Daphnia magna (water flea): 116916858 Help Entry 116916858         CDS       T07514                                  Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism dmk  Daphnia magna (water flea) Brite KEGG Orthology (KO) [BR:dmk00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dmk04121]     116916858 Enzymes [BR:dmk01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      116916858 Ubiquitin system [BR:dmk04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     116916858 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR UIM OHCU_decarbox Motif Other DBs NCBI-GeneID:  116916858 NCBI-ProteinID:  XP_045025589 LinkDB All DBs Position LG2:complement(14667389..14684719) Genome browser AA seq 5124 aa AA seqDB search MASSSPGSDWSSILQKRCLARRAENETQSNLLDVAKCVEKTENSFSANDENDFNPTLSIL LADFFVRNASQRNLTFGGIISTSCKIIMPSLLGALRKSSNDLLAQNPSLQAVQPSHVLLA LKALSTGALEMNDTDFELLESYLKDLEKSKDTECLVSETVKKNRPDLNAALLDQFVSVIP GAMFEKAMTQLMSEGEAATFTRKDSTTQNLSTVCSQNIANLCSLDVADTIVNFCQSLPNV ASFIEKWNGAMEGLGLGLPSSLSEAQLIKQNITNLKEDMLLAKKALNLPLLEPLTKERLR LLTQIGMGCLLAAISVATSHSIFAAASSVPTKSVGSSNPNMAPSKQSASPNAAAAVCNRE EEWESNAVTVVETAVEIYQILASLVQKSPRSSRVYYDNFLYIAAWLLLSGLQGQMTNTSQ AGSEKGNKEDKGKSPSKHKDGSRINLTKIQQGYGGLSVVLASQALATLEKLLEPNGILNA EENQVMPGTLVGLDVTEDYSHSQRISRLLSDLPLTQLLFHIATVSYRKSCNLKRIQKNGD GETVSLSDSATYYDDDDFSCSEESSAAEEEEDDDDSEPILGHWFEETITPPEPKGGKNKG GPHDSEDARNASKSCQRNLDISLSVPDKGEPHGYIVLATQIFAFMNDHMLCSPRLRQYTT NSLSEHQLILLAAILKDLDRETARTETGTIAVFFGQTLGQLFSRFSQSLARYTHNLLAYE LMSPPLQIALLNHLNINPWSEEEDWPLLVHPRSLAVLAQVLLSKHRKDSKEEARQTSEAA CLSIWKRLLETMIKYIEDPHVAGDRDKEAEDLNVEHAQLLLFLFHSLQLMQKKAILLLCA QTLIRAAQAAFSIIPLHDTQLMLLARILLLLEYLIKNLYDAPVAMLEQIQWNLLSSAGLS STGRADDAQQPSRMYNCCQELEDNYRKYGSEDEGCYIRPRFYLLSNVDSNNQDLPKLDGL ACSFLLAPSDSFKYSTLYGAILNVLHVVHQCEFHSVRKDKRDYSALCAVQYCFNAGWRLV QCLPPSVPVMEGLSTAGVDLEPSALLHALLWGPRSAHKVYNAWITDCLVKQGLTTQKAIF IVKAAAKHANSTPFLVKVAKQLGQGMRQSSRLKDIAAVPDLWDVLVMDMVIARLRLLYDE CANKDNGDESYRVLDSPTEKLPKTSKISKEIFMELCDLVDSVASLSRRCVLHDALGNSTD TPTLEGSSEAEALQHLLAISSTRGCKLANITPTLALCLPPFLRAALDRWNSSNSDFPAFF SWRSGQSGDLIPSESYLNGILSAHLQLLSSQSVFSPASSLRHLLNAAVRLANDLVVWYPN SEEAEKELVGVFFPIALDACFENLVDLVQLVMERLVGAADSDRYQDIASYIVISHCHSLV TACAAPVRCLEEKALEECIRFLESCVDNPLTRHPLSRFYTFEEEVHSLWDIIFSTTTPEL SSTYRKSVYSFINKLLKSSDTNDTDLDNLCLTLLNLERIDEDRLEAWIEFAILRHLTGQD DEESQQQQQPAGSSTPVVVRSDTAEEEKSATVAGGSGGKPGPQDGISLLQNLTQFAFRKG EAENFSRTLLKMLLKHLSPNSRGNVTPDLVLVMVTLAGVGQGSGHRDLYLAALDWLLKYQ QVMPTESWIALNQEDLSSPPPELASFCCLLQYTTDVLYALRVLSSSSTNGAGVANEHATA ETSAGGLLESIEGNPLTADVEDWVDELGLGDDVESDGDESDEDLLCNQLCTFVITQKEFM NQHWYHCHTCRMVDGVGVCSVCAKVCHRDHDVTYAKFGSFFCDCGAKEDSTCQALVRRPP QPEEDNSSRSRDSVSARRLPHTTVDQALLQQLGFGGTAAMSYVPYRGDLDGSDPRFGDLV ASDELSERRRNLTKQLEPYLNELLEVTVSCELPAAIVDILDSLLPSVERASKRLSPVGSL