KEGG   Dasypus novemcinctus (nine-banded armadillo): 101444276
Entry
101444276         CDS       T07872                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
dnm  Dasypus novemcinctus (nine-banded armadillo)
Pathway
dnm00562  Inositol phosphate metabolism
dnm01100  Metabolic pathways
dnm01521  EGFR tyrosine kinase inhibitor resistance
dnm01522  Endocrine resistance
dnm01524  Platinum drug resistance
dnm04012  ErbB signaling pathway
dnm04014  Ras signaling pathway
dnm04015  Rap1 signaling pathway
dnm04024  cAMP signaling pathway
dnm04062  Chemokine signaling pathway
dnm04066  HIF-1 signaling pathway
dnm04068  FoxO signaling pathway
dnm04070  Phosphatidylinositol signaling system
dnm04071  Sphingolipid signaling pathway
dnm04072  Phospholipase D signaling pathway
dnm04081  Hormone signaling
dnm04140  Autophagy - animal
dnm04150  mTOR signaling pathway
dnm04151  PI3K-Akt signaling pathway
dnm04152  AMPK signaling pathway
dnm04210  Apoptosis
dnm04211  Longevity regulating pathway
dnm04213  Longevity regulating pathway - multiple species
dnm04218  Cellular senescence
dnm04360  Axon guidance
dnm04370  VEGF signaling pathway
dnm04380  Osteoclast differentiation
dnm04510  Focal adhesion
dnm04550  Signaling pathways regulating pluripotency of stem cells
dnm04611  Platelet activation
dnm04613  Neutrophil extracellular trap formation
dnm04620  Toll-like receptor signaling pathway
dnm04625  C-type lectin receptor signaling pathway
dnm04630  JAK-STAT signaling pathway
dnm04650  Natural killer cell mediated cytotoxicity
dnm04660  T cell receptor signaling pathway
dnm04662  B cell receptor signaling pathway
dnm04664  Fc epsilon RI signaling pathway
dnm04666  Fc gamma R-mediated phagocytosis
dnm04668  TNF signaling pathway
dnm04670  Leukocyte transendothelial migration
dnm04722  Neurotrophin signaling pathway
dnm04725  Cholinergic synapse
dnm04750  Inflammatory mediator regulation of TRP channels
dnm04810  Regulation of actin cytoskeleton
dnm04910  Insulin signaling pathway
dnm04914  Progesterone-mediated oocyte maturation
dnm04915  Estrogen signaling pathway
dnm04917  Prolactin signaling pathway
dnm04919  Thyroid hormone signaling pathway
dnm04923  Regulation of lipolysis in adipocytes
dnm04926  Relaxin signaling pathway
dnm04929  GnRH secretion
dnm04930  Type II diabetes mellitus
dnm04931  Insulin resistance
dnm04932  Non-alcoholic fatty liver disease
dnm04933  AGE-RAGE signaling pathway in diabetic complications
dnm04935  Growth hormone synthesis, secretion and action
dnm04960  Aldosterone-regulated sodium reabsorption
dnm04973  Carbohydrate digestion and absorption
dnm05010  Alzheimer disease
dnm05017  Spinocerebellar ataxia
dnm05020  Prion disease
dnm05100  Bacterial invasion of epithelial cells
dnm05132  Salmonella infection
dnm05135  Yersinia infection
dnm05142  Chagas disease
dnm05146  Amoebiasis
dnm05160  Hepatitis C
dnm05161  Hepatitis B
dnm05162  Measles
dnm05163  Human cytomegalovirus infection
dnm05164  Influenza A
dnm05165  Human papillomavirus infection
dnm05166  Human T-cell leukemia virus 1 infection
dnm05167  Kaposi sarcoma-associated herpesvirus infection
dnm05168  Herpes simplex virus 1 infection
dnm05169  Epstein-Barr virus infection
dnm05170  Human immunodeficiency virus 1 infection
dnm05171  Coronavirus disease - COVID-19
dnm05200  Pathways in cancer
dnm05203  Viral carcinogenesis
dnm05205  Proteoglycans in cancer
dnm05206  MicroRNAs in cancer
dnm05207  Chemical carcinogenesis - receptor activation
dnm05208  Chemical carcinogenesis - reactive oxygen species
dnm05210  Colorectal cancer
dnm05211  Renal cell carcinoma
dnm05212  Pancreatic cancer
dnm05213  Endometrial cancer
dnm05214  Glioma
dnm05215  Prostate cancer
dnm05218  Melanoma
dnm05220  Chronic myeloid leukemia
dnm05221  Acute myeloid leukemia
dnm05222  Small cell lung cancer
dnm05223  Non-small cell lung cancer
dnm05224  Breast cancer
dnm05225  Hepatocellular carcinoma
dnm05226  Gastric cancer
dnm05230  Central carbon metabolism in cancer
dnm05231  Choline metabolism in cancer
dnm05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
dnm05415  Diabetic cardiomyopathy
dnm05417  Lipid and atherosclerosis
dnm05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dnm00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101444276 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101444276 (PIK3CA)
   04014 Ras signaling pathway
    101444276 (PIK3CA)
   04015 Rap1 signaling pathway
    101444276 (PIK3CA)
   04370 VEGF signaling pathway
    101444276 (PIK3CA)
   04630 JAK-STAT signaling pathway
    101444276 (PIK3CA)
   04668 TNF signaling pathway
    101444276 (PIK3CA)
   04066 HIF-1 signaling pathway
    101444276 (PIK3CA)
   04068 FoxO signaling pathway
