Drosophila miranda: 108162059 Help Entry 108162059         CDS       T06132                                  Name (RefSeq) protein purity of essence   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism dmn  Drosophila miranda Brite KEGG Orthology (KO) [BR:dmn00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dmn04121]     108162059 Enzymes [BR:dmn01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      108162059 Ubiquitin system [BR:dmn04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     108162059 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR Htt_N-HEAT_1 Poty_PP LEDGF Motif Other DBs NCBI-GeneID:  108162059 NCBI-ProteinID:  XP_033248918 LinkDB All DBs Position 4:16466844..16486242 Genome browser AA seq 5377 aa AA seqDB search MSSHSGGIDWNSVIKALLLSRTGALNKNEVVNLLKAITRCEHEFLDDEGSFVPFYTAFAA LAADKLMQIKSICQTQICQLHDATAVLIRFILFRLPKVSVFESKWLLAALKMLCEGRENA SSAVAQFDYSAVAGVVRSSKHPESSNKSIMSMAGSTTGGAGAGGSNDKESPKLEIKRSRS DLSSVILQQLLAPLEPGKMTWVPLSEEITDCTEQLLAANVEVFQEANGVDTLLDICVGLP ILSRYRMKYMETINAGKPLYLPLTQAEATTVKSSMNHMLTDLSIVGQAYALIVMQPLTPS RIEKLSMCGISALYNAVLTSIATSVLSMGQASSAQKQQQQQTAAAASTSQGSGGGLSSVQ TSKDHDEFEEQASGIVNKALEIYSSIGEMFKSSARMYIYQNHLCYGSWLLISGIQGAMGA SGSASAETAAKATAATKVASKTESITAPSTPIARVNLFKVQQGFGELNAAIANHSIKLLS ELIEDLKIESACGQSSVTDPETLPEPAQFDILQNYTSLERIVRVLNTATLHQLFTFLATV AYRKACTLKRASTKDRTECDPISYSDSTTCLNESMSYSDNSEEDDSESYLGHWFKETLSP ETHDDNANTSSQERSGEQKSALVPKLDEPHEYLELSADIFCFLDQFLANRHAYMQRYVKA GVSDQQMLLMANIIKDFDRDVMRNDSEQQSPPSTAAAVAAATGAGSSGSSAKWQASMIRF SGAAGRYIHNLISTGLLSEQLQSNLLQHLAISPWSTDTNTWPLQVYPSTLSVLVQILLLK PTQEKEAACLSVWHRLINTLVDGVCSSSSAGDSDYEDINIEHAQLLLFLFHSLNLMQKKS ILLLTAGGVIRCAEVCRGISVERVVRNSQMMLLSRLLVFLEYLMKHLYHAPPELLDQVRW ILFSVSSMPETQKVSDLINSRTKLNSYCRQDIEEKFRKSSGEYGSNIRPTFYSLVLKEPE KAYWVSEFKLDGLAWNFILCTPDKLKYPLLVDALVDILNIADMSSFSRKENSESNSIHNL CAMQYCFTNTWKLLLGLPPSTSHVEALRIERAPNLHSLVWSTRLPLATSHYLIVNSLIKQ GMYTQYAESLYTQVGDTTADIRYNLKQTILGVEAFNQQMSNKGIPRLSELILFDALVAHM QAVAWAEKEGFKLLRKDCEDSSGGDQSSCTSAASSSCGGNATDHDHPEVYSSNESIDEEK SKHEDDQGLSTETLERNQMINELLIKLMDSYRYLSEIVREQMLKQLSSTTPEHVLNLIVP IVSDKPAIMLELHAAFLKLLPNEDKQLIANEWPKCLMVNDSAFDGKQHPVEPYTLNVIDA HITELTRGSGGVAYSTLHTLKHCLKTILHLMELLLPYDSNCCEMDAQLKPLLIASMLDMR TDYLQGQSEQCLREILSGLTLEAQKLLLYEHMIGYCYRMLIEFAAELRQPAAGGTPLDQE RALFNESMLFAVLKTFIKMLEKPTAVQAMRQFFHDQKTGSLITLLLSFTGTTLPLSYARK MLQFVERLFEQSTRADSQFQHEDLVDCFSDLATVDVARLKLWLAHIIYGPNMTAGDVSNS ETMDPTCRLLTSIMQPSSSSSSNAQTPTNMATVSAMPSISDQLDAMDIDYDCGAGAAPNT SQILSLWQAAQPNPSEESSQACDHSEGGEQRQSERNGGLLLSITKYLVRDQSKAGPIAAP LFQALLQLGQTLISPPHDGCDFADVLQIMITLADASPARGHVALFNTTLLWLELAKLQLP DKHLRHAENVSALLRYLSELLQSIGYRGSRQHMPPWDDELQTDIDDLYDELAEEEQDSLL DDSDEDTLNNKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKY GNFFCDCGAKEDGSCQALSRRLGSGEVRESVGPGGSSSCNYLPSHMSLLAGKKRSNTASG ATQQQQQHGAPARKDSISSERIQLLGKLLEPYRETLQHQEQWMLVVRCILEYFDVLLPSI RENCTLYSIVGCHRRATAALERLHQLEQSFQITDQLMFATLGSQEGAFENVRMNYSGDQG