QRARRTLHQLHHETKTIVASESLMIPTLGSQEGAFENVRMSFTGDQGQTIRQLLSAHVLR RVSMCCLSSLYGRRQHLAMSHEKGKVTVLQLSSLLKQADASKKKLTLTRLSSAPVPFTVL SMASNPANEDVLAVCGLKEVHVMTLTSGGSVQDHLALHPQLETGNFIIKAVWLPGHPTQL AVITADFVKIYDLSLDVLSPQYFFLLPSGKVRDCAFWFRQDGAQFTFFISSSGYIYWQPL SQDSSARHGPFYVTNILDVSHPEVKESNGQTGGGGVSVYYSHCLQLLCFSYAQGKTFMAS VTEDGRNELQLGPLHSVHIPAKSSATASGGSSLKLGTPSTGSSSAPQTPGSHQPLCQWTE VQGHPGLLLTLTQSSYTPVVIMVEPERILVEEIKVVPAKVKVTDLVAVRHIVNTGQDKTE PRTTLILLCDDGSLRIFMASSEMTNFWLTPTLQPPILSTTQPKMVRKESVNGTKGGSGST TPTFPTDFFESCTTMNDVEYGGNDLLHVYNSAQLKHRLNTSGLYIACTKQAGFSVEITNP DTSNVIVGVRILVGSQDVQRAPTCVEIFGRNIPFVLQRHRWYDIPLTKEESLQADKKLVL AFGSSNDPLGVTMIDSIKVYGKTKEVFGWPEDAEDQMTGAVGSNGALNLPPSQGHQLQSP TMQSSGSCSKLAMQSPAQLMLDQLVGGAVALLEGSLSLPVTSVTPACSPTTKDHVLRLST QILTMTWSAGSCVPGVIKLLLAAIHPSRAAYHDYKDRILLTAVVNDLKAIMDETSPIHLD PEAFYNVLTITKSVATTQPQNLIQFTNDNFLGDLLSVGRRLHRERARNPLLSPVGQLGVA QIDFCVQSVVDILFSVALTEPHRWMAPVMDHYISLLLCDDASVSHAAKAALQRTMKTGCT GKSIPSTAQPGHQAMHSDEDDIMQLAIAMSLEGATGATSAPETNDEEVREMSSMSAECFR QLRLALLKRITDDLPELKKKGGVKSIHFLQVLLILVSELRPSDPTERSELHRTLAKAVCE LDLERDAAIEVAGQRTPQHEVQLLIMKFFGFLLSTHHHKSSSGSSKASHSQRRGTSTSLS TVASVAAKVLLDAGLMERCLVLLQAILLHWKATGGDESPVVAGLLKNPVAPTAFDLSPFF SRTLTHRNTGYIFEGFSQLLTEMALRLPYLVKKVNSAVQLDQRWVECLCQYVAAPTPSSV KRHVRKLLLFHCGSKEKYRQCRDLLTIETHFKDVKKLALEHGFDAILEGNHDGLVLPYDD LVIVMEHLKVCLDVAATRTANWQLYCQQNGDTLSFLVQLVCFIDEGLCCTLLQLLRFAFC PLKTASSSSVSAAVTSATNTNQPIAKKSSECDLTAEPWDLDSSCTGVEGCVCGVFVQQLH RTVERRLISRLIFRFLLDCNVSAVRWHAHALIHSFCRHSSVVQQQDLVALMWSLWSGLQL YGRKASQFVDLLGYFTIKTPGMENSLPGYVDRAVALLKEENQLIVRHPNTVLYNALASLV HLDGYYLERDPCLACSTLEVPFSAVKLTTLKADVRFTTSTHIVKLVSSHIVNRFALRITD IKRTKMVRTINIYYNNRPVQAAVELKNRPGVWLKAKKLSLTPGQAEVKVDLPLPITCCNL KIEFAAFYENLHASSEMLQCPRCSASVPAHPGVCSNCGENVYQCHKCRSINYDEKDPFLC NACGFCKYAKFELTLSAKPCCTVEPVESEDDRKKSLLAINGFLEKADRLQGQMAYAREGL EVLISKLGENSGIDVLAGNDVSSGSSSGLPGNSGGSSTTAAANGNGSVTAGGPGTGQINK TIQQICQRYHSECKSTFEELSKIAQRVAACRRDIVAYDASQRQKAVRRSSPGQGAVGFDG SQFVPLPTGATCCYGCASAALDHCLTLLRAMATKPLLRRLMFEQGLLQELLHFNIAQGSA QSRGEVRDLLCLLTLNNADAVDCLNQKLMESVDGVLKRSGHSLALLNSIRHEMALFAASL QCQDTCWEKRLRSVIQLFLKSTHHLQSPAVMDVITLPCLRIIQELIQGTSGTVQIHVKES SKAGHVDVLMDLKRWLQGDPQQSFDAWKSRVLSRYDSPVLGKRPEQVRQLHLMQKYGARW RDKYQLRQQQQRPVSCQLSGSNWLQSMLFNPNSRLSRQTACVFLEGLARVPQRRQEIVNL LTSFLAQLGQAGPYGAEFFALYMSLVRKEHWRYYLVSRGLLPKLADWIEIEINGLTRQEM VGRSSELSQGHAMKSLVELLSFFLEETSVRQAYKGRLVGHVLNGYLNLRRLVLQRTRLVE DTQELLLQLLGDMTTGTEAETKQFMSVCVQTLRQCLVDDLVTPVFVVERLCSIIHPEEKD DVEFLMSLDKDPQQEDFLQGRMQGNPYSSTEPGLGPLMRDIKNKICQDCELVALLEDDTG MELLVCNKIMSLDLPVRDVYRKVFLSENNEAEPMRIVYRMRGLLGDATEEFIERFDDKRQ RPANDEETYKLANVMGECGGLDVLLERLSCVRDIQGEGRPLLGALVKLLSFCTKVQTNRS LLITPELNAVQRLLGALKLCLQAQQNMPPFTEQLLEVMEAILCQASAQSVDQYALFSSTF GTKEDLDFLLQLSAQMAGSKTVTSILTHLTRVIPFLTFVNNTKMDVLIEYFRQSLDFNQY DREHSTEQAVKLELFCALTSGIEHNAIGNTLKDRLVASKVVYTALDYLLQNAPTIRSAIA