Dipodomys merriami (Merriam's kangaroo rat): 138839309
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Entry
138839309 CDS
T11079
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
dmer Dipodomys merriami (Merriam's kangaroo rat)
Pathway
dmer05012
Parkinson disease
dmer05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
dmer00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
138839309 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
138839309 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
dmer01001
]
138839309 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
dmer04131
]
138839309 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
dmer04147
]
138839309 (Lrrk2)
Enzymes [BR:
dmer01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
138839309 (Lrrk2)
Protein kinases [BR:
dmer01001
]
Serine/threonine kinases: TKL group
LRRK family
138839309 (Lrrk2)
Membrane trafficking [BR:
dmer04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
138839309 (Lrrk2)
Exosome [BR:
dmer04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
138839309 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR-B
Ras
COR-A
LRR_14
LRR_9
WD40_CDC20-Fz
WDR55
Arf
LRR_NXF1-5
Beta-prop_EML
Beta-prop_WDR36-Utp21_1st
Ank_2
Beta-prop_EML_2
T2SSE
LRR_13
nSTAND3
AAA_22
MMR_HSR1
TrwB_AAD_bind
ABC_tran
AAA_16
AAA_7
Kdo
MobB
Pox_A32
G-alpha
PduV-EutP
GTP_EFTU
Beta-prop_RIG_2nd
Beta-prop_THOC3
Septin
NACHT
TsaE
FtsK_SpoIIIE
AAA_29
TniB
NB-ARC
cobW
LRR_6
ResIII
nSTAND_NTPase5
ARM_LIN_2nd
Motif
Other DBs
NCBI-GeneID:
138839309
NCBI-ProteinID:
XP_069894985
LinkDB
All DBs
Position
Unknown
AA seq
2530 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLLVRLNNVQEGKQIETLVQILEDMLVFTYCDHASKLFEGKN
FHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPDTLQSLMGPQDVGNDWEVLGIHQLIL
KMLTVHHANVNLSTIGLKALELLLTSGKITLLILDEESDIFLLIFDAMNTFSANEEVQKL
GCKALHVLFERVSEEQLIEFVENKDYRILLSALQNFKGEEEIVLHVLHCLYSLAVPCSNV
EVLMSGNVRCYNIVIDAMRAFPIHEKIQQVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
ERYPKNAVLQISALSCLALLTETIFLNQDLEEKNETPECEKEEEEEEEEEKLFWLEACYR
ALTWHRKNKHVQEAACWALNNLLMYQNGLHKKIGDEDDQFPAHREVMLAMLMHSCSKEVF
QASATALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLLEGSNT
SLDTMAVVVPKIITIMKSHQTSLSVQLEALRAIVHFIVPGMPDVSRDEFQRKLNMVKKQS
FRNDIYKLVLSALNRFIGNPGIQRCGLKVISSLAHFPDVLEMLSLDGAVDSVLHTLQMYP
DDQEVQCLGLQLLGCLSTKKNICIGTGHLLAKILVSSLQRFKDVLEVQIIGFQTILAILD
LSEPFSKLLLHHSFESVIFHQMSLGITEPKGPQFLNLCCKCFAKLVMDPELKSMMLQRAC
DQNNSIMVECLLLLGADANQAKEATSLICQVCEKESSPKLVELLLNSGSREQDVRKALMI
SVQKGDSHIISLLLRRLALDLANNSICLGGFGIGKIEPSWLAPLFPDKISNLRKQTNMGS
MLARMVLRHQMRSTVEEGAAAGSDENFSEDVLDKLSEWTFIPDSSMDSVFGQSDDLDSEG
SESSFLVKKKSNSISVGEFYHDPALQRCSPNLQRHSNSLGPVFDHEDILKRKIKILSSDD
SVRSSKLPSHMRHSDSISSLASEREYITALDLSANELRDIDALSQKCCISGHLEHLEKLE
LHQNALTNFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCLAHLDASRNDIGLPVVLD
PALKCPTLKQFNLSYNQLSSVPENLAEAVEKLEQLILEGNKISEICSPLSLKELKVLNLS
KNNISSLPENFLKACPKVESFSARMNFLAAMPFLPSSITSLKLSQNKFTCVPDVILSLPH
LRSLDMSSNDIENLPGPSHWKSLNLRELLFSHNQISILDLSEKAHTWSRVEKLHLSHNKL
KEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHVGCKAKD
IIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGIQGATVGIDVKDWP
IQIRGKKRKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFN
IKARASSSPVILVGTHLDVSDEKQRKACIGKITKELLNKRGFPAIRDYHCVNATEESDAL
AKLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPFEFPVIDRKRLLQLV
KENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVDPKWLCKVMAQILTVKVEG
YPKHPKGIISRKDVEKFLSKKKRFPKNYMIQYFKLLEKFQIALPLGEEYLLVPSSLSDHR
PVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQG
IYLNWSPEAYCLVRSEILDNHPESFLKIIVPSCRKGCILLGQVVDHIDSLMEEWFPGLLE
IDICGEGETLLKKWALYSFNDGEDHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAP
DLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLL
RQELVVLCHLHHPSLISLLAAGIRPRMLVMELASRGSLDRLLQQDKASLTRTLQHRIALH
VADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPG
FRAPEVARGNVIYNQQADVYSFGLLLYDILTAGGRIVEGLKFPNEFDELALQGKLPDPVK
EYGCTPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMKHISIPENIIAECMVA
TNSNSKNVSIWLGCGHSDKGQLSFLDLNTEEHITEEVTDSRILCLAFVHLPAEKESWIVS
GTQSGVLLVIDAEDRTKRHSLEKMTDSITCLYCNCFSKQSKQKNFLLVGTANGNLAIFED
KAVKCNGAAPLKTLSLGDASTPLMCLSESMNSSEKHIMWGGCGTKVFSFSNDFSVQKLIE
TRTNQLFSYAAFSDSNIIAVAVDTALYVAKKNSPVVEVWDKKTEKLCELIDCVQFLKEVM
VKISKESKHNLCYAGRVKALCLQKNTALWIGTGGGHILLLDLSTRRIIRIINNFCDSVRV
MVTAQLGNLKNVMLVLGYKQKSTEGTQQQKEIQSCLSIWDINLPHEVQNLEKHIEVRKEL
AEKMRKTSIE
NT seq
7593 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcagggatgcgaagaggaggacgaggaaactctgaagaagttg
ctagtcagactgaacaatgtccaggaaggaaaacagatagagacgctagttcaaatcctg
gaggacatgctggtgttcacctactgcgatcacgcctccaagttatttgaaggcaaaaat
ttccacgtgcctctgctgatcgttttggattcctatatgagagtcgccagtgtgcagcag
gtgggctggtcacttctgtgtaaattaatagaagtctgtccagatacattgcaaagctta
atgggaccccaggatgttggaaatgattgggaagtccttggtattcaccaactgattctt
aaaatgctaacagttcatcatgctaatgtaaacctgtcaacaattggactgaaggcctta
gagctcctgctaacttcaggcaagatcacattgctgattctggatgaagaaagtgatatt
ttcttgttaatctttgatgccatgaacacattttcagccaacgaagaggtccagaaactt
ggatgcaaggcgttacatgtgctgtttgaaagagtgtctgaggaacaattgattgaattt
gttgagaacaaagattataggatattgttaagtgcattacaaaacttcaaaggtgaagag
gaaattgtgctccatgtactgcactgtttgtattctctagcagttccttgcagtaatgtt
gaagtcctcatgagtggcaatgtcaggtgttacaacattgtgatagatgctatgcgagca
ttccccatccatgaaaagattcagcaggtcagttgctgcttgctccatcggctgacctta
ggtaattttttcaatattctggtattaaacgaggtccatgagtttgtggtgaaggctgtg
gagagatatccaaagaatgcagtgttacaaatctcagctctcagctgcttagcactcctg
actgagaccattttcttaaatcaagacttagaggaaaagaatgagactcccgagtgtgag
aaggaggaggaggaggaggaagaagaagaaaaactgttctggctagaagcctgttataga
gctttaacatggcacagaaagaataaacatgtgcaggaggctgcatgttgggcattaaac
aatcttctcatgtaccaaaatggtttacacaagaagattggcgatgaagatgaccagttt
ccagctcacagggaagtgatgcttgctatgctgatgcattcttgctccaaggaagtcttc
caggcgtctgcaactgcattgtcaactctcttggaacaaaatgttaattttagaaaaatc
ctgctgtcaaaaggaatatacctgaatgttttggagttaatgcagaaacacatacattct
ccggaagtggctgaaagtggatgtaagatgctcaatcatcttcttgaaggaagtaacacg
tccctggataccatggcagtagtggtccccaagataataaccattatgaaaagccatcag
acgtcattgtccgtgcagctggaggctcttcgggctattgtgcatttcatagtgcctggc
atgccagatgtttctagagatgaatttcagcgtaaactaaatatggttaagaaacaatct
ttcaggaatgatatttacaagctggtcttatcggctttgaacaggttcattggcaatcct
