Dipodomys ordii (Ord's kangaroo rat): 105987537
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Entry
105987537 CDS
T07834
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
dord
Dipodomys ordii (Ord's kangaroo rat)
Pathway
dord05012
Parkinson disease
dord05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
dord00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
105987537 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
105987537 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
dord01001
]
105987537 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
dord04131
]
105987537 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
dord04147
]
105987537 (Lrrk2)
Enzymes [BR:
dord01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
105987537 (Lrrk2)
Protein kinases [BR:
dord01001
]
Serine/threonine kinases: TKL group
LRRK family
105987537 (Lrrk2)
Membrane trafficking [BR:
dord04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
105987537 (Lrrk2)
Exosome [BR:
dord04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
105987537 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR
Ras
LRR_14
LRR_9
WD40_2
WDR55
WD40_CDC20-Fz
Beta-prop_EML
LRR_NXF1-5
Arf
Beta-prop_RSE1_2nd
LRR_13
Beta-prop_EML_2
Ank_2
nSTAND3
T2SSE
AAA_22
WD40_MABP1-WDR62_2nd
MMR_HSR1
TrwB_AAD_bind
Arm
ABC_tran
AAA_16
LRR_6
Kdo
AAA_7
G-alpha
GTP_EFTU
PduV-EutP
Septin
cobW
Pox_A32
MobB
Beta-prop_RIG_2nd
TsaE
AAA_29
TniB
Beta-prop_WDR19_1st
NACHT
FtsK_SpoIIIE
ResIII
AAA_23
ARM_LIN_2nd
Motif
Other DBs
NCBI-GeneID:
105987537
NCBI-ProteinID:
XP_012874266
Ensembl:
ENSDORG00000010126
UniProt:
A0A1S3FCQ6
LinkDB
All DBs
Position
Unknown
AA seq
2530 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLLVRLNNVQEGKQIETLVQILEDILVFTYCDHASKLFEGKN
FHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPDTLQSLMGPQDVGNDWEVLGIHQLIL
KMLTVHHANVNLSTVGLKALELLLTSGKITLLILDEESDIFLLIFDAMNTFSANEEVQKL
GCKALHVLFERVSEEQLIEFVENKDYRILLSALQNFKGEEEIVLHVLHCLHSLAVPCSNV
EVLMSGNVRCYNIVIDAMRAFPIHEKIQQVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
ERYPKNAVLQISALSCLALLTETIFLNQDLEEKNETPESEKEEEEEEQEKLFWLEACYRA
LTWHRKNKHVQEAACWALNNLLMYQNGLHKKIGDEDDQFPAHREVMLAMLMHSCSKEVFQ
ASATALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTS
LDTMAVVVPKIITIMKNHQTSLSVQLEALRAIVHFIVPGMPDVSRDEFQRKLNMVKKQSF
RNDIYKLVLSALNRFIGNPGIQRCGLKVISSLAHFPDVLEMLSLDGAVDSVLHTLQMYPD
DQEVQCLGLQLLGCLSTKKNICIGTGHLLAKILVSSLQRFKDVLEVQIIGFQTILAILDL
SEPFSKLLLHHSFESVIFHQMSLGITEPKGPQFLNLCCKCFAKLVMDPELKSVMLQRACD
QNNSIMVECLLLLGADANQAKEATSLICQVCERESSPKLVELLLNSGSREQDVRKALMIS
MQKGDSHIISLLLRRLALDLANNSICLGGFGIGKIEPSWLAPLFPDKISNLRKQTNMGSM
LARMVLRHQMRSTVEEGAAAGSDENFSEDVLDKLGEWTFIPDSSMDSVFGQSDDLDSEGS
ESSFLVKKKSNSISVGEFYRDPALQRCSPNLQRHSNSLGPVFDHEDMLKRKIKILSSDDS
VRSSKLPSHMRHSDSISSLASEREYITALDLSANELRDIDALSQKCCISGHLEHLEKLEL
HQNALTNFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMSCLAHLDASRNDIGLPVVLDP
ALKCPTLKQFNLSYNQLSSVPENLAEAVEKLEQLILEGNKISEICSPLSLKELKVLNLSK
NNISSLPENFLKACPKVESFSARMNFLAALPFLPSSVTSLKLSQNKFTCVPDVILNLPHL
RSLDMSSNDIESLPGPSHWKSLNLRELLFSYNQISILDLSEKAHTWSRVEKLHLSHNKLK
EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHVGCKAKDI
IRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGIQGATVGIDVKDWPI
QIRGKKKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNI
KARASSSPVILVGTHLDVSDEKQRKACIGKITKELLNKRGFPAIRDYHCVNATEESDALA
KLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVK
ENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVDPKWLCKVMAQILTVKVEGY
PKHPKGIISRKDVEKFLSKKKRFPKNYMIQYFKLLEKFQIALPLGEEYLLVPSSLSDHRP
VIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGI
YLNWSPEAYCLVRSEILDNHPESFLKIIVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEI
DICGEGETLLKKWALYSFNDGEDHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPD
LILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLR
QELVVLCHLHHPSLISLLAAGIRPRMLVMELASRGSLDRLLQQDKASLTRTLQHRIALHV
ADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGF
RAPEVARGNVIYNQQADVYSFGLLLYDILTAGGRIVEGLKFPNEFDELALQGKLPDPVKE
YGCTPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMKHISIPENIIAECMVAT
NSNGKNVSIWLGCGHSDKGQLSFLDLNTEEHITEQEVTDSRILCLAFVHLPAEKESWIVS
GTQSGLLLVIDAEDRTKRHSLEKMTDSITCLYCNCFSKQSKQKNFLLVGTANGNLAIFED
KAVKCNGAAPLKTLSLGDASTPLMCLSESMISSEKHIMWGACGTKVFSFSNDFSVQKLIE
TRTNQLFSYAAFSDSNIIAVAVDTALYVAKKNSPVVEVWDKKTEKLCELIDCVQFLKEVM
IKISKESKHNLCYAGRVKALCLQKNTALWIGTGGGHILLLDLSTRRIIRIINNFCDSVRV
MVTAQLGSLKNVMLVLGYKQKSTEGTQQQKEIQSCLSIWDINLPHEVQNLEKHIEMRKEL
AEKMRKTSIE
NT seq
7593 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcagggatgcgaagaggaggacgaggaaactctgaagaagttg
ctagtcagactgaacaatgtccaggaaggaaaacagatagagacgctagttcaaatcctg
gaggacatactggtgttcacctactgcgatcacgcctccaagttatttgaaggcaaaaat
ttccacgtgcctctgctgatcgttttggattcctatatgagagtcgccagtgtgcagcag
gtgggctggtcacttctgtgtaaattaatagaagtctgtccagatacattgcaaagctta
atgggaccgcaggatgttggaaatgattgggaagtccttggtattcaccaactgattctt
aaaatgctaacagttcatcatgctaatgtaaacctgtcaacagttggactgaaggcctta
gagctcctgctaacttcaggcaagatcacattgctgattctggatgaagaaagtgatatt
ttcttgttaatctttgatgccatgaacacattttcagccaacgaagaggtccagaaactt
ggatgcaaggcgttacatgtgctgtttgaaagagtgtctgaggaacaattgattgaattt
gttgagaacaaagattataggatattgttaagtgcattacaaaacttcaaaggtgaagag
gaaattgtgctccatgtactgcactgtttgcattctctagcggttccttgcagtaatgtt
gaagtcctcatgagtggcaatgtcaggtgttacaacattgtgatagatgctatgcgagca
ttccccatccatgaaaagattcagcaggtcagttgctgtttgctccatcggcttacctta
ggtaattttttcaatattctggtattaaacgaggtccatgagtttgtggtgaaggctgtg
gagagatatccaaagaatgcagtgttacaaatctcagctctcagctgcttagcactcctg
actgagaccattttcttaaatcaagacttagaggaaaagaatgagactccggagagtgag
aaggaggaggaggaggaagaacaagaaaaactgttctggctagaagcctgttatagagct
ttaacatggcacagaaagaataaacatgtgcaggaggctgcatgttgggcattaaacaat
cttctcatgtaccaaaatggtttacacaagaagattggagatgaagatgaccagtttcca
gctcacagggaggtgatgcttgctatgctgatgcattcttgctccaaggaagtcttccag
gcgtctgcaactgcattgtcaactctcttggaacaaaatgttaattttagaaaaatcctg
ctgtcaaaaggaatatacctgaatgttttggagttaatgcagaaacacatacattctccg
gaagtggctgaaagtggatgcaagatgctcaatcatctttttgaaggaagtaacacatcc
ctggataccatggcagtagtggtccccaagataataacaattatgaaaaaccatcagacg
tcgttgtccgtgcagctggaggctcttcgggctattgtgcatttcatagtgcctggcatg
ccagatgtttctagagatgaatttcagcgtaaactaaatatggttaagaaacaatctttc
aggaatgatatttacaagctggtcttgtcggctttgaacaggttcattggcaatcctggg
attcagagatgcggattgaaagtaatttcttcgctggcacatttccctgatgtgctggag
atgctgtccctggatggtgcagtggactcagtgcttcacacactgcagatgtatccagat
gaccaagaagttcagtgtctgggtttacaactcttaggatgcttgagtaccaagaagaat
atatgcataggaactggacacctgctggctaagattttagtgtccagtttacaacgattt
aaagatgttcttgaagtgcagatcataggatttcagactatcttggccattctggacttg
tcagaacccttttctaagctgctcttgcaccattcatttgagtctgtaatattccatcag
atgtctttgggcatcacggaaccaaagggcccacagtttctcaatctctgttgcaaatgt
tttgcaaaactggtgatggaccccgagttaaaaagtgtgatgttacaaagagcctgtgat
cagaataatagcatcatggtagaatgcttgcttctcctgggagcggatgccaatcaagcc
aaggaggcaacttctttaatttgtcaggtctgtgagagggagagcagccctaaattggtg
gagctgctgctgaatagcgggtcgcgtgaacaggatgtacggaaagcgctgatgatcagc
atgcagaagggtgacagccacatcatcagcttgctcttaaggaggctggccctggacctg
gccaacaacagcatctgcctgggagggtttggtataggaaaaattgaaccttcttggctg
gctcctttatttccagataagatatccaatttaaggaaacaaacaaacatgggttctatg
ctagcgaggatggtactcaggcaccagatgagaagcaccgtggaggaaggagcagctgca
ggcagtgatgaaaatttctctgaagatgtactggataagcttggtgaatggactttcatt
ccggattcttccatggacagcgtgtttggtcaaagtgatgatctggatagtgaaggaagt
gaaagttcatttcttgtgaagaagaaatccaattccattagtgtgggagaattttaccgt
gatcctgcgttgcaacgttgctccccaaatttgcaaaggcattccaattcattggggcct
gtttttgatcatgaagatatgctgaagcggaaaataaaaatattgtcttcagatgattca
gtcaggtcatcaaaacttccatctcacatgaggcattcagacagcatttcttccctggct
tctgagagagagtatattacggcattagacctttcagccaatgaactcagagatattgat
gccctgagccagaaatgctgtataagtggtcatttggagcatcttgaaaagttggaactt
caccagaatgcactcaccaacttcccacagcaactatgtgaaaccctgaagtgtttgaca
cacttggatttgcacagtaataagttcacatcctttccctcctacttgttgaaaatgagt
tgccttgcccacctcgatgcctctcgaaatgacattggactcccagtggtgttagatccc
gccttgaagtgccccaccctgaagcagttcaacttgtcatataaccagctctcttcagta
cccgagaacctcgctgaagctgtggaaaaactggagcagctcattttagaagggaataaa
atatcagaaatatgttcccctttgagcctgaaggaattgaaggttttaaaccttagtaag
aacaacatctcatccctgccagagaactttcttaaagcttgtccaaaagtagagagtttc
agtgccagaatgaattttcttgctgctctgcctttcttgccttcttccgtaacaagccta
aaactatctcaaaataaatttacatgtgttccagatgtaattttaaatctaccacactta
cggtccttggatatgagcagcaatgacattgaaagtctgcctggaccttcacactggaaa
tctttgaacttaagggaactcttgtttagctacaatcagatcagcatcttggacttgagc
gaaaaagcacacacatggtctagagtagagaaactacacctttcccataataaactgaag
gagattcctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaac
ttggaactgagatcatttcccaatgagatggggaaattaagcaaaatatgggatcttcct
ctggatgaattgcgtctaaattttgattttaaacatgtcggatgcaaagccaaagacatc
atcagatttcttcaacagcggttaaaaaaggctgtgccttacaaccgaatgaaactcatg
attgtgggaaatactgggagtggcaaaactaccttactgcagcaattaatgaaaaccaag
aaatcggatcttgggattcagggtgccacggttggcattgatgtgaaagactggcccatc
caaatcaggggcaagaagaagaaggacctcatactaaacgtgtgggattttgcaggtcgt
gaagaattctacagcactcacccccacttcatgacccagcgagcactttaccttgctgtc
tatgatctcagcaaggggcaggcggaagtggatgccatgaaaccctggctcttcaatata
aaggctcgcgcatcctcctccccggtcattcttgtgggcacacatctggacgtttctgat
gagaagcagcgcaaggcctgcatagggaaaatcaccaaggagctgttgaacaagcgaggc
tttcccgcaatccgagattaccactgtgtgaacgccacagaggaatctgatgctctagct
aaacttcggaaaactatcataaacgagagtctgaatttcaagattcgagaccagcctgtt
gtggggcagctaattccagactgctacgtggaacttgagaaaatcattttatcagagcgc
aaaaatgtgccaattgaatttcctgtaattgataggaaacgattactacaactagtgaaa
gaaaaccagctacagttagatgaaaatgagctccctcatgcggtacatttcttaaatgaa
tcaggagtccttcttcattttcaagacccagcactgcagttaagtgacttatattttgtg
gaccccaagtggctttgtaaagttatggcccagattttgacagtaaaagtggaaggctat
ccaaaacatcctaaaggaattatctcacggaaagatgtggaaaaatttctttcaaagaag
aaaagatttccaaagaactacatgatacagtactttaaactcttagaaaagttccagatt
gccttgccactaggagaagagtatttactggttccaagcagtttatctgaccacagacct
gtgatagagcttcctcactgtgagaactctgaaattatcattcgactctatgaaatgccc
tattttcccatgggattctggtcaagattaatcaatcgattgcttgaaatttcaccttac
atgctttctggaagagaacgagcacttcgcccaaacagaatgtactggcggcaaggcatc
tacttgaattggtctcctgaggcttattgtctggtgagatctgaaatcttagacaatcat
ccagagagtttcttaaaaatcatagttccttcttgtagaaaaggctgcattcttttgggc
caagttgtggaccacattgattctctcatggaagaatggtttcctgggttgctggagatt
gatatctgtggtgaaggtgaaactctgttgaagaaatgggcattatacagttttaacgat
ggcgaagatcatcagaaaatcttacttgacgacttgatgaagaaagcagaagaaggagac
cttctagtaaacccagatcaaccaaggctcaccattccgatctctcagattgcccctgac
ctgattttggctgacctgcctagaaatattatgttgaataatgatgagttggaatttgag
caagctccagaatttctcttaggtgatggcagttttggatctgtttaccgagcagcctat
gaaggtgaggaagtggctgtgaagatttttaataaacatacatcacttaggctgttacga
caagagctggtggtgctttgccacctccatcaccccagcttaatatctttgctggcagct
gggattcgtcctcgaatgttggtgatggagttggcctccaggggctccttagatcgcctg
cttcagcaggacaaagccagcctcacccgaactctccagcacaggatcgcccttcatgtg
gctgatggcttgagatacctgcactcggccatgattatataccgagacttgaagccccat
aatgtgctgctttttaccctgtatcccaatgcggccatcattgcaaagattgctgactat
gggatcgctcagtactgctgcagaatgggaatcaagacgtcagagggaacaccgggattt
cgagcacctgaagttgctagaggaaatgtcatttataaccagcaggctgatgtttactcc
tttggcctgttactctatgacattttgacagctggaggtagaatagtagaaggtttgaag
tttccaaatgagtttgatgaattagccctgcaaggaaaattacctgatccagtcaaagaa
tatgggtgcaccccatggcctatggttgagaagctaattaaaaaatgtttgaaagaaaac
cctcaggaaaggcctacttctgcccaggtctttgacattctgaattcagctgagttaatc
tgtctgatgaagcacatttccataccggaaaacattatagctgaatgcatggttgctaca
aattcgaatggcaagaatgtgagcatttggttaggctgtgggcacagtgacaaaggccag
ctctcctttcttgacttaaacacagaagaacacattactgagcaggaagttaccgacagt
agaatattgtgcttggcctttgtgcatctccctgctgaaaaggagagctggatcgtgtca
gggactcagtctggtcttctcctggtcattgatgctgaagaccggaccaaaagacattca
ctggaaaagatgactgattccattacttgtttgtattgtaattgcttttccaagcagagc
aagcagaaaaattttcttttggtgggaactgctaatggtaacttagcaatttttgaagat
aaagctgttaagtgtaatggagcagctcccttgaagactttgagcctgggagatgcgagc
actccactcatgtgcttgagtgaatcgatgatctcctctgagaaacacatcatgtgggga
gcatgcggcacgaaggtgttctcattctctaatgacttctccgttcagaaactcattgag
accaggacaaaccagctgttttcctatgcagctttcagtgattcaaacatcatagcagtt
gctgtagacacagccctctatgttgcaaagaaaaacagcccagttgtggaagtgtgggac
aagaagacagaaaagctctgtgaactaatagactgtgtgcagtttttaaaagaagtcatg
ataaaaataagcaaggaatcaaagcacaatctgtgttatgctgggagagtgaaggccctc
tgccttcagaagaacacagcgctctggataggaactggaggaggccatattttacttctg
gatctttccacgcggcgaattatacggataattaacaacttctgtgattccgttcgagtc
atggtgacagcacagttaggaagccttaaaaatgtcatgctggttttggggtacaaacag
aaaagtactgaaggtactcaacaacaaaaagagatacagtcttgcttatctatttgggat
atcaatcttccacatgaagtgcaaaatttggaaaaacacattgaaatgaggaaagaatta
gctgaaaaaatgagaaaaacatccattgaatag
DBGET
integrated database retrieval system