RDSPEWKEFVAKPSLKFVLRLLTGLAHSHVTTQLALAVDSIPLFHHLEQISSDEHVGSLA ENLLEAMRGHPTVAERIEEVRQQTKREKKRLAMAMRENQLRALGMKTNALGQVKAENPIL QQLVDMGLGEEPGPVCVICREGYRFQPGRVLAIYTFSRRCQLEDLESQLWYGSPHASSTA SSPPVSSGRSRKTLGYYTVSHFNVVHVECHLSAVRLARARDEWESAALQNANTRCNGLLP LWGPQVPESAFATCLARHNTYLQECTGHRDIGYVSTCHDLKLLILRFALERSFSDESGGG GPQSNMHFLPYLLHAALYVLNTTRSWSREEKNLRSFLETARGEKWVENHVESDSAFYYTT LALLLQSCQRWNTNRLTYLGRLLVTAHCRAHQSKGSDQRHEKQILDYSVYKPALVFFSIV NGIFNIVLKNVTVGEIDADWPGTVAEYIRHNDEAVLRATDKLLNAYQNDFLTCGSFDEFC DVAGLLEDIPSPDEFIRGLLQGIP NT seq 15375 nt NT seq  +upstreamnt  +downstreamnt atggctagcagtagcccaggatcggattggagttcgattttgcaaaaacgatgtttggca cgtagagccgaaaacgaaacacaaagtaatcttcttgatgttgcgaaatgcgttgagaaa actgaaaacagcttttcagctaatgatgaaaatgatttcaaccctacattaagcatcttg ctggcagatttctttgttcgaaatgcttctcaaaggaacctgacatttggaggaatcata tcaaccagttgcaagattatcatgcctagtttattaggagctctgcgaaaatcttctaat gatttgttggctcaaaatcctagcttgcaagctgttcagcctagtcatgttcttcttgca ttaaaagccttgagcacaggagcactggagatgaatgacacagactttgaattgctggaa agctatcttaaagatttagagaaatcaaaagatacagaatgtctagtttctgaaactgta aagaaaaatagaccagatttgaatgctgccttgttggatcagtttgtatcagtgatccca ggtgccatgttcgaaaaagctatgacccagctcatgagtgaaggagaagcggcgactttc actagaaaagacagcactacccaaaatttgtcgacagtgtgtagtcaaaacattgctaac ctatgcagcctagatgttgccgacaccatcgtcaatttttgccaatcattacccaatgta gcaagttttatcgagaagtggaacggagccatggaagggttaggactagggctaccttcc tccttaagtgaagcccaactgataaagcaaaatattactaacctaaaagaagacatgctt cttgcgaagaaggctctaaatttaccgctacttgaaccactaacgaaagaacgtttacgt cttctgacacaaattggaatgggttgtttattggctgccatttccgttgcgacgtcccac agtatctttgcggctgccagttcggtccccaccaaatcggtgggaagcagcaatccgaac atggctccttctaaacagtcagcaagtcctaatgcggctgcagccgtctgtaatcgggaa gaagaatgggaaagtaatgcagtcaccgtcgtcgaaacagcggttgagatttatcaaatc ttggcatctctcgtccagaaatcacctcgcagcagccgggtgtactatgataattttctg tacatagccgcttggcttttactgtctggattacagggtcaaatgaccaacactagtcag gcgggatcagaaaagggaaacaaagaagataaaggcaagtccccgagtaaacacaaggat ggctccaggattaatttgactaaaattcagcaaggttatggcggcttgtctgtagtcttg gcttcgcaggcgcttgccaccttggaaaaattattggaacctaatggtatactgaacgca gaagaaaatcaagttatgcccggaaccttggtgggtttggatgtcaccgaagattatagc catagccaacgaatttctcggttgctgtcggacttgcctctgacacaactgctctttcat atcgccaccgtgagctaccgaaaatcgtgcaatttgaaacgtatacagaaaaatggcgac ggtgaaactgtatcgctgtccgattcagctacctattacgacgatgacgatttcagttgc tcagaggagagcagcgcagccgaggaagaagaagatgacgacgatagtgaacccattctc ggtcactggtttgaagagacgattacgccacccgagcctaaagggggcaagaacaaaggt ggacctcacgattcagaggatgcacgaaacgcttcgaagtcttgtcaacggaatctggat atttccctttccgttcctgacaagggcgaaccacatggctacatcgtgttagctacgcaa atctttgcctttatgaacgatcacatgctttgttcaccccgtctgaggcagtatacaacc aacagtttgtccgaacaccagttgatcctcttggccgctattctcaaggatctagaccgt gaaacggcgcgaaccgagacgggaacaattgccgtatttttcggacaaacccttggccag