Dipodomys ordii (Ord's kangaroo rat): 105980376 Help Entry 105980376         CDS       T07834                                  Symbol Ryr2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism dord  Dipodomys ordii (Ord's kangaroo rat) Pathway dord04020   Calcium signaling pathway dord04024   cAMP signaling pathway dord04260   Cardiac muscle contraction dord04261   Adrenergic signaling in cardiomyocytes dord04371   Apelin signaling pathway dord04713   Circadian entrainment dord04911   Insulin secretion dord04921   Oxytocin signaling pathway dord04972   Pancreatic secretion dord05020   Prion disease dord05022   Pathways of neurodegeneration - multiple diseases dord05410   Hypertrophic cardiomyopathy dord05412   Arrhythmogenic right ventricular cardiomyopathy dord05414   Dilated cardiomyopathy dord05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:dord00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105980376 (Ryr2)    04020 Calcium signaling pathway     105980376 (Ryr2)    04024 cAMP signaling pathway     105980376 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     105980376 (Ryr2)    04921 Oxytocin signaling pathway     105980376 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     105980376 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     105980376 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     105980376 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     105980376 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     105980376 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     105980376 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     105980376 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     105980376 (Ryr2)    05414 Dilated cardiomyopathy     105980376 (Ryr2)    05415 Diabetic cardiomyopathy     105980376 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dord04040]     105980376 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:dord04990]     105980376 (Ryr2) Ion channels [BR:dord04040]  Voltage-gated cation channels   Ryanodine receptor    105980376 (Ryr2) Domain-containing proteins not elsewhere classified [BR:dord04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    105980376 (Ryr2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  105980376 NCBI-ProteinID:  XP_012864681 Ensembl:  ENSDORG00000005086 UniProt:  A0A1S3EK00 LinkDB All DBs Position Unknown AA seq 4988 aa AA seqDB search MLMLKPCAYMNTVFHSYPATSKNALSSYTSAESGVLTVSFSSSSLQDDEVVLQCTATIHK EQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLDQSLSVRALQEMLANTMEKSE GQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQ EDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGTGLHVDAAFQQTL WSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHA RSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGRYLSLLEDKNLLLMDKEKADVKSTAFTF RSSKEKLDVGIRKEVDGMGTSEIKYGDSVCFIQHVDTGLWLTYQSVDVKSARMGSVQRKA IMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKAPSVDLPIES VSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGVISLVLECIDRLHVYSSA AHFADVAGREAAQSWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGI LEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHL ICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEAT HLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLQLWAGCVARTVSSPNQHLLRT DDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEF KFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPVPVDTSQ IVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNY NLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPS QEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLR EAVRTLLGYGYSLEAPDQDHAARNEAGSGPGERFRIFRAEKTYAVRAGRWYFEFEAVSAG DMRVGWSRPGCQPDLELGSDERAFAFDGFKAQRWHQGNEHYGRAWQAGDVVGCMVDMNEH TMVFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVGQVGRMNFGKDVSTLKYFTICG LQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTTDSSPCLKVTQKSFG SQNSTSDIMFYRLSMPIECAEVFSKTVPGGLSGAGLFVPKNDLEDYDTDSDFEVLMKTAH GHLVPDRIDKDKEATKSEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLA DDRDDYEYLMNTSTYYYSVRIFPGQEPANVWVGWITSDFHQHDPGFDLDRVRTVTVTLGD EKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYY QVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFL SHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELL RFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRTGYYDLLIDIHL SSYATARLMMNNEFIVPMTEETKTITLFPDENKRHGLPGIGLSTSLRPRMRFSSPSFVGV SSECYQYSPEFPLDILKAKTIQMLTEAVEEGSLHARDPVGGTTEFLFVPLIKLFYTLLIM GLFHNEDLKHILQLIEPRVFKEAATLEEDGDRQEKELSAEDSRLEGAGEDEAKVGMRPKE GLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQAL NMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIEL DEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVASDATKSSSLQQLISETMVRWAQ ESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLS VRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPK MVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNN ELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGE SVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSRT LDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGD LVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVG FLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHT VYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLT NHYERCWKYYCLPGGWGNFGTTSEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSA VAGALPPDYMESNYVNLMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDK WSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRVER TREGDSMALYNRTRRISQTSQVSVDTAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNI WAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLE LDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLI DQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFESVMRTVMK TGLDSVKSALRAFLDNAAEDLEKTIENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSS LFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGGCLAAFAGAFP VAFLETHLDKHNIYSIYNTKSSRERAALSLPANVEDVCPNIPSLEKLMEEIVELAESGIR YTQMPHVMEVVLPMLCSYMSRWWEHGPENNPERAEACCTALNSEHMNTLLGNILKIIYNN LGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGD MSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWS KSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIV AALKRLLPVGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRTNIHLQGKLEDPAIRWQ MALYKDLPNRTEDASDPERTVERVLDIANVLFHLEQKSKYTGRRYYSLGKHPQRSKKAVW HKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKP GAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDG EEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATL KLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGM VTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNMTVNIIISTVDYLL RVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSR LWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQM VDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYT QSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQTFL ELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNE GGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSASKEEGDKERPEDEGPRMSFFSLL TLRSALLALRYNVLTLMRMLSLKSLKKQVKKAKKMTLGDMLAAFFSSYWGVFLTLLHFVA SVCRGFFRIVCSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDAEDGERRPPETALP SEDLMDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLGDLMANPTPVPDMQEKL QEQKAKEEKEEKEEIKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF WKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSPSE NTHVAISLDSSTPHIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVI FKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGE FYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSF LYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVY LYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEY EIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFD TVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFR KQYEDQLN NT seq 14967 nt NT seq  +upstreamnt  +downstreamnt atgctgatgctgaagccgtgtgcttacatgaacaccgtgtttcacagttacccagctaca tcaaagaatgcattatcctcgtacacttcagccgagtcgggggtcctcactgtttccttc tcctcctcttctttgcaggatgacgaggtggtcctgcagtgcactgccaccattcacaaa gagcagcagaagctgtgcttggcggccgaaggctttggcaacagactgtgcttcctggag tccacatccaattccaagaatgtccccccagacctgtccatctgcacctttgtcctggac cagtccctgtccgtgcgtgccctgcaagagatgctggccaacaccatggagaaatcggaa gggcaagttgatgtggaaaaatggaaattcatgatgaagacagctcagggtggtggccat cggaccctcctctatggacacgccatattgctccgccactcctacagtggcatgtatttg tgctgtctgtcaacctcccggtcctcaactgacaagctggcttttgacgtgggcttgcaa gaggataccacaggtgaggcgtgctggtggaccatccaccccgcctccaagcagcggtca gaaggagagaaggtccgcgtgggagatgacctcatcttggtcagcgtgtcctcggagagg tacttgcacttgtcctacggcaccggcttgcacgtggacgcggccttccagcagactctg tggagcgtggcccccatcagctcaggaagcgaagccgcccaagggtacctcatcggtggt gatgtcctccggctgctccatggccacatggatgagtgcctcactgtcccctctggagag cacggggaagagcagaggagaactgtccattatgaaggtggagctgtatctgttcacgca cgctccctttggagactagagacgctaagagttgcgtggagcgggagccacatccgatgg ggccagcccttccggcttcgccacgtcaccaccggcaggtacttaagtctcctggaggac aaaaacctgctgctcatggacaaagaaaaagctgatgtgaaatcaacagcatttaccttc cggtcttccaaggaaaaattagatgttggaataagaaaagaagtcgatggcatgggcacg tcagaaataaaatacggggactctgtctgcttcatccagcacgttgacacaggcctgtgg ctcacctaccagtctgtggatgtgaaatccgcaagaatgggatccgtccagcgcaaggct attatgcaccatgaagggcacatggatgatggcttaaatttatccagatctcagcacgag gaatctcgcacggctcgggtcatccgcagcaccgtcttcctcttcaataggtttataagg ggcctcgatgctctgagcaagaaagccaaggcacccagcgtggacttgcccatcgagtca gtaagcctgagtctgcaggacctcatcggctacttccaccccccggatgagcacctggag cacgaggacaagcagaaccgactgcgagccctaaagaaccggcagaacctcttccaggag gagggggtgatcagcctggtgctggagtgcatcgaccggctgcacgtctacagcagcgct gcgcactttgctgacgtggctgggagagaagcagcccagtcctggaagtccattctcaac tctctctacgaactgctggctgccctcattagaggaaatcgcaagaactgtgctcagttt tctggttccctggactggctcatcagcagactggaaagactagaagcttcctcaggcatt cttgaagtgctacattgtgtgctcgtggaaagccctgaagcactaaatataattaaagaa ggacacatcaaatccatcatctcacttttagataagcacggaagaaaccacaaagtcctg gatgtcctgtgctcgctctgtgtgtgccatggggtcgctgtgcgatcgaaccagcacctc atctgtgacaatctcctgccaggaagagacctgttgttgcagacccgtctggtgaatcat gtcagcagcatgaggcccaatatcttcctgggcgtcagcgaaggatccgctcagtataag aaatggtactatgagctcatggtggaccacacggaacccttcgtgacggccgaggccacc cacctgcgggtgggctgggcttccaccgaaggctactccccctaccccggagggggcgag gagtggggcggcaatggagtcggcgacgacctcttctcctacgggttcgatggccttcag ctctgggcaggttgcgtggcccggacagtcagctcccccaaccagcacctcctgaggact gacgatgtcatcagctgctgtttggatctgagcgcccccagcatctctttccgcatcaac ggacaacctgttcaagggatgtttgagaatttcaacatcgacggcctcttctttcccgtg gtcagcttctctgcaggcatcaaggtgcgttttctgctaggagggcgacatggagaattt aaattcctccctccacccgggtatgcgccttgttatgaagctgttcttccaaaagaaaaa ttgaaagtggagcacagcagagaatacaagcaagaaaggacgtacacgcgagacctgctg ggccccaccgtctccctcacccaggccgccttcacccccgttcctgtggacaccagtcag atcgttttacctcctcacctcgaaaggatcagagaaaagctggcggagaatatccatgag ctctgggttatgaataaaattgaacttggctggcagtatggtccggtcagagatgataat aagagacagcacccgtgcctggtggagttctgcaagctgcccgaacaggaacgcaattac aatttgcagatgtcccttgagaccctgaagaccttgctggctctggggtgtcacgtgggg atagcagatgaacatgcggaagaaaaggtgaagaagatgaagcttcccaagaattaccag ctgacgagtggttacaagcccgcacccatggacttgagcttcataaagctcaccccctct caggaagcgatggtggacaagttggcagaaaatgctcacaacgtgtgggcccgggatcga atccggcagggctggacatacggcatccagcaggatgtaaagaacaggaggaatccccgc ctggtgccctatgccctcctggatgaccggaccaaaaaatccaacaaggacagcctccgg gaggcggtgcgcacgttgctgggctacggctacagcctggaggccccggaccaggaccac gcagcccgcaatgaggcgggcagtggccccggcgagcggttccgcatcttccgtgcggag aagacgtatgctgtgcgcgccgggcgctggtactttgagttcgaggccgtgtcggccggg gacatgcgcgtgggctggagccggccaggctgccagcccgacctggagctcggctccgac gagcgcgccttcgccttcgatggcttcaaggcccagcggtggcaccagggcaatgagcac tacggccgcgcgtggcaggctggggatgtggtgggctgcatggtggacatgaacgagcac accatggtgttcacactcaacggggagatcctgctggacgactcaggctctgagttggcg ttcaaggacttcgacgtgggcgatggattcattcctgtatgtagccttggagtgggacag gtgggcaggatgaacttcggaaaggacgtcagcaccttgaaatacttcaccatctgtggc ttgcaggagggctatgagccattcgctgttaacacaaacagggacatcaccatgtggctg agcaagagactgcctcagtttctacaggttccatccaaccatgagcacattgaggtgacc aggatagatggcaccacggacagctccccgtgcctgaaggttacccagaagtcctttggc tctcagaacagcacctcagacatcatgttttaccgcctgagcatgcccattgagtgcgct gaggtcttctccaagacggtgcccggggggctctcaggcgctggcctctttgtgcccaag aatgatctggaagactacgacacggattctgactttgaggttctcatgaagacggctcac ggccatctcgtgcctgaccgcattgataaagacaaagaagccacaaagtctgagtttaat aaccataaagactacgctcaggaaaagccctcccgcctgaaacaaagatttttacttaga agaacaaagccagattatagcaccagccattctgccaggctcactgaagacgtcctggcc gacgaccgggatgactatgaatacctcatgaacacttccacgtattattactcggtgagg atcttccctgggcaagagccggcaaatgtctgggtgggctggatcacgtctgacttccac cagcacgaccctggctttgatttggacagagtccggacagtgaccgtcacgctgggagac gaaaagggaaaagtccatgaaagcatcaaacgcagcaactgctacatggtgtgtgcaggc gagagcatgagccccgggcaaggccgtaacaacaacggcttggagatcggctgtgtggtg gatgcagccagcgggctgctcacgttcattgccaatggcaaggagctgagcacttactac caggtggagccaagcacaaaattattccccgctgtgtttgcacaagctacaagccccaat gttttccagtttgagttgggaagaatcaagaatgtgatgcctctgtcggcgggcttgttc aagagcgagcacaaaaacccggtgccccagtgccccccacgcctgcacgtgcagttcctg tcccatgtcctgtggagccggatgcccaaccagtttttgaaggtggatgtgtctcgcatc agtgagcgtcaaggctggctggtgcagtgtttggacccactgcagttcatgtccctccac atccccgaggagaacagatctgtggacatcttagagttgacggagcaggaggagttgctg cgatttcactaccacacactgcggctctactcggccgtgtgcgccctcggaaaccaccgg gtggcccacgcgctgtgcagccacgtggacgagcctcagctgctctacgccatcgagaac aagtacatgcctggcctgctacgcacgggctactacgacctgctgatcgacatccacctc agctcctacgccacggccaggctcatgatgaacaacgagttcattgtccccatgacggag gagacaaagaccatcacgctcttcccggatgagaacaagaggcatgggctccccggcatc ggcctgagcacctcactccggccccgcatgcggttctcctcccccagcttcgtcggcgtc agcagtgagtgctaccagtacagccccgagttccctctggacatcctgaaggccaagacc atccagatgctgacggaggcggtggaggagggcagcctccacgcgcgcgaccccgttggg gggaccacagaattcctctttgtgcccctcatcaagctcttctacaccctgctcatcatg ggactcttccacaacgaggacctgaagcacatcctgcagctgatcgagcccagggtgttc aaggaagccgccactctggaggaggatggggaccggcaggagaaggagctcagtgccgag gactccaggctggaaggggcgggtgaagacgaggccaaggtgggcatgcggcctaaggag ggcctcctgcagatgaagctgcctgagccggtgaaactgcagatgtgcctcttgcttcag tacctctgtgactgccaggtccggcaccggatcgaagcgatcgtggccttctcagatgac tttgtggccaagctccaggacaatcagcgtttccgctacaacgaagtgatgcaggcctta aacatgtcagcggcactcacggccaggaaaaccaaggaattccgctcacccccccaagaa cagatcaacatgctcctcaacttcaaagatgacaaaagtgaatgtccatgtcctgaagaa atccgtgaccaactcctggatttccatgaggatttgatgacacattgtggaattgagctg gatgaagatggctctttggatggaaacagtgacttaaccatcaggggacgtctattgtcc ctggtagaaaaggtgacatacctgaagaagaagcaagcagaaaagccagtggccagtgac gccaccaagtcctccagcctccagcagctgatttcggagaccatggttcggtgggctcag gagtctgtcatcgaggacccggagttggtgagggccatgttcgtgctgctgcaccggcag tacgatggcattggaggcctggtccgggccctgcctaagacctataccatcaacggggtg tctgtggaggacaccatcaacctgctggcctctctcgggcagattcgttccctgttaagc gtgaggatgggcagagaggaggagaagctgatgattcgtggattgggagatatcatgaat aacaaagtgttttaccaacaccctaacctcatgagggccctgggcatgcacgagacagtg atggaggtcatggtgaatgtcctgggcgggggagagtccaaggagatcacctttcccaag atggtggccaattgttgccgttttctctgttacttctgtcgtataagtagacagaatcaa aaagctatgtttgatcatctcagttacttactggaaaacagcagtgttggtcttgcctcc cccgccatgagaggctccaccccgctcgacgtggctgcagcatcagtgatggataataac gaacttgccctagccttgcgggagccagatctagagaaggttgtgcgttacctggccggc tgtgggctgcagagctgccagatgctggtgtcaaagggttacccggacattggctggaat cctgtagagggagagcgataccttgatttcctccgatttgctgtcttctgcaatggggag agtgtggaagaaaacgcaaatgtcgtggtgagattgctcatccggaggcccgagtgcttt gggcctgcgttgagaggggaaggtgggaatggactccttgctgccatggaagaagccata aaaatagctgaggacccttcccgcgatggcccctcgcctacaagtggctccagccggaca ctagacacagaagaggaggaagatgacaccatccatatggggaacgcaatcatgaccttc tatgcggccctgattgacctcttaggtcgctgcgcccctgagatgcacttgattcatgct ggaaagggagaggccatcagaatcaggtctattttgagatctctcattccactgggagac ctggtgggtgtgattagcatcgcttttcagatgccaaccatcgccaaagatgggaatgtg gtggaacctgacatgtccgcggggttttgcccagatcacaaggcagccatggttttgttc cttgacagggtctatgggattgaggtgcaagacttcctcctccacctccttgaggttggc tttctgccagatctccgggccgccgcctctctagacacggccgctctgagtgctacagac atggccttggccctcaataggtacctttgcacagctgtcctacctttgttaaccagatgt gctcctctgttcgcgggcacggagcaccatgcctccctcatcgactcgcttcttcacact gtgtatagactgtccaagggctgctccctcaccaaagcccagcgggactccatagaagtg tgcctgctctccatttgtggccagttgagaccttctatgatgcaacacttgctcagaaga cttgtgtttgacgtcccgttattaaatgaacatgcaaagatgcctctgaagctgttgaca aaccactatgagagatgctggaaatactactgcctgcccggtggctggggcaatttcggt actacctcagaagaagaactgcatttatcacgaaagctgttctggggtatttttgatgcc ttgtctcaaaagaaatatgaacaagaacttttcaaactggcgctgccttgcctgagtgcc gttgcaggggctttgcctcccgactacatggagtcaaactatgtgaatctgatggaaaaa cagtcgtccatggattctgaagggaactttaacccccaacctgttgatacctcaaatatt acaattcctgagaagttggaatacttcattaacaaatatgcagagcattctcatgacaaa tggtccatggacaagttggcaaatggatggatttatggagaaatatattcagactcttca aaggttcagccattaatgaagccttataaactattatctgaaaaggaaaaagaaatttat cgctggccaatcaaagagtctctgaaaaccatgctggcgtggggctggcgggtggagagg 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aaactaggaattgcaatcttaaacggcggcaattccacagtgcaacagaagatgctcgac tacctgaaggagaagaaggacgtgggtttcttccagagcctggcaggcctgatgcagtcc tgcagtgtccttgacctaaatgcatttgagaggcaaaacaaagctgaaggcctgggcatg gtgacagaggaaggatcaggagagaaggtgctgcaggatgatgagttcacctgtgatctc ttccgcttcctgcagctgctctgtgagggacacaactcagattttcaaaattatctgaga acacagactggcaacaatatgacggtcaacatcattatctctactgtggactatctctta agggttcaggaatccattagtgatttctattggtattactctgggaaagatgtcattgat gagcagggacaacggaacttctccaaagccattcaagtagcaaaacaagtctttaacact ctcacagagtatattcagggaccttgcacgggcaaccagcagagcctggcacacagcagg ctgtgggacgcggtggtgggcttcctccacgtctttgcccacatgcagatgaagctgtcg caggattccagccaaatcgagctgttgaaggaattaatggatctccagaaggacatggtg gtcatgttgctgtccatgttagaaggtaacgttgtcaatgggacgattggcaagcagatg gtcgatatgctcgtggaatcttccaacaacgtggagatgatcctgaagttttttgacatg ttcttaaaactaaaagacttgacctcttcggacacatttaaagagtacgacccggatggc aaaggtgtcatttccaaaagggatttccacaaagcgatggagagccacaagcactacacg cagtctgaaaccgagttcctcttgtcgtgtgcggagaccgacgagaatgagaccctggac tacgaggagtttgtcaagcggtttcacgagccggctaaggacatcggcttcaatgtcgcc gtactcctgaccaacctttccgagcacatgcccaatgactctaggctgcagacgttcctg gagctggccgaaagcgtgctcaactacttccagcccttcctgggccgcatcgagatcatg ggcagtgccaagcgcattgagcgggtatactttgagatcagcgagtccagccgcacccag tgggagaagccccaggtgaaggagtccaagaggcagttcatcttcgacgtggtcaacgag ggcggggagaaggagaagatggagctcttcgtgaatttctgcgaggacactatcttcgag atgcagctggcggcccagatctcagagtcggatttgaatgagcgatcggccagtaaagag gagggcgacaaggagaggccggaggatgagggccccaggatgagcttcttctccctcctg accctcaggtccgccctgctggcgctcaggtacaacgttctgaccctgatgcgcatgctc agcctgaagagcctgaagaagcaggtgaagaaggccaagaagatgacactgggggacatg ctggcggccttcttctcctcctactggggcgtcttcctcacgctcctgcacttcgtggcc agcgtttgcaggggcttcttccgcattgtgtgcagcctgctgctgggaggcagcctggtc gagggggccaagaagatcaaggtggcggagctcctggccaacatgcctgaccccacgcag gatgaggtgcggggggatgcggaggacggggagaggcggcccccggagaccgcactaccc tctgaagacctcatggacctgaaggagctgacggaggagagcgatctcctttccgacatc ttcggcttagacctgaagcgggaaggagggcagtacaagctcatcccccacaaccccaac gcgggcctcggcgacctcatggccaatcccacccccgtccccgacatgcaggaaaagctt caggaacagaaggcaaaagaagaaaaggaagaaaaagaggaaattaaatcagaacctgaa aaggctgagggggaagatggagagaaagaagaaaaagccaaggaggacaaaggcaagcag aagctgagacagcttcacacgcacagatatggagagccagaggtcccggagtcggccttc tggaagaagatcatagcgtaccaacagaaactgctcaactattttgctcgcaacttttac aacatgagaatgctggccttgtttgtcgcatttgcgatcaatttcatcctgctgttttat aaggtctccacttcttctgtggttgaaggaaaggagctgcccactcgaagccccagtgaa aatacccacgtggccatcagcctggacagcagcacaccccacatcatcacggtccactat gtcctggaggagagcagcggttacatggagcccacgctgcgcatccttgccatcctccac accgttatctccttcttctgcatcattggatactattgcttgaaggtcccattggttatt ttcaagcgagagaaggaagttgcccggaaactggaatttgacgggctctacatcacagag cagccctcagaggacgacatcaagggccagtgggacaggctggtcatcaacacgcagtca tttcccaacaactactgggataaatttgttaaaagaaaggttatggataagtatggggag ttctacggccgggacaggatcagcgagctgctgggtatggacaaggcagcattggacttc agcgatgctagggaaaagaagaagcccaagaaagacagctccctgtcggccgtgctgaac tccattgatgtgaagtatcagatgtggaaactgggagttgttttcacagacaattccttc ctctacctggcctggtatatgactatgtccgttcttggacactacaacaacttttttttt gctgctcatcttctcgacattgctatgggcttcaagaccctgagaaccatcctctcctct gtgactcacaatggcaaacagctcgttctgactgtgggcttgttagctgttgttgtgtac ctctacactgtggtggcattcaattttttccggaagttctacaacaaaagtgaagatgga gacaccccagatatgaaatgcgatgatatgctaacatgttacatgttccacatgtacgtg ggggtccgtgccggagggggcattggtgatgaaattgaggaccctgcaggtgacgagtat gagatctacagaatcatcttcgacatcaccttcttcttcttcgtcatcgtcatcctcctg gccatcatacaaggtttaatcatcgatgcttttggagagctgagagaccagcaggagcag gtcaaggaggacatggagaccaagtgctttatctgcggcattggcaacgattacttcgac acagtgccacatggcttcgaaacccacacattacaggagcacaacttggccaattacctg ttttttctgatgtatctcataaacaaagatgaaacagaacacacaggtcaggaatcgtac gtctggaagatgtatcaagagagatgttgggagtttttcccagctggagattgcttccgg aaacaatatgaagaccagctaaattaa

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