Drosophila persimilis: 6602213 Help Entry 6602213           CDS       T01063                                  Name (RefSeq) protein purity of essence   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism dpe  Drosophila persimilis Brite KEGG Orthology (KO) [BR:dpe00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:dpe04121]     6602213 Enzymes [BR:dpe01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      6602213 Ubiquitin system [BR:dpe04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     6602213 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N zf-UBR Htt_N-HEAT_1 Poty_PP LEDGF Motif Other DBs NCBI-GeneID:  6602213 NCBI-ProteinID:  XP_026843604 LinkDB All DBs Position Unknown AA seq 5381 aa AA seqDB search MSSHSGGTDWNSVIKALLLSRTGALNKNEVVNLLKAITRCEHEFFDDEGSFVPFYTAFAA LAADKLMQIKSICQTQICQLHDATAVLIRFILFRLPKVSVFESKWLLAALKMLCEGRENA SSAVAQFDYSAVAGVVKSSKHPESSNKSIMSMAGSTTGGAGAGGSNDKESPKLEIKRSRS DLSSVILQQLLAPLEPGKMTWVPLSEEITDCTEQLLAANVEVFQEANGVDTLLDICVGLP ILSRYRMKYMETINAGKPLYLPLTQAEATTVKSSMNHMLTDLSIVGQAYALIVMQPLTPS RIEKLSMCGISALYNAVLTSIATSVLSMGQASSAQKQQQQQTAAAASTSQGSGGGLSSVQ TSKDHDEFEEQASGIVNKALEIYSSIGEMFKSSARMYIYQNHLCYGSWLLISGIQGAMGA SGSASAETAAKAAAATKVSSKTESITAPSTPIARVNLFKVQQGFGELNAAIANHSIKLLS ELIEDLKIESACGQSSVTDPETLPEPAQFDILQNYTSLERIVRVLNTATLHQLFTFLATV AYRKACTLKRASTKDRTECDPISYSDSTTCLNESMSYSDNSEEDDSESYLGHWFKETLSP ETHDDNANTSSQERSGEQKSALVPKLDEPHEYLELSADIFCFLDQFLANRHAYMQRYVKA GVSDQQMLLMANIIKDFDRDVMRNDSEQQSPPSTAAAVAAATGAGSSGSSAKWQASMIRF SGAAGRYIHNLISTGLLSEQLQSNLLQHLAISPWSTDTNTWPLQVYPSTLSVLVQILLLK PIQEKEAACLSVWHRLINTLVDGVCSSSSAGDSDYEDINIEHAQLLLFLFHSLNLMQKKS ILLLTAGGVIRCAEVCRGISAERVVRNSQMMLLSRLLVFLEYLMKHLYHAPPELLDQVRW ILFSVSSMPETQKVSDLINSRTKLNSYCRQDIEEKFRKSSGEYGSNIRPTFYSLVVKEPE KAYWVSEFKLDGLAWNFILCTPDKLKYPLLVDALVDILNIADMSSFSRKENSESNSIHNL CAMQYCFTNTWKLLLGLPPSTSHVEALRIERAPNLHSLVWSTRLPLATSHYLIVNSLIKQ GMYTQYAESLYTQVGDTTADIRYNLKQTILGVEAFNQQMSNKGIPRLSELILFDALVAHM QAVAWAEKEGFKLLRKDCEDSSGGDQSSCTSAASSSGGGNATDHDHPEVYSSNESIDEEK SKHEDDQGLSTETLQRNQMINELLIKLMDSYRYLSEIVREQMLKQLSSTTPEHVLNLIVP IVSDKPAIMLELHAAFLKLLPNEDKQLIANEWPKCLMVNDSAFDGKQHPVEPYTLNVIDA HITELTRGSGGVAYSTLHTLKHCLKTILHLMELLLPYASNCTEMDAQLKPLLIASMLDMR TDYLQGQSEQCLREILSGLTLEAQKLLLYEHMIGYCYRMLIEFAAELRQPAAGGTPLDQE RALFNESMLFAVLKTFIKMLEKPTAVQAMRQFFHDQKTGSLTTLLLSFTGTTLPLSYARK MLQFVERLFEQSTRADSQFQHEDLVDCFSDLATVDVARLKLWLAHIIYGPNMTAGDVSNS ETMDPTCRLLTSIMQPSSSSSSNAQTPTNMATVSAMPSISDQLDAMDIDYDCGAAAGAAG AAPNTSQILSLWQAAQPNPSEESSQACDHSEGGEQRQSERNGGLLLSITKYLVRDQSKAG PIAAPLFQALLQLGQTLISPPHDGCDFADVLQIMITLADASPARGHVALFNTTLLWLELA KLQLPDKHLRHAENVSALLRYLSELLQSIGYRGSRQHMPPWDDELQTDIDDLYDELAEEE QDSLLDDSDEDTLNNKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDV SYAKYGNFFCDCGAKEDGSCQALSRRLGSGEVRESVGPGGSSSCSYLPSHMSLLASKKRS NTAPGATQQQHGAPARKDSISSERIQLLGKLLEPYRETLQHQEQWMLVVRCILEYFDVLL PSIRENCTLYSIVGCHRRATAALQRLHQLEQSFQITDQLMFATLGSQEGAFENVRMNYSG