KEGG   DRUG: トロンチネマブ
エントリ  
D12509                      Drug                                   
一般名   
トロンチネマブ;
Trontinemab (USAN/INN)
組成式   
C8602H13332N2310O2719S56
質量    
194288.0331
分子量   
194407.49
配列    
(Heavy chain)
GNTHKPYGYV RYFDVWGQGT LVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVEDYFP
EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV
DEKVEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP
EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP
IEKTISKAKG QPREPQVYTL PPCRDELTKN QVSLWCLVKG FYPSDIAVEW ESNGQPENNY
KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGGGSGG
GGSGGGGSGG GGSQSMQESG PGLVKPSQTL SLTCTVSGFS LSSYAMSWIR QHPGKGLEWI
GYIWSGGSTD YASWAKSRVT ISKTSTTVSL KLSSVTAADT AVYYCARRYG TSYPDYGDAS
GFDPWGQGTL VTVSSASVAA PSVFIFPPSD EQLKSGTASV VCLLNNFYPR EAKVQWKVDN
ALQSGNSQES VTEQDSKDST YSLSSTLTLS KADYEKHKVY ACEVTHQGLS SPVTKSFNRG
EC
(heavy chain)
QVELVESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA INASGTRTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARGK GNTHKPYGYV RYFDVWGQGT
LVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVEDYFP EPVTVSWNSG ALTSGVHTFP
AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DEKVEPKSCD KTHTCPPCPA
PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP
REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVCTL
PPSRDELTKN QVSLSCAVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLVSKLT
VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
AIQLTQSPSS LSASVGDRVT ITCRASQSIS SYLAWYQQKP GKAPKLLIYR ASTLASGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ NYASSNVDNT FGGGTKVEIK SSASTKGPSV
FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV
VTVPSSSLGT QTYICNVNHK PSNTKVDKKV EPKSC
(light chain)
DIVLTQSPAT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GASSRATGVP
ARFSGSGSGT DFTLTISSLE PEDFATYYCL QIYNMPITFG QGTKVEIKRT VAAPSVFIFP
PSDRKLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H153-H209, H229-L215, H235-h235, H238-h238, H270-H330, H376-H434, H363-H358, H494-H565, H622-H682, H702-l215, h22-h96, h153-h209, h229-l'215, h270-h330, h376-h434, L23-L88, L139-L195, l23-l89, l135-l195, l'23-l'89, l'135-l'195)
  タイプ
Peptide
効能    
認知症治療薬
  タイプ
モノクローナル抗体, 二重特異性抗体
ターゲット 
Amyloid beta [CPD:C16514 C16515]
TFRC (CD71) [HSA:7037] [KO:K06503]
  パスウェイ
hsa04066  HIF-1 シグナル伝達経路
hsa04144  エンドサイトーシス
hsa04145  ファゴソーム
hsa04216  フェロトーシス
hsa04640  造血細胞系譜
階層分類  
ターゲットに基づく医薬品分類 [BR:jp08310]
 ペプチダーゼとインヒビター
  金属ペプチダーゼ
   ファミリー M28
    TFRC (CD71)
     D12509  トロンチネマブ
リンク   
CAS: 2568868-35-7
PubChem: 497620922
LinkDB    

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