cttttcagccgtttttcacaatctttagcccgttatacgcataacttgttggcttatgaa ctaatgagtccgccattacaaattgcgctgctcaaccatctgaacatcaacccttggtcc gaagaagaggactggccactgctggttcatcctagaagcttggctgttttggcccaggtg cttctctccaaacaccgcaaagacagcaaagaagaggcacgtcaaaccagcgaagccgca tgtctctctatttggaagcgacttctggaaacgatgataaaatacatagaagatccgcat gttgccggcgatagagataaggaggccgaagacctcaacgttgagcacgctcagctcctc ctctttctttttcactcattgcagctaatgcaaaagaaggctatcttacttctatgtgct cagacattgatccgtgctgcccaggcagccttcagtatcattcctttgcatgatacacag ttaatgctactggcacgtattctgctgttgctggaatatctgatcaaaaatctttacgat gcacctgttgcaatgctagaacagatacaatggaatttgcttagttcggccggcctttcc agcactggcagagccgatgacgcgcaacaacccagcagaatgtacaattgttgtcaagaa ttagaagacaactaccgaaaatatggttctgaagatgaaggatgttacattcgtcctcga ttttatctgctgagtaatgttgatagcaacaatcaggaccttcccaaattagacggattg gcttgcagcttccttttggctccatctgattcgttcaaatactccactttgtacggtgcc attttgaatgtcctgcacgttgttcaccagtgcgagtttcacagcgttcgcaaagataag cgcgactatagcgcattatgcgcagttcagtattgcttcaatgccggttggagacttgtc cagtgcctaccgccttctgttcccgttatggagggtctgtcgactgctggagtggatctg gagccttccgctttgcttcacgccttgctgtggggtccacgctcggctcacaaggtttac aatgcgtggatcaccgattgtttggttaaacagggcctcacgacgcagaaagctatcttt atcgtcaaagcggctgccaaacatgctaatagtacaccttttttggtaaaagttgccaag caattaggccaaggaatgcgccaatcatcgcgcctcaaagacattgctgccgtccctgat ttatgggatgtcctggtcatggatatggttatcgcaagattacgccttctgtacgatgaa tgcgctaacaaagacaatggtgacgagtcgtatcgcgtgctggatagtccaacagagaaa ctacccaaaacatcgaaaatatccaaagagatctttatggaactctgcgatttagttgat tcggtggccagtctgtcaaggcgctgtgttttacatgatgcgctagggaacagcactgat actccgacattggaaggttctagcgaagctgaagcactccagcatttacttgccatttct tcaacgcgaggctgcaaactagccaatatcacgccgacgttggcgttgtgcctcccacct ttcttacgtgctgcgttagaccgctggaacagcagcaactctgattttcctgcatttttc tcctggcgttctggccagtcgggtgatctcatcccgtcagagtcataccttaacggtatc ttaagcgcccatctgcagcttttgtcatcccagtccgtcttcagtcctgcctcgtcgttg cgccatttgttgaatgcggctgttcgactggccaatgatctggtcgtgtggtatcccaac tcggaggaggcagaaaaggagctggtgggcgtcttcttccccattgcactggatgcttgt ttcgaaaacctagtagatcttgtacagctagtcatggaacgacttgtaggagccgctgac agtgatcgctatcaagacattgcatcctatatcgtcatcagtcattgtcattcgttggtt actgcatgcgcagcgccggtacgatgcctggaagaaaaggcactggaggaatgcatccgc tttctggaatcttgcgttgataatccgcttactcgccatcccctttctcgtttctatact tttgaagaggaagttcattcattatgggacatcattttctcgactacaacgcccgagctg tcgtcaacataccggaaatcggtctacagcttcatcaacaagctgctgaagtcttcagat accaacgacacagatttagataatctctgtttgactttattaaacttggagaggatcgac gaagatcgtttggaagcttggattgaatttgcgatcttacgccatctaaccggccaggat gatgaggaaagccagcaacagcagcaaccagctggcagtagtacgccggtggttgtaagg tctgatacggcggaagaagagaaaagtgcgactgtcgcaggaggctctggtgggaagcct ggtccacaagatggaatttccctactgcagaatttgacacagttcgctttccgtaagggt gaagcggagaatttctcccgaacgcttcttaaaatgcttttgaagcacctgtctcccaat