KEGG   Desmodus rotundus (common vampire bat): 112300421
Entry
112300421         CDS       T05907                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
dro  Desmodus rotundus (common vampire bat)
Pathway
dro01521  EGFR tyrosine kinase inhibitor resistance
dro04010  MAPK signaling pathway
dro04014  Ras signaling pathway
dro04015  Rap1 signaling pathway
dro04020  Calcium signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04360  Axon guidance
dro04510  Focal adhesion
dro04520  Adherens junction
dro05100  Bacterial invasion of epithelial cells
dro05144  Malaria
dro05200  Pathways in cancer
dro05202  Transcriptional misregulation in cancer
dro05205  Proteoglycans in cancer
dro05206  MicroRNAs in cancer
dro05208  Chemical carcinogenesis - reactive oxygen species
dro05211  Renal cell carcinoma
dro05218  Melanoma
dro05223  Non-small cell lung cancer
dro05225  Hepatocellular carcinoma
dro05226  Gastric cancer
dro05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:dro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112300421 (MET)
   04014 Ras signaling pathway
    112300421 (MET)
   04015 Rap1 signaling pathway
    112300421 (MET)
   04020 Calcium signaling pathway
    112300421 (MET)
   04151 PI3K-Akt signaling pathway
    112300421 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112300421 (MET)
   04520 Adherens junction
    112300421 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    112300421 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112300421 (MET)
   05202 Transcriptional misregulation in cancer
    112300421 (MET)
   05206 MicroRNAs in cancer
    112300421 (MET)
   05205 Proteoglycans in cancer
    112300421 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    112300421 (MET)
   05230 Central carbon metabolism in cancer
    112300421 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    112300421 (MET)
   05226 Gastric cancer
    112300421 (MET)
   05218 Melanoma
    112300421 (MET)
   05211 Renal cell carcinoma
    112300421 (MET)
   05223 Non-small cell lung cancer
    112300421 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    112300421 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    112300421 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112300421 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:dro01001]
    112300421 (MET)
Enzymes [BR:dro01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     112300421 (MET)
Protein kinases [BR:dro01001]
 Receptor tyrosine kinases (RTK)
  MET family
   112300421 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone
Other DBs
NCBI-GeneID: 112300421
NCBI-ProteinID: XP_024411541
LinkDB
Position
Unknown
AA seq 1382 aa
MKAPAGLAPGILVLLFTLVQKSDGECKEALVKSEMNVDMKYQLPNFTAETLIQNVVLHKH
HIYVGAINYIYVLNDKDLQKVAEYRTGPMLEHPDCFPCQNCSHKANFSGGIWKDNINMAL
LVDTYYDDQLISCGSVWRGTCQRHVLPRYNTADIQSKVHCMYSPQADEEPSQCPDCVVSA
LGTKVLMSEKHRFINFFVGNTINSSYLPDYSIHSISVRRLKETQDGFKFLTDQSYIDVLP
EFQDSYPIKYIHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI
LTEKRRKRSPRQEVFNILQAAYVSKPGAHLARQIGANLNDDILYGVFAQSKPDSAEPMKR
SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVHSDEYRTE
FTTALQRVDLFMGQFNQVLLTSITTFIKGDLTIANLGTSEGRFMQVVVSRSGSSTPHVNF
RLDSHPVSPEAVVAQPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPPFVQCG
WCHDKCVRLEKCPSGAWTQEICHPTIYEVFPASAPLEGGTTLTICGWDFGFRRNSKFDLK
KTRILLGNESCTLTLSESTTNMLKCTVAPAVNEHFNMSIIISSDRGTAQYSTFSYVDPII
TSISPSYGPKTGGTLLTLTGKYLNSGNSRHISIGGKTCALKSVSDSTLECYTPAQTTPTE
FPVKLKIDLANRETDSFSYQEDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVLRMVINV
HEVGRNFTVACRHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVVISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYSHSEAILCTVPND
LLKLNSELNIEWKQAVSSTVLGKVIVQPDQNFTGLIVGVVTISVILLLLLGLFLWLKRRK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEEQFPNSSQNG
SCRQMQYPLMDLSPILTGGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLENDDKKIHCAVKSLNRITDLGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPKAELRPSFSELVSRISTIFSTFIGEHYVHVNATYVNVKCVSPYPSLLSSQDKVDGEG
DT
NT seq 4149 nt   +upstreamnt  +downstreamnt
atgaaggcccctgctgggcttgcacctggcatccttgtgcttctgtttaccttggtgcag
aagagtgatggggagtgcaaggaggcactagtaaaatctgaaatgaatgtggacatgaag
tatcagcttcctaacttcactgcagaaacactcatccagaatgttgttttacacaagcat
cacatttatgtcggggccattaattatatttatgttttaaatgacaaagaccttcagaag
gttgctgagtacaggactggacctatgctggaacacccagattgtttcccatgtcagaac
tgcagccacaaagccaatttttcaggtggtatttggaaagataatatcaacatggctctg
cttgttgacacatactatgatgatcaactcattagctgtggaagtgtctggagagggacc
tgccagcgacatgtccttcctcgctacaatactgctgacatacagtcgaaagtacattgc
atgtactccccacaggcagatgaagagcccagccagtgtcctgactgtgtagtgagtgcc
ctgggaaccaaggtcctgatgtctgaaaagcaccggttcatcaacttctttgtgggcaat
accataaattcttcttaccttccagattattcaatacattcgatatcagtgagaaggcta
aaggaaacacaagatggttttaagtttttgacagatcagtcctatattgatgttttacct
gaattccaagattcttaccctattaagtatatccacgcctttgaaagcaaccattttatt
tacttcttgacagtccaacgggaaactcttgatgctcagacttttcacacaagaataatc
aggttctgttctgtagactctggattgcattcttacatggaaatgcctctggagtgtatt
ctcacagaaaaaagaagaaagagatcaccaaggcaggaagtgtttaatattctccaagct
gcatatgtcagtaagcctggggcccatctcgctaggcaaataggtgccaacctgaatgat
gacattctgtatggggtgtttgcacaaagcaagccagattctgctgaaccaatgaaacgc
tctgctgtctgtgcattccctatcaagtatgtcaatgaattcttcaacaagatcgtcaac
aaaaacaatgtgagatgtctccagcacttttatggacccaaccatgaacactgctttaat
cggacacttttgagaaattcatcaggttgtgaagtacacagtgatgaatatcgaacggag
tttaccacagctttgcagcgtgttgacttattcatgggccaattcaaccaagtcctctta
acatctataaccaccttcattaaaggagacctcaccatcgctaatctggggacttcagag
ggtcgctttatgcaggttgtagtttctcgatcaggatcatcaacccctcacgtgaacttt
cgcctggattcccaccctgtgtctccagaagccgtggtggcacagccattaaaccaaaat
ggctacacactggttgtcacggggaagaagatcaccaagatccctctgaacggcctgggc
tgtgaacatttccagtcctgcagtcagtgcctctctgcccctccctttgtacagtgtggc
tggtgccatgacaaatgtgtaagattggagaaatgccccagtggagcatggactcaagag
atttgtcatcctacaatctatgaggttttcccagctagtgcccctctggaaggagggaca
acattgaccatatgcggctgggactttggattcaggaggaatagtaaatttgatttaaag
aaaaccagaattctccttggaaatgagagctgcaccttgaccttaagtgaaagtacaaca
aatatgttaaaatgcacagttgctcctgcagtgaatgagcatttcaatatgtccataatt
atttcaagtgatcgagggacagcgcaatatagtacattttcttatgtggatcctataata
acaagtatttctccaagttatggtcctaagactggtggcactttacttactttaactgga
aagtacctaaatagtgggaactctagacacatttcaattggtggaaaaacctgtgcttta
aaaagtgtgtcagatagtactcttgaatgttataccccagcccaaaccactccaactgag
tttcctgttaagttgaaaattgacttagccaaccgagagactgacagcttcagttaccag
gaagaccctattgtctatgaaattcatccaaccaaatcttttattagtggtgggagcaca
ataacaggtgttggaaaaaacctgaattcagttagtgtcctaaggatggtaataaatgtg
catgaagtaggaaggaacttcacagtggcatgtcgacatcgctctaattcagagataatc
tgctgtactactccttcactacagcagctgaatctgcaactccccctgaaaactaaagcc
tttttcatgttagatgggatccattccaaatacttcgatctcatttatgtacataatcct
gtgtttaagccttttgaaaagccagtggtgatctcaataggcaatgaaaatgtactggaa
attaagggaaatgacattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaat
aagagctgtgagactatatactcacattctgaagctattttatgtacggtccccaatgac
ctgctgaaattgaacagtgagctaaatatagagtggaagcaagcagtttcttcaactgtc
cttggaaaagtaatagttcaaccagatcagaatttcacaggattgattgttggtgttgtc
acaatatctgtaatactcttgttattacttgggcttttcctgtggctgaaaaggagaaag
caaattaaagatctgggcagcgaattagttcgctatgatgcaagagtacacactcctcat
ttggataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaa
tctgtagactaccgagctacttttccagaagagcagtttcctaactcatctcagaatggg
tcatgcagacaaatgcagtatcctctgatggacctgtccccaatcctgactggtggggac
tctgatatatccagtccattactgcaaaataccgtccacattgacctcagtgctctaaat
ccagagctggttcaggcagtccagcacgtagtgattgggcctagtagcctgattgtgcat
ttcaatgaagtcataggaagaggtcattttgggtgcgtataccatgggactttgttggaa
aatgatgacaagaaaattcattgtgctgtgaaatccttgaatagaatcactgacctagga
gaagtttcccaatttctgactgagggaatcatcatgaaagattttagtcatcccaatgtt
ctctcactcttgggaatctgccttcgaagtgaggggtctccactggtggtcctaccgtac
atgaaacatggagatcttcgaaatttcattagaaatgagactcataacccaactgtgaaa
gatcttattggttttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaag
tttgttcacagagacttggcagcaagaaactgtatgctggatgaaaaattcactgtcaaa
gttgctgattttggtcttgccagagacatgtatgataaagaatactacagtgtacacaat
aaaacaggagcaaaactgccagtaaagtggatggctttagaaagtctacaaactcagaag
tttaccaccaagtcagatgtgtggtcctttggtgtgctcctctgggagctgatgacaaga
ggagcaccaccttatcctgatgtcaacacctttgatataacagtttacttgttgcaaggc
cgaaggctcttacaacctgaatactgcccagatcccttatatgaagtgatgctaaaatgc
tggcaccccaaagccgaacttcgcccatccttttcagaactggtctccaggatatcaacg
atattctctactttcattggggagcactacgtccatgtgaatgctacttatgtgaatgtc
aaatgtgtctctccatacccttctctgttgtcatcacaagataaagttgatggcgaggga
gacacatga

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