DQGQTIKHLLTSGTIRRVAFCCLSSPHGRRQQLAVSHEKGKVTILQLSALLKQADASKRK LTLTQLSSAPIACTVLSLAANPCNEDCLAVCGLKECHVLTFSSSGSTNEHIVITPQLENG NFLKKAMWLPGSQTLLAIVTTDYVKIYDLSVDTISPKYYYLVAVGKIKDCTFMYHQQDGS GSYFMLSFTSSGYIYTQQLDQQSLAVHGDFYVTNTLELSHQHIKDINGQVCGGGVSIYYS HALQLLFYSYTCGRSFCSPLTNVNEGVKGIYHLDINNTAASTASKSSSASKVPLQSLVGW TEVAGHPGLIYASMHTSNNPVILMITPERIYMQEIKAQSAKSRIMDVVGIRHSVAGTEKT TLLLLCEDGSLRIFSAQPEHTSFWLSPQVQPFGNQLYSSTLLAKNTTNNPQGKSKGGGSA AAGKLLHRKASSQQHQKQLTSGGQPIFPIDFFEHCNMLADVEFGGNDLLQIYNKQKLKTR LFSTGMFVASTKATGFTLEVVNNDPNVVMVGFRVMLGTQDIQRAPVSVTILGRTIPTTMR KARWFDIPLTREEMFQSDKMLKVVFAKSQDPEHVTLLDSIEVYGKSKELVGWPDDSEDVP APSSGPTPVTATQQSAAANFGEGFNCITQLDRMVNHLLEVLDCALHLLGGSAVAAPLRSK VVKTASGLLLLPTPNPVQTQARYVLATLYGSRAAYHSFKDGVILHFVHGELQAMQPKLQQ LESLQEIDPEAFYRLILLVRGVANSRPQSLAKICLENSYDLVPDLMRIVLELHKITPDLD EPVNIVRRGLCQPETIVHCLVEIMYGFALADPGQVGRMTQYFIDLLKHDATVISHSAKEA LILLLSPRMKRRKVAAIAVITPPACSTPTPQMQALQAVAASAANDIIEEAAGVAAGQDQD NAAAALLEAVEGGLPGQQPNHQLLNLEAFMGGGFPRLLGLPEDGDDEAIMDIAIALSLQQ HGGADANALHSLQQGLANIQGIRQAAANAAAASVSVSVSAGGSDDEGSNVATDGSTLRTS PAEPAGSGGSESGGSGVESIGGTSARSSNFGDHPNTTSPRQSCSSVKDGEPGEEQQPGPS GSGGSASAPGGGLSAMSSTEDNNEINEDEKLQKLHDLRIAVLESIIQHLGTFDLCNGLQA IPLIQVIHMLTTDLNGNNERDQQVLQELLQALVEYVEIGKRGAASRMENKCPGNEVRLAL LSLFGVMMGKTKSKQTGTTSPPHQFKDNSSFVASTTANVLSKSGAFVYALEALNTLLVHW KTVLGDPYAPGQAAAPIASGGATSGPGVQLLKPVKHGPKPDISILIPQNYLKNYPDIFES YDGLLTEIIVRLPYQILRLSSAHPDNYDSSFCEAMTFTLCEYMMLNLNTLLRRQVRKLLM YICGSKEKFRMYRDGHSLDAHFRVVKRVCSIVSSKTGAPYNANPPMLSYDSLVDLTEHLR TCQEISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVSPIIIQLLQAAVCNMPANKQQ QQQQPPPAVVSASSKLRSEREKSEDTDAYYSKFDPAQCGTFVHQIFRYACDALIIRFVRI FLLENNISQLRWQAHSFMTGLFEHANERQREKLLTIFWNLWPLVPTYGRRTAQFVDLLGY LTLTTRSITERLPEFVSRAVEVLRTQNELLCKHPNAPVYTTLESILQMNGYYLESEPCLV CNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTISKLIVRIADLKRTKMVRTINVYY NNRSVQAVVELKNRPALWHKARSVSLQSGQTELKIDFPLPITACNLMIEFADFFETVSGS SENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCKYAKFDFS MYARVCCAVDPIESAEDRAKTVLMIHTSLERADRIYHQLLANKQLLELLIQKVAEHRIND RLVEDNMASVHSTSQVNKIIQLLAQKYCVESRASFEELSKIVQKVKACRSELVAYDRQQQ DLPPSNLALVLGAENPTTNRCYGCALASTEQCLTLLRAMAYNYDCRMGLYSQGLVSELAE HNLRRGTPQIQNEVRNLLVVLTKDNAEACMHLLQLVTSRVKSALMGSIPLISLEAAVHQE MTLLEVLLSQDDLCWEYKLKVIFELFISNCKLPRGPVASVLHPCLRILQSLINPTISGSG SGGKPVSAIELSNIKLPEGNTIDYRAWLNSDQNHEYLAWSNRMPISHHQQDAPAGTKPKS SKQQQSAGTETPPRKTKEAARAAYLGEKFGKRWRSNVLDKQRVTKPLVFNAEWIQPLLFN ENSRFGRQLACTLLGGLARTHERKQQALNLLTSFLYHVGEAGEASNEYLALYRSIATESP WLQYLVLRGVLCKISSLLATEIAKVHCMEEHSLSSDLTLGYALRRYVELLWLFLECPNIR RTYKTRLLGPVLESYLALRSLVVQRTRHIDEAQEKLLEMLEEMTSGTEEETRAFMEILID TVDKTRMNDIKTPVFIFERLYSIIHPEEHDESEFYMTLEKDPQQEDFLQGRMLGNPYPSG EMGLGPLMRDVKNKICTDCELIALLEDDNGMELLVNNKIISLDLPVKDVYKKVWLAEGGD RDAMRIVYRMRGLLGDATEEFVETLNNKSQEAVDTEQLYRMANVLADCNGLRVMLDRIGS LQRISRQRELIQVLLKLFLICVKVRRCQEVLCQPEIGAINTLLKVLQMCLQSENDSIQSA VTEQLLEIMETLLSKAASDTLDSFLQFSLTFGGPEYVSALISCTDCPNVRNNPSVLRHLI