gggattcagagatgcggattgaaagtaatttcttcgctggcacatttccctgatgtgctg
gagatgctgtccctggatggtgcagtagactcagtgcttcacacactgcagatgtatcca
gatgaccaagaagttcagtgtctgggtttacaactcttaggatgcttgagtaccaagaag
aatatatgcataggaactggacacctgctggctaagattttagtgtccagtttacaacga
tttaaagatgttcttgaagtgcagatcataggatttcagacaatcttggccattctggac
ttgtcagaacccttttctaagctgctcttgcaccattcatttgagtccgtaatattccat
cagatgtctttgggcatcacggaaccaaagggcccacagtttctcaatctctgttgcaaa
tgttttgcaaaactggtgatggaccccgagttaaaaagtatgatgttacaaagagcctgt
gatcagaataatagcatcatggtagaatgcttgcttctcctgggagcggatgccaatcaa
gccaaggaggcaacctctttaatttgtcaggtctgtgagaaagagagcagccctaaattg
gtggagctgctgctgaatagcgggtcccgtgaacaggatgtacggaaagcgctgatgatc
agcgtgcagaagggtgacagccacatcatcagcttgctcttaaggaggctggccctggac
ctggccaacaacagcatctgcctgggagggtttggtataggaaaaattgaaccttcttgg
ctggctcctttatttccagataagatatccaatttaaggaaacaaacaaacatgggttct
atgctagcaaggatggtcctcaggcaccagatgagaagcactgtggaggaaggagcagct
gcagggagtgatgaaaatttctctgaagatgtactggataagctcagtgaatggactttc
attccagattcttccatggacagcgtgtttggtcaaagtgatgatctggatagtgaagga
agtgaaagttcatttcttgtgaagaagaaatccaattccattagtgtgggagaattttac
catgatcctgcattgcaacgttgctccccaaatttgcaaaggcattccaattcattgggg
cctgtttttgatcatgaagatatactgaagcgaaaaataaaaatattgtcttcagatgat
tcagtcaggtcatcaaaacttccatctcacatgaggcattcagacagcatttcttccctg
gcttctgagagagagtatattacggcattagacctttcagccaatgaactcagagatatt
gatgccctgagccagaaatgctgtataagtggtcatttggagcatcttgaaaagttggag
cttcaccagaatgcactcaccaacttcccacagcaactatgtgaaaccctgaagtgtttg
acacacttggatttgcacagtaataagttcacatcctttccctcctacttgttgaaaatg
aattgccttgcccacctcgatgcctctcgaaatgacattggactcccagtggtgttagat
cccgccttgaagtgccccaccctgaagcagttcaacttgtcatataaccagctctcttct
gtacccgagaacctcgctgaagctgtggagaaactggagcagctcattttagaagggaat
aaaatatcagaaatatgttcccctttgagcctgaaggaattgaaggttttaaaccttagt
aagaacaacatctcatccctgccagagaactttcttaaagcttgtccaaaagtagagagt
ttcagtgccaggatgaattttcttgctgctatgcctttcttgccttcttccataacaagc
ctaaaactatctcaaaataaatttacatgtgttccagatgtaattttaagtctaccacac
ttacggtccttggatatgagcagcaatgacattgaaaatctgcctggaccttcacactgg
aaatctttgaacttaagggaactcttgtttagccacaatcagatcagcatcttggacttg
agcgaaaaagcacacacatggtctagagtagagaaactacacctttcccataataaactg
aaggagattcctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttac
aacttggaactgagatcatttcccaatgagatggggaaattaagcaaaatatgggatctt
cctctggatgaattgcgtctaaattttgattttaaacatgtcggatgcaaagccaaagac
atcatcagatttcttcaacagcggttaaaaaaagctgtgccttacaaccgaatgaaactc
atgattgtaggaaatactgggagtggcaaaactaccttactgcagcaattaatgaaaacc
aagaaatcggatcttgggattcagggtgccacggttggcattgatgtgaaagactggccc
atccaaatcaggggcaagaagaggaaggacctcattctaaacgtgtgggattttgcaggt
cgtgaagaattctacagtactcacccccacttcatgacccagcgagcactataccttgct
gtctatgatctcagcaaggggcaggcggaagtggatgccatgaaaccttggctcttcaat
ataaaggctcgtgcgtcctcctccccggtcattcttgtgggcacacatctggacgtttct
gatgagaagcagcgcaaggcctgcatagggaaaatcaccaaggagctgttgaacaagcga
ggctttcccgcaatccgagattaccactgtgtgaacgccacggaggaatctgatgctcta
gctaaacttcggaaaactatcataaacgagagtctgaatttcaagattcgagaccagcct
gttgtggggcagctaattccagactgctacgtggaacttgagaaaatcattttatcagag