agccgcggaaatgttacaccggatctggtgcttgttatggtcacattggcaggcgtaggt caaggttccgggcatcgtgatttgtacttagcagcgttggattggctgctcaaatatcaa caagttatgcctaccgaatcgtggatagctcttaaccaggaagacttaagttcgcctcca cccgaacttgcatcgttctgttgtttgctccagtacacaacggacgtcctctacgctctc agagtgctgagtagcagcagcaccaatggcgcgggagtggcgaacgagcatgcgactgct gaaacatcggccggtggattgcttgaatccatcgaaggtaatcccctcacagcagacgta gaagactgggtggatgaattaggtctcggcgatgatgttgaaagtgatggtgatgaatcc gatgaggacctcctttgtaaccaattatgcaccttcgttataacacaaaaagaatttatg aatcaacattggtatcattgccatacctgccggatggtggacggtgtcggcgtttgctcc gtgtgtgctaaagtttgtcatcgggatcacgatgtgacgtacgcgaaatttggcagtttc ttctgtgattgtggtgccaaagaggacagtacctgtcaagcattggtgcgtcgacctcct caaccggaagaagataattcttcacgctcacgagacagcgtttcagccagacgtcttccc cataccacagtcgatcaagcgcttctccagcaattgggttttggaggcacagcagccatg tcttatgttccgtatcgtggtgatttagatggctcggatcctagatttggtgatttggtt gcaagtgacgaactttctgagagacggcgaaacctgacgaaacagctggagccttacctg aacgagctgttagaagttactgtatcgtgtgaacttccggctgccatcgtagacattctt gattctttgctaccttccgttgaacgagcaagtaaacgactttcaccggtcggtagcctt cagcgcgctcgacgcacactccatcagctgcatcatgaaactaagacaattgtagcttct gaatctcttatgatcccaactctgggatcacaggaaggagctttcgaaaacgtgcggatg agtttcaccggcgatcaaggtcagactattcgtcaattgctctctgctcacgtgctacgc agggtttcaatgtgctgcctatcctcgctgtacggtcgtagacaacatctagcgatgagc cacgagaaaggcaaagtgacagtactgcaattaagctctctgttgaaacaggcggatgct tcgaaaaagaaattgacgcttacacggctcagctcggctcctgttccgtttactgtgttg agcatggcgagtaatccggcgaacgaagatgtgctggctgtttgcggcctgaaggaggtt catgtgatgactcttacgtcaggtggctctgtccaagaccacctagcactacatcctcag ttggagacgggaaatttcatcatcaaggccgtctggctgcccggccatcccacccagctg gcggtcatcacagccgattttgttaaaatctatgacttgtctttggatgtcctcagccca caatactttttcctgttaccaagtggcaaagtgcgcgattgtgcattttggttccgtcag gatggcgcccaatttactttttttatctcttcatccggatacatctattggcagccgctc agtcaggatagctcagcccgccatggcccattctatgtcactaatatactagatgtctct catcccgaagtgaaagagagcaatggccaaacgggaggtggaggcgtatcagtctattac tcccattgccttcagcttctctgctttagctacgcccaaggcaaaactttcatggcttct gtgactgaagatggtcgcaacgagttgcaactgggcccactccattccgttcacatcccg gcaaaaagcagcgcaaccgcaagcggaggaagttccctgaaactgggaactccatcgaca ggttcgagctcggctccacagactcctggatctcaccagccactttgccaatggacagaa gtgcaaggccatccgggattgttgttgacgctgactcaaagttcttacacgcccgtggtc attatggttgaacctgaacgaatcctggtggaagaaatcaaagtcgtgccggccaaagtt aaagttacggatttagtggcagtccgccatattgtcaatactggccaggacaaaacggaa ccgcgtacaacgttgatcctcttgtgcgatgatggttcgctgagaattttcatggcctct tcggaaatgacaaatttttggctgacgcccacacttcaaccgcccattctttcgaccaca cagcctaagatggttcgcaaagagagcgttaatggaaccaagggaggttccggctctacc acaccgacatttccaacggatttctttgagagctgcacgaccatgaatgatgtcgagtat gggggcaacgacctgttgcacgtgtacaactcggcacagttgaaacataggctcaacacg agtggtctctacatcgcctgcactaaacaggcgggcttttccgtcgagatcaccaatcct gatacatccaacgtcatcgtaggagttcgcattctcgtcggctcccaagacgttcagcga