RVLAALVYGNEVKMALLCEHFKDTLNFKRFDKERTPEEEFKLELFCVLTNQIEHNCIGGT LKDYIVSLGIVERSLAYITEHAPCVKPTLLRTDSDELKEFISRPSLKYILRFLTGLSNHH EATQVAISKDIIPIIHRLEQVSSDEHVGSLAENLLEALSTDAATAARVQQVRDFTRAEKK RLAMATREKQLDALGMRTNEKGQVTAKGSILQKIEKLRDETGLTCFICREGYACQPEKVL GIYTFTKRCNVEEFELKSRKTIGYTTVTHFNVVHVDCHTSAIRLTRGRDEWERASLQNAN TRCNGLLPLWGPSVLETTFSASMTRHSSYMQESTQRCDISYTSSIHDLKLLLVRFAWERS FHDDAGGGGPQSNMHFVPYLLFYSIYMLLSSRSAARDSKTVLAYLTAPPSDKWLECGFEV EGPLYMITISVTLHSRELWNKHKVAHLKRMLAVAQARHVSPSVLCKALLAPADRQVKDYS VYKPYLMMWAMIDMIYNILFKLVTMPKEEAWPVSLFDYIRKNDEAMLKSTDGILHILTEE LLPCTSFGEFCDVAGLLTLIEQPDSFIEDLLASLPSTTSSS NT seq 16146 nt NT seq  +upstreamnt  +downstreamnt atgtcgtcccatagcggcgggaccgattggaactccgtaataaaagctttgcttttaagc cgcacgggtgcattaaacaaaaacgaagtggttaatttgctaaaagcaataaccagatgc gaacacgaatttttcgacgatgaaggcagtttcgtaccattttacacggcctttgcggca ctggctgccgacaaacttatgcaaatcaaatcaatttgtcagacacagatatgccagctg cacgatgccacggcagtgcttattcgctttatactcttccgtctgccaaaagtgtcggtc tttgaatcgaaatggctattggcagccctcaaaatgctctgcgagggcagggagaatgct tcttcggctgtcgcacagttcgactacagtgccgtggctggggtggtgaagagctccaaa catccggaatcatccaataagagtattatgtcaatggcaggtagcaccacaggtggtgct ggtgctggcggcagcaacgataaagagtcaccaaaattggagattaaacgctcgcgctcg gacctatcatcggttatccttcagcagctgttggcgccgctggagccgggaaagatgacc tgggtgcccctcagcgaagagatcaccgactgcactgagcaacttttggcagccaatgtg gaggtgttccaggaggcaaatggcgtcgataccctgttggacatctgcgtgggcctgccc attctcagtcgctatcgcatgaagtacatggagacgataaatgctgggaaacccctctac ctgccactcacacaggcggaggccacaactgtgaaatcatcgatgaatcacatgcttaca gatctctcgattgtgggccaggcctatgctttgatagtcatgcagccgctgacaccgagc cgcattgaaaagctttccatgtgcggcatctcggcgctgtacaatgctgtcctcacctcg atagccaccagtgtcttgagcatgggccaggcgagcagcgcgcagaaacaacagcaacaa cagacggctgctgcagcgtccaccagccagggcagcggcggtggtttgtccagtgtccag acaagcaaagatcacgacgaatttgaagaacaggctagcgggattgtaaacaaagccctc gaaatctattcgagcattggcgagatgttcaaatcctcggccaggatgtatatatatcag aatcatttgtgctacggcagctggctgctcatcagcggcatccagggagccatgggtgcc agtggcagtgcctcggcagaaacggcagccaaagcggcagccgccacaaaagtatcatcc aaaacagagtcgattacagcgcccagtacaccaatagccagggtgaatctgttcaaagtc caacagggctttggagaattgaatgcagctattgccaatcacagcattaagctgctgtcc gaactgattgaggatctaaagattgaatccgcctgcggacagagcagtgtcacagatccc gaaacgctgccagagccagcgcaatttgacatcctgcagaattacacatcgctggaaagg attgtgcgggtcctaaacactgccacgctgcatcagctgttcacttttctggccaccgtg gcctaccgcaaggcatgcactctgaagcgtgcttcaactaaagaccgcaccgaatgcgat ccgattagctattcggactccacgacctgcctgaatgagtccatgtcctattcggacaac tctgaagaagatgacagcgaaagctatctggggcattggttcaaggaaaccctctccccg gaaacgcacgacgacaatgccaatacttcgtcgcaagagcgcagtggagagcagaagagc gctttggtaccgaaactagatgagccgcacgagtatctggagctgtcggcagacatcttc tgcttcctggatcaattcctagccaaccgacatgcctacatgcagcgctatgtgaaggca ggcgtcagcgatcagcagatgctgctgatggccaacataatcaaggactttgatcgcgat gtgatgcgcaacgacagcgaacagcagtcgccaccaagtacggctgctgctgtggctgct gccacaggagctggatcttctggttcctctgccaagtggcaggcgtcgatgatacgtttc