    101444276 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    101444276 (PIK3CA)
   04072 Phospholipase D signaling pathway
    101444276 (PIK3CA)
   04071 Sphingolipid signaling pathway
    101444276 (PIK3CA)
   04024 cAMP signaling pathway
    101444276 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    101444276 (PIK3CA)
   04152 AMPK signaling pathway
    101444276 (PIK3CA)
   04150 mTOR signaling pathway
    101444276 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101444276 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101444276 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    101444276 (PIK3CA)
   04218 Cellular senescence
    101444276 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101444276 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    101444276 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101444276 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101444276 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    101444276 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    101444276 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    101444276 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    101444276 (PIK3CA)
   04660 T cell receptor signaling pathway
    101444276 (PIK3CA)
   04662 B cell receptor signaling pathway
    101444276 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    101444276 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    101444276 (PIK3CA)
   04670 Leukocyte transendothelial migration
    101444276 (PIK3CA)
   04062 Chemokine signaling pathway
    101444276 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101444276 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    101444276 (PIK3CA)
   04929 GnRH secretion
    101444276 (PIK3CA)
   04915 Estrogen signaling pathway
    101444276 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    101444276 (PIK3CA)
   04917 Prolactin signaling pathway
    101444276 (PIK3CA)
   04926 Relaxin signaling pathway
    101444276 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    101444276 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    101444276 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101444276 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101444276 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    101444276 (PIK3CA)
   04722 Neurotrophin signaling pathway
    101444276 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101444276 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    101444276 (PIK3CA)
   04380 Osteoclast differentiation
    101444276 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    101444276 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    101444276 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101444276 (PIK3CA)
   05206 MicroRNAs in cancer
    101444276 (PIK3CA)
   05205 Proteoglycans in cancer
    101444276 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    101444276 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    101444276 (PIK3CA)
   05203 Viral carcinogenesis
    101444276 (PIK3CA)
   05230 Central carbon metabolism in cancer
    101444276 (PIK3CA)
   05231 Choline metabolism in cancer
    101444276 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101444276 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101444276 (PIK3CA)
   05212 Pancreatic cancer
    101444276 (PIK3CA)
   05225 Hepatocellular carcinoma
    101444276 (PIK3CA)
   05226 Gastric cancer
    101444276 (PIK3CA)
   05214 Glioma
    101444276 (PIK3CA)
   05221 Acute myeloid leukemia
    101444276 (PIK3CA)
   05220 Chronic myeloid leukemia
    101444276 (PIK3CA)
   05218 Melanoma
    101444276 (PIK3CA)
   05211 Renal cell carcinoma
    101444276 (PIK3CA)
   05215 Prostate cancer
    101444276 (PIK3CA)
   05213 Endometrial cancer
    101444276 (PIK3CA)
   05224 Breast cancer
    101444276 (PIK3CA)
   05222 Small cell lung cancer
    101444276 (PIK3CA)
   05223 Non-small cell lung cancer
    101444276 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101444276 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    101444276 (PIK3CA)
   05161 Hepatitis B
    101444276 (PIK3CA)
   05160 Hepatitis C
    101444276 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    101444276 (PIK3CA)
   05164 Influenza A
    101444276 (PIK3CA)
   05162 Measles
    101444276 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    101444276 (PIK3CA)
   05163 Human cytomegalovirus infection
    101444276 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101444276 (PIK3CA)
   05169 Epstein-Barr virus infection
    101444276 (PIK3CA)
   05165 Human papillomavirus infection
    101444276 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101444276 (PIK3CA)