gctcctacctgcgtcgagattttcggacgtaacattcctttcgttttgcagcgccatcgc tggtacgacatacccttaacgaaagaagaaagtctccaggcggataagaaactcgtccta gctttcggatcttccaacgatccattaggtgtcaccatgattgattcaatcaaagtttat gggaaaacgaaggaagtctttggatggccggaagacgccgaagatcagatgactggagca gtcggcagtaatggagcactcaatttaccaccatcacaaggtcaccagctccaaagccct actatgcaatcaagtggctcctgcagtaaattggcgatgcaaagccctgctcagctaatg ctggatcagttagttggaggagctgtggctcttcttgaaggttctctgtcactaccggtt accagcgtgactcctgcttgttcccctactaccaaagatcacgtcctccgtctgtcgacg caaatcttgacgatgacatggagtgcgggaagttgcgtcccaggtgtcataaagcttctt ttggctgccattcatccatctagagctgcctatcatgactacaaggaccgcatactattg actgctgttgtgaacgatctcaaagctattatggacgaaacgtctcccatccatctggat ccggaagcattctacaatgtgttgaccatcaccaaatcagtggccactacccaaccgcaa aacttaattcagtttacaaatgacaacttccttggcgatttgttgtccgttggacggcgg ctacatcgtgaacgggcgcgtaacccacttttgagtcctgtaggacaactgggcgtggct cagattgatttctgcgttcaatccgttgttgacatcctcttctcagttgctttaacggaa ccgcatcgatggatggcacctgtaatggatcattatattagtctgctactttgtgatgac gcaagcgtcagtcacgctgctaaagctgctctccagcggaccatgaaaacgggctgcact ggcaaatcaataccctccacagctcagcctggacaccaagccatgcacagtgatgaagat gatattatgcagctggccattgccatgagtctggaaggagccactggtgccacatctgct ccggaaacgaatgatgaggaagtgcgggaaatgtccagcatgtctgcggagtgcttccgt caattacgattggctctactgaaaagaatcactgacgaccttccggaattgaagaaaaag gggggtgttaagtccattcatttcctccaagttttgcttatcttggtgtctgagttgcgg ccgtctgacccaacggaaaggagcgaactgcatcggacattggctaaggctgtttgcgaa ctagacctagaaagagatgcagccattgaagtagctgggcagcgtacaccgcagcacgaa gtgcaactcttgataatgaaattttttggatttcttttgtcgacccaccatcataaatcc agcagcggaagcagcaaagccagccattcacaacggcgaggtacttctacgtctctgtca actgtcgcttcggtggctgcaaaagttctcttggatgctgggctcatggaacgttgcctt gtgctcctgcaagctattctactgcattggaaagctaccggtggagatgaatcgcccgtt gttgctggccttctcaaaaaccccgtagctcccacagctttcgatctctcacctttcttc tccagaacgttgacacatcgcaatacgggatacatctttgaagggttttcccaattgcta accgaaatggctttacgtctaccataccttgtcaaaaaagtaaacagtgccgtccagctg gatcaacgctgggtggaatgcctttgtcaatacgttgcagcacctaccccgtcatcggtc aaacgccacgtgcgtaaactgttgctgtttcactgcggctccaaggaaaaataccgtcag tgtcgagatctgttgacgatcgaaacgcatttcaaagacgtcaaaaaactagcgttggaa cacggattcgatgcaatcctagaaggcaatcacgatggattggtattgccatatgatgat ctcgtgattgtcatggaacacttgaaggtgtgcctcgatgtggctgcgacgcgcacggcc aactggcagctctattgtcaacaaaatggagatacattgtcattcctagtccagctggtc tgtttcattgacgaaggcctgtgctgcacactgctccagctactacgctttgccttttgt ccattgaagaccgcgtcttcatcatccgttagtgccgcggtaacatcagccaccaacact aatcaaccgatagccaagaaatcgtcggaatgtgatctcacggcagagccgtgggacttg gatagttcctgtacgggcgttgaaggttgcgtttgtggcgtctttgtccagcagttacat cgaacagtagagcgtcgtctgattagccgtctcattttccgcttcctcctggattgcaac gtgagtgctgtccgctggcatgcccacgccctgatccattccttctgtcgacattcttcc gtggtccagcaacaagatctcgttgctctgatgtggtccttatggtcaggacttcaactt