tcgggtgctgctggtcgatacatacacaacctgatctccacgggactgctctccgagcag ctccaatcgaatctgctgcaacatttggccatctctccgtggtccacggatacgaataca tggcccctacaggtctatcccagcaccctttccgttcttgtgcagatactgctgctgaaa cccatacaggagaaggaggccgcctgcctgtcggtgtggcatcgcttgatcaacacgctg gttgatggcgtctgctcctcttcgtctgccggtgactcggactacgaggatatcaacatt gagcatgcccagctgctgctctttctgttccactcgctcaatctcatgcaaaagaaatcc atcctgctgctaactgcgggcggggtgatacgctgcgccgaagtctgtcgcggcatcagt gccgagcgtgtcgtcaggaacagccaaatgatgcttctatcgcgcttgctcgtattccta gagtatctgatgaaacatctgtatcacgcaccgcccgaactgttggatcaagtccgctgg atactgttcagcgtgagcagcatgccggagacgcagaaggtctccgatttgatcaacagt cgtaccaaactgaactcgtattgccgtcaggatattgaagagaagttccgcaagtcttca ggagaatatggatcgaatatacggcccacgttttatagcctggtcgtaaaggagcccgaa aaggcgtattgggtgagcgaattcaaattggacggcctggcctggaactttatactctgc acaccggacaaactcaagtatccgctgctggtggacgccctcgtggatatcctgaacata gcggacatgtcctcgttttcccgaaaggagaacagcgagagcaacagcatacacaatctg tgtgccatgcagtattgttttaccaacacctggaaactgctgctgggcctgcccccatcc acctctcacgtggaggcgctccgcattgagcgggcacccaatttgcattcgctggtgtgg agcacacgcctgcccttggccacgtcacattatctgattgtcaatagcctcataaagcag ggcatgtacacacagtacgcagagtcgttgtacacccaagtgggggataccacagccgat atacgatataatttgaagcaaacaatccttggtgtagaggccttcaatcagcagatgagt aacaaaggtattccacgcctctcggaactcatactctttgatgccttggtggcccacatg caggccgtggcctgggccgaaaaggagggcttcaagctgctgcgcaaggactgcgaggat agcagcggtggcgaccaatcatcgtgcaccagtgcggcctccagtagtggtggtggcaat gccacagaccatgatcatcccgaggtgtattcctccaacgaatccatcgatgaagagaaa tccaagcacgaggatgaccagggtctatccacggaaacgctgcaacgcaatcaaatgatc aacgagctgctgatcaagctaatggactcgtatcgctacctatcggagattgtgcgcgag caaatgctcaagcagctgtcgagcaccacgcccgagcatgtcctcaacttgatagtgccc attgtgagcgataagccggccataatgctggagctgcatgcggcattccttaagctgctg ccgaatgaggataagcaattgatagccaatgaatggcccaagtgtttgatggtcaatgat tcggccttcgatggaaaacagcatcccgtggagccatacaccctgaatgttattgatgca cacattacagagctgaccagaggcagcggcggtgtggcctattccactttgcatacgctc aaacactgcctgaagacgatactccatttgatggagctgctgctgccctacgcctccaat tgcaccgaaatggatgcccagttgaagccgctgctgattgcctcaatgctggacatgcgc accgactatctgcagggccagagcgagcagtgtctgagggaaatcttgagcggactgacc ctagaggcgcagaaactgttgctgtacgagcacatgattggctactgctatcgtatgctg atcgaatttgccgcagaattgcgacagccagcggcgggaggcaccccattggatcaagag agagccttgttcaatgaatcaatgctgtttgctgtcctaaagacattcatcaagatgctg gagaagcccacagctgtgcaggccatgcgccagttcttccatgaccagaagacgggcagc ttgaccacgctgctgctgtcctttacgggtaccacgctgcccctgagctatgcccgcaaa atgctgcagtttgtcgaacgtttgtttgagcaatccactcgagcggactcccagttccag catgaggacttggtggattgtttcagcgatctggccacagtcgatgtggcacgtctgaag ctgtggctggcccacataatctatggcccaaatatgacggcaggcgatgtcagcaactcc gagaccatggatccgacatgccgcctgctcacgagcatcatgcagccttcgagcagctcc agtagcaatgcccagacacccacaaacatggccacagtgtcggctatgcccagtatctct gatcagctagatgccatggacatagattacgactgcggggcagcagcaggagcggcagga gctgcacccaacacttcacagatcttgagcctgtggcaggcagcgcagccgaatccctcg gaggagtcctcacaggcctgcgatcacagcgaagggggagagcagcgccaaagcgaacgc aatggaggactactgctgtccatcaccaagtacctagtacgcgatcagagcaaggcaggt ccgatagcagcgcccctcttccaggccctcctacagctgggtcagactttgatcagcccg cctcacgatggctgtgactttgcggatgtcctacagataatgatcaccctggcggatgcc tctccagcacgcggacacgtggcgttgttcaatacgacgctgctgtggctggagctggcc aaactgcagctccccgacaagcatttgcgacacgcggaaaatgtgagcgccctgctgcgg tacctcagcgaactgttgcagagcattggctaccgtggcagtcgccagcatatgcccccg tgggacgacgaactgcagacggacattgacgatctgtacgatgagttggccgaagaggaa caggactcgctgctggatgactccgatgaggacacgctgaacaacaagctgtgcacattc tcgcagacccaaaaggagttcatgaaccagcactggtaccactgtcacacctgcaacatg atcaacacggtcggcgtgtgctctgtgtgtgcccgggtgtgccacaaggggcacgatgtc agctatgccaagtacgggaacttcttctgcgactgtggtgccaaggaggatggctcgtgt caggcgttgagtcgcagattgggctctggagaggtacgcgagtcggtgggacctggcggc agcagcagctgcagctacttgccctcgcacatgagtctcctggcgagtaagaagagaagc aacacagcaccaggagccacacagcagcagcatggagcgcctgcccgcaaggactcgatc agcagtgagagaatccagcttttggggaaactcctcgaaccctaccgtgagacgttgcag catcaggaacaatggatgctcgtggtccgatgcatactcgagtactttgatgtgctgctg ccgtcgataagggagaactgcacgctctactcgattgtgggatgccacaggcgtgccact gccgccttgcagcgtctgcatcagctggagcagagtttccagatcaccgatcaactgatg ttcgccactctgggctcccaggagggggccttcgagaatgtgcggatgaattactccgga gatcaggggcagaccatcaagcacttgctgacctctggcacgatacgccgcgtggccttt tgttgcctgtcctcgccgcacggacgccgccagcagttggccgtgtcgcatgagaaggga aaggtcaccatactgcagctatcggcgttgctcaagcaggcagatgcctccaagcggaag ttgactctcacgcaactgagttccgcgcccattgcctgcactgtgctctcgctggcggcc aatccctgcaatgaggactgcctggccgtgtgtggactgaaagagtgccatgtgctgacc ttctcgagcagcggcagcaccaatgaacacattgtcatcacgccccaattggagaatggc aacttcctgaagaaggccatgtggctgcctggctcccagactctgctggccattgtcacc acggattacgtgaagatctacgacctgtcggtggacacaatcagtccgaagtactactat ctcgtggctgttggcaagatcaaggactgcacgttcatgtaccatcagcaggatggcagc gggagctatttcatgctcagttttaccagctctggctacatctatacgcagcagctggat cagcagagtctggccgtgcacggcgacttttatgtgacaaataccctcgagttgagccat cagcatatcaaggatatcaatggacaggtgtgcggcggtggtgtgtccatctattactcg cacgcgctgcagctgctcttctacagctacacctgcggcaggagcttctgttcgcccctg acgaacgtaaacgagggtgtcaagggcatctatcacttggacatcaacaacacagcagca tcgacggccagcaaatcatcgtcggcttcgaaggtgccgctccagtcgcttgtgggttgg acagaggtggccgggcatcccggactgatctatgccagcatgcatacgtccaataatcca gtgatactgatgatcacacccgaacgcatatacatgcaggagatcaaggcccagtcggcc aaatcgaggataatggatgtggtgggcatacgccatagcgtggcggggactgagaaaacc accctactgctcctgtgcgaggacggcagcctcaggatcttctcggcccaaccagagcac acgagtttctggctgtcgccgcaggtgcaacctttcggcaatcaattgtacagctccacg ctgctggcaaagaataccacaaacaatccgcaggggaaaagcaagggaggcggctctgca gcggctggaaagctgctccatcgcaaggccagcagccaacagcaccagaagcaactgaca tctggaggccagcccatattcccgattgatttctttgagcattgcaacatgctggcggac gtggagtttggcggcaacgatctcttgcagatctacaacaaacagaagctcaagacgcgc ctcttctccacgggaatgtttgtggccagcacaaaggccacgggattcacactggaggtg gtgaacaacgatccaaatgtagtcatggtgggcttccgtgtgatgctgggcacccaggat atccaacgggcacccgtatcagttacgatcctcggacgcaccatacccacaacgatgagg aaggcgcgatggtttgatatacccctgacgcgcgaggaaatgttccaatcggacaaaatg ctgaaggtggtgtttgccaagtcgcaggaccccgaacatgtcacactcctggactctatc gaggtctatggcaagtccaaggagctcgtgggctggcccgacgatagcgaagacgtaccg gcacccagctctggtccgacgcccgtgacggccacgcaacagagtgccgccgccaacttt ggcgagggcttcaattgcatcacccagctggatcgcatggttaaccatctgctggaggtg ctggactgcgccctgcatctgctgggcggcagtgccgtggctgccccactgcgctcgaag gtcgtgaagacagccagcggactgctgctgttgcccacaccgaatcccgttcaaacccag gcccgctatgtgctggccaccctctatggcagtcgggcggcctatcacagcttcaaggat ggcgtgatcctgcacttcgtgcacggcgaactgcaggccatgcagccgaagctgcagcaa ctagaatctctgcaagaaatcgatccggaggccttctatcgcctgatattgctggtacgc ggcgtggccaactcccgtccccagtcactggccaagatctgtctggagaacagctacgat ttggtgcccgacctgatgaggattgtcctggagctgcacaagatcacccccgatctggac gagccagtgaatattgtgagacgcggcctgtgccagccggagaccatcgtccattgtttg gtggagattatgtatggctttgcattggccgatcccggtcaagtgggtcgcatgacccag tacttcattgatctgctcaagcacgatgccaccgtgatcagtcacagcgccaaggaggca ctgatccttctcctcagtccacgcatgaagcgccgcaaggtggcggccatagccgtcatt acgccgcctgcctgctccacgcccacgcctcaaatgcaggccctgcaagcggtggctgca tcggcggccaacgacatcatcgaagaggcagcaggcgtggctgccggacaggatcaagac aatgcagcggccgctctgctcgaggcagtggagggaggactccccggacagcagccgaac caccagctgctcaatctggaggcgttcatgggcggcggtttcccccgattgctgggtcta cccgaagatggcgacgacgaggccatcatggacatagccattgccctgagtctccaacag catggcggagccgatgccaatgccctgcattctctgcagcagggattggccaatatccag ggcatcagacaggcggcagccaatgctgcagcggccagtgtttcggtctctgtgtctgcg ggaggctccgatgatgagggctccaatgtggccaccgatggctccacgctgcgcacctca cccgcagagccggcaggcagtgggggatccgagagcggtggcagtggtgtggagagcatt ggcggcacatcggcgcgcagcagtaactttggcgatcatccgaatacaacgtcaccgcga cagagttgcagttccgtcaaggatggagagccgggcgaggagcagcagccaggacccagt ggctctggtggctctgcctctgccccaggaggcggcctgagcgccatgagcagcaccgag gacaacaacgagatcaacgaagatgaaaagctgcagaaactgcacgatttaaggattgct gttttggagagcattatccagcacttgggcacattcgatctgtgcaatggtctgcaggcc ataccgctcatccaggtgatacacatgctgaccacagatctcaatggcaacaacgaaagg gaccagcaggtgctccaggagctgcttcaggctctagtggagtacgtggaaataggcaaa cgtggagcggcctcaaggatggagaacaaatgtcccggaaatgaagtacgccttgctcta ttgtcgctctttggtgtgatgatgggcaagaccaaatcgaagcaaactggcaccacctcg ccaccgcatcagttcaaggataacagctcatttgtggccagcaccacagcgaatgttctg agcaagagtggggcctttgtctatgctttggaggcactcaacacgctcctcgtgcactgg aaaaccgtgctaggggatccctatgcgccaggccaagccgcagcaccgatcgcgagtggg ggagccacctcgggaccgggcgtacagctgctcaaacccgttaaacacggccccaaacca gatatatccatactgataccgcagaactatctgaagaactatccagatatctttgagtcg tacgacggactgctcacggagatcattgtgcggctgccctaccagattctgcggctaagc agcgcccatccggacaactacgacagcagcttctgtgaggccatgacatttaccttgtgc gagtacatgatgctcaatctgaatacactgctgcgaaggcaggtgcgtaagctgctgatg tacatttgcggcagcaaagagaagttccgcatgtaccgcgatggtcactcgttggatgcg catttccgtgtggtcaagagagtgtgcagcattgtaagcagcaagactggtgccccgtac aatgccaatccgccaatgctcagctacgactcgttggtggatttgacagagcatctgcgc acctgccaggagatcagccaaatgcgcactggcaattggcaaaagttctgtgtggttcat gaggatgccttggccatgctaatggagattgcctgctatcagctagatgatggcgtgtct cccattattatacagctgctgcaggcggccgtttgcaatatgccagccaacaagcagcag caacaacagcagccaccgccagcagtcgtgtcggcgtcttcgaagctgcgcagcgagcgt gagaaaagcgaggacaccgacgcctactattcgaaattcgatccggcacagtgcgggaca tttgtccatcagatatttcggtatgcctgcgatgctttgatcatacgcttcgtaaggatc ttcctgctggagaataatatcagtcagctgcgctggcaggcgcactccttcatgacgggg ctgttcgagcatgccaacgagcggcagcgcgagaagctgttgaccattttctggaacctg tggcccctggtgcccacctatggccgaaggacagcacaatttgtggatctattgggatac ctcactctgacaacacgcagcataaccgaacgcctgccagagtttgtctcgcgggcagtc gaagtactccggacacagaacgagctgctgtgcaagcacccgaatgcccccgtctacacc accctggagtcgatactgcagatgaacggatactatctggaatcggagccctgtttggtg tgcaacaacccggaggtgccgatggccaacatcaagctgccgtcggtcaagtccgactca aaatataccaccacaacgatgatctacaagctggtgcagtgccacaccatctcgaagctg attgtgcggattgcggatctgaagcgcacgaagatggtgcgcacgatcaatgtgtactac aacaatcgcagtgtccaggcggtggtcgagctgaagaaccgccctgcgctgtggcacaag gcccgctccgtttcgctgcaatcgggacagacagagctgaagattgatttcccattgccc atcacggcctgcaatctgatgattgaatttgcggacttctttgagactgtgagcggttcc agcgagaatctgcagtgtccgcgctgcagtgccgctgtgccagcgtatccgggcgtgtgc ggcaactgcggggagaatgtgttccagtgccacaagtgtcgggccatcaactatgacgaa aaggatccgttcttgtgccactcgtgtggcttctgcaagtacgccaaattcgattttagc atgtatgcacgcgtctgctgtgccgtggatccgatcgaatcggccgaggatcgagccaag actgtattgatgatacacacctcactggagcgtgcggatcgcatctaccaccagctgttg gccaacaaacagctgctcgagctgctcatccagaaggtggccgagcatcgcatcaatgat cgtcttgtcgaggacaacatggccagtgtgcatagcacttcgcaggtgaacaagatcatc cagctgctcgcccagaaatactgcgtggaatcacgcgccagcttcgaggaactaagcaag attgtccagaaagtcaaagcctgccgcagcgagctggtggcctacgatcgccaacaacag gatctgccgcccagcaatctggctttggtcttgggcgccgagaatcccacaacgaaccgt tgctatggctgcgccttggcctccactgagcagtgccttaccctgctgcgggccatggcc tacaattatgactgtcgcatgggtctctatagccagggactggtcagcgagctggcggag cataatctgcgccgtggaacaccgcagatccagaacgaggtgcgcaatctgctggtggtg ttgaccaaggacaatgccgaagcgtgcatgcatctgctgcagctggtcacgtcgcgtgtg aagagcgctttgatggggtccattcccctgattagtctggaggcagccgtgcatcaggag atgacgctgctggaggtgcttctcagccaagatgatttatgctgggaatacaagctgaag gtgatctttgagctgtttatcagcaattgcaagttgccccgtggaccggtggcttcagtg ctgcatccctgcctgcgcattctgcagagtctgattaatcccacgatctctggcagcggc agcggcggcaagccagtatctgccattgagttgagcaacattaaactgcccgaaggcaac accatcgactatcgggcgtggctcaactcggatcagaatcacgagtacttggcctggagc aatcgcatgcctatcagccaccaccaacaggatgcaccggcaggcaccaagccaaagagc agcaaacagcagcagtcggcgggcacggagacaccgccaagaaagaccaaggaagccgcc agggcggcatatctgggcgagaagtttggcaaacgttggcgttcgaatgtgctggacaag cagcgtgtgaccaagccgctggtgttcaatgcagagtggatccaaccgttgctcttcaac gaaaactcccgctttggccggcaactggcgtgcacgctgctcggcggacttgcacgcacg cacgaacgcaagcagcaggctctcaatttgctcacgtccttcctgtatcatgtgggggag gcgggagaggccagcaacgagtatttggctctctaccggagcattgccaccgagtcgccc tggctgcagtatttggtgctgaggggagtgctgtgcaagatctcgtcgctgctggctacg gagatagccaaagtgcattgcatggaagagcattcgctgtcctcggacctgacgctcggc tatgccctgcgccgatatgtggagctcttgtggctcttcctcgagtgccccaacatacgc aggacctacaagacccgtctgctgggccccgtgctcgagagctacttggctctgagaagt ctggtggttcagcgaacccgacacattgacgaggcgcaggagaagctgctcgaaatgctg gaggagatgaccagcggcaccgaagaagagacgcgtgcctttatggagattctcattgat acggtcgacaagacgcgcatgaatgacatcaagacgccggtgtttatctttgagcgtctg tattcgatcatacatccggaggagcacgacgagagcgagttctacatgaccctggagaag gatccacagcaggaggacttcctgcagggccgcatgctcggcaatccctatccctccggc gaaatgggtctgggccccctgatgcgagatgtaaagaacaaaatctgcacggactgtgaa ttgattgccctgctggaggatgacaacggcatggagctgctggtgaacaataagatcatt agcttggacctgcccgtcaaggatgtgtacaaaaaggtgtggctggccgagggcggcgat cgcgatgccatgcgtattgtctatcgcatgcgcggactgctgggcgatgccaccgaggag tttgtcgagacgctgaacaacaagagtcaggaggcggtggacacagagcagctataccgc atggccaacgtactggccgattgtaatggccttcgtgtgatgctggacaggattggcagt ctgcagagaatctcccgccagcgtgaacttatccaggttctactcaagctcttcctgatc tgtgtaaaagtgcgccgctgccaggaggtcctgtgccagcccgagattggggccattaat acactgctgaaggtgctacagatgtgcctgcaatcggagaatgactcaatacagtcggca gtcaccgaacaactgctggagattatggaaacgctgctctcgaaggcagccagtgatacg ctggactcgttcctgcagttctccctgacgttcggagggcccgagtatgtgtcggcattg atctcctgcacggattgtccgaatgtacgcaacaatccttcggtgttgcggcatctcatt cgtgtgctggccgccctggtctacgggaatgaggtgaagatggccctgctgtgtgagcat ttcaaggacacactcaacttcaaacgctttgacaaagaacgcacacccgaggaggagttc aagcttgagctcttctgcgtcctgaccaatcagatcgagcacaattgcattggcggcacc ctcaaggattacattgtcagtctgggcattgtggaacgctcgttggcctacatcacagag catgccccatgtgtgaagcccacactcctgcgcaccgactccgacgagctgaaggagttc atttcgcgccctagtctcaagtatatactgcgcttccttaccggactctccaatcatcac gaggccactcaggtggccatcagcaaggacattataccgattatacatcgcctagagcaa gtgtccagcgatgagcatgtcggcagtctggccgagaatcttctagaggctttgtcaacc gatgcagccaccgcggcccgcgtccagcaagtgcgtgacttcacgcgcgccgaaaagaaa cgtctggccatggccacgcgcgagaaacaactggatgccttgggtatgcgtacgaacgag aagggacaggtgacggccaagggctctatactgcaaaagatcgagaaactgcgcgacgag actgggctgacgtgtttcatctgccgcgaggggtatgcctgccagcccgaaaaggtgctg ggcatctatacgttcaccaagcgctgcaacgtggaggaattcgagctgaagtcccgcaaa accattggctacaccacggtgacccatttcaatgtggtccatgtggactgtcacacctca gcgattcgtttgacccgcggccgtgatgaatgggagcgggctagtctgcagaatgccaat acccgatgcaatggtctgctgccgctctggggtccgtccgtgctcgagacgaccttctcc gcctcgatgacgcgtcacagcagctacatgcaggagagcacccagcgttgtgacatctcc tacacgagcagcatacacgacctgaagctgctgctggtgcgtttcgcctgggagcgtagc ttccacgatgatgccggcggcggtggtccccagtccaatatgcactttgtgccctacctg ctcttctattcgatctacatgctgctgtcctcgcgctcggcggccagggatagcaagacg gtactcgcctatctaacagccccgcccagcgataagtggctcgagtgtggcttcgaggta gagggaccgctgtacatgatcaccatttcggtgacgctgcacagtcgcgagctgtggaac aagcacaaggtggcgcatctgaaacgaatgctggccgtggcccaggcacgacacgtctca ccatcggtgctgtgcaaggctctgcttgcgccggccgatcgccaggtgaaggattacagt gtgtacaagccgtacctgatgatgtgggccatgatcgatatgatatacaacatcctgttc aaattggtgaccatgcccaaggaggaggcctggccagtttccctgttcgattacatacgc aaaaatgacgaggctatgcttaagtcaacagatggcatcctacacatcctgactgaggag ctattgccgtgcacttcgtttggcgagttctgcgatgtggcaggacttctaactctgatc gaacagccggacagcttcatcgaggatctgctggcctccctgccttcgaccacaagttct agttaa

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