QTIKHLLTSGTIRRVAFCCLSSPHGRRQQLAVSHEKGKVTILQLSALLKQADASKRKLTL TQLSSAPIACTVLSLAANPCNEDCLAVCGLKECHVLTFSSSGSTNEHIVITPQLENGNFL KKAMWLPGSQTLLAIVTTDYVKIYDLSVDTISPKYYYLVAVGKIKDCTFMYHQQDGSGSY FMLSFTSSGYIYTQQLDQQSLAVHGDFYVTNTLELSHQHIKDINGQVCGGGVSIYYSHAL QLLFYSYTCGRSFCSPLTNVNEGVKGIYHLDINNTAATTASKSSSASKVPLQSLVGWTEV AGHPGLIYASMHTSNNPVILMITPERIYMQEIKAQSAKSRIMDVVGIRHSVAGTEKTTLL LLCEDGSLRIFSAQPEHTSFWLSPQVQPFGNQLYSSTLLAKNTTNNLQGKNKGGSSAAAG KLLHRKASSQQHQKQLTSGGQPIFPIDFFEHCNMLADVEFGGNDLLQIYNKQKLKTRLFS TGMFVASTNVTGFTLEVVNNDPNVVMVGFRVMLGTQDIQRAPVSVTILGRTIPTTMRKAR WFDIPLTREEMFQSDKMLKVVFAKSQDPENVTLLDSIEVYGKSKELVGWPDDSEDVLAPS SGPTPVTATQQSAAANFGEGFNCITQLDRMVNHLLEVLDCALHLLGGSAVAAPLRSKVVK TASGLLLLPTPNPVQTQARYVLATLYGSRAAYHSFKDGVVLHFVHGELQAMQPKLQQLES LQEIDPEAFYRLILLVRGVANSRPQSLAKICLENSYDLVPDLMRIVLELHKITPDLDEPV NIVRRGLCQPETIVHCLVEIMYGFALADPGQVGRMTQYFIDLLKHDATVISHSAKEALIL LLSPRMKRRKVAAIAVITPSACSTPTPQMQALQAVAASAANDIIEEAAGVAAGQDQDNAA AVLLEAVEGGLPGQQPNQQLLNLEAFMGGGFPRLLGLPEDADDEAIMDIAIALSLQQHGG ADANALHSLQQGLANIQGIRQAAANAAAASVSVSVSAGGSDDEGSNVATDGSTLRTSPAE PAGSGGSESGGSGVESIGGTSARSSNFGDHPNTTPPRQSCSSVKDGEQGEEQQPGPSGSG GSASVPGGGLSAMSSTEDNNEINEDEKLQKLHDLRIAVLESIIQHLGTFDLCNGLQAIPL IQVIHMLTTDLNGNNERDQQVLQELLQALVEYVEIGKRGAASRMENKCPGNEVRLALLSL FGVMMGKTKSKQTGTTSPPHQFKDNSSFVASTTANVLSKSGAFVYALEALNTLLMHWKTV LGDPYAPGQAAAPTASGGATSGPGVQLLKPVKHGPKPDISILIPQNYLKNYPDIFESYDG LLTEIIVRLPYQILRLSSAHPDNYDSSFCEAMTFTLCEYMMLNLNTLLRRQVRKLLMYIC GSKEKFRMYRDGHSLDAHFRVVKRVCSIVSSKTGAPYNANPPMLNYDSLVDLTEHLRTCQ EISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVSPIIIQLLQAAVCNMPANKQQQQQ QPPPAVVSASSKLRSEREKSEDTDAYYSKFDPAQCGTFLHQIFRYACDALIIRFVRIFLL ENNISQLRWQAHSFMTGLFEHANERQREKLLNIFWNLWPLVPTYGRRTAQFVDLLGYLTL TTRSITERLPEFVSRAVEVLRAQNELLCKHPNAPIYTTLESILQMNGYYLESEPCLVCNN PEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTISKLIVRIADLKRTKMVRTINVYYNNR SVQAVVELKNRPALWHKARSVSLQSGQTELKIDFPLPITACNLMIEFADFFETVSGSSEN LQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCKYAKFDFSMYA RVCCAVDPIESAEDRVKTVLMIHTSLERADRIYHQLLTNKQLLELLIQKVAEHRINDRLV EDNMASVHSTSQVNKIIQLLAQKYCVESRASFEELSKIVQKVKACRSELVAYDRQQQDLP PSNLALVLGAENPTTNRCYGCALASTEQCLTLLRAMSYNYDCRMGLYSQGLVSELAEHNL RRGTPQIQNEVRNLLVVLTKDNAEACMHLLQLVTSRVKSALMGSIPLISLEAAVHQEMTL LEVLLSQDDFCWEYKLKVIFELFISNCKLPRGPVASVLHPCLRILQSLINPTISGSGSGG KPVSAIDLSSIKLPEGNTIDYRAWLNSDQNHEYLAWSNRMPISHHQQDAPVSTKLKSSKQ QQSAGTETPPKTKEAARAAYLGEKFGKRWRSNVLDKQRVTKPLVFNAEWIQPLLFNENSR FGRQLACTLLSGLARTHERKQQALNLLTSFLYHVGEAGEASTEYLALYRSIATESPWLQY LVLRGVLCKISSLLATEIAKVHCMEEHSLSSDLTLGFALRRYVELLWLFLECPNIRRTYK TRLLGPVLESYLALRSLVVQRTRHIDEAQEKLLEMLEEMTSGTEEETRAFMEILIDTVDK TRMNDIKTPVFIFERLYSIIHPEEHDESEFYMTLEKDPQQEDFLQGRMLGNPYPSGEMGL GPLMRDVKNKICTDCELIALLEDDNGMELLVNNKIISLDLPVKDVYKKVWLAEGGDRDAM RIVYRMRGLLGDATEEFVETLNNKSQEAVDTEQLFRMANVLADCNGLRVMLDRIGSLQRI SRQRELIQVLLKLFLICVKVRRCQEVLCQPEIGAINTLLKVLQMCLQSENDSIQSAVTEQ LLEIMETLLSKAASDTLDSFLQFSLTFGGPEYVSALISCTDCPNVRNNPSVLRHLIRVLA