tacggccgaaaagcctcccagtttgtcgatctactcggctattttacaataaaaactccc gggatggaaaattctctgcccggctatgttgaccgagctgtggcgttgttaaaggaagaa aaccaactcatcgtccgtcatccgaacacagttctgtacaatgcactagccagtctcgtt cacttggatggttattacctggagcgagatccttgtttggcctgttccactcttgaggtt ccattctcggccgtaaagttaacaacactgaaagccgatgtgcgcttcacaacatcgaca cacattgttaagctagtcagcagccatatcgtcaatcgttttgcattgcgcatcactgat attaaacggaccaaaatggtgcgtaccattaacatctattacaacaatcgacctgtccag gccgccgttgagctcaagaaccgtccaggcgtctggcttaaggctaagaaattatcgctg acccctggccaggctgaagtcaaagtagatttaccgctaccgatcacctgctgcaatttg aagatcgaatttgcggccttttatgaaaatcttcacgcttcatcggaaatgttgcagtgc cctcgctgttccgcctccgttccagctcatccgggtgtttgttccaactgcggtgagaac gtataccagtgtcacaaatgccgttccatcaattacgacgaaaaagacccattcctgtgc aacgcctgtggtttctgcaagtacgcaaaattcgaattgacgttatctgccaagccttgc tgcactgtggagcctgtcgaaagcgaggacgatcgtaaaaaatcattattggctattaat ggattcttggaaaaagccgatcgactccagggacaaatggcttatgctagggaaggattg gaagtactgatcagtaagcttggtgaaaattccggcatcgatgtcttagcaggaaatgat gtgagctctggatcgtcgtcggggctacctggaaattcaggagggtcatctactacagcc gcagctaatggcaatgggtctgtcactgctggaggacccggaacaggacagataaacaaa acaatccaacagatttgccaacgctatcattcagagtgtaaatcaacttttgaggaattg agcaaaatagctcaacgggtggcggcctgtcgccgcgatatcgttgcctatgatgccagc cagaggcaaaaagctgtaagacgctcaagtcccggacaaggggccgttggattcgatggt agccaattcgtaccactacctactggagcgacttgttgctacgggtgtgccagtgccgct ctagatcactgtctgactctcttgcgcgcaatggcaaccaagcctctgctgcggcggcta atgttcgaacagggactgcttcaagaattgctccactttaatatcgcacaaggatcggcc caatcacgtggcgaagtccgtgatctgctctgcttgttgacgctgaataacgctgacgcc gtcgactgccttaaccagaaactgatggagagcgttgacggagttcttaaacgttccggt catagcttagctttgctcaactccattcgacacgaaatggctttgttcgcagctagcctt caatgccaggacacgtgctgggagaagcgtctgcgctcggtcatccagctatttttgaaa tcaactcaccatctgcagtcaccagctgtcatggatgtcatcactctaccttgtctgcga atcattcaagaactcatccaaggtacttctgggacggtgcaaatccacgttaaagaatct tcaaaggccggccatgttgatgttctcatggacctgaaacggtggcttcaaggtgatcca caacagagctttgatgcttggaagtcgcgcgtactgtcacgatacgactctcctgtactc ggaaaaaggccagaacaagtacggcagctccacctcatgcaaaaatatggagctcgctgg cgcgataagtaccagctgaggcaacaacaacagcgaccggtatcttgtcaactgtcgggc tccaattggcttcagtctatgttgtttaatccaaactcgcgattgagtcgccaaacggca tgtgtcttcctcgagggactcgctcgcgtaccccaacgccgacaggaaatcgtcaacctt ttgactagttttttggcacagctgggccaagctggtccgtatggcgcggaatttttcgca ttatacatgtccttggttcgaaaggagcattggcgctactatctagtgagtcgtggatta ctacccaaattagcggattggatcgagatcgaaatcaatggattgactcgacaagaaatg gtcggcagatcatccgagctgtcgcagggccatgctatgaaatcgctggtggaactgctt tccttttttttggaagagacatctgttcgccaagcgtacaaagggcgcctagttggtcat gttttaaacggttacttgaacttacgacgcttggtccttcaacgtacgcggctcgtcgag gacactcaagaacttcttctacagcttcttggagacatgacaacaggaactgaagccgag acgaaacagttcatgtctgtgtgcgttcaaactctacgtcaatgcctcgttgatgacctc gtaacgcccgtctttgtagtcgaacgtctatgttctatcatccacccggaagagaaagac