cgcaaaaatgtgccatttgaatttcctgtaattgataggaaacgattactacaactagtg
aaagaaaaccagctacagttagatgaaaatgagctccctcatgcggtacatttcttaaat
gaatcaggagtccttcttcattttcaagacccagcactgcagttaagtgacttatatttt
gtggaccccaagtggctttgtaaagttatggcccagattttgacagtaaaagtggaaggc
tatccgaaacatcctaagggaattatctcacggaaagatgtggaaaaatttctttcaaag
aagaaaagatttccaaagaactacatgatacagtattttaaactcttagaaaagttccag
attgccttgccactaggagaagagtatttactggttccaagcagtttatctgaccacaga
cctgtgatagagcttcctcattgtgagaactctgaaattatcattcgactctatgaaatg
ccctattttcccatgggattctggtcaagattaatcaatcgattgcttgaaatttcacct
tacatgctttctggaagagaacgagcacttcgcccaaacagaatgtactggcggcaaggc
atctacttgaattggtctcctgaggcttattgtctggtgagatctgaaatcttagacaat
catccagagagtttcttaaaaatcatagttccttcttgtagaaaaggctgcattcttttg
ggccaagttgtggaccacattgattctctcatggaagaatggtttcctgggttgctggag
attgatatctgtggtgaaggtgaaactctgttgaagaaatgggcattatacagttttaac
gatggcgaagatcatcagaaaatcttacttgacgacttgatgaagaaagcagaagaagga
gaccttctagtgaacccagatcaaccgaggctcactattccgatctctcagattgcccct
gacctgattttggccgacctgcctagaaatattatgttgaataatgatgagttggaattt
gagcaagctccagaatttctcttaggtgatggcagttttggatctgtttaccgagcagcc
tatgaaggtgaggaagtggctgtgaagatttttaataaacatacatcacttaggctgtta
cgacaagagctggtggtgctttgccacctccatcaccccagcttaatatctttgctggcg
gctgggattcgtcctcgaatgttggtgatggagttggcctccaggggctccttagatcgc
ctgcttcagcaggacaaagccagcctcacccgaactctccagcacaggatcgcccttcat
gtggctgatggcttgagatacctgcactcggccatgattatataccgagacttgaagccc
cataatgtgctgctttttaccctgtatcccaatgcggccatcattgcaaagattgctgac
tatgggatcgctcagtactgctgcagaatgggaatcaagacatcagagggaacaccggga
tttcgagcacctgaagttgctagaggaaatgtcatttataaccagcaggccgatgtttac
tcctttggcctgttactctatgacattttgacagctggaggtagaatagtagaaggtttg
aagtttccaaatgagtttgatgaattagccctgcaaggaaaattacctgatccagtcaaa
gaatatgggtgcaccccatggcctatggttgagaagctaattaaaaaatgtttgaaagaa
aaccctcaggaaaggcctacttctgcccaggtctttgacattctgaattcagctgagtta
atctgtctgatgaagcacatttcgataccagaaaacattatagctgaatgcatggttgct
acaaattctaatagcaagaatgtgagcatttggttaggctgtgggcacagtgacaaaggc
cagctctcctttcttgacttaaacacagaagaacacattactgaggaagttaccgacagt
agaatattgtgcttggcctttgtgcatctccctgctgaaaaggagagctggatcgtgtca
gggacgcagtctggtgttctcctggtcattgatgctgaagaccggaccaaaagacattca
ctggaaaagatgactgattccattacttgtttgtattgtaattgcttttccaagcagagc
aagcagaaaaattttcttttggtgggaactgctaatggtaacttagcaatttttgaagat
aaagctgttaagtgtaatggagcggctcccttgaagactttgagcctgggagatgcgagc
actccactcatgtgcttgagtgaatcaatgaactcctctgagaaacacatcatgtgggga
ggatgtggcacgaaggtgttctcattctctaatgacttctccgttcagaaactcattgag
accaggacaaaccagctgttttcctatgcagctttcagtgattcaaacatcatagcagtt
gccgtagacacagccctctatgttgcaaagaaaaacagcccagttgtggaagtgtgggac
aagaagacagaaaagctctgtgaactaatagactgtgtgcagtttttaaaagaagtcatg
gtaaaaataagcaaggaatcaaagcacaatctgtgttatgctgggagggtgaaggccctc
tgccttcagaagaacacggcgctctggataggaactggaggaggccatattttactcctg
gatctttccacgcggcgaattatacggataattaacaacttctgtgattccgttcgagtc
atggtgacagcacagttaggcaaccttaaaaatgtcatgctggttttggggtacaaacag
aaaagtactgaaggtactcaacaacaaaaagagatacagtcttgcttatctatttgggat
atcaatcttccacacgaagtgcaaaatttggaaaaacacattgaagtgaggaaagaatta
gctgaaaaaatgagaaaaacatccattgaatag
DBGET
integrated database retrieval system
