Desmodus rotundus (common vampire bat): 112306096 Help Entry 112306096         CDS       T05907                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism dro  Desmodus rotundus (common vampire bat) Pathway dro04020   Calcium signaling pathway dro04024   cAMP signaling pathway dro04260   Cardiac muscle contraction dro04261   Adrenergic signaling in cardiomyocytes dro04371   Apelin signaling pathway dro04713   Circadian entrainment dro04911   Insulin secretion dro04921   Oxytocin signaling pathway dro04972   Pancreatic secretion dro05020   Prion disease dro05022   Pathways of neurodegeneration - multiple diseases dro05410   Hypertrophic cardiomyopathy dro05412   Arrhythmogenic right ventricular cardiomyopathy dro05414   Dilated cardiomyopathy dro05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:dro00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112306096 (RYR2)    04020 Calcium signaling pathway     112306096 (RYR2)    04024 cAMP signaling pathway     112306096 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     112306096 (RYR2)    04921 Oxytocin signaling pathway     112306096 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     112306096 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     112306096 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     112306096 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     112306096 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     112306096 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     112306096 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     112306096 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     112306096 (RYR2)    05414 Dilated cardiomyopathy     112306096 (RYR2)    05415 Diabetic cardiomyopathy     112306096 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dro04040]     112306096 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:dro04990]     112306096 (RYR2) Ion channels [BR:dro04040]  Voltage-gated cation channels   Ryanodine receptor    112306096 (RYR2) Domain-containing proteins not elsewhere classified [BR:dro04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    112306096 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  112306096 NCBI-ProteinID:  XP_024417708 LinkDB All DBs Position Unknown AA seq 4964 aa AA seqDB search MRSSRDDSPGPPNPEVLLLPAFLRYFCNDDDEVVLQCTAAAHKEQQKLCLAAEGFGNRLC FLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLL YGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK VRVGDDLILVSVSSERYLHLSYGGSSFHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVL RLLHGHLDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQP FRLRHVTTGKYLSLLEDKTLLLVDKEKADVKSTAFTFRSSKEKLDAGVRKEVDGMGTSEI KYGDSVCYIQHVNTGLWLTYQAVDVKSVRMGATQRKAIMHHEGHMDDGINLSRSQHEESR TARVIRSTVFLFNRFIRGLDALSRKVRAAPGDLPIESVSLSLRDLIGYLHPPDEHLDHED KQNRLRALKNRQNLFQEEGMIGLVLQCVDRLHVYSSAAHFADVAGRDAGASWKSILNSLY ELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHI KSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSS MRPNIFLGISEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWG GNGVGDDLFSYGFDGLHLWAGCIASTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQP VQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKV EHSREYKQERTYTRDLLGPTVPLTQAAFTPVPVDTSQIVLPPHLERVREKLAENIHELWV MNKIELGWQYGPVRDDNKRQHPCLVEFSQLPEQERNYNLQMSLETLKTLLALGCHVGISD EHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQ GWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYSLEAPDQDHAAR AEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGADEHA FAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKD FDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKR LPQFLQVPSNHEHIEVTRIDGTVDSSPCLKVTQKSFGAQNSSTDIMFYRLSMPIECAEVF SRPAAGALPGAGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRADKDKDTPKPEFNNHK DYTQEKPSRLKQRFLLRKTKPDYSTSHSARLTEDVLADDRDDHDYLMQTSTYYYSVRIFP GQEPANVWVGWITSDFHQYDTCFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGEST SPGQGRSNSGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQ FELGRIKNVMPLSAGLFKSEHRNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRVSER QGWLVQCVDPLQFMSLHIPEENRSVDILELTEQEELLRFHSHTLRLYSAVCALGNHRVAH ALCSHVDEAQLLYAIESKYMPGLLRTGYYDLLIDIHLSAYATARLMMNNEFIVPMTDETK SITLFPDEHKEHGLPGIGLSTSLRPRMRFSSPSFVSLNHDCYQDSPEFPLDTLKAKTMQM LTEAVREGGLRARDPVGGTTEFLFVPLIKLFYTLLTMGVFQGEDLKHILQLIEPRVFTEA ALQEERQAPPMEPRTDDARPEGARGDAAEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRI EAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINTLLNFKDD KNECPCPAEIRDQLLDFHGDLMAHCGIELDEDGSPDGNGDLTIRGRLLSLVEKVTYLKKR QAEKPVASDPNKASTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLARAL PKTYTISAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLM RALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLL ENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVS RGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAVEEAIKIAEDPSRDGPSPTSGSSRTLDTDEEDDTVHMGNAIMTFYAALIDLLGRCA PEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFPMPTIAKDGSVVEPDMSAGFCPD HKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTA VLPLLRRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTRAQRDSIEVCLLSICGQLRPS MMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRK LFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDAEGNFNP QPVETSNITIPEKLEYFINKYAEHSHDRWSMDKLANGWIYGETYSDSSKVQPLMKPYKLL SEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYSRTRRISQTSQVSVDAAHGYSP RAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKTELESKGGGNHPLLVPYDTLTAKEKA KDREKAQDILKFLQINGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEF DGGSRSKGQHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEM VTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDS AAEDLEQTLENLKQGQFAHTRHQPRGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLIL EDVQVSCYRILTSLYALGTSKSIYVERQRSSLGECLAAFAGAFPVAFLETHLDKHNSYSI YNTKSSRERAALNLPASVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPLLC SYMSRWWEHGPENHPGKAEACCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFS QPIINKVKPQLLKTHFLPLMEKLKKKAAVVVSEEDHLKAEARGDMSEAELLILDEFTTLA RDLYAFYPLLIRFVDNNRAKWLKEPTPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQN EINNMSFLITDTKSKMSKAAVSDQERKKMRRKGDRYSVQTSLIVAALKRLLPIGLNICAP GDQELIALAKNRLSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDSSD PEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHR AVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGLKRVDPLHQLILLFSRTA LTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEATGSQRSKEKEMEKQKLLYQ QARLHERGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDV GFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLC EGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFS KAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIEL LKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFNMFLKLKDLT SSDTFKEYDPDGKGVISKRDFHKAMESHKHYTPSETEFLLSCAETDENETLDYEEFVKRF HEPAKDISFNVAVLLTNLSEHMPNDTRLQTFLELADSVLNYFQPFLGRIEIMGSAKRIER VYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQIS ESDLNERSASKEESEKERPEEQGPGMGFFSILTVQAALLALRYNLLTLLRMLSLKSLKKQ MKKVKKMTLRDMVSALFSSYWGVLMSLAHFVASVLRGFSRVVGSLLLGGSLVEGAKKMRV AELLANMPDPTQDEVRGDGEEAERRPLEAALPSEDLTDLKELAEESDLLSDIFGLDLKRE GGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKLQEQEVKEEDKEEKEENKSEPEKADGEDG EKEEKAKDEKGRQKLRSIHTHRYGEPEAPESAFWKKIIAYQQKLLNYFARNFYNMRMLAL FVAFAINFILLFYKVSTSSVVEGKELPPRSTSGNTRVGILDSSPNSGPPGAAAVHYVLEE SSGYMEPALRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSE DDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAR EKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHL LDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPD MKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQ GLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLM YLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14895 nt NT seq  +upstreamnt  +downstreamnt atgcgtagtagcagagatgactctcctggccctccaaacccagaagtcctgttactgcct gcgttcctgcgttacttctgcaatgatgacgatgaggtggtgctgcagtgcacggcggcc gcccacaaggagcagcagaagctgtgtttggcagctgaaggatttggcaacagactctgt ttcctggagtccacctcaaattccaagaatgtgccccctgacctctccatctgcaccttt gtgctggagcagtccctctccgtccgggccctgcaggagatgctggcgaacacggtggag aagtcagaagggaaattcatgatgaagactgctcaaggtggtggtcaccggacgctcctg tacggccacgccatcctgctgcgccattcctacagcggcatgtacctgtgctgcctgtcc acctcccggtcttccactgacaaactggcctttgacgttggcttgcaagaagacaccaca ggtgaggcttgctggtggaccatccaccccgcctccaagcagcggtcggaaggagagaag gtgcgcgttggtgatgacctcatcctagtgagtgtgtcctcggaaaggtacttgcacctg tcctatggtggcagcagcttccacgtggatgcggctttccagcagactctctggagcgtg gccccaatcagctcaggaagtgaagcggcccaagggtatctgatcggtggggacgtcctc aggctgctgcacggacacttggacgagtgcctcactgtcccctcgggagagcacggggag gagcagcggaggactgttcattatgaaggtggagccgtatctgtgcacgcgcggtccctg tggagactggagacgctgcgagtcgcgtggagtggaagccatataagatggggccagcct ttcagactgcgccacgtcacaacggggaagtacctgagcctcctggaagacaaaaccctt ctcctggtggacaaagagaaagctgatgtaaagtcgacagcgtttaccttccggtcttcc aaggaaaagttggacgcaggggtgagaaaagaagtcgatggcatggggacctctgagata aagtacggagactcggtctgctacatccagcacgtgaacacaggcctgtggctgacctac caggccgtggacgtgaagtctgtgcgaatgggggccacacagcgtaaggcgatcatgcac cacgaaggccacatggacgacggcataaatctgtcccggtcgcagcatgaggagtctcgg acagctcgcgtgatccgcagcactgtcttcttgttcaataggtttataaggggcctagac gctctcagcaggaaggtgagggcggcgcctggggacttgcccatcgaatcagtcagcctg agcctgcgggacctgattggctacctgcacccgccagacgagcacctggaccacgaggac aagcagaacaggctgagagccctgaagaaccggcagaatctcttccaggaggaggggatg atcggcctcgtgctgcagtgcgtggacaggctgcacgtctacagcagcgcggcccatttt gctgacgtcgctgggagggacgccggcgcgtcctggaagtccatcctgaattctctgtat gagttgctggcggctctcattagaggaaatcgtaaaaactgtgcccagttttctggctcc ctggactggctgatcagccgactagaaagactggaagcttcttcaggtattctggaagtc ttgcactgcgtgttagtagaaagtccagaagctctaaacatcatcaaagaagggcacatc aagtccatcatttcacttctagacaagcacggaagaaatcacaaggttctggacgtcctg tgctccctctgcgtctgccacggagtggctgtccgctccaaccagcacctcatctgcgac aacctccttccaggacgggatctgctgctgcagacgcgcctggtgaaccacgtcagcagc atgaggcccaatattttcctgggcatcagtgaagggtccgctcagtacaagaagtggtac tacgagctgatggtggaccacacggagcccttcgtgacagccgaagccactcacctacgc gtgggctgggcctccacggaggggtactccccctaccccggcgggggcgaggagtggggc gggaacggcgttggagacgacctcttttcctatgggtttgatggcctgcatctctgggca ggttgcatcgccagcaccgtgagttcgcccaaccagcacctgctgcggacagatgacgtc atcagttgctgtttagatctcagcgcgccgagcatctcatttcgaatcaacgggcaacct gtccaaggaatgtttgagaatttcaacatcgatggcctcttctttcctgttgttagcttc tctgcagggataaaggtgcgcttcctgcttggggggaggcacggagaatttaaatttctc cctccacctggctatgctccttgctatgaagctgttctgccgaaagagaagttgaaggtg gaacacagccgagagtacaagcaagaaagaacttacacccgggacctgctgggccccacg gtgccgctgactcaggctgccttcacgccggttcctgtggacaccagccagatcgtgttg cctccccacttggagagggtccgagaaaaactggcagagaatatccatgagctctgggtt atgaacaaaattgaacttggctggcagtatggcccggtcagagacgacaacaagaggcag cacccgtgcctggtggagttctcccagctgcccgagcaggaacgcaattacaacctacag atgtcgctggagaccctgaagactttgttggcattaggatgtcacgtgggcatatcagat gaacacgctgaagaaaaggtgaaaaagatgaagctacccaagaattaccagctgacgagt ggatacaagcctgccccgatggacctgagctttatcaaactcactccgtctcaggaagcg atggtggacaagttggcagaaaatgctcacaacgtgtgggcccgtgatcggatccggcag ggctggacctacggcatccagcaggatgtaaagaacagaagaaaccctcgccttgtcccc tacacgcttcttgatgacagaaccaagaagtccaacaaggacagcctccgggaggctgtg cgcacgctgctggggtacggctacagcctggaggcgccggaccaggaccacgcagcccgg gctgaagtgtgtagcggcaccggggagcggttccggatcttccgtgcggagaaaacttac gctgtgaaggctgggaggtggtacttcgagttcgaggcggtcacggccggagacatgcgg gtcggctggagcaggccaggctgtcagcccgatcaggagctgggcgccgatgagcacgcc ttcgcttttgatggcttcaaggcccagcggtggcaccagggcaatgagcactatgggcga tcttggcaagctggcgacgtcgtgggctgtatggtcgacatgacggagcacaccatgatg ttcacgctgaacggcgagatcctgctcgacgactcaggctccgaactggccttcaaggac tttgacgtgggtgacggattcatacctgtgtgcagccttggggtggctcaggtgggaagg atgaactttggcaaggacgtgagcaccttgaagtacttcaccatctgcggcttacaggag ggctatgaaccgttcgccgttaacacgaacagggacatcaccatgtggctaagcaagcga cttcctcagtttctccaggtcccgtcaaaccatgaacacatcgaggtgaccaggatcgat ggcaccgtggacagctccccgtgtttaaaggtcacgcagaagtcattcggcgcccagaac agcagcactgacatcatgttctaccgcctgagcatgcccatcgagtgtgcggaggtcttc tccaggccagcggctggggcgctgccgggggctggcctctttgggcccaagaacgattta gaggattatgatgtagactccgactttgaggttctgatgaagacagcacatggccacctg gtgcccgatagagctgacaaagacaaggacactccaaaaccagagtttaataaccacaaa gattacacgcaggagaagccctcgcgtctgaaacaaagattcctgctcaggaagacaaag ccagattacagcacaagccactcggcgagactcaccgaagacgtcctcgcagatgaccgg gacgaccacgactacctgatgcagacatccacgtactattactcagtgagaatcttcccc ggacaagaacctgctaacgtctgggtgggctggatcacgtccgatttccatcagtacgac acctgctttgacttggacagagttcgcacagtaaccgttactctcggagacgaaaaagga aaagtgcatgaaagcatcaaacgcagcaactgctacatggtgtgtgcgggcgagagcacg agccccgggcagggacgcagcaacagcggactggagatcggctgcgtggtggacgccgcc agtgggctgctcaccttcacggccaacggcaaggagctgagcacgtactaccaggtggag ccgagtaccaaattgtttcctgcggtttttgcacaagctacaagtcccaacgtctttcag tttgagttgggaagaataaagaacgtgatgcctctgtctgcgggactcttcaagagtgag cacagaaaccctgtgcctcagtgccccccacggctgcatgtccagttcctgtcacacgtc ctgtggagcagaatgcccaaccagttcctgaaggtggatgtgtcccgggtcagcgagcgc cagggctggctggtacagtgcgtggaccccctgcagttcatgtccctgcacatccccgag gagaacaggtctgtggacatcctggagctgaccgagcaggaggagctgctgcgcttccac tcgcacaccctgcggctctactcggccgtgtgcgccctgggcaaccaccgcgtggcgcat gcgctctgcagccacgtggatgaggcgcagctgctctacgccatcgagagcaagtacatg cctggcctgctgcgcaccggttactacgacctgctcatcgatatccacctgagcgcctac gccaccgcccggctcatgatgaacaacgagttcattgtgcccatgaccgatgagaccaag agcatcacactcttccccgacgagcacaaggagcacgggctgcctggcatcggcctcagc acctcactgcggccacgcatgcgcttctcctcacccagctttgtgagcctcaaccacgac tgctaccaggacagccccgagttcccactggacacgctcaaggccaagaccatgcaaatg ctgactgaggctgtgcgggagggtggactgcgggcgcgggaccctgtagggggcactacc gagttcctctttgtgccgctcatcaagctcttctacacgctgctcaccatgggtgtcttc caaggcgaggacttgaagcacatcctgcagctgatcgagccccgggtgttcacggaggct gccctgcaggaggagaggcaggcaccacccatggagccccgcaccgatgacgccaggccc gagggcgcacgtggggatgcagcagaggggctgctgcagatgaagcttcctgagcccgtg aagctgcagatgtgcctgctccttcagtacctctgtgactgccaggtccgacaccggata gaagccattgtggccttttcagatgactttgtcgccaagctgcaagacaaccagcgcttc cgctacaatgaggtgatgcaggccttaaacatgtcggccgcgctcacagccaggaagaca aaggagttcaggtccccgcctcaagaacagatcaacacgcttctcaactttaaggatgac aaaaacgagtgtccgtgtcctgcggaaatccgggaccagctcctggattttcacggagat ctcatggcacattgtggaattgagctggatgaagacggctctccggatggcaacggcgac ttaacaatcagaggccgcctgctgtccctggtagaaaaggtgacgtacctgaagaagaga caagcggaaaagccagtggcgagcgaccccaacaaggcctccactctgcagcagctgatc tcggagaccatggtccggtgggctcaggagtccgtcatagaggaccccgagctggtacgg gccatgtttgtgctgctgcaccggcagtacgatggcatcggcgggctggcgcgggctctg cccaagacctacacgatcagcgccgtgtccgtggaggacaccatcaacctgctggcctcc ctcgggcagatccgctcgctgctgagcgtgaggatgggccgagaagaggagaagcttatg attcggggattaggggacatcatgaataataaagtgttctaccagcaccctaacctcatg agggcgctggggatgcacgagacggtgatggaggtcatggtgaacgtcctgggcggtggg gagtccaaggagatcacttttcccaagatggtggccaactgttgccgttttctctgttac ttctgtcgtataagtcggcagaaccagaaagctatgtttgatcatctcagttatttattg gaaaacagcagcgttggtctcgcctcaccagcaatgcgagggtcgaccccgctggatgtg gccgccgcctcagtgatggataacaatgagctggccttggcactgcgtgagccagatctg gaaaaggtcgtgcgatatctggccggctgcggactgcagagctgccagatgctggtgtcc agggggtacccggacatcgggtggaacccagtcgaaggggagcgatacctcgactttctg cgattcgctgtcttctgtaatggggagagtgtggaggagaacgccaacgtggtggtgagg ctgctcatccggaggcccgagtgtttcggccccgccctgcggggggagggcgggaacggt cttcttgctgctgtggaagaggccatcaagatagctgaggacccttctcgagacggtccc tcaccaaccagcgggtccagcagaacccttgacacagatgaggaggacgacactgtccac atggggaacgccatcatgaccttttacgctgctctgattgacctgctgggacgctgtgcc cctgaaatgcatttgattcatgccggtaagggagaagccatcaggatcagatccattctg agatccctcattccgctgggagacttggtgggagtgatcagcatcgctttcccgatgccc acgatagccaaggatgggagtgtggtggagcccgacatgtctgcggggttttgcccagac cacaaggcagccatggttttgttccttgacagggtctatgggattgaggtccaagatttc ctcctccacctgctagaggtcggctttctgccagatctccgggctgctgcttctttagat acggcggccctgagtgctacggacatggccttggccctcaaccggtacctctgcacagct gtgctgcccctgctgaggaggtgcgccccgctcttcgccggcaccgagcaccacgcttcc ctcatcgactcgctgctccacaccgtgtacaggctgtcgaagggctgctcgctgaccagg gcccagcgggactccatagaagtttgcttgctgtccatctgcggccaactgagaccttcc atgatgcagcacttactgagaagattagtgttcgacgttccgttgttaaatgaacatgca aagatgcctcttaagctgctgacaaatcattatgaaaggtgctggaaatactactgtctg cctggagggtgggggaacttcggagctgcctcagaagaagaacttcatttatcaagaaaa ttgttctggggaatttttgatgccctgtctcaaaagaaatatgaacaagaacttttcaaa ctggccctgccttgcctgagtgctgtggccggagctttgcctccagactacatggagtcc aattacgtcagcatgatggaaaaacagtcctccatggatgccgaaggcaacttcaaccca caacctgtggaaacctcaaatatcacaattcccgagaagctggaatacttcattaacaaa tatgctgagcactcccatgacagatggtccatggacaagttggccaatggatggatttat ggggaaacatattcagactcatctaaagttcaaccgttaatgaaaccatataaactatta tctgaaaaggagaaagaaatttatcgctggcccatcaaagaatccttaaagacgatgctg gcatggggctggaggatcgagcgcacgcgggagggggacagcatggcgctctacagccgg acgcggcgcatctcgcagaccagccaggtttctgtagacgctgcccatgggtacagcccc cgggccattgacatgagcaacgtcacgctgtccagagacctgcatgccatggcagaaatg atggctgaaaactaccacaatatatgggcaaagaaaaagaaaacggagctggagtccaaa ggagggggaaaccaccccctgctggtgccttatgacacgctgacagccaaggagaaagcc aaggacagggagaaagctcaggacatcctcaagtttctgcagatcaacgggtacgccgtg tccaggggcttcaaggacctggacttggacacgccgtccattgagaagcggttcgcctac agtttccttcagcagctcatccgctacgtggacgaggcccatcagtacatcctggagttc gatggcggcagcagaagcaaaggacagcatttcccttacgaacaagaaatcaagttcttt gctaaagttgttctgcctttaattgatcagtatttcaaaaaccatcgtttgtacttcttg tctgcagcgagcagaccgctctgctctggaggacatgcctcaaacaaggaaaaagaaatg gtgacgagcctgttctgcaaactcggagttcttgtcaggcataggatttcactgtttgga aatgatgcaacatcgattgtcaactgcctgcacattctgggccagactttggatgcgagg acggtcatgaagacgggcctggagagcgtgaagagcgccctccgggcgttcctggacagc gccgcagaggacctggagcagacgctggagaacctgaagcagggccagtttgcccacacc cgccaccagcccaggggcgtcacccagatcatcaactacaccacggtggcactgctgccc gtgctgtcctcgctgtttgagcacatcggccagcaccagtttggagaagacctgatactg gaagatgtgcaggtatcctgttacagaattctaaccagcttatatgctttggggacgagc aagagtatttatgtggaaaggcagcgctcctcgctgggggagtgtctggcagccttcgcg ggtgcctttcccgtggcgtttctggaaactcatctcgacaaacataatagctactccatc tataacaccaagtcttcacgagagagagcagctctcaatctgccagcaagtgtggaagat gtctgtccaaacataccatctttggagaagctcatggaggagatcgtggaactagccgag tctggtatccgctacacgcagatgccgcacgtgatggaagtcatcctgcccctgctgtgc agctacatgtcccgctggtgggagcacgggcccgagaaccacccgggcaaggcagaggcc tgctgcacagccctgaactccgagcacatgaacaccctgctggggaacatactgaagatc atctacaacaacctggggattgacgagggggcctggatgaagaggctagcagtgttttcc cagcctataataaataaagtgaagccgcagctcctgaaaacgcatttcttgccattgatg gagaaactgaagaaaaaggcagccgtggtggtttcagaggaagaccatctgaaagccgag gcccggggggacatgtctgaggctgaacttctcatcctggacgagttcaccacgctggcc agggacctgtatgccttctaccctctcctgattcgatttgtggacaataacagggcaaag tggctcaaagagcctaccccggaggccgaggaccttttccgcatggtggccgaagtgttt atctactggtcaaaatcccacaacttcaagagagaagagcagaacttcgtcgtccagaat gaaatcaacaacatgtctttcctgattactgacaccaagtcaaagatgtcaaaggctgcg gtttccgaccaggagcggaagaagatgaggcggaagggcgaccgctactccgtgcagacc tcgctcatcgtggccgccctgaagcggctgctgcccatcgggctgaacatctgcgcacct ggagaccaggagctcatcgctctggccaagaatcggctgagtatgaaagacactgaggat gaggtccgagatataatccgcagtaatattcatttacaaggcaagttggaggaccctgct attaggtggcaaatggccctttacaaagacttacctaacaggactgaagacagttcagat cctgagaagacggtggagagagtcctggacatagccaacgtgctcttccaccttgaacag gtggagcaccctcagagatctaagaaggccgtctggcacaagctgctctccaagcagagg aagagggcggtggtggcctgcttccggatggcccctctctacaacctgccaaggcatcgg gccgtcaatctcttccttcagggatatgaaaagtcctggattgaaacggaagaacattac tttgaagataaactgatagaagatttagcaaaacctggagcagaacctcccgaggaggac gaaggcttgaagagagtggaccctctgcatcagctcatcctcctgttcagtcgcacggcc ctcacggagaaatgcaaactggaggaagattttttatacatggcttatgcagatattatg gcaaagagttgtcatgatgaagaagatgacgacggtgaagaggaagtgaagagttttgaa gccacaggatcccagcgcagcaaggagaaggagatggagaagcagaagcttctgtaccag caagcccggctgcacgagcgtggcgccgccgagatggtgctgcagaccatcagcgccagc aaaggggaaaccggaccgatggtggctgctactctgaaacttggaattgctatcctgaat ggcggcaactccacagtacagcagaaaatgctcgactacctcaaggagaaaaaggacgtg ggtttcttccagagcctggctggcctgatgcagtcctgcagcgtcctcgacctgaatgca tttgagcggcagaacaaagccgaaggacttggaatggtgacagaggaaggatcaggagaa aaggttcttcaggatgacgagttcacctgtgacctcttccgcttcctgcaactgctctgt gagggacacaactcagattttcagaactatctgagaacccagaccggcaacaacaccacc gtcaacatcatcatctccaccgtggattacctgctgagggttcaggaatcgatcagtgat ttctactggtattactctgggaaagatgtcatcgatgagcaagggcagcggaacttctcc aaagccattcaagtagcaaaacaagtcttcaacacgctcacggagtacattcagggcccc tgcaccggcaaccagcagagcctggcccacagccggctctgggacgccgtcgtgggcttc ctccacgtgttcgcccacatgcagatgaagctgtcgcaggactccagtcaaatcgagctg ctgaaagaactcatggacctccagaaggacatggtggtcatgctgctgtccatgctggaa ggtaacgtcgtcaatggaaccatcggcaagcagatggtcgacatgcttgtggagtcttcc aacaacgtggagatgattctcaaattcttcaacatgttcttaaaactgaaggacttgaca tcttctgatacatttaaggaatacgaccctgatggcaagggggttatttccaagagggac ttccacaaagccatggaaagccacaagcactacacgccgtcagaaactgagttccttctg tcctgtgcggaaacagatgagaatgaaaccctagactacgaggaatttgtcaaacggttc cacgagcccgcgaaggacatcagcttcaacgtcgccgtcctcctgaccaacctctcggag cacatgcccaatgacacacggctacagaccttcctagaactggcggacagcgtgctcaac tacttccagcccttcctgggccgcatcgagatcatgggcagtgccaagcgcatcgagaga gtttactttgagatcagtgagtccagccggacgcagtgggagaagccccaggtcaaggag tccaaaaggcagttcatctttgacgtggtcaatgagggtggcgagaaggagaagatggag ctcttcgtgaacttctgcgaggacaccatatttgagatgcagctggcggcccagatctca gagtcggacctgaacgagaggtcggccagcaaggaggagagcgagaaggaacggccggag gagcagggcccggggatgggcttcttctccatcctgactgtgcaggcagccctgctggcc ctcaggtacaacctcctgaccctcctgcgcatgctcagcctgaagagcctgaagaagcag atgaagaaggtgaagaagatgactctgagggacatggtctcggccctcttctcctcctac tggggtgtcctgatgagcctcgcacacttcgtggccagtgtcctccgtggcttctcccgc gtagtgggcagcctgctcctggggggcagcttggtggaaggcgccaagaagatgagagtg gcagagctcctggcaaacatgccagaccccacgcaggacgaggtgaggggcgacggggag gaggccgagaggaggcccctggaggccgccctgccctcggaggacctcacggacctgaag gagctggcggaggaaagtgaccttctctcggacatatttggcttggacctgaagcgagaa ggagggcagtacaaactcattcctcataacccgaatgcgggcctcagcgacctcatgagc aaccccgtgcccattcccgaggtgcaggaaaagcttcaggaacaggaggtgaaagaggag gacaaggaagaaaaagaagaaaacaaatcggaacctgaaaaagccgatggagaagacgga gagaaagaggagaaggccaaggatgagaagggcaggcagaagctccggtcgatccacaca cacagatacggagagccagaggctcctgagtcggcattctggaagaaaatcatagcttat caacagaagcttctaaactattttgctcgcaacttttacaacatgagaatgttagcctta tttgtcgcatttgcaatcaatttcatcttgctcttttataaggtgtccacttcttctgtg gttgaaggaaaggagctcccccctcgcagcacaagtggaaacaccagagtgggcatcctg gacagcagccccaacagcggcccgcccggtgcggcggctgtgcactacgtcctggaggag agcagcggctacatggagcccgccctgcgcatcctggccgtgctgcacaccgtcatctcc ttcttctgcatcatcggctactactgcttgaaagtcccgctggttatttttaagcgtgaa aaggaagtagctcgaaaattggaatttgatgggctttatattacagaacagccttcggaa gatgatattaaaggccagtgggatagactcgtgatcaacacacagtcatttcccaacaac tactgggacaaatttgttaaaagaaaggttatggataaatatggagagttttatggcagg gacagaattagtgagctgctcgggatggacaaagcggctctggacttcagtgacgcccgg gagaagaagaagccgaagaaagacagctccctgtcagctgtgctgaactccatcgatgtg aagtatcagatgtggaaacttggagtggtcttcactgacaactccttcctctaccttgcc tggtacatgaccatgtccattcttggacactacaacaacttcttctttgctgctcacctt ctcgacattgctatggggttcaagacgctgagaaccatcttgtcatcagtaactcacaat ggcaagcagcttgtgttaactgtgggcttattagccgttgttgtgtacctgtacactgtc gtggcgttcaacttcttccggaaattctacaataaaagtgaagatggcgacaccccagac atgaaatgtgatgacatgctcacgtgctacatgttccacatgtacgtgggcgtgcgtgcc ggagggggcatcggcgacgagatcgaagaccccgcgggcgatgagtatgagatctatcgg atcatcttcgacatcaccttcttcttcttcgtcatcgtcatcctcctggccataatacaa ggtttaattattgatgcatttggagaactaagagaccaacaggaacaagtgaaggaagac atggagaccaaatgcttcatctgtgggataggcaatgattacttcgacacggtgccgcac ggcttcgaaacccacaccttacaggagcacaacttggccaattacctgttttttctgatg tatctcataaataaagacgaaacggagcacacaggacaggagtcttacgtctggaagatg tatcaggaaagatgctgggagtttttccccgcaggggactgtttccggaaacagtacgaa gaccagctgaattaa

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