gatgtcgaattccttatgtcgcttgacaaagatcctcaacaagaggatttcttgcaaggg cgaatgcaaggtaatccttacagcagcacggagcccggccttggtccgttgatgcgtgac attaaaaacaaaatctgccaagactgtgaattagttgctcttctggaagacgatactggt atggaactactggtgtgcaataaaattatgagtctagatctgccagtccgagatgtctat cgcaaagttttcctttctgaaaataatgaagccgagccaatgaggatcgtgtataggatg cgaggcttattaggagatgctacggaagaatttatcgaacggtttgacgataaacgtcag cgcccggctaacgacgaagagacttacaaactggcaaatgtcatgggggaatgtggtgga ttagatgttcttttggagcgcttgagttgtgtccgggatattcagggcgaaggtcggcca cttcttggtgccttagtcaaacttctgtctttctgcaccaaagtacagaccaaccgctct ctcctgattactccggaactgaatgccgtccaacgacttcttggtgctcttaaattatgc ttacaggctcaacagaacatgcctccatttacagaacaacttttggaagttatggaagcc attttatgtcaagcctccgcacagagcgttgatcaatatgcccttttttcgtcgacgttt ggtaccaaggaagatctggacttcttgttgcagttgtcggcccaaatggcgggttccaag acagtcactagcattttgacccatttaactcgtgttattcctttcttgacgttcgtcaac aacaccaagatggatgtgcttattgagtatttccggcaaagtttagatttcaaccagtat gacagagaacacagtaccgagcaggccgttaaactggaattgttctgtgctctcacttcg ggtattgaacacaacgctataggcaatactttgaaggatcgcctagtggcttcgaaggtg gtctacactgcgctggattatctccttcagaatgcgcctaccatccgctcggccatcgcc cgagacagtcccgaatggaaagaatttgttgcaaaaccatcgttgaagtttgttttgcgt ctcctgacagggttggctcacagtcacgtcacaacccaattggcgttagccgtcgattcg attccactctttcatcatttggaacaaatttcatccgatgaacacgttggttctcttgct gagaatttgttagaggccatgcgaggccatcctacggttgccgagcggattgaagaagtt cgccaacagacaaagcgagagaagaagcggttggctatggcgatgagagaaaatcaactt cgagctctcggaatgaaaactaacgcacttggtcaggttaaagccgaaaatcccattcta caacagttagttgatatgggattgggtgaagaacctggtcccgtctgcgtcatctgtcgt gaaggttaccgcttccagccgggtagagtgttggccatttacacttttagtcgacgctgc caactggaggatctcgagtcccagctttggtatggctcaccacatgcttcttccaccgcg tcatcgccgcctgtgagttctggacgtagccgcaaaaccttaggatactacactgtctcg cacttcaacgtcgtccacgtggaatgccatctttcggctgttcgtttggccagagctcgt gatgaatgggagtcagctgcattgcaaaatgccaacacccgttgcaatggtcttttgcct ctgtggggccctcaagttccggagtctgcttttgcaacctgccttgctcgtcacaacacc tacctccaggaatgcacaggtcatcgggacatcggatacgtgtctacgtgccacgacctg aagttgctcattttgcgcttcgcgctggaacggtctttcagtgatgagtctggtggaggt ggcccgcaatccaacatgcacttccttccatatcttcttcatgcagcgctttacgtctta aatacgacacgttcctggagtcgcgaagagaaaaacctgagaagttttctggaaactgct cgaggagaaaaatgggtggagaatcatgtcgaatccgatagcgccttctattacacgact ttggctctgcttctgcagagctgccagcgctggaatacgaatcggctaacctaccttggt cgccttttggtgacggcacattgccgtgcccatcagtcaaagggaagcgaccaacgtcat gaaaaacagatacttgattacagtgtttataaacctgcactcgtctttttttcgatcgtc aacggaattttcaacattgtattgaagaacgtaacagtgggagaaattgacgctgactgg cctggaacagtagccgaatatattcgtcacaacgacgaagccgttttaagggccactgac aaactactcaacgcgtatcaaaatgattttctgacttgcggctcatttgacgaattttgc gatgttgctggtttattagaggatattccatctcccgatgaattcatccgaggtttactc caaggcataccttag

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