ALVYGNEVKMALLCEHFKDTLNFKRFDNERTPEEEFKLELFCVLTNQIEHNCIGGTLKDY IVSLGIVERSLAYITEHAPCVKPTLLRTDSDELKEFISRPSLKYILRFLTGLSNHHEATQ VAISKDIIPIIHRLEQVSSDEHVGSLAENLLEALSTDAATAARVQQVRDFTRAEKKRLAM ATREKQLDALGMRTNEKGQVTAKGSILQKIEKLRDETGLTCFICREGYACQPEKVLGIYT FTKRCNVEEFELKSRKTIGYTTVTHFNVVHVDCHTSAIRLTRGRDEWERASLQNANTRCN GLLPLWGPSVLETTFSASMTRHSSYMQESTQRCDISYTSSIHDLKLLLVRFAWERSFHDD AGGGGPQSNMHFVPYLLFYSIYMLLSSRSATRDSKTLLTYLTAPPSEKWLECGFEVEGPL YMITISLTLHSRELWNKHKVAHLKRMLAVAQARHVSPSVLCKALLAPADRQVKDYSVYKP YLMMWALIDMIYNFLFNLVTMPKEEAWPVSLFDYIRKNDEAMLKSTDGILHILTEELLPC TSFGEFCDVAGLLTLIEQPDSFIEDILASLPSTTSSS NT seq 16134 nt NT seq  +upstreamnt  +downstreamnt atgtcgtcccatagcggcgggatcgattggaactccgtaataaaagctttgcttttaagc cgcacgggcgcattaaacaaaaacgaagtagttaatttgctaaaagcaataaccagatgt gaacacgaatttttggacgatgaaggcagtttcgtaccattttacacggcctttgcggca ctggctgccgacaaacttatgcaaatcaaatcaatttgtcagacacagatatgccagctg cacgatgccacggcagtgcttattcgctttatactcttccgtctgccaaaagtgtcggtc tttgaatcgaaatggctattggcagccctcaaaatgctctgcgagggcagggagaatgct tcttcggctgtcgcacagttcgactacagtgccgtggctggggtggtgaggagctccaaa catccggaatcatccaacaagagtattatgtcaatggcaggtagcaccacaggtggtgct ggtgctggtggcagcaacgataaagagtcaccaaaattggagattaaacgctcgcgctcg gacctatcgtcggttatcctgcagcagctgttggcgccgctggagccgggaaagatgacc tgggtgccgctcagcgaagagatcactgactgcactgagcaacttttggcagccaatgtg gaggtgttccaggaggcaaatggcgtcgataccctgttggacatctgcgtgggcctgccc attctcagtcgctatcgcatgaagtacatggagacgataaatgctggcaaacccctctac ctgccactcacacaggcggaggccacaactgtgaaatcatcgatgaatcacatgctaaca gatctctcgattgtgggccaggcctatgctttgatagtcatgcagccgctgacaccgagc cgcatcgaaaagctttccatgtgcggcatctcggcgctgtacaatgctgttctcacctcg atagccaccagtgtcttgagcatgggtcaggcgagcagcgcgcagaaacaacagcaacaa cagacggctgctgcagcgtccaccagccagggcagtggcggtggcttgtccagtgtccag acaagcaaagatcacgacgaatttgaagaacaggctagcgggattgtaaacaaagccctc gaaatctattcgagcattggcgagatgttcaaatcctcggccaggatgtatatctatcag aaccatttgtgctacggcagctggctgctcatcagcggcatccagggagccatgggtgcc agtggcagtgcctcggcagaaacggcagcaaaagcgacagccgccacaaaagtagcatcc aaaacagagtcgattacagcgcccagtaccccaatagccagggtgaatctgttcaaagtc caacagggctttggagaattgaatgcagccattgccaatcacagcattaagctgctgtcc gaactgattgaggatctaaagattgaatccgcctgcggacagagcagtgtcacagatcct gaaacgctgccagagccagcgcaatttgatatcctgcagaactatacatcgctggagagg attgtgcgcgtcctaaacactgccacgctgcatcagctgttcacttttctggccaccgtg gcctaccgcaaggcatgcaccctgaagcgtgcctcaactaaagaccgcaccgaatgcgat ccgattagctattcggactcgacgacctgcctgaatgagtccatgtcctattcggacaac tctgaagaagatgacagcgaaagctatctggggcattggttcaaggaaaccctctccccg gaaacgcacgacgacaatgccaatacttcgtcgcaagagcgcagtggagagcagaagagc gctttggtaccgaaactagatgagccacacgagtatctggagctgtcggcagacatcttc tgcttcttggatcaattcctagccaaccgtcatgcctacatgcagcgctatgtgaaggca ggagtcagcgatcagcagatgctgctgatggccaacataatcaaggactttgatcgcgat gtgatgcgcaacgacagcgaacagcagtcgccaccaagtacggctgctgctgtggctgct gccacaggagctggatcttctggttcctctgccaagtggcaggcgtcgatgatacgtttc tcgggggctgctggtcgatacatacacaacctgatctccacgggactgctctccgagcag ctccaatcgaatctgctgcaacacttggccatctctccatggtccacggatacgaataca tggcccctacaggtctaccccagcacactttccgttcttgtgcagatactgctgctgaag cccacacaggagaaggaggccgcctgcttgtcggtgtggcatcgcctgatcaacacgctg gttgatggcgtctgctcctcttcgtctgccggtgactcggactacgaagatatcaacatt gagcatgcccagctgctgctctttctgttccactcgctcaatctcatgcaaaagaaatcc atcctgctgctaactgcaggcggggtgatacgctgcgccgaagtctgtcgcggcatcagt gtcgagcgtgtcgtcaggaatagccaaatgatgcttctatcgcgcttgctcgtattccta gagtatctgatgaagcatctgtatcacgcaccgcccgaactgttggatcaagtccgctgg atactgtttagcgtgagcagcatgccggagacgcagaaggtctccgatttgatcaacagt cgcaccaaactgaactcgtattgccgtcaggatattgaagagaagttccgcaagtcttca ggagaatatggatcgaatatacggcccacgttttatagcctggtcctaaaggagcccgaa aaagcctattgggtgagcgagttcaaattggacggcctggcctggaactttatactctgc acaccggacaaactcaagtatccactgctggtggacgccctcgtggatatcctgaacata gcggacatgtcctcgttttcccgaaaggagaacagcgagagcaacagcatacacaatctg tgtgccatgcagtattgttttaccaacacctggaaactgctgctgggcctgcccccatcc acctctcacgtggaggcgctgcgcattgagcgggcacccaatttgcattcgctggtgtgg agcacacgcctgcccttggccacgtcacattatctgattgtcaatagcctcataaagcag ggcatgtacacacagtacgcggagtcgttgtacacccaagtgggggataccacagccgat atacgatataatttgaagcaaacgatccttggtgtagaggccttcaatcagcagatgagt aacaaaggtattccacgcctctcggaactcatactctttgatgctttggtggcccacatg caggccgtggcctgggccgaaaaggagggcttcaagctgctgcgcaaggactgcgaggat agcagcggtggcgaccaatcatcgtgcaccagtgcggcttccagtagttgtggtggcaat gccacagaccatgatcatcccgaagtgtattcctccaacgaatccatcgatgaagagaaa tccaagcacgaggatgaccagggtttatccacggaaacgctggaacgcaatcaaatgatc aacgagctgctgatcaagctaatggactcgtatcgctacctatcggagattgtgcgcgag caaatgctcaagcagctgtcgagcaccacacccgagcatgtcctcaacttgatagtgcct attgtgagcgataagccggccataatgctggagctgcatgcggcattccttaagctgctt ccgaatgaggataagcaattgatagccaatgaatggcccaagtgtttgatggtcaatgat tcggccttcgatggaaaacagcatcccgtggagccatacaccttgaatgtgattgatgca cacattacagagctgaccagaggcagcggcggtgtggcctattccactttgcatacgctc aaacactgcctgaagacgatactccatttgatggagctgctgctgccctacgactccaat tgctgcgaaatggatgcccagttgaagccgctgctgattgcctcaatgctggacatgcgc accgactatctgcagggccagagcgaacagtgtctgagggaaatcttgagcggactgacc ctagaggcgcagaaactgttgctgtacgagcacatgattggctactgctatcgtatgctg atcgaatttgccgcagaattgcgacagccagcggcaggaggcaccccattggatcaggag agagccttgtttaatgaatccatgctgtttgctgtgctaaagacattcatcaagatgctg gagaagcccacagctgtgcaggccatgcgtcagttcttccatgaccagaagacgggcagt ttgatcacgctgctgctgtcctttacgggtaccacgctgcccctgagctatgcccgcaaa atgttgcagtttgtcgaacgtttgtttgagcaatccactcgagcggactcccagttccag catgaggacttggtggattgtttcagcgatctagccacagtcgatgtggcacgattgaag ctgtggttggcccacataatctatggcccaaatatgacggcaggcgatgtcagcaactcg gagaccatggatccgacatgcagactactcacgagcatcatgcagccttcgagcagctcc agtagcaatgcccagacacccacaaatatggccacagtgtcggctatgcccagcatctcc gatcagctggatgccatggacatagattacgactgcggggcaggagctgcacccaacact tcacagatcttgagcctgtggcaggcagcgcagccgaatccctcggaggagtcctcacag gcctgcgatcacagcgaagggggagagcagcgccaaagcgaacgcaatggaggactactg ctgtccatcaccaagtacctagtacgcgatcagagcaaggcaggacctatagcagcgccc ctattccaggcgctcctacagctgggtcagactttgataagtccgccccacgatggctgt gacttcgcggatgtcctacagataatgatcaccttggcggatgcctctccagcacgcgga cacgtggcgctgttcaatacgacgctgctgtggctggaactggccaaactgcagctcccc gacaagcatttgcgacacgcggaaaatgtgagcgccctactgcggtacctaagcgaattg ttgcagagcattggctaccgtggcagtcgccagcatatgcccccgtgggacgacgaactg cagacggacattgacgatctgtacgatgagctggccgaagaggagcaggactcgctgctg gatgactccgatgaggacacgctgaacaacaagctgtgcacattctcgcagacccaaaag gagttcatgaaccagcactggtaccactgtcacacctgcaacatgatcaacacggtcggc gtgtgctctgtgtgtgctcgggtgtgccacaaggggcacgatgtgagctatgccaagtac gggaacttcttctgcgactgtggagccaaagaggatggctcgtgtcaggcgttgagtcgc agattgggctctggagaggtacgcgagtcggtgggacctggcggcagcagcagctgcaac tacttgccctcgcacatgagtctcctggcgggtaagaagagaagcaacacagcatcagga gccacacagcagcagcagcagcacggagcgcctgcccgcaaggactcgatcagcagtgag agaatccagcttttggggaaactcctcgaaccctaccgtgagacgttgcagcatcaggaa caatggatgctcgtggtccgctgcatactcgagtactttgatgtgctgctgccttcgata agggagaactgcacgctctattcgattgtgggatgccacaggcgtgccactgccgccttg gagcgtctgcatcagctggagcagagtttccagatcaccgatcaactgatgttcgccact ctgggctcccaggagggggccttcgagaatgtgcggatgaattactccggagatcagggg cagaccatcaagcacttgctgacctctggcacgatacgccgcgtggccttttgttgcctg tcctcgccgcacggacgccgccagcagttggccgtgtcgcatgagaagggaaaggtcacc atactgcagctatcggcgttgctcaagcaggcagatgcatccaagcggaagttgactctc acgcaactcagctccgcgcccattgcctgcactgtgctctcgctggcggccaatccctgc aatgaggactgtctggccgtgtgtggactgaaagagtgccatgtgctgaccttttcgagc agcggcagcaccaatgaacacattgtcatcacgccccaattggagaatggcaacttcctg aagaaggccatgtggctgcctggctcccagactctgctggccattgtcaccacggattac gtgaagatctatgacctgtcggtggacacaatcagtccgaagtactactatctagtggct gtgggcaagatcaaggactgcacgttcatgtaccatcagcaggatggcagcgggagctat ttcatgctcagttttaccagctctggctacatctatacgcagcagctggatcagcagagc ctggccgtgcacggagacttttatgtgacaaataccctcgagttgagccatcagcatatc aaggatatcaatggacaggtttgcggcggtggtgtgtccatctattactcgcacgcgctg cagctgctcttctacagctacacctgcggcaggagcttctgttcgcccctgacgaacgta aacgagggtgtcaaaggcatctatcacttggacatcaacaacaccgcggcaacgacggcc agcaaatcatcgtcggcttcgaaggtgccgctccagtcgcttgtgggttggacagaggtg gccgggcatcccggactgatctatgccagcatgcatacgtccaataatccagtgatactg atgatcacacccgaacgcatatacatgcaggagatcaaggcacagtcggccaaatcgaga ataatggatgtggtgggcatacgccatagcgtggcggggaccgagaaaaccaccctactg ctcctgtgcgaagacggcagcctcaggatcttctcggcccagccagagcacacgagtttc tggctgtcgccgcaggtacaacctttcggcaatcaactgtacagctccacgctgctggca aagaataccacaaacaatctgcagggcaaaaacaagggaggcagctctgcagcggctgga aagctgctccatcgcaaggccagcagccaacagcaccagaagcaactgacatctggagga cagcccatcttcccgattgatttctttgagcattgcaacatgctggcggacgtggagttt ggcggcaacgatctcttgcagatctacaacaaacagaagctcaagacgcgcctcttctcc acggggatgtttgtggccagcacaaacgtcacgggattcacactggaggtggtgaacaac gatccaaatgtggtcatggtgggtttccgtgtgatgctgggcacccaggatatccaacgg gcacccgtatcagttacgatcctcggacgcaccatacccacaacgatgaggaaggcgcga tggtttgatatacccctgacgcgcgaggaaatgttccaatcggacaaaatgctgaaggtg gtgtttgccaagtcgcaggaccccgaaaatgtcacactcctggactctatcgaggtctat ggcaagtccaaggagctcgtgggctggcccgacgatagcgaagacgtactggcacccagc tctggtccgacgcccgtgacggccacgcaacagagtgccgccgccaattttggcgagggc ttcaattgcatcacccagctggatcgcatggttaaccatctgctggaggtcctggactgc gccctgcatctgctgggcggcagtgccgtggctgccccactgcgctcgaaggtcgtgaag acagccagcggactgctgctgctgcccacaccgaatcccgttcaaacccaggcccgctat gtgctggccaccctctatggcagtcgggcggcctatcacagcttcaaggatggcgtggtc ctgcatttcgtgcacggcgaactgcaggccatgcagccgaagctgcaacaactagaatct ctgcaagaaatcgatccggaggccttctatcgcctgatattgctggtacgcggcgtggcc aactcccgtccccagtcactggccaagatctgtctggagaacagctacgatttggtgccc gacctgatgaggatcgtcctggagctgcacaagatcacccccgatctggacgagccagtg aatattgtgagacgcggcctgtgccagccggagaccatcgtccattgtttggtggaaatt atgtatggctttgcattggccgatcccggtcaggtgggtcgcatgacccagtacttcatt gatctgctcaagcacgacgccaccgtgatcagtcacagtgccaaggaggcactgatcctt ctcctcagtccacgcatgaagcgccgcaaggtggcggccatagccgtcattacgccgtct gcctgctccacgcccacgcctcaaatgcaggccctgcaagcggtggctgcatcggcggcc aacgatatcatcgaagaggcagcaggcgtggctgccggacaggatcaagacaatgcagcg gccgtgctgctcgaggcagtggagggaggactccccggacagcagccgaaccagcagctg ctcaatctggaggcgttcatgggcggcggtttcccccgattgctgggtctacccgaagat gccgacgacgaggccatcatggacatagccattgccctgagtctccaacagcatggcgga gctgatgccaatgccctgcattctctgcagcagggattggccaatatccagggcatcaga caggcggcagccaatgctgcagcagctagtgtttcggtctctgtgtctgcgggaggctcc gatgatgagggctccaatgtggccaccgatggctccacgctgcgcacctcacccgcagag ccggcaggcagcgggggctccgagagcggtggcagtggtgtggagagcattggcggcaca tcggcgcgcagcagtaactttggcgatcatccgaatacaacgccaccgcgacagagttgc agttccgtcaaggatggagagcagggcgaggagcagcagccaggacccagtggctctggt ggctctgcctctgtcccaggaggcggcctgagcgccatgagcagcaccgaggacaacaac gagatcaacgaagatgaaaagctgcagaaactgcacgatttaaggattgctgttttggag agcattatccagcacttgggcacattcgatctgtgcaatggtctgcaggccataccgctc atccaggtgatacacatgctgaccacagatctcaatggcaacaacgaaagggaccagcag gtgctccaggagctgcttcaggctctagtggagtacgtggaaataggcaaacgtggagcg gcctcaaggatggagaacaaatgtcccggaaatgaagtacgccttgctctattgtccctc tttggtgtgatgatgggcaagaccaaatcgaagcaaacgggcaccacctccccgccacat cagttcaaggataacagctcatttgtggccagcaccacggcgaatgttctgagcaagagt ggggcctttgtctatgctttggaggcactcaatacgctgctcatgcactggaaaaccgtg ctaggggatccctatgcgccgggacaagccgcagcaccgaccgcgagtgggggagccact tcgggaccgggcgtacagctgcttaaacccgttaaacacggccccaaaccagatatatcc atactgataccgcagaactatctgaagaactatccagatatctttgagtcgtacgacgga ctgctcacggagatcattgtgcggctgccctaccagattctgcggctaagcagcgcccat ccggacaactacgacagcagcttctgtgaggccatgacctttaccctgtgcgagtacatg atgctcaatctgaatacactgctgcgaaggcaagtgcggaagctgctgatgtacatttgc ggcagcaaagagaagttccgcatgtaccgcgatggtcactcgttggatgcgcatttccgt gtggtcaagagagtgtgcagcattgtaagcagcaagaccggtgccccgtacaatgccaat ccgccgatgctcaactacgactcgttggtggatttgacagagcatctgcgcacctgccag gagatcagccaaatgcgcactggcaattggcaaaagttctgtgtggttcatgaggatgcc ttggccatgctaatggagattgcctgctatcagctagatgatggcgtgtcgcccattatt atacagctgctgcaggcggccgtttgcaatatgccagccaacaagcagcagcaacagcag cagccaccgccagcagtcgtgtcggcgtcttcgaagctgcgcagcgagcgtgagaaaagc gaggataccgacgcctactattcgaaattcgatccggcacagtgcgggacatttctccat cagatatttcgatatgcctgcgatgctttgatcatacgcttcgtaaggatcttcctgctg gagaataatatcagtcagctgcgctggcaggcgcactccttcatgacggggctgttcgag catgccaacgagcggcagcgcgagaagctgttgaacatattctggaacctgtggcccctg gtgcccacctatggccgaaggacagcacaatttgtggatctattgggatacctcactctg acaacacgcagcataaccgaacgcctgccagagtttgtctcgcgggcagtcgaagtactc cgggcacagaacgagctgctgtgcaagcacccgaatgcccccatctacaccaccttggag tcgatactgcagatgaacggatactatctggaatcggagccctgtttggtgtgcaacaac ccggaggtgccgatggccaacatcaagctgccgtcggtcaagtccgactcaaaatataca accacaacgatgatctacaagctggtgcagtgccacaccatctcgaagctgattgtgcgg attgcggatctaaagcgcacgaagatggtgcgcacgatcaatgtgtactacaacaatcgc agtgtccaggcggtggtcgagctgaagaaccgccctgcgctgtggcacaaggcacgctcc gtttcgctgcaatcgggacagacagagctgaagattgattttccattgcccatcacggcc tgcaatctgatgattgaatttgcggacttctttgagactgtgagcggttccagcgagaat ctgcagtgtccgcgctgcagtgccgctgtgccagcgtatccgggcgtgtgcggcaactgc ggggagaatgtgttccagtgccacaagtgtcgggccatcaactatgacgaaaaggatccg ttcttgtgccactcgtgtggcttctgcaagtacgccaaattcgattttagcatgtatgca cgcgtctgctgtgccgtggatccgatcgaatcggccgaggatcgagtcaagactgtattg atgatacacacctcactggagcgtgcggatcgcatctaccaccagctgctgaccaacaaa cagctgctcgagctgctcatccagaaggtggccgagcatcgcatcaatgatcgtcttgtt gaggacaacatggccagtgtgcatagcacttcgcaggtgaacaagatcatccagctgctg gcccagaaatactgcgtggaatcacgcgccagcttcgaggaactaagcaagattgtccag aaagtcaaagcctgtcgcagcgagctggtggcctacgatcgccagcaacaggatctgccg cccagcaatctggctttggtcttgggcgccgagaatcccacaacgaaccgttgctatggc tgcgccttggcctccaccgagcagtgtcttaccctcctgcgggctatgtcctacaattat gactgtcgcatgggtctctatagccagggactggtcagcgagctggcggaacataatctg cgccgtggaacaccgcagatccagaacgaggtgcgcaatctgctggtggtgttgaccaag gacaatgccgaggcgtgcatgcatctgctgcagctggtcacgtcgcgtgtgaagagcgct ttgatggggtccattcccctgattagtctggaggcagccgtgcatcaggagatgacgctg ctggaggtgcttctcagccaagacgatttctgctgggaatacaagctaaaggtgatcttt gagctgtttatcagcaattgcaagttgccccgtggaccggtggcttcagtgctgcatccc tgcctgcgtattctgcagagtctgattaatcccacgatctctggcagcggcagcggcggc aagccagtatctgccattgatttgagcagcattaaactgcccgaaggcaacaccatcgac tatcgggcgtggctcaactcggatcagaatcacgagtacttggcctggagcaatcgcatg cctatcagccaccaccaacaggatgcaccggtatccaccaagctaaagagcagtaaacag cagcagtcggcgggcacggagacaccgccaaaaaccaaggaagccgccagggcggcatat ctcggcgagaagtttggcaaacgctggcgttcgaatgtgctggacaagcagcgtgtgacc aagccgctggtgttcaatgccgagtggatccaaccgttgctcttcaacgaaaactcccgc tttggccggcaactggcgtgcacgctgctaagcggactggcacgcacgcacgaacgcaag cagcaggccctcaatttgctcacgtccttcctgtatcatgtgggggaggcgggagaggcc agcaccgagtatttggctctctaccggagcattgccaccgagtcgccctggctgcagtat ttggtgctgaggggagtgctgtgcaagatctcgtcgctgctggctacggagatagccaaa gtgcattgcatggaagagcattcgctgtcctcggacctgacgctcggctttgccctgcgc cgatatgtggagctcttgtggctcttcctcgagtgccccaacatacgcaggacctacaag acccgtctgctgggccccgtgctcgagagctacttggctctgagaagtctggtggttcag cgcacccgacacattgacgaggcgcaggagaagctgctcgaaatgctggaggagatgacc agcggcaccgaagaagagacgcgtgcctttatggagattctcattgatacggtggacaag acgcgcatgaatgacatcaagacgccggtgtttatctttgagcgtctgtattcgatcata catccggaggagcacgacgagagcgagttctacatgaccctggagaaggatccacagcag gaggacttcctgcagggtcgcatgctcggcaatccctatccctcgggtgaaatggggctg ggccccctgatgcgagatgtaaagaacaaaatctgcacggactgtgaattgattgccctg ctggaggatgacaacggcatggagctgctggtgaacaataagatcattagcttggacctg cccgtcaaggatgtgtacaaaaaggtgtggctggccgagggcggcgatcgcgatgccatg cgtattgtctatcgcatgcgcggactgctgggcgatgccaccgaggagtttgtcgagacg ctgaacaacaagagtcaggaggcggtggacacagagcagctattccgcatggccaacgta ctggccgattgtaatggccttcgtgtgatgctggacaggattggcagtctgcagagaatc tcccgccagcgtgaacttatccaggttctgctcaagctcttcctgatctgtgtaaaagtg cgccgctgccaggaggtcctgtgccagcccgagattggggccattaatacactgctgaag gtgctacagatgtgtctgcaatcggagaatgattccatacagtcggcagtcaccgaacaa ctgctggagattatggaaacgctgctctcgaaggcagccagtgatacgctggactcgttc ctgcagttctccctgacgttcggagggcccgagtatgtgtcggcattgatctcctgcacg gattgtccgaatgtacgcaacaatccttcggtgttgcggcatctcattcgtgtgctggcc gccctggtctacgggaatgaggttaagatggccctgctgtgtgagcatttcaaggacaca ctcaacttcaaacgctttgacaacgaacgcacacccgaggaggagttcaagcttgagctc ttctgcgtcctgaccaatcagatcgagcacaattgcattgggggcaccctcaaggattac attgtaagtctgggcattgtggagcgctcgttggcctacatcacagagcatgccccatgt gtgaagcccacactcctgcgcaccgactccgacgagctgaaggagttcatttcgcgccct agtctcaaatatattctgcgcttcctaaccggcctctccaatcatcacgaggccactcag gtggccatcagcaaggacattataccgattatacatcggctggagcaagtgtccagcgat gagcatgtcggcagtctggccgagaatcttctagaggctttgtcaaccgatgcagccacc gcggcccgagtccagcaagtgcgtgacttcacgcgcgctgaaaagaaacgtctggccatg gccacgcgcgagaaacaactggatgctttgggtatgcgtacgaacgagaagggacaggtg acggcaaagggctctatactgcaaaagatcgagaaactgcgcgacgagacagggctgacg tgtttcatctgccgcgagggatatgcctgccagcccgaaaaggtgctgggcatctatacg ttcaccaagcgctgcaacgtggaggaattcgagctgaagtcgcgcaaaaccattggctac accacggtgacccatttcaatgtggtccatgtggactgtcacacctcagcgattcgtttg acccgcggccgcgatgaatgggagcgggctagtctgcagaatgccaatacccgatgcaat ggcctgctgccgctctggggtccgtccgtgctcgagacgaccttctccgcttcgatgacg cgtcacagcagctacatgcaggagagcacccagcgttgcgacatctcctacacgagcagc atacacgacctgaagctgctgctggtgcgtttcgcctgggagcgtagcttccacgatgat gccggcggcggtggtccccagtccaatatgcactttgtgccctacctcctcttctattcg atctacatgctgctgtcctcgcgctcggcgaccagggatagcaagacgttactcacctat ctgacagccccgcccagcgagaagtggctcgagtgtggcttcgaggtggagggaccgctg tacatgatcaccatttcgttgacgctgcacagtcgcgagctgtggaacaagcacaaggtg gcgcatctgaaacgaatgctggccgtggcccaggcacggcacgtctcaccatcggtgctg tgcaaggctctgcttgcgccggccgatcgccaggtgaaggattacagtgtgtacaaaccg tacctgatgatgtgggccctgatcgatatgatatacaacttcctgttcaatttggtgacc atgcccaaggaggaggcctggccggtttccctgttcgattacatacgcaaaaatgacgag gctatgcttaagtcaacagatggcatcctacacatcctgactgaggagctattgccgtgc acttcgtttggcgagttctgcgatgtggcaggacttctaactctgatcgaacagccggac agcttcatcgaggatatcctggcctccctaccttcgaccacaagttctagttaa

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