KEGG   Dipodomys ordii (Ord's kangaroo rat): 105989246
Entry
105989246         CDS       T07834                                 
Symbol
Plcb3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
dord  Dipodomys ordii (Ord's kangaroo rat)
Pathway
dord00562  Inositol phosphate metabolism
dord01100  Metabolic pathways
dord04015  Rap1 signaling pathway
dord04020  Calcium signaling pathway
dord04022  cGMP-PKG signaling pathway
dord04062  Chemokine signaling pathway
dord04070  Phosphatidylinositol signaling system
dord04071  Sphingolipid signaling pathway
dord04072  Phospholipase D signaling pathway
dord04081  Hormone signaling
dord04082  Neuroactive ligand signaling
dord04261  Adrenergic signaling in cardiomyocytes
dord04270  Vascular smooth muscle contraction
dord04310  Wnt signaling pathway
dord04371  Apelin signaling pathway
dord04540  Gap junction
dord04611  Platelet activation
dord04613  Neutrophil extracellular trap formation
dord04621  NOD-like receptor signaling pathway
dord04713  Circadian entrainment
dord04720  Long-term potentiation
dord04723  Retrograde endocannabinoid signaling
dord04724  Glutamatergic synapse
dord04725  Cholinergic synapse
dord04726  Serotonergic synapse
dord04728  Dopaminergic synapse
dord04730  Long-term depression
dord04742  Taste transduction
dord04750  Inflammatory mediator regulation of TRP channels
dord04911  Insulin secretion
dord04912  GnRH signaling pathway
dord04915  Estrogen signaling pathway
dord04916  Melanogenesis
dord04918  Thyroid hormone synthesis
dord04919  Thyroid hormone signaling pathway
dord04921  Oxytocin signaling pathway
dord04922  Glucagon signaling pathway
dord04924  Renin secretion
dord04925  Aldosterone synthesis and secretion
dord04926  Relaxin signaling pathway
dord04927  Cortisol synthesis and secretion
dord04928  Parathyroid hormone synthesis, secretion and action
dord04929  GnRH secretion
dord04933  AGE-RAGE signaling pathway in diabetic complications
dord04934  Cushing syndrome
dord04935  Growth hormone synthesis, secretion and action
dord04961  Endocrine and other factor-regulated calcium reabsorption
dord04970  Salivary secretion
dord04971  Gastric acid secretion
dord04972  Pancreatic secretion
dord04973  Carbohydrate digestion and absorption
dord05010  Alzheimer disease
dord05016  Huntington disease
dord05017  Spinocerebellar ataxia
dord05022  Pathways of neurodegeneration - multiple diseases
dord05142  Chagas disease
dord05143  African trypanosomiasis
dord05146  Amoebiasis
dord05163  Human cytomegalovirus infection
dord05200  Pathways in cancer
dord05415  Diabetic cardiomyopathy
dord05417  Lipid and atherosclerosis
Module
dord_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dord00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105989246 (Plcb3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105989246 (Plcb3)
   04310 Wnt signaling pathway
    105989246 (Plcb3)
   04371 Apelin signaling pathway
    105989246 (Plcb3)
   04020 Calcium signaling pathway
    105989246 (Plcb3)
   04070 Phosphatidylinositol signaling system
    105989246 (Plcb3)
   04072 Phospholipase D signaling pathway
    105989246 (Plcb3)
   04071 Sphingolipid signaling pathway
    105989246 (Plcb3)
   04022 cGMP-PKG signaling pathway
    105989246 (Plcb3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105989246 (Plcb3)
   04081 Hormone signaling
    105989246 (Plcb3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105989246 (Plcb3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105989246 (Plcb3)
   04613 Neutrophil extracellular trap formation
    105989246 (Plcb3)
   04621 NOD-like receptor signaling pathway
    105989246 (Plcb3)
   04062 Chemokine signaling pathway
    105989246 (Plcb3)
  09152 Endocrine system
   04911 Insulin secretion
    105989246 (Plcb3)
   04922 Glucagon signaling pathway
    105989246 (Plcb3)
   04929 GnRH secretion
    105989246 (Plcb3)
   04912 GnRH signaling pathway
    105989246 (Plcb3)
   04915 Estrogen signaling pathway
    105989246 (Plcb3)
   04921 Oxytocin signaling pathway
    105989246 (Plcb3)
   04926 Relaxin signaling pathway
    105989246 (Plcb3)
   04935 Growth hormone synthesis, secretion and action
    105989246 (Plcb3)
   04918 Thyroid hormone synthesis
    105989246 (Plcb3)
   04919 Thyroid hormone signaling pathway
    105989246 (Plcb3)
   04928 Parathyroid hormone synthesis, secretion and action
    105989246 (Plcb3)
   04916 Melanogenesis
    105989246 (Plcb3)
   04924 Renin secretion
    105989246 (Plcb3)
   04925 Aldosterone synthesis and secretion
    105989246 (Plcb3)
   04927 Cortisol synthesis and secretion
    105989246 (Plcb3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105989246 (Plcb3)
   04270 Vascular smooth muscle contraction
    105989246 (Plcb3)
  09154 Digestive system
   04970 Salivary secretion
    105989246 (Plcb3)
   04971 Gastric acid secretion
    105989246 (Plcb3)
   04972 Pancreatic secretion
    105989246 (Plcb3)
   04973 Carbohydrate digestion and absorption
    105989246 (Plcb3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    105989246 (Plcb3)
  09156 Nervous system
   04724 Glutamatergic synapse
    105989246 (Plcb3)
   04725 Cholinergic synapse
    105989246 (Plcb3)
   04728 Dopaminergic synapse
    105989246 (Plcb3)
   04726 Serotonergic synapse
    105989246 (Plcb3)
   04720 Long-term potentiation
    105989246 (Plcb3)
   04730 Long-term depression
    105989246 (Plcb3)
   04723 Retrograde endocannabinoid signaling
    105989246 (Plcb3)
  09157 Sensory system
   04742 Taste transduction
    105989246 (Plcb3)
   04750 Inflammatory mediator regulation of TRP channels
    105989246 (Plcb3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105989246 (Plcb3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105989246 (Plcb3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    105989246 (Plcb3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105989246 (Plcb3)
   05142 Chagas disease
    105989246 (Plcb3)
   05143 African trypanosomiasis
    105989246 (Plcb3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105989246 (Plcb3)
   05016 Huntington disease
    105989246 (Plcb3)
   05017 Spinocerebellar ataxia
    105989246 (Plcb3)
   05022 Pathways of neurodegeneration - multiple diseases
    105989246 (Plcb3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105989246 (Plcb3)
   05415 Diabetic cardiomyopathy
    105989246 (Plcb3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105989246 (Plcb3)
   04934 Cushing syndrome
    105989246 (Plcb3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dord04131]
    105989246 (Plcb3)
Enzymes [BR:dord01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105989246 (Plcb3)
Membrane trafficking [BR:dord04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105989246 (Plcb3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105989246 (Plcb3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 105989246
NCBI-ProteinID: XP_012876625
Ensembl: ENSDORG00000001633
UniProt: A0A1S3FJY3
LinkDB
Position
Unknown
AA seq 1233 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSMDMTQPLSSYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGVPGS
SVRKRPLEQSNSALSEGSAATEPSSPQLGSPSSDSCPGLSNGEEMGLEKPRLEPQKSLGE
ESLPRGPDVLGPADREDDEEEEEEEESTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPLEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVPMQLNAGVFEYNGRSGYLLKPEFMRRPDKTFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRVAAFEEGGRFVGHRVLPVAAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPESSQESQSQQA
GSQISSNPTPCPLDTSPRRPPGPATSPTNTSLSSPGQRDDLIASILSEVAPTPLEELRAH
KSLVKLRARQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGRCRPGPGVLGGATDVED
VKEEEEAKQYREFQNRQVQSLLELREAQADTEAERRLEHLRQAQQRLREIVLDAHTTQFK
RLKEMNEREKKELQKILDRKRHNSITEAKTREKHKKEAELTEINRRHITESVNSIRRLEE
AQKQRHERLVAGQQQVLQQLAEEEPKLLAQLTQECQEQRARLPQEIRRSLLGETPEGLGD
RSLVACASNGHAPGSSGHLSGADSESQEENTHL
NT seq 3702 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtgaccctgcgtgtggaccccaatggcttctttttatactggacaggacccaacatggag
gtggacacactggacattagttcaatcagggacactcggacgggccgctatgcccgcctg
cccaaggaccccaagattcgggaagtgctgggctttgggggcccagatgcccggctggag
gagaagctgatgactgtggtggccgggcctgacccggtgaacaccactttcttgaacttc
atggcggtgcaggatgacacagtgaaggtctggtctgaggagctgtttaagctggctatg
aacatcctggctcagaacgcctctcggaataccttcctgcgtaaagcatacacaaaacta
aagctgcaggtgaaccaggatggacggattccagtcaagaacatcctgaagatgttctca
gcggacaagaagcgggtggagacagcgctggaatcctgtggtctcaatttcaaccggagt
gagtccatccggcctgatgagttttccttggaaatcttcgagcggttcctgaacaagctg
tgtctgcggccagacattgacaagatcctgctggagataggtgccaagggcaagccatac
ctgaccctggagcagctcatggacttcatcaaccagaagcaaagggacccgagactgaat
gaggttctctacccgcccctgcggccctcacaggcccggctgctcatcgagaagtatgaa
cctaaccagcaattcctggagcgcgaccagatgtctatggagggtttcagccgctacctg
ggtggggaggagaacggcatcttgccgctggaggccctggatctgagcatggacatgacc
cagccgctgagctcctacttcatcaactcctctcacaacacctacctcacagcggggcag
ctggctgggacctcgtcggtggagatgtaccgccaggcgctgctgtggggctgccgctgt
gtggagctggacgtgtggaaggggcggccccccgaagaggagcccttcatcacccatggc
ttcaccatgaccaccgaggtgcccctgcgagacgtgctggaggccatcgccgaaaccgcc
ttcaagacctcgccctaccccgtcattctctccttcgagaaccacgtggactcggcgaag
cagcaggccaagatggccgagtactgtcgctccatctttggggacgcgttgctcattgac
cccctggacaagtacccgctggccccgggggtccccctgcccagcccccaagacctgatg
ggccgcatcctggtgaagaacaagaagcgacaccggcccagcaccggtgtcccgggcagc
tccgtgcgcaagcggccgctggagcagagcaactcggcactgagcgaaggctctgctgcc
accgagccctcctcgccccagctcgggtcccccagctctgacagctgcccaggcctgagc
aatggggaagagatggggctggagaagcccagactggagccccagaagtccctaggtgag
gagagcctgccccggggccctgatgttcttggacctgcagaccgtgaagatgacgaggaa
gaggaagaagaggaggaatcaacagaccccaaaaagccaaccacagatgagggcacagcc
agcagtgaggtgaatgccactgaggagatgtcgactcttgtgaactacattgaacctgtc
aagttcaagtccttcgaggctgctcgcaagaggaacaagtgctttgagatgtcgtccttt
gtggagaccaaggccatggagcagctgaccaagagccccctggagtttgtggaatacaac
aagcagcagctgagccgcatctaccccaagggcacccgggtagactcgtccaactacatg
ccccagctcttctggaacgtgggctgccagcttgttgcgctcaacttccagaccctggac
gtgcccatgcagctcaacgcaggtgtgtttgagtacaatgggcgaagtgggtacttgctc
aagcccgagttcatgaggcggccggacaagaccttcgaccccttcaccgaggtcatcgtg
gatggcattgtggccaatgccctgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggacatgtttggtctcccagtggacacgcggcgc
aaataccgcacacggacctcacaggggaactcattcaaccccgtgtgggacgaggagccc
ttcgacttccccaaggtagtgctgcccactctggcttcacttcgtgtggcagcatttgag
gaaggtggcagattcgtggggcaccgggtcttgcctgtggctgcgatccgctcagggtac
cactatgtctgcctgcgaaacgaagccaaccagccgctctgcctgccagccctgctcatc
tacactgaggcctcggactacatccccgacgaccaccaggactatgcagaggccctgatc
aaccccatcaaacatgtcagcctgatggaccagcgggccaagcagctggccgcgctcatt
ggggagagcgaggctcaggctggcccagaatcaagccaggagtcccagtctcagcaggca
gggtcccagatctcttcgaaccccaccccttgcccactggacaccagcccccgccggccc
ccagggccagccacctcccccaccaacacctccctcagcagcccaggacagcgggatgat
ctcatcgccagcatcctttcagaggtggctcccacccctctggaggagctccgggcccac
aagtccctcgtgaagctgcgagcccggcaggatcgagacctgcgggagctccacaagaag
caccagcggaaggccgtggccctcacccgccgcttgctcgatggcctcgcccaggcacgg
gccgagggcaggtgccggcctgggccaggtgtcctgggtggagccactgatgtggaagat
gtgaaggaagaggaagaggcaaagcagtatcgagagttccagaacaggcaggtgcagagc
ttgcttgagctgagggaggcccaggcagacacagaggctgaaaggaggctggagcacctg
agacaggctcagcagcgactcagggagattgtcctggatgcacatacaactcaattcaaa
agactgaaggagatgaatgaaagggagaagaaagagctgcagaagattctggataggaaa
cgccacaacagcattacagaggccaagacgagagagaaacataagaaggaggcggagctg
acagaaatcaaccggaggcatatcactgaatcggtcaactccatccgtagactggaggag
gcgcagaagcagcggcatgagcgcctggtggctgggcagcagcaggtcctccagcaattg
gcagaagaagagcccaagctgctagcccagctgacccaggagtgtcaggagcagcgggcc
aggctgccccaggagatccgcaggagcctgctgggcgagacgccagaaggactgggggac
aggtccctagtggcctgtgccagcaacggccatgcgccagggagcagcgggcatctgtcc
ggcgctgactcggagagccaggaggagaacacacacctctga

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