   05135 Yersinia infection
    101444276 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    101444276 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101444276 (PIK3CA)
   05142 Chagas disease
    101444276 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101444276 (PIK3CA)
   05017 Spinocerebellar ataxia
    101444276 (PIK3CA)
   05020 Prion disease
    101444276 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101444276 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    101444276 (PIK3CA)
   05415 Diabetic cardiomyopathy
    101444276 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101444276 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    101444276 (PIK3CA)
   04931 Insulin resistance
    101444276 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101444276 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101444276 (PIK3CA)
   01524 Platinum drug resistance
    101444276 (PIK3CA)
   01522 Endocrine resistance
    101444276 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dnm04131]
    101444276 (PIK3CA)
Enzymes [BR:dnm01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101444276 (PIK3CA)
Membrane trafficking [BR:dnm04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101444276 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 101444276
NCBI-ProteinID: XP_004479033
Ensembl: ENSDNOG00000014019
LinkDB
Position
Unknown
AA seq 791 aa
MLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIK
ILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLP
RAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLN
PIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSISREAGFNYSHAGLSNRL
ARDNELRENDKEQLRAICTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSR
DEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQ
VLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGM
YLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNP
AHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQII
RIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTL
HQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHF
LDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANL
FINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDW
IFHTIKQHALN
NT seq 2376 nt   +upstreamnt  +downstreamnt
atgcttggaaggatgcccaatttgatgttgatggctaaagaaagcctctactctcaacta
ccaatggattgttttacaatgccatcttattccagacgcatctccacagctacaccatat
atgaatggagaaacatctacaaaatctctttgggttataaatagtgcactcagaataaaa
attctttgtgccacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgc
acaggtatctaccatggaggagaacccttatgtgacaatgtgaacacccagagagtacca
tgttctaatcccaggtggaatgaatggctgaattatgatatatacattcctgatcttcct
cgtgctgctcgactttgcctttccatttgttctgttaaaggtcgaaagggtgctaaagag
gaacactgtccactggcctggggaaatataaacctgttcgactacacagatactctggta
tctggaaaaatggctttgaatctttggccagtacctcatggattagaagatttgctgaac
cctattggtgttactgggtcaaatccaaataaagaaactccatgtttagagctggagttt
gactggttcagcagtgtggtaaagtttccagatatgtcagtgattgaagaacatgccaat
tggtctatatcccgagaagcaggatttaattattcccatgcaggactgagtaacagacta
gctagagacaatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacga
gatcctttatctgaaatcactgagcaagaaaaagattttctgtggagccacagacactat
tgtgtaactattcctgaaattctacccaaattgcttctgtcagttaaatggaattctaga
gatgaagtagcccagatgtactgcttggttaaagattggccaccaatcaaacctgaacaa
gctatggagcttctggactgtaattacccagatcctatggttcgaggttttgctgtaaga
tgcttagaaaaatatttgacagatgacaaactttctcagtatctaattcagctagtacag
gtcctaaaatatgaacaatacttggataacctgcttgtgaggtttttactcaagaaagca
ctgactaatcaaaggattggacattttttcttttggcatttaaaatctgagatgcacaat
aaaacagttagtcagaggtttggcctgcttttggaatcctattgtcgggcatgtggaatg
tatttgaagcatctgaataggcaagtcgaggctatggaaaagctcattaacttaactgac
attctcaaacaagagaagaaagatgaaacacaaaaggtacaaatgaagtttctagttgag
caaatgaggcgaccagattttatggatgctcttcaaggctttctttctcctctaaaccct
gctcatcagctaggaaatctcaggcttgaagagtgccgaattatgtcctctgcaaaaagg
ccactgtggttgaattgggagaatccagacatcatgtcagagttactgtttcagaacaat
gagatcatctttaaaaacggggatgatttacggcaagatatgctaacacttcaaattatt
cgcattatggaaaatatctggcaaaatcaaggtcttgatcttcggatgttaccttatgga
tgtctgtcaattggtgactgtgtgggactgattgaggtagtgagaaattctcacactatc
atgcaaattcagtgcaaaggtggcctaaaaggtgctttgcagttcaacagccacacacta
catcagtggctcaaagacaagaacaaaggagaaatatatgatgcagccattgatttgttt
acacgttcatgtgctggatattgtgttgccaccttcattttgggaattggagatcgtcac
aatagtaacatcatggtcaaagatgatggacaactgtttcatatagattttggacacttt
ttggatcataagaagaaaaaatttggttataaaagagaacgtgtgccgtttgttttgaca
caagatttcctaatagtgattagtaaaggtgcccaagaatgcacaaagacaagagaattt
gagaggtttcaggagatgtgttacaaggcttatctagctattcggcagcatgccaatctc
ttcattaatcttttctcaatgatgcttggctctggaatgccagaactacaatcttttgat
gatattgcatacattcgaaagaccctagccttagataaaactgagcaagaggctttggaa
tatttcatgaagcaaatgaatgatgcacatcatggtggctggacaacaaaaatggattgg
atcttccacacaattaagcagcatgctttgaactga

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