgaggagcactgcagtgtggagcagcagcgccacatggccaaggtg
ttcaaggaggtgctgggtgacctgctgctgacccggcccacggaggtcagtgccgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggtccc
cgaggggacgtcgatgtcaatgtggaggacaagaaggacgagcaccggcagcagggggag
ctgtgcatgtgggactccattgaccagaagtggactcgccactactgtgccatcgccgac
gccaaactgtccttcagcgatgacatcgaacagaacgtggaggaggagccaccccaggat
actccccccacggagctgcacctgggggaaaaatggttccacaagaaggtggagaagagg
acgagcgcggagaagctgatgcaggagtactgcctggagacgggggccaaggacggcacc
ttcctggtgcgggagagcgagacctaccccgacaactacacgctgtccttctggcgctca
ggccgcgtgcagcactgcctcatccgctccaccgtggagggcggggccaagaagtactac
ctgaccgacaacctcaccttccccagcatctacgcgctggtccagcactaccgcgaggcg
cacctgcgctgcgcagagttcgagctgaggctcacggacgccgtgcccaaccccaaccca
cacgagtccaagccgtggtactacggccagctgagccggggcgaggccgaggacatgctc
atgcgagtgccccgcgacggggccttcctcatccggcggcgggaggggaccgactcctac
gccatcaccttcagggcccggggcaaggtgaagcactgtcgtatcagccgggacggccgg
cacttcgtgctgggcacctccgcctacttcgagagcctggtggagctggtcagctactac
gagaagcacgcgctgtaccgcaagatgaggctgcgctaccccgtgacgcccgagctgctg
gagcgctacagcgtggagagagacgtgaactccctctatgacgtcagccgcatgtacgtg
gaccccagcgagatcagcccctccatgccccagaggaccgtgaaggctctctacgactac
aaggccaagcgcgctgatgagctgaccttctgccggggcgccctcatccacaacgtctgc
aaggagccggggggctggtggaagggggactacgggacccgagtccagcagtacttcccg
tccaactacgtggaggacgtctcggccggtgaccccgagggcctggagaagcagattatg
gaagataaccccctaggatctctctgcagagggatcctggacctgaataactacaacgtg
gtaaaagccccgcatggaaagaaccagaaacctttcgtcttcatcctggagcccaagaag
cagggggacccccccgtggagttcgccgcggacagcgtggaggagctcttcgagtggttc
cagagcattcgacagatcacctggaagatcgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccattgagctctccgacttggttgtctactgcaagccgacc
agcaaaaccaaggacaatctagagaaccccgacttccgagagatccgctcctttgtggag
accaaggcggacagcatggtgcggcagaagccccgggagctgctgcggtacaaccagaag
ggcctgacgcgcgtctaccccaaaggacagcgcgtggactcctccaactacgacccgttc
cgcctgtggctgtgcggcgcccagatggtggccctcaacttccagaccgcagacaaatac
atgcagatgaaccatgcgctgttctcgctcaatggccggacaggctacgtcctgcagccc
gagagcatgcgcggggagaagtacgacccgctaccgcccgagtcacagaggagggtcgtg
atgacgctcactgtcaaggtccttggcgctcgccacctccccaagctcggccgaagtatt
gcttgccccttcgtggaggtggagatctgtggggcggagtacgacaacaataagtttaag
acaacggtcgtgaatgacaatgggctcagccctgtgtgggctcccactcaggagaaggtg
acctttgagatttatgaccccagcctggccttcctgcgcttcgtggtctacgaggaagac
atgttcagcgaccccaacttcctggcccacgccacctaccccatcaaaggcatcaagtca
gggttcagatccgtgcctctgaagaatgggcacagcgaggacatcgagctggcttccctc
ctggttttctgtgagatgcggcccgtcttggagtgtgaggaggagctgtattcctcctgt
cgccagctgcgaaggaggcaggaagaactcaacaaccagctcttcttgtacgacacacac
cagaacctgcgtaatgccaaccgagatgctctggtgaaggagttcaacgtcaacgaaaac
cagctccagctgtaccaggacaggtgcaaccggaggctgcgagagaagagggtcagcaac